Compounds > 4-nitroquinoline-1-oxide
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4-nitroquinoline-1-oxide and Carcinoma

4-nitroquinoline-1-oxide has been researched along with Carcinoma in 25 studies

4-nitroquinoline N-oxide : A quinoline N-oxide carrying a nitro substituent at position 4.

Carcinoma: A malignant neoplasm made up of epithelial cells tending to infiltrate the surrounding tissues and give rise to metastases. It is a histological type of neoplasm and not a synonym for cancer.

Research Excerpts

ExcerptRelevanceReference
"An important rat model using the chemical carcinogen 4-nitroquinoline-1-oxide (4NQO) has been described for the study of the process of oral carcinogenesis."8.31Proposal of a secure and efficient protocol for a murine oral carcinogenesis model induced by 4-nitroquinoline-1-oxide (4NQO). ( Campagnol, D; Castilho, RM; Danilevicz, CK; Garcez, TNA; Martins, MAT; Martins, MD; Michel, CHT; Schmidt, TR; Schuch, LF; Vargas, PA, 2023)
"An important rat model using the chemical carcinogen 4-nitroquinoline-1-oxide (4NQO) has been described for the study of the process of oral carcinogenesis."4.31Proposal of a secure and efficient protocol for a murine oral carcinogenesis model induced by 4-nitroquinoline-1-oxide (4NQO). ( Campagnol, D; Castilho, RM; Danilevicz, CK; Garcez, TNA; Martins, MAT; Martins, MD; Michel, CHT; Schmidt, TR; Schuch, LF; Vargas, PA, 2023)
"One differentiated squamous cell carcinoma (SCC) cell line (RSC3-E2) and two undifferentiated tumor cell lines (RSC3-LM and RSC3-E2R) with different metastatic potential were established from a 4-nitroquinoline N-oxide (4NQO)-induced differentiated SCC in F344 rat tongue."1.31Isolation of differentiated squamous and undifferentiated spindle carcinoma cell lines with differing metastatic potential from a 4-nitroquinoline N-Oxide-induced tongue carcinoma in a F344 rat. ( Fukushima, S; Kurita, K; Moriuchi, T; Nakanishi, H; Takeuchi, S; Tatematsu, M; Tonoki, H; Tsukamoto, T; Yamamoto, S; Yoshida, K, 2000)
"Invasive carcinomas were either endophytic or exophytic."1.27Experimental tongue carcinoma of rats induced by oral administration of 4-nitroquinoline 1-oxide (4NQO) in drinking water. ( Ohne, M; Satoh, T; Takai, H; Yamada, S, 1985)

Research

Studies (25)

TimeframeStudies, this research(%)All Research%
pre-199010 (40.00)18.7374
1990's8 (32.00)18.2507
2000's1 (4.00)29.6817
2010's4 (16.00)24.3611
2020's2 (8.00)2.80

Authors

AuthorsStudies
Aziz, Z1
Washington, MK1
Jacobse, J1
Choksi, Y1
Schuch, LF1
Campagnol, D1
Schmidt, TR1
Michel, CHT1
Garcez, TNA1
Danilevicz, CK1
Castilho, RM1
Martins, MAT1
Vargas, PA1
Martins, MD1
Sawant, S1
Dongre, H1
Kanojia, D1
Jamghare, S1
Borges, A1
Vaidya, M1
de Souza, MV1
Servato, JP1
Loyola, AM1
Cardoso, SV1
Chammas, R1
Liu, FT1
Silva, MJ1
de Faria, PR1
Abbasi, MM1
Helli, S1
Monfaredan, A1
Jahanban-Esfahlan, R1
Vered, M1
Grinstein-Koren, O1
Reiter, S1
Allon, I1
Dayan, D1
ENDO, H1
KUME, F1
MORI, K1
HIRAFUKU, I1
Sekigawa, K1
Hirao, F1
Yoshimoto, T1
Namba, M1
Wilson, DF2
Vreugdenburg, A1
Wiebkin, OW2
Patel, V2
Poulopoulos, AK1
Levan, G1
Game, SM1
Eveson, JW2
Prime, SS2
Tanaka, T1
Kojima, T1
Hara, A1
Sawada, H1
Mori, H1
Nishimura, A1
Jiang, DJ1
Pierce, AM1
Davies, M1
Paterson, IC1
Stone, A1
Huntley, S1
Curtis, R1
Matthews, JB1
Pring, M1
Seo, YR1
Lee, SH1
Han, SS1
Ryu, JC1
Takeuchi, S1
Nakanishi, H1
Yoshida, K1
Yamamoto, S1
Tonoki, H1
Tsukamoto, T1
Fukushima, S1
Moriuchi, T1
Kurita, K1
Tatematsu, M1
Hennings, H1
Shores, R1
Balaschak, M1
Yuspa, SH1
Tonogi, M1
Takaki, T1
Satoh, T2
Yamada, S2
Ohne, M1
Takai, H1
Kobayashi, A1

Other Studies

25 other studies available for 4-nitroquinoline-1-oxide and Carcinoma

ArticleYear
A method for scoring 4-nitroquinoline 1-oxide-induced murine esophageal squamous neoplasia.
    Veterinary pathology, 2023, Volume: 60, Issue:3

    Topics: 4-Nitroquinoline-1-oxide; Animals; Carcinogens; Carcinoma; Esophageal Neoplasms; Esophageal Squamous

2023
Proposal of a secure and efficient protocol for a murine oral carcinogenesis model induced by 4-nitroquinoline-1-oxide (4NQO).
    Pathology, research and practice, 2023, Volume: 247

    Topics: 4-Nitroquinoline-1-oxide; Animals; Carcinogenesis; Carcinogens; Carcinoma; Male; Mice; Rats; Rats, W

2023
Role of Electron Microscopy in Early Detection of Altered Epithelium During Experimental Oral Carcinogenesis.
    Microscopy and microanalysis : the official journal of Microscopy Society of America, Microbeam Analysis Society, Microscopical Society of Canada, 2019, Volume: 25, Issue:6

    Topics: 4-Nitroquinoline-1-oxide; Animals; Carcinogens; Carcinoma; Disease Models, Animal; Early Diagnosis;

2019
Expression of APC protein during tongue malignant transformation in galectin-3-deficient mice challenged by the carcinogen 4-nitroquniline-n-oxide.
    International journal of clinical and experimental pathology, 2014, Volume: 7, Issue:6

    Topics: 4-Nitroquinoline-1-oxide; Adenomatous Polyposis Coli Protein; Animals; Carcinogens; Carcinoma; Cell

2014
Hesa-A Improves Clinical Outcome of Oral Carcinoma by Affecting p53 Gene Expression in vivo.
    Asian Pacific journal of cancer prevention : APJCP, 2015, Volume: 16, Issue:10

    Topics: 4-Nitroquinoline-1-oxide; Animals; Carcinoma; Gene Expression; Genes, p53; Male; Phytotherapy; Plant

2015
The effect of desalivation on the malignant transformation of the tongue epithelium and associated stromal myofibroblasts in a rat 4-nitroquinoline 1-oxide-induced carcinogenesis model.
    International journal of experimental pathology, 2010, Volume: 91, Issue:4

    Topics: 4-Nitroquinoline-1-oxide; Actins; Animals; Carcinoma; Cell Proliferation; Cell Transformation, Neopl

2010
COMPARATIVE STUDIES ON THE BIOLOGICAL ACTIONS OF 4-NITROQUINOLINE 1-OXIDE AND ITS REDUCED COMPOUND, 4-HYDROXYAMINOQUINOLINE 1-OXIDE.
    Gan, 1963, Volume: 54

    Topics: 4-Hydroxyaminoquinoline-1-oxide; 4-Nitroquinoline-1-oxide; Animals; Carcinogens; Carcinoma; Carcinom

1963
HISTOGENESIS OF LUNG CARCINOMA IN MICE INDUCED BY 4-NITROQUINOLINE 1-OXIDE: CARCINOMA ARISING FROM AREAS OF ADENOMA.
    Gan, 1964, Volume: 55

    Topics: 4-Nitroquinoline-1-oxide; Adenocarcinoma; Adenoma; Animals; Carcinogens; Carcinoma; Lung Neoplasms;

1964
[Microangioarchitecture of 4-nitroquinoline 1-oxide (4NQO)-induced tongue carcinoma in rats].
    Shika gakuho. Dental science reports, 1983, Volume: 83, Issue:8

    Topics: 4-Nitroquinoline-1-oxide; Animals; Autoradiography; Carcinoma; Carcinoma in Situ; Male; Microcircula

1983
[Experimental lung cancer in rabbits, mice and rats induced by chemical carcinogens (author's transl)].
    Nihon Kyobu Shikkan Gakkai zasshi, 1981, Volume: 19, Issue:11

    Topics: 4-Nitroquinoline-1-oxide; Adenocarcinoma; Animals; Benzopyrenes; Carcinoma; Carcinoma, Squamous Cell

1981
Proteoglycan changes in carcinogen (4NQO)-treated rat tongue mucosa.
    Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology, 1995, Volume: 24, Issue:3

    Topics: 4-Nitroquinoline-1-oxide; Administration, Topical; Animals; Body Water; Carcinoma; Connective Tissue

1995
Loss of expression of basement membrane proteins reflects anomalies of chromosomes 3 and 12 in the rat 4-nitroquinoline-N-oxide model of oral carcinogenesis.
    Carcinogenesis, 1995, Volume: 16, Issue:1

    Topics: 3T3 Cells; 4-Nitroquinoline-1-oxide; Animals; Basement Membrane; Carcinoma; Carcinoma, Squamous Cell

1995
Chemoprevention of oral carcinogenesis by DL-alpha-difluoromethylornithine, an ornithine decarboxylase inhibitor: dose-dependent reduction in 4-nitroquinoline 1-oxide-induced tongue neoplasms in rats.
    Cancer research, 1993, Feb-15, Volume: 53, Issue:4

    Topics: 4-Nitroquinoline-1-oxide; Animals; Carcinoma; Dose-Response Relationship, Drug; Drug Screening Assay

1993
Changes in Bcl-2 and Bax expression in rat tongue during 4-nitroquinoline 1-oxide-induced carcinogenesis.
    Journal of dental research, 1999, Volume: 78, Issue:6

    Topics: 4-Nitroquinoline-1-oxide; Animals; Apoptosis; bcl-2-Associated X Protein; Carcinogens; Carcinoma; Ce

1999
Oral cancer: role of the basement membrane in invasion.
    Australian dental journal, 1999, Volume: 44, Issue:2

    Topics: 4-Nitroquinoline-1-oxide; Animals; Basement Membrane; Carcinogens; Carcinoma; Cell Movement; Collage

1999
Loss of differentiation of 4NQO-induced rat malignant oral keratinocytes correlates with metastatic dissemination and is associated with a reduced cellular response to TGF-beta1 and an altered receptor profile.
    Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology, 1999, Volume: 28, Issue:9

    Topics: 4-Nitroquinoline-1-oxide; Animals; Carcinoma; Carcinoma, Squamous Cell; Cell Differentiation; Cell T

1999
Effect of p53 tumor suppressor on nucleotide excision repair in human colon carcinoma cells treated with 4-nitroquinoline 1-oxide.
    Research communications in molecular pathology and pharmacology, 1999, Volume: 104, Issue:2

    Topics: 4-Nitroquinoline-1-oxide; Carcinogens; Carcinoma; Colonic Neoplasms; Comet Assay; DNA Damage; DNA Re

1999
Isolation of differentiated squamous and undifferentiated spindle carcinoma cell lines with differing metastatic potential from a 4-nitroquinoline N-Oxide-induced tongue carcinoma in a F344 rat.
    Japanese journal of cancer research : Gann, 2000, Volume: 91, Issue:12

    Topics: 4-Nitroquinoline-1-oxide; Animals; Carcinogens; Carcinoma; Carcinoma, Squamous Cell; Clone Cells; Ka

2000
Sensitivity of subpopulations of mouse skin papillomas to malignant conversion by urethane or 4-nitroquinoline N-oxide.
    Cancer research, 1990, Feb-01, Volume: 50, Issue:3

    Topics: 4-Nitroquinoline-1-oxide; 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinoma; Cocarcinogenesis; Mi

1990
[Experimental study on the effects of peplomycin on tongue carcinoma induced by 4-nitroquinoline 1-oxide (4 NQO) in rats. Part 2. Effects of peplomycin on tongue-epithelium lesions induced by 4NQO in rats].
    Shika gakuho. Dental science reports, 1988, Volume: 88, Issue:6

    Topics: 4-Nitroquinoline-1-oxide; Animals; Bleomycin; Carcinoma; Peplomycin; Rats; Rats, Inbred Strains; Ton

1988
[Cell proliferation in the carcinogenetic processes of tongue carcinoma induced by 4-nitroquinoline-1-oxide in rats. 1. Relation between morphology and microvascular architecture of the filiform papillae of dorsal surface of the tongue in normal albino ra
    Shika gakuho. Dental science reports, 1986, Volume: 86, Issue:3

    Topics: 4-Nitroquinoline-1-oxide; Animals; Arterioles; Carcinoma; Cell Division; Cell Transformation, Neopla

1986
[The developmental process of tongue carcinoma induced by 4-nitroquinoline 1-oxide (4NQO)in rats].
    Tohoku Shika Daigaku Gakkai shi, 1987, Volume: 14, Issue:3

    Topics: 4-Nitroquinoline-1-oxide; Animals; Carcinoma; Male; Rats; Tongue Neoplasms

1987
[Induction of tongue carcinoma in the rats by oral administration of 4-nitroquinoline 1-oxide (4NQO) solution. The incidence and morphological characteristics].
    Tohoku Shika Daigaku Gakkai shi, 1987, Volume: 14, Issue:3

    Topics: 4-Nitroquinoline-1-oxide; Animals; Carcinoma; Male; Rats; Rats, Inbred Strains; Tongue Neoplasms

1987
Experimental tongue carcinoma of rats induced by oral administration of 4-nitroquinoline 1-oxide (4NQO) in drinking water.
    Oral surgery, oral medicine, and oral pathology, 1985, Volume: 59, Issue:6

    Topics: 4-Nitroquinoline-1-oxide; Administration, Oral; Animals; Carcinoma; Carcinoma in Situ; Male; Neoplas

1985
[Histological and vascular changes in rat tongue and tongue carcinoma after cryosurgery].
    Shika gakuho. Dental science reports, 1985, Volume: 85, Issue:8

    Topics: 4-Nitroquinoline-1-oxide; Animals; Carcinoma; Cryosurgery; Male; Necrosis; Rats; Rats, Inbred Strain

1985