Compounds > 4-nitroquinoline-1-oxide
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4-nitroquinoline-1-oxide and Carcinoma, Squamous Cell

4-nitroquinoline-1-oxide has been researched along with Carcinoma, Squamous Cell in 221 studies

4-nitroquinoline N-oxide : A quinoline N-oxide carrying a nitro substituent at position 4.

Carcinoma, Squamous Cell: A carcinoma derived from stratified SQUAMOUS EPITHELIAL CELLS. It may also occur in sites where glandular or columnar epithelium is normally present. (From Stedman, 25th ed)

Research Excerpts

ExcerptRelevanceReference
"Based on a critical review of published studies, we aimed to develop a good practice guide for using 4-nitroquinoline-1-oxide (4NQO) as an inducer of oral carcinogenesis in Wistar rats."9.224-nitroquinoline-1-oxide (4NQO) induced oral carcinogenesis: A systematic literature review. ( Carrard, VC; Martins, MAT; Martins, MD; Schmidt, TR; Schuch, LF; Silveira, FM; Wagner, VP; Zigmundo, GCO, 2022)
" We used the 4-nitroquinoline-1-oxide (4-NQO) murine model of oral carcinogenesis and the Meadows-Cook model of alcohol abuse to assess changes in the expression of molecular markers during the initial stages of ESCC."7.81Initiation of esophageal squamous cell carcinoma (ESCC) in a murine 4-nitroquinoline-1-oxide and alcohol carcinogenesis model. ( Gudas, LJ; Osei-Sarfo, K; Scognamiglio, T; Tang, XH; Urvalek, AM, 2015)
"The aim of this study was to evaluate the chemopreventive activity of an apple extract following medium-term oral carcinogenesis assay induced by 4-nitroquinoline-1-oxide (4NQO)."7.80Chemopreventive activity of apple extract following medium-term oral carcinogenesis assay induced by 4-nitroquinoline-1-oxide. ( Aguiar, O; Barbisan, LF; Catharino, RR; de Moura, CF; Ferreira, MS; Gollucke, AP; Ribeiro, DA; Ribeiro, FA; Spadari, RC, 2014)
"The objective of the present investigation was to study the effect of combination of telmisartan with cisplatin in oral cancer cachexia induced by applying 0."7.79Combination of telmisartan with cisplatin controls oral cancer cachexia in rats. ( Damle, D; Patel, BM, 2013)
"The multistep process of oral carcinogenesis provides a biological rationale for the use of chemoprevention in individuals at increased risk of developing oral cancer."5.62Can propranolol act as a chemopreventive agent during oral carcinogenesis? An experimental animal study. ( Carrard, VC; Castilho, RM; Gaio, EJ; Nör, F; Rösing, CK; Spuldaro, TR; Wagner, VP, 2021)
"Lymph node metastasis is one of the most important prognostic factors in oral squamous cell carcinoma."5.39Development of a 4-nitroquinoline-1-oxide model of lymph node metastasis in oral squamous cell carcinoma. ( Li, J; Liang, F; Qing, H; Yang, Y; Yu, D, 2013)
"Based on a critical review of published studies, we aimed to develop a good practice guide for using 4-nitroquinoline-1-oxide (4NQO) as an inducer of oral carcinogenesis in Wistar rats."5.224-nitroquinoline-1-oxide (4NQO) induced oral carcinogenesis: A systematic literature review. ( Carrard, VC; Martins, MAT; Martins, MD; Schmidt, TR; Schuch, LF; Silveira, FM; Wagner, VP; Zigmundo, GCO, 2022)
" To address this gap in knowledge, we conducted preclinical trials using the 4-nitroquinoline-1-oxide 4NQO carcinogen model of oral carcinogenesis."3.96Impact of dietary vitamin D on initiation and progression of oral cancer. ( DeJong, H; Hershberger, PA; Seshadri, M; Verma, A; Vincent-Chong, VK, 2020)
" We used the 4-nitroquinoline-1-oxide (4-NQO) murine model of oral carcinogenesis and the Meadows-Cook model of alcohol abuse to assess changes in the expression of molecular markers during the initial stages of ESCC."3.81Initiation of esophageal squamous cell carcinoma (ESCC) in a murine 4-nitroquinoline-1-oxide and alcohol carcinogenesis model. ( Gudas, LJ; Osei-Sarfo, K; Scognamiglio, T; Tang, XH; Urvalek, AM, 2015)
"The aim of this study was to evaluate the chemopreventive activity of an apple extract following medium-term oral carcinogenesis assay induced by 4-nitroquinoline-1-oxide (4NQO)."3.80Chemopreventive activity of apple extract following medium-term oral carcinogenesis assay induced by 4-nitroquinoline-1-oxide. ( Aguiar, O; Barbisan, LF; Catharino, RR; de Moura, CF; Ferreira, MS; Gollucke, AP; Ribeiro, DA; Ribeiro, FA; Spadari, RC, 2014)
"The objective of the present investigation was to study the effect of combination of telmisartan with cisplatin in oral cancer cachexia induced by applying 0."3.79Combination of telmisartan with cisplatin controls oral cancer cachexia in rats. ( Damle, D; Patel, BM, 2013)
"4-nitroquinoline-1-oxide(4NQO) was used to induce oral carcinogenesis in the mucosa of SD rats and immunohistoche-mical technique was used to study the expression of CK19 and Cx43 in various stages of oral carcinogenesis."3.79[Expression of cytokeratin 19 and connexin 43 in 4-nitroquinoline-l-oxide-induced rat tongue carcinogenesis]. ( Feng, Y; Kang, X; Li, C; Nie, M, 2013)
"In the 4-NQO model, squamous cell carcinoma, dysplasia, and hyperkeratosis were observed in 75."2.87Met Receptor Tyrosine Kinase and Chemoprevention of Oral Cancer. ( El-Naggar, AK; Fan, YH; Feng, L; Foy, JP; Hong, WK; Kim, ES; Lang, W; Lee, JJ; Lingen, MW; Lippman, SM; Mao, L; Papadimitrakopoulou, V; Saintigny, P; William, WN; Zhang, L, 2018)
"In summary, the 4-NQO-induced murine oral cancer model is relevant for investigating human oral carcinogenesis, including the immune microenvironment, and for evaluating therapeutic and chemoprevention agents."2.72The 4-NQO mouse model: An update on a well-established in vivo model of oral carcinogenesis. ( Bertolus, C; Bouaoud, J; Darido, C; De Souza, G; Elkabets, M; Saintigny, P; Tortereau, A, 2021)
"Human oral cancer is the sixth largest group of malignancies worldwide and single largest group of malignancies in the Indian subcontinent."2.434-nitroquinoline-1-oxide induced experimental oral carcinogenesis. ( Kanojia, D; Vaidya, MM, 2006)
"Head and neck cancer is the sixth most common malignancy, and there is an urgent need to identify physiological processes contributing to tumorigenesis."1.91GPR68 limits the severity of chemical-induced oral epithelial dysplasia. ( Amin, ARMR; Graffeo, V; Griggs, N; McAleer, JP; Shore, D; Xu, Y; Zha, XM, 2023)
"Periodontitis was stimulated by placing a ligature subgingivally, while oral carcinogenesis was induced by systemic administration of 4NQO in the drinking water for 20 weeks."1.72Periodontal disease affects oral cancer progression in a surrogate animal model for tobacco exposure. ( Carrard, VC; Castilho, RM; Gaio, EJ; Nör, F; Rösing, CK; Spuldaro, TR; Squarize, CH; Wagner, VP, 2022)
"Oral cancer was induced on the tongue by nitroquinoline oxide (4-NQO), diluted in the water for 16 weeks."1.72Laser photobiomodulation does not alter clinical and histological characteristics of 4-NQO-induced oral carcinomas and leukoplakia in mice. ( Cherubini, K; Estrázulas, M; Koth, VS; Neculqueo, GW; Salum, FG, 2022)
"Knockdown of HSD11B2 in oral cancer cells promotes cellular proliferation, invasion and expression of angiogenic biomarkers EGFR and VEGFA."1.72Modulation of the oral glucocorticoid system during black raspberry mediated oral cancer chemoprevention. ( Anderson, K; Iwenofu, H; Jordanides, PP; Lamenza, FF; Nedungadi, D; Oghumu, S; Rakotondraibe, L; Riedl, KM; Ryan, N; Swingler, MJ, 2022)
"Two histologic subtypes of squamous cell carcinomas (SCCs) were identified-SCCs with exophytic and invasive components associated with papillary lesions (pSCCs) and invasive SCCs without exophytic histology (iSCCs)."1.62The Histopathology of Oral Cancer Pain in a Mouse Model and a Human Cohort. ( Albertson, DG; Bandary, D; Bhattacharya, A; Brar, B; Chen, J; Dolan, JC; Janal, MN; Naik, K; Schmidt, BL; Zhang, S, 2021)
"Oral squamous cell carcinoma (OSCC) is the most common subsite of head and neck cancer, with a 5-year survival rate of only 50%."1.624NQO induced carcinogenesis: A mouse model for oral squamous cell carcinoma. ( Curry, JM; Han, JYS; Martinez-Outschoorn, U; Philp, NJ; Sagheer, SH; Whitaker-Menezes, D, 2021)
"The multistep process of oral carcinogenesis provides a biological rationale for the use of chemoprevention in individuals at increased risk of developing oral cancer."1.62Can propranolol act as a chemopreventive agent during oral carcinogenesis? An experimental animal study. ( Carrard, VC; Castilho, RM; Gaio, EJ; Nör, F; Rösing, CK; Spuldaro, TR; Wagner, VP, 2021)
"Oral squamous cell carcinomas (OSCCs) are the most common cancers of the oral cavity, but the molecular mechanisms driving OSCC carcinogenesis remain unclear."1.56Mutations in long-lived epithelial stem cells and their clonal progeny in pre-malignant lesions and in oral squamous cell carcinoma. ( Gudas, LJ; Melis, M; Scognamiglio, T; Zhang, T, 2020)
"This carcinogenesis model was quantitatively evaluated by FI."1.51Method for diagnosing neoplastic lesions by quantitative fluorescence value. ( Kasahara, M; Kosugi, A; Mori, T; Nakamura-Takahashi, A; Shibahara, T; Yang, L, 2019)
"The incidence of extraoral neoplasms was significantly lower (16%) in the younger cohort."1.48Impact of Age on Disease Progression and Microenvironment in Oral Cancer. ( DeJong, H; Hershberger, PA; Merzianu, M; Patti, A; Rich, LJ; Seshadri, M; Vincent-Chong, VK, 2018)
"Esophageal cancer occurs as either squamous cell carcinoma (ESCC) or adenocarcinoma."1.48Dek overexpression in murine epithelia increases overt esophageal squamous cell carcinoma incidence. ( Cimperman, KA; Ehrman, LA; Guasch, G; Haas, SR; Komurov, K; Lane, A; Matrka, MC; Waclaw, RR; Wells, SI; Wikenheiser-Brokamp, KA, 2018)
"The majority of cases of oral squamous cell carcinoma (OSCC) develop from oral potentially malignant disorders, which have been confirmed to be involved in chronic oxidative stimulation."1.48Proteomics-based investigation of multiple stages of OSCC development indicates that the inhibition of Trx-1 delays oral malignant transformation. ( Chen, X; Cheng, B; Hu, Q; Wang, C; Wu, T; Xia, J; Yang, L, 2018)
"Patients with oral cancer report severe pain during function."1.46Tumor necrosis factor alpha secreted from oral squamous cell carcinoma contributes to cancer pain and associated inflammation. ( Bhattacharya, A; Dolan, JC; Hickman, DN; MacRae, J; Scheff, NN; Schmidt, BL; Sharma, AK; Ye, Y, 2017)
"Oral squamous cell carcinoma (OSCC) was induced by using 4- nitroquinoline-1-oxide (4NQO) as a carcinogen."1.46Comparison of injectable doxorubicin & its nanodrug complex chemotherapy for the treatment of 4-nitroquinoline-1-oxide induced oral squamous cell carcinoma in rats. ( Abbasi, MM; Abdal, K; Abdollahi, B; Aghbali, AA; Fotohi, S; Hamishehkar, H; Khiavi, MM; Salehi, R; Sina, M, 2017)
"All mice were exposed to a low dose of oral cancer carcinogen 4-nitroquinoline 1-oxide and rates of oral squamous cell carcinoma (OSCC) and proliferation and differentiation in the cancerous and non-cancerous oral epithelium of these mice were examined."1.46p120-Catenin Is Required for Dietary Calcium Suppression of Oral Carcinogenesis in Mice. ( Bikle, DD; Chen, Y; Deng, X; Ji, S; Jiang, Y; Liao, E; Liao, L; Shrestha, C; Xie, Z; Yuan, Y, 2017)
"miR-211 expression in human oral squamous cell carcinoma (OSCC) has been implicated in poor patient survival."1.43MicroRNA-211 Enhances the Oncogenicity of Carcinogen-Induced Oral Carcinoma by Repressing TCF12 and Increasing Antioxidant Activity. ( Chang, KW; Chen, YF; Kao, SY; Lin, SC; Liu, CJ; Yang, CC, 2016)
"The incidence of buccal squamous cell carcinoma (buccal SCC) is considered to be the second highest out of all oral cancers, but the unsatisfactory in vivo tumorigenicity and metastatic potential of the widely used cell lines have greatly delayed studies on the mechanisms of tumor progression."1.43Establishment of a highly metastatic buccal squamous cell carcinoma cell line from a Sprague-Dawley Rat. ( Chen, W; Lv, Z; Qin, X; Xu, Q; Yan, M; Zhang, J, 2016)
"The TGS was able to discriminate oral squamous cell carcinoma (OSCC) from normal oral mucosa in 3 independent datasets."1.43The dynamics of gene expression changes in a mouse model of oral tumorigenesis may help refine prevention and treatment strategies in patients with oral cancer. ( Bertolus, C; Caulin, C; Chabaud, S; Foy, JP; Goudot, P; Hong, WK; Lachuer, J; Lang, W; Lavergne, E; Le Texier, V; Lippman, SM; Perol, D; Saintigny, P; Thomas, E; Tortereau, A, 2016)
"Head and neck squamous cell carcinoma (HNSCC) development is a multistage process includes the normal, dysplasia and squamous cell carcinoma (SCC) stages."1.43Modulation of IL-1β reprogrammes the tumor microenvironment to interrupt oral carcinogenesis. ( Cheng, B; Hong, Y; Hu, Q; Jia, L; Wang, J; Wu, J; Wu, T; Xia, J, 2016)
"Oral squamous cell carcinomas (OSCCs) induced in F344 rats by 4-nitroquinoline-1-oxide (4-NQO) demonstrate considerable phenotypic similarity to human oral cancers and the model has been widely used for carcinogenesis and chemoprevention studies."1.43Identification of reliable reference genes for quantitative gene expression studies in oral squamous cell carcinomas compared to adjacent normal tissues in the F344 rat model. ( McCormick, DL; Peng, X, 2016)
"Head and neck squamous cell carcinoma (HNSCC) is a frequently fatal disease due, in large part, to a high rate of second primary tumor (SPT) formation."1.43STAT3 as a Chemoprevention Target in Carcinogen-Induced Head and Neck Squamous Cell Carcinoma. ( Acquafondata, M; Freilino, M; Gooding, WE; Grandis, JR; Johnson, DE; Li, H; Peyser, ND; Satake, M; Sen, M; Wang, L; Wang, Z; Zeng, Y, 2016)
"Preventive measures against oral carcinogenesis are urgently warranted to lower the high morbidity and mortality associated with this malignancy worldwide."1.42Grape seed extract and resveratrol prevent 4-nitroquinoline 1-oxide induced oral tumorigenesis in mice by modulating AMPK activation and associated biological responses. ( Agarwal, C; Agarwal, R; Deep, G; Orlicky, DJ; Sclafani, RA; Shrotriya, S; Tyagi, A; Wang, XJ; Wisell, J, 2015)
"Oral squamous cell carcinomas (OSCC) were induced in male F344 rats by 4-nitroquinoline-1-oxide (NQO; 20 ppm in the drinking water for 10 weeks)."1.42Suppression of Rat Oral Carcinogenesis by Agonists of Peroxisome Proliferator Activated Receptor γ. ( Horn, TL; Johnson, WD; Lubet, RA; McCormick, DL; Peng, X; Steele, VE, 2015)
"Oral squamous cell carcinomas (OSCC) induced in F344 rats by 4-nitroquinoline-1-oxide (4-NQO) demonstrate considerable phenotypic similarity to human oral cancers."1.42Overexpression of lipocalins and pro-inflammatory chemokines and altered methylation of PTGS2 and APC2 in oral squamous cell carcinomas induced in rats by 4-nitroquinoline-1-oxide. ( Johnson, WD; Li, W; McCormick, DL; Peng, X; Torres, KE, 2015)
"Despite intensive investigation, oral squamous cell carcinomas (OSCC) represent a clinical challenge resulting in significant morbidity and mortality."1.42Mcl-1 is an important therapeutic target for oral squamous cell carcinomas. ( Das, SK; Dash, R; Fisher, PB; Maji, S; Panda, S; Pattanaik, L; Pellecchia, M; Quinn, BA; Samal, SK; Sarkar, D, 2015)
"One of the theories regarding oral carcinogenesis is that the tumor growth is initiated from cancer stem cells (CSCs) that self-renew and give rise to differentiated tumor cells, like stem cells do in normal tissues."1.40Expression of cancer stem cell marker during 4-nitroquinoline 1-oxide-induced rat tongue carcinogenesis. ( Choi, H; Im, Y; Jeon, S; Kim, J; Kim, O; Kim, S; Lee, G; Lee, JY; Lim, W; Moon, YL; Ni, K; Oh, HK; Song, SY; You, JW, 2014)
"Oral squamous cell carcinoma (OSCC) remains as one of the most difficult malignancies to control because of its high propensity for local invasion and cervical lymph node dissemination."1.40Novel DOX-MTX nanoparticles improve oral SCC clinical outcome by down regulation of lymph dissemination factor VEGF-C expression in vivo: oral and IV modalities. ( Abbasi, MM; Hamishehkar, H; Jahanban- Esfahlan, R; Monfaredan, A; Seidi, K, 2014)
" Our results indicated that IV dosage of MTX-DOX is more effective than free DOX (12 fold) in inhibiting the activity of MMP-2 in OSCCs (P<0."1.40Oral and IV dosages of doxorubicin-methotrexate loaded- nanoparticles inhibit progression of oral cancer by down- regulation of matrix Methaloproteinase 2 expression in vivo. ( Abbasi, MM; Hamishehkar, H; Jahanban-Esfahlan, R; Khiavi, MM; Monfaredan, A; Seidi, K, 2014)
"Regarding oral squamous cell carcinoma (OSCC) development, chewing areca is known to be a strong risk factor in many Asian cultures."1.40Methylation-associated gene silencing of RARB in areca carcinogens induced mouse oral squamous cell carcinoma. ( Chang, NW; Chen, CM; Chen, HL; Cheng, JC; Fan, SR; Lai, ZL; Tsai, MH; Tsou, YA, 2014)
"Lymph node metastasis is one of the most important prognostic factors in oral squamous cell carcinoma."1.39Development of a 4-nitroquinoline-1-oxide model of lymph node metastasis in oral squamous cell carcinoma. ( Li, J; Liang, F; Qing, H; Yang, Y; Yu, D, 2013)
"Head and neck squamous cell carcinoma (HNSCC) is the sixth most common type of cancer affecting humans worldwide."1.39The molecular features of tongue epithelium treated with the carcinogen 4-nitroquinoline-1-oxide and alcohol as a model for HNSCC. ( Gudas, LJ; Osei-Sarfo, K; Scognamiglio, T; Tang, XH; Urvalek, AM, 2013)
"The cells of origin of oral cavity squamous cell carcinoma (OCSCC) are unknown."1.39Basal stem cells contribute to squamous cell carcinomas in the oral cavity. ( Gudas, LJ; Scognamiglio, T; Tang, XH, 2013)
"The sequencing of the head and neck cancer has provided a blueprint of the most frequent genetic alterations in this cancer type."1.39PTEN deficiency contributes to the development and progression of head and neck cancer. ( Abrahao, AC; Castilho, RM; Gutkind, JS; Lingen, MW; Molinolo, A; Squarize, CH, 2013)
"0."1.37Fenofibrate exhibits a high potential to suppress the formation of squamous cell carcinoma in an oral-specific 4-nitroquinoline 1-oxide/arecoline mouse model. ( Chang, NW; Chiu, CF; Chu, PY; Hsu, HT; Lin, C; Tsai, MH; Yeh, CM; Yeh, KT, 2011)
"Chemoprevention of head and neck squamous cell carcinoma (HNSCC), a disease associated with high mortality rates and frequent occurrence of second primary tumor (SPT), is an important clinical goal."1.37Inhibition of EGFR-STAT3 signaling with erlotinib prevents carcinogenesis in a chemically-induced mouse model of oral squamous cell carcinoma. ( Bednash, JS; Freilino, ML; Gooding, WE; Grandis, JR; Joyce, SC; Leeman-Neill, RJ; Lingen, MW; Neill, DB; Panahandeh, MC; Seethala, RR; Singh, SV; Thomas, SM, 2011)
"Lycopene treatment significantly decreased the incidence of 4-NQO induced tongue carcinogenesis."1.37Histological and immunohistochemical evaluation of the chemopreventive role of lycopene in tongue carcinogenesis induced by 4-nitroquinoline-1-oxide. ( El-Rouby, DH, 2011)
"In pre-neoplastic lesions and squamous cell carcinomas induced after 12 and 20 weeks following carcinogen exposure, respectively, oxidative DNA damage was also increased (P < 0."1.37Oxidative DNA damage is a preliminary step during rat tongue carcinogenesis induced by 4-nitroquinoline 1-oxide. ( Carvalho, JG; Miranda, SR; Noguti, J; Oshima, CT; Ribeiro, DA, 2011)
"The incidence of squamous cell carcinoma (SCC) increased from 20% (8/41) to 43% (17/40; P < 0."1.37Ethanol promotes chemically induced oral cancer in mice through activation of the 5-lipoxygenase pathway of arachidonic acid metabolism. ( Chen, X; Guo, Y; Sun, Z; Wang, X; Zhang, X, 2011)
"In well-differentiated squamous cell carcinoma induced after 20 weeks of treatment with 4NQO, Wnt1 was expressed in the majority of the dysplasic cells and tumor cells."1.36Wnt/beta-catenin signalling pathway following rat tongue carcinogenesis induced by 4-nitroquinoline 1-oxide. ( Fracalossi, AC; Oshima, CT; Ribeiro, DA; Silva, Mde S, 2010)
" Furthermore, we show that the inhibition of mTOR by the chronic administration of rapamycin halts the malignant conversion of precancerous lesions and promotes the regression of advanced carcinogen-induced SCCs."1.35Targeting mammalian target of rapamycin by rapamycin prevents tumor progression in an oral-specific chemical carcinogenesis model. ( Amornphimoltham, P; Czerninski, R; Gutkind, JS; Molinolo, AA; Patel, V, 2009)
" We determined that 8 weeks of 100 microg/mL 4-NQO in the drinking water was the optimal dosage and duration to cause a sufficient incidence of hyperkeratoses, dysplasias, and HNSCC over a period of 32 weeks with minimal morbidity and mortality."1.35ABT-510 is an effective chemopreventive agent in the mouse 4-nitroquinoline 1-oxide model of oral carcinogenesis. ( Hasina, R; Jalil, A; Jones, CL; Kasza, K; Lingen, MW; Martin, LE, 2009)
"Our data show that IFP is increased in tongue cancer."1.35High interstitial fluid pressure in rat tongue cancer is related to increased lymph vessel area, tumor size, invasiveness and decreased body weight. ( Haug, SR; Heyeraas, KJ; Ibrahim, SO; Raju, B, 2008)
"The incidence of tongue squamous cell carcinomas (SCC) in the 4-NQO-treated rats was 64%, while that in the rats given ONO-8711 after 4-NQO exposure was 29 (P<0."1.34A prostaglandin E2 receptor subtype EP1-selective antagonist, ONO-8711, suppresses 4-nitroquinoline 1-oxide-induced rat tongue carcinogenesis. ( Fujitsuka, H; Kobayashi, A; Makita, H; Maruyama, T; Miyamoto, S; Mutoh, M; Shibata, T; Suzuki, R; Tanaka, T; Toida, M; Wakabayashi, K; Yasui, Y; Yonemoto, K, 2007)
"Tongue squamous cell carcinoma (SCC) was confirmed by pathological examination in 61 rats."1.34Response of lymphocyte subsets and cytokines to Shenyang prescription in Sprague-Dawley rats with tongue squamous cell carcinomas induced by 4NQO. ( Chen, W; He, D; Jiang, C; Qiu, W; Ye, D; Zhang, P; Zhang, X; Zhang, Z, 2007)
"To establish a monoclone cell line of squamous cell carcinoma (SCC) in rat buccal mucosa and to study its biological characteristics."1.34[Establishment and identification of biological characteristics of rat monoclone cell line Rca-B]. ( Chen, WT; Feng, YY; Jiang, CH; Li, NY; Ye, DX; Zhou, XJ, 2007)
"Esophageal and tongue cancers have both been associated with dietary zinc deficiency (ZD), and cyclooxygenase (COX-2) is often overexpressed in these cancers."1.33Dietary zinc modulation of COX-2 expression and lingual and esophageal carcinogenesis in rats. ( Farber, JL; Fong, LY; Jiang, Y; Zhang, L, 2005)
"In well-differentiated squamous cell carcinoma induced after 20 weeks of treatment with 4NQO, bcl-2 was expressed in some cells of tumour islands."1.33Abnormal expression of bcl-2 and bax in rat tongue mucosa during the development of squamous cell carcinoma induced by 4-nitroquinoline 1-oxide. ( Marques, ME; Ribeiro, DA; Salvadori, DM, 2005)
"Head and neck squamous cell carcinoma (HNSCC) is a leading cause of cancer mortality worldwide."1.33Identification of biomarkers that distinguish human papillomavirus (HPV)-positive versus HPV-negative head and neck cancers in a mouse model. ( Lambert, PF; Pitot, HC; Strati, K, 2006)
"Oral squamous cell carcinoma (SCC) develops from pre-malignant lesions, but the role of cell adhesion molecules such as E-cadherin (E-CD) and P-cadherin (P-CD) in the pre-malignant stage has not been elucidated."1.32Changing expression of E- and P-cadherin during rat tongue carcinogenesis induced by 4-nitroquinoline 1-oxide. ( Kadota, H; Kakudo, K; Sakaki, T; Tamura, I, 2003)
"One differentiated squamous cell carcinoma (SCC) cell line (RSC3-E2) and two undifferentiated tumor cell lines (RSC3-LM and RSC3-E2R) with different metastatic potential were established from a 4-nitroquinoline N-oxide (4NQO)-induced differentiated SCC in F344 rat tongue."1.31Isolation of differentiated squamous and undifferentiated spindle carcinoma cell lines with differing metastatic potential from a 4-nitroquinoline N-Oxide-induced tongue carcinoma in a F344 rat. ( Fukushima, S; Kurita, K; Moriuchi, T; Nakanishi, H; Takeuchi, S; Tatematsu, M; Tonoki, H; Tsukamoto, T; Yamamoto, S; Yoshida, K, 2000)
"After 50 weeks of 4NQO exposure, tongue squamous cell carcinomas (SCCs) occurred in XPA(-/-) mice only, no tumors being observed in XPA(+/-) and XPA(+/+) animals."1.31Xeroderma pigmentosum group A gene action as a protection factor against 4-nitroquinoline 1-oxide-induced tongue carcinogenesis. ( Ide, F; Ishikawa, T; Kusama, K; Nakatsuru, Y; Oda, H; Sakashita, H; Tanaka, K, 2001)
"Squamous cell carcinomas were found in 4 out of 20 rats treated with 514."1.30Photofrin-mediated photodynamic therapy of chemically-induced premalignant lesions and squamous cell carcinoma of the palatal mucosa in rats. ( Nauta, JM; Nikkels, PG; Roodenburg, JL; Star, WM; van Leengoed, HL; Vermey, A; Witjes, MJ, 1997)
" This was based on a dose-response study for normal tissue damage by photodynamic therapy (PDT) in this animal model, because the underlying rationale was to study photo-detection as a method of locating additional (early) malignancies in patients treated by PDT."1.30In vivo photo-detection of chemically induced premalignant lesions and squamous cell carcinoma of the rat palatal mucosa. ( Nauta, JM; Nikkels, PG; Roodenburg, JL; Speelman, OC; Star, WM; van Leengoed, HL; Vermey, A; Witjes, MJ, 1997)
"The incidence of tongue cancer in rats treated with 4NQO for 9 weeks, 13 weeks, 16 weeks and then observed for 32 weeks was 50."1.30[A rat model of tongue mucosa squamous cell carcinoma induced by oral administration of 4NQO in drinking water]. ( Chen, W; He, R; Liu, X, 1999)
"Eighteen (72%) of 25 squamous cell carcinomas showed a diploid pattern, while 7 (28%) showed a diploid plus tetraploid pattern."1.29Nucleolar organizer regions in tongue carcinomas induced in rats: comparison with DNA cytofluorometric analysis. ( Itoh, T; Takahashi, H; Yamamoto, Y, 1994)
"This study was conducted to determine the possible carcinogenic role of N-Nitrosonornicotine (NNN) when combined with subcarcinogenic doses of strong carcinogens dimethylbenz (a) anthracene (DMBA) and 4-nitroquinoline-N-oxide (4NQO) in the hamster cheek pouch."1.29The cancer-promoting effect of N-nitrosonornicotine used in combination with a subcarcinogenic dose of 4-nitroquinoline-N-oxide and 7,12-dimethylbenz (A) anthracene. ( Altuwairgi, OS; Doku, HC; Papageorge, MB, 1995)
"Larger invasive squamous cell carcinomas consistently lost the wild-type allele, whereas preneoplastic lesions and small tumors were heterozygous for ras."1.29Harvey ras (H-ras) point mutations are induced by 4-nitroquinoline-1-oxide in murine oral squamous epithelia, while squamous cell carcinomas and loss of heterozygosity occur without additional exposure. ( Ackermann, DM; Hawkins, BL; Hendler, FJ; Heniford, BW; Yuan, B, 1994)
"However, in spite of mutagenic activity, squamous carcinomas were not induced by 4NQO exposure at any stage of regeneration."1.29Stage-dependent genetically-based deformities of the regenerating newt limb from 4-nitroquinoline-N-oxide mutagenesis: potential embryonic regulation of cancer. ( Parchment, RE; Zafiratos, CS; Zilakos, NP, 1996)
"Precancerous lesions and squamous cell carcinomas (SCCs) were induced in the oral mucosa of outbred male Sprague-Dawley rats by repeated application of the carcinogen 4-nitroquinoline-1-oxide."1.28Temporal alterations in cytokeratin expression during experimental oral mucosal carcinogenesis. ( Boyd, NM; Reade, PC, 1991)
"The papillomas are heterogeneous in their potential for progression to carcinomas, a property apparently induced at the time of initiation."1.28Malignant conversion, the first stage in progression, is distinct from phorbol ester promotion in mouse skin. ( Hennings, H, 1991)
"The incidence of animals developing squamous cell carcinomas was similar in both groups, but tumour development was significantly earlier in iron-deficient animals (mean 183 days) compared to controls (mean 229 days)."1.27The effect of iron deficiency on experimental oral carcinogenesis in the rat. ( MacDonald, DG; Prime, SS; Rennie, JS, 1983)
"Oral epithelial atypia and squamous cell carcinoma were observed with increasing prevalence as the period of carcinogen exposure was increased."1.27Experimental induction of oral squamous cell carcinomas in mice with 4-nitroquinolone-1-oxide. ( Reade, PC; Steidler, NE, 1984)
"Two were classified as squamous cell carcinoma, one was as a leiomyosarcoma and the other two were undifferentiated sarcoma."1.26Electron microscopic studies of placental and uterine tumors induced in rats. ( Kakudo, K; Miyaji, T; Onishi, S; Sugaya, T, 1976)
"A high incidence of squamous cell carcinomas of the forestomach was found in groups 4 and 5."1.25Effects in rats of sodium chloride on experimental gastric cancers induced by N-methyl-N-nitro-N-nitrosoguanidine or 4-nitroquinoline-1-oxide. ( Fukushima, S; Hananouchi, M; Shirai, T; Takahashi, M; Tatematsu, M, 1975)

Research

Studies (221)

TimeframeStudies, this research(%)All Research%
pre-199028 (12.67)18.7374
1990's42 (19.00)18.2507
2000's53 (23.98)29.6817
2010's79 (35.75)24.3611
2020's19 (8.60)2.80

Authors

AuthorsStudies
Chao, JL1
Korzinkin, M1
Zhavoronkov, A1
Ozerov, IV1
Walker, MT1
Higgins, K1
Lingen, MW5
Izumchenko, E1
Savage, PA1
Nedungadi, D1
Ryan, N1
Anderson, K1
Lamenza, FF1
Jordanides, PP1
Swingler, MJ1
Rakotondraibe, L1
Riedl, KM1
Iwenofu, H1
Oghumu, S1
Spuldaro, TR2
Wagner, VP3
Nör, F2
Gaio, EJ3
Squarize, CH2
Carrard, VC4
Rösing, CK3
Castilho, RM3
Zigmundo, GCO1
Schuch, LF1
Schmidt, TR1
Silveira, FM1
Martins, MAT1
Martins, MD1
Yin, P1
Chen, J3
Wu, Y1
Gao, F1
Wen, J1
Zhang, W1
Su, Y1
Zhang, X3
Neculqueo, GW3
Estrázulas, M3
Cherubini, K3
Koth, VS3
Salum, FG3
Shore, D1
Griggs, N1
Graffeo, V1
Amin, ARMR1
Zha, XM1
Xu, Y1
McAleer, JP1
Coeli-Lacchini, FB1
da Silva, G1
Belentani, M1
Alves, JSF1
Ushida, TR1
Lunardelli, GT1
Garcia, CB1
Silva, TA1
Lopes, NP1
Leopoldino, AM1
Sahu, SR1
Thakur, S1
Peroumal, D1
Utkalaja, BG1
Dutta, A1
Kumari, P1
Subhadarsini, I1
Acharya, N1
Verma, A1
Vincent-Chong, VK2
DeJong, H2
Hershberger, PA3
Seshadri, M4
Melis, M1
Zhang, T2
Scognamiglio, T7
Gudas, LJ8
Wei, T1
Buehler, D1
Ward-Shaw, E1
Lambert, PF3
Naik, K1
Janal, MN1
Bandary, D1
Brar, B1
Zhang, S1
Dolan, JC2
Schmidt, BL2
Albertson, DG1
Bhattacharya, A2
Sequeira, I1
Rashid, M1
Tomás, IM1
Williams, MJ1
Graham, TA1
Adams, DJ1
Vigilante, A1
Watt, FM1
Monteiro de Oliveira Novaes, JA1
Hirz, T1
Guijarro, I1
Nilsson, M1
Pisegna, MA1
Poteete, A1
Barsoumian, HB1
Fradette, JJ1
Chen, LN1
Gibbons, DL1
Tian, X1
Wang, J2
Myers, JN1
McArthur, MJ1
Bell, D1
William, WN2
Heymach, JV1
Bouaoud, J1
De Souza, G1
Darido, C1
Tortereau, A2
Elkabets, M1
Bertolus, C2
Saintigny, P3
Sagheer, SH1
Whitaker-Menezes, D1
Han, JYS1
Curry, JM1
Martinez-Outschoorn, U1
Philp, NJ1
Dogan, R1
Hafız, AM1
Kiziltan, HS1
Yenigun, A1
Buyukpinarbaslili, N1
Eris, AH1
Ozturan, O1
Khiavi, MM2
Abdal, K2
Abbasi, MM3
Hamishehkar, H4
Aghbali, AA1
Salehi, R1
Sina, M1
Abdollahi, B1
Fotohi, S1
Siddappa, G1
Kulsum, S1
Ravindra, DR1
Kumar, VV1
Raju, N1
Raghavan, N1
Sudheendra, HV1
Sharma, A1
Sunny, SP1
Jacob, T1
Kuruvilla, BT1
Benny, M1
Antony, B1
Lakshminarayan, P1
Hicks, W1
Suresh, A2
Kuriakose, MA2
Miki, K2
Orita, Y2
Gion, Y2
Takao, S2
Ohno, K2
Takeuchi, M2
Ito, T3
Minoura, A2
Tachibana, T2
Marunaka, H2
Makino, T2
Matsukawa, A2
Nishizaki, K2
Yoshino, T2
Sato, Y2
Mohan, S1
Thiagarajan, K1
Chandrasekaran, R1
Hingorani, DV1
Lemieux, AJ1
Acevedo, JR1
Glasgow, HL1
Kedarisetty, S1
Whitney, MA1
Molinolo, AA2
Tsien, RY1
Nguyen, QT1
Scheff, NN1
Ye, Y1
MacRae, J1
Hickman, DN1
Sharma, AK1
Chen, X4
Hu, Q2
Wu, T2
Wang, C1
Xia, J3
Yang, L2
Cheng, B3
Oballe, HJR1
Muniz, FWMG1
Bueno, CC1
Klein, IP1
Matrka, MC1
Cimperman, KA1
Haas, SR1
Guasch, G1
Ehrman, LA1
Waclaw, RR1
Komurov, K1
Lane, A1
Wikenheiser-Brokamp, KA1
Wells, SI1
Foy, JP2
Papadimitrakopoulou, V1
Lang, W2
Zhang, L3
Fan, YH1
Feng, L1
Kim, ES1
El-Naggar, AK1
Lee, JJ1
Mao, L1
Hong, WK2
Lippman, SM3
Rich, LJ1
Patti, A1
Merzianu, M2
Liu, H1
Li, J3
Yang, Y2
Liu, L2
Yu, L1
Tu, M1
Yuan, R1
Yue, W1
Luo, Q1
Ruan, Y1
Dai, X1
Teixeira Buck, MG1
Souza Cabral Tuci, P1
Perillo Rosin, FC1
Pinheiro Barcessat, AR1
Corrêa, L1
Zhou, YX1
Fuentes-Creollo, G1
Ponce, F1
Langley, SA1
Jen, KY1
Celniker, SE1
Mao, JH1
Snijders, AM1
Tsai, CY1
Fang, HY1
Shibu, MA1
Lin, YM1
Chou, YC1
Chen, YH2
Day, CH1
Shen, CY1
Ban, B1
Huang, CY1
Chen, YF2
Liu, CJ4
Lin, LH1
Chou, CH1
Yeh, LY1
Lin, SC4
Chang, KW4
Kosugi, A1
Kasahara, M1
Nakamura-Takahashi, A1
Shibahara, T2
Mori, T1
Razzo, BM1
Ludwig, N1
Hong, CS1
Sharma, P1
Fabian, KP1
Fecek, RJ1
Storkus, WJ1
Whiteside, TL1
Moradzadeh Khiavi, M1
Anvari, E1
Feng, Y2
Kang, XJ1
Li, CH1
Nie, MH1
Abrahao, AC1
Molinolo, A1
Gutkind, JS2
Chu, TH1
Yang, CC3
Lui, MT1
Osei-Sarfo, K3
Tang, XH7
Urvalek, AM3
Kang, X1
Li, C2
Nie, M1
da Silva, JM1
Queiroz-Junior, CM1
Batista, AC1
Rachid, MA1
Teixeira, MM1
da Silva, TA1
de Visscher, SA1
Witjes, MJ6
van der Vegt, B1
de Bruijn, HS1
van der Ploeg-van den Heuvel, A1
Amelink, A1
Sterenborg, HJ1
Roodenburg, JL7
Robinson, DJ1
Shrotriya, S1
Tyagi, A1
Deep, G1
Orlicky, DJ1
Wisell, J1
Wang, XJ1
Sclafani, RA1
Agarwal, R1
Agarwal, C1
Zhao, J1
Wang, Z2
Han, J1
Qiu, X1
Pan, J1
Patel, BM1
Damle, D1
Fixler, D1
Ankri, R1
Kaplan, I2
Novikov, I1
Hirshberg, A3
Ribeiro, FA1
de Moura, CF1
Gollucke, AP1
Ferreira, MS1
Catharino, RR1
Aguiar, O1
Spadari, RC1
Barbisan, LF1
Ribeiro, DA7
Lim, W1
Choi, H1
Kim, J1
Kim, S1
Jeon, S1
Ni, K1
Song, SY1
Oh, HK1
Im, Y1
Lee, G1
Lee, JY1
Moon, YL1
You, JW1
Kim, O1
Tseng, SH1
Yu, EH1
Chang, C1
Lee, YS1
Monfaredan, A2
Seidi, K2
Jahanban- Esfahlan, R1
Lai, ZL1
Tsou, YA1
Fan, SR1
Tsai, MH3
Chen, HL1
Chang, NW3
Cheng, JC1
Chen, CM1
Chen, MF2
Kuan, FC1
Yen, TC2
Lu, MS1
Lin, PY2
Chung, YH1
Chen, WC2
Lee, KD1
Wang, S2
Du, Z1
Luo, J1
Wang, X2
Li, H2
Liu, Y1
Zhang, Y1
Ma, J1
Xiao, W1
Wang, Y3
Zhong, X1
Jahanban-Esfahlan, R1
Paparella, ML1
Abrigo, M1
Bal de Kier Joffe, E1
Raimondi, AR1
Peng, X3
Li, W1
Johnson, WD2
Torres, KE1
McCormick, DL3
Chen, PT1
Hsieh, CC1
Wu, CT1
Maji, S1
Samal, SK1
Pattanaik, L1
Panda, S1
Quinn, BA1
Das, SK1
Sarkar, D1
Pellecchia, M1
Fisher, PB1
Dash, R1
Bothwell, KD1
Shaurova, T1
Johnson, CS1
Chen, Y2
Jiang, Y5
Liao, L2
Zhu, X1
Tang, S1
Yang, Q1
Sun, L1
Li, Y1
Gao, S2
Xie, Z2
Wang, L3
Cao, NN1
Man, HW1
Li, PF1
Shan, BE1
Horn, TL1
Lubet, RA3
Steele, VE1
Qin, X1
Yan, M1
Zhang, J1
Xu, Q1
Lv, Z1
Chen, W4
Hong, Y2
Jia, L1
Wu, J1
Caulin, C1
Le Texier, V1
Lavergne, E1
Thomas, E1
Chabaud, S1
Perol, D1
Lachuer, J1
Goudot, P1
Liu, YC1
Ho, HC1
Lee, MR1
Yeh, CM2
Tseng, HC2
Lin, YC1
Chung, JG1
Kao, SY1
Peyser, ND1
Zeng, Y1
Acquafondata, M1
Freilino, M1
Sen, M1
Gooding, WE2
Satake, M1
Johnson, DE1
Grandis, JR2
Hanakawa, H1
Yuan, Y1
Shrestha, C1
Ji, S1
Deng, X1
Liao, E1
Bikle, DD1
Tamura, T1
Ichikawa, T1
Nakahata, S1
Kondo, Y1
Tagawa, Y1
Yamamoto, K4
Nagai, K1
Baba, T1
Yamaguchi, R1
Futakuchi, M1
Yamashita, Y1
Morishita, K1
Chen, CH1
Lu, HI1
Wang, YM1
Lo, CM1
Huang, WT1
Li, SH1
Umemura, T1
Maeda, M2
Kijima, A1
Ishii, Y1
Tasaki, M1
Okamura, T1
Inoue, T1
Hirose, M1
Nishikawa, A1
Schoop, RA2
Baatenburg de Jong, RJ2
Noteborn, MH2
Czerninski, R1
Amornphimoltham, P1
Patel, V4
Lv, N1
Tao, X1
Sheu, JJ1
Hua, CH1
Wan, L1
Lin, YJ1
Lai, MT1
Jinawath, N1
Lin, CF1
Lin, CC1
Hsieh, LJ1
Wang, TL1
Shih, IeM1
Tsai, FJ1
Vairaktaris, E2
Goutzanis, L2
Yapijakis, C2
Vassiliou, S2
Spyridonidou, S2
Vylliotis, A1
Nkenke, E1
Lazaris, AC1
Strantzias, P2
Patsouris, E2
Hasina, R1
Martin, LE1
Kasza, K1
Jones, CL1
Jalil, A1
Morrison, BH1
Haney, R1
Lamarre, E1
Drazba, J1
Prestwich, GD1
Lindner, DJ1
Baba, S1
Yamada, Y2
Hatano, Y1
Miyazaki, Y1
Mori, H8
Shibata, T2
Hara, A4
Fracalossi, AC1
Silva, Mde S1
Oshima, CT2
Albert, M1
Naoi, K1
Sunagawa, N1
Yoshida, I1
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Nakashima, M1
Ishihara, M1
Fukamachi, K2
Itoh, Y1
Tsuda, H2
Yoshimi, N3
Suzui, M2
Park, JW1
Pitot, HC2
Strati, K2
Spardy, N1
Duensing, S1
Grompe, M1
Lin, C1
Hsu, HT1
Chu, PY1
Chiu, CF1
Yeh, KT1
Leeman-Neill, RJ1
Seethala, RR1
Singh, SV1
Freilino, ML1
Bednash, JS1
Thomas, SM1
Panahandeh, MC1
Joyce, SC1
Neill, DB1
El-Rouby, DH1
Fong, LY4
Rawahneh, ML1
Smalley, KJ1
Croce, CM2
Farber, JL2
Huebner, K2
Rivera, CA1
Droguett, DA1
Kemmerling, U1
Venegas, BA1
Miranda, SR1
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Su, YX1
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Liang, LZ1
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da Silva, VH1
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de Faria, PR1
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Kadota, H1
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Denda, A3
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Kuniyasu, H2
Kirita, T2
Ide, F2
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Sakashita, H2
Kusama, K2
Tanaka, K2
Ishikawa, T2
Ohyama, M2
Hirayama, Y4
Tanuma, J3
Hirano, M2
Semba, I2
Shisa, H3
Hiai, H3
Sugihara, K1
Kitano, M5
Knudsen, B1
Bemis, D1
Tickoo, S1
Gannot, G1
Buchner, A2
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Nakahara, Y1
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Matsumura, T1
Hamakawa, H1
Fávero Salvadori, DM1
da Silva, RN1
Ribeiro Darros, B1
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Kwon, HJ1
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Xiong, P1
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Clayman, GL1
Weber, RS1
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Makita, H4
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Yonemoto, K1
Kobayashi, A3
Fujitsuka, H1
Toida, M1
Miyamoto, S1
Yasui, Y1
Suzuki, R1
Wakabayashi, K2
Tanaka, T9
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Takasuka, N1
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Shirai, T2
Hirano, S1
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Jiang, C1
Ye, D1
Qiu, W1
He, D1
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Silva, RN1
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Haug, SR1
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Sorsa, T1
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MacDonald, DG2
Rennie, JS1
Steidler, NE3
Reade, PC7
Fisker, AV3
Philipsen, HP3
Ohne, M2
Takaki, T3
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Mochizuki, A2
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Muramatsu, H2
Nagai, Y2
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Hirao, F2
Yoshimoto, T2
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Svensson, S1
Heyden, G2
Yamamoto, Y4
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Thomas, DW1
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Hagemeijer, A1
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Papageorge, MB1
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Ackermann, DM1
Hawkins, BL1
Hendler, FJ4
Jiang, DJ3
Wilson, DF3
Smith, PS1
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Matsuuchi, H1
Braams, JW1
Vaalburg, W1
Thomas, GR1
Chen, Z1
Van Waes, C1
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Paterson, IC1
Stone, A2
Huntley, S1
Curtis, R1
Pring, M1
Takeuchi, S1
Nakanishi, H1
Yoshida, K1
Yamamoto, S1
Tonoki, H1
Tsukamoto, T1
Fukushima, S2
Moriuchi, T1
Kurita, K1
Tatematsu, M2
Shiotani, H1
Endoh, T1
Sasaki, Y1
Tsutsumi, N1
Sugimura, M1
Konishi, Y1
Oda, H1
Nakatsuru, Y1
Balasenthil, S1
Ramachandran, CR1
Nagini, S1
Niwa, S1
Ueno, S1
Shirasu, R1
Liu, X2
He, R2
Higuchi, M1
Nishikawa, H1
Yasaki, S1
Ogura, T1
Azuma, I1
Taniyama, T1
Kishimoto, S1
Yamamura, Y1
Takeuchi, J1
Miura, K1
Usizima, H1
Katoh, Y1
Lekholm, U1
Wallenius, K2
Takahashi, M1
Hananouchi, M1
Ahlström, U1
Mark, J1
Sugaya, T1
Onishi, S1
Miyaji, T1
Kojima, T2
Morishita, Y1
O'Grady, JF1
Game, S1
Scully, C5
Prime, S1
Okumura, A1
Boyd, NM1
Miller, JA1
Hennings, H1
Kandarkar, SV1
Booth, DR1
Reibel, J2
Dabelsteen, E2
Pitigala-Arachchi, A2
Crane, IJ2
Johansson, SL2
Hirsch, JM2
Larsson, PA2
Saidi, J1
Osterdahl, BG1
Vahlne, A1
Sawyer, DR1
Rennie, J1
Malamos, D1
Rosser, T1
Rosser, TJ1
Davies, LS1
Overvad, K1
Rich, AM2

Clinical Trials (2)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Observational Study on the Carcinogenesis of SOX-9 in Oral Cancer, and Chemopreventive Possibility for the Treatment of Oral Cancer Using SOX-9 Inhibitor.[NCT01919567]255 participants (Anticipated)Observational2011-11-30Recruiting
Pharmacokinetics Study of Antitumor B in Healthy Volunteers[NCT04230057]12 participants (Actual)Observational2019-12-12Active, not recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

4 reviews available for 4-nitroquinoline-1-oxide and Carcinoma, Squamous Cell

ArticleYear
4-nitroquinoline-1-oxide (4NQO) induced oral carcinogenesis: A systematic literature review.
    Pathology, research and practice, 2022, Volume: 236

    Topics: 4-Nitroquinoline-1-oxide; Animals; Carcinogenesis; Carcinoma, Squamous Cell; Rats; Rats, Wistar; Ton

2022
The 4-NQO mouse model: An update on a well-established in vivo model of oral carcinogenesis.
    Methods in cell biology, 2021, Volume: 163

    Topics: 4-Nitroquinoline-1-oxide; Animals; Carcinogenesis; Carcinogens; Carcinoma, Squamous Cell; Mice; Mout

2021
4-nitroquinoline-1-oxide induced experimental oral carcinogenesis.
    Oral oncology, 2006, Volume: 42, Issue:7

    Topics: 4-Nitroquinoline-1-oxide; Animals; Biomarkers, Tumor; Carcinogens; Carcinoma, Squamous Cell; Cell Tr

2006
Host genes controlling the susceptibility and resistance to squamous cell carcinoma of the tongue in a rat model.
    Pathology international, 2000, Volume: 50, Issue:5

    Topics: 4-Nitroquinoline-1-oxide; Animals; Carcinogens; Carcinoma, Squamous Cell; Chromosome Mapping; Geneti

2000

Trials

2 trials available for 4-nitroquinoline-1-oxide and Carcinoma, Squamous Cell

ArticleYear
Spontaneous alveolar bone loss after 4NQO exposure in Wistar rats.
    Archives of oral biology, 2018, Volume: 89

    Topics: 4-Nitroquinoline-1-oxide; Alveolar Bone Loss; Animals; Carcinogenesis; Carcinogens; Carcinoma, Squam

2018
Met Receptor Tyrosine Kinase and Chemoprevention of Oral Cancer.
    Journal of the National Cancer Institute, 2018, 03-01, Volume: 110, Issue:3

    Topics: 4-Nitroquinoline-1-oxide; Animals; Antineoplastic Agents; Biomarkers, Tumor; Carcinoma, Squamous Cel

2018

Other Studies

215 other studies available for 4-nitroquinoline-1-oxide and Carcinoma, Squamous Cell

ArticleYear
Effector T cell responses unleashed by regulatory T cell ablation exacerbate oral squamous cell carcinoma.
    Cell reports. Medicine, 2021, 09-21, Volume: 2, Issue:9

    Topics: 4-Nitroquinoline-1-oxide; Amino Acid Sequence; Animals; Antigens, Neoplasm; Carcinogens; Carcinoma,

2021
Modulation of the oral glucocorticoid system during black raspberry mediated oral cancer chemoprevention.
    Carcinogenesis, 2022, 02-11, Volume: 43, Issue:1

    Topics: 4-Nitroquinoline-1-oxide; Animals; Carcinogenesis; Carcinogens; Carcinoma, Squamous Cell; Cell Line,

2022
Periodontal disease affects oral cancer progression in a surrogate animal model for tobacco exposure.
    International journal of oncology, 2022, Volume: 60, Issue:6

    Topics: 4-Nitroquinoline-1-oxide; Animals; Carcinogenesis; Carcinoma, Squamous Cell; Disease Models, Animal;

2022
Chemoprevention of 4NQO-Induced Mouse Tongue Carcinogenesis by AKT Inhibitor through the MMP-9/RhoC Signaling Pathway and Autophagy.
    Analytical cellular pathology (Amsterdam), 2022, Volume: 2022

    Topics: 4-Nitroquinoline-1-oxide; Animals; Autophagy; Carcinogenesis; Carcinoma, Squamous Cell; Chemoprevent

2022
Laser photobiomodulation does not alter clinical and histological characteristics of 4-NQO-induced oral carcinomas and leukoplakia in mice.
    Journal of photochemistry and photobiology. B, Biology, 2022, Volume: 237

    Topics: 4-Nitroquinoline-1-oxide; Animals; Carcinogens; Carcinoma, Squamous Cell; Female; Lasers, Semiconduc

2022
Laser photobiomodulation does not alter clinical and histological characteristics of 4-NQO-induced oral carcinomas and leukoplakia in mice.
    Journal of photochemistry and photobiology. B, Biology, 2022, Volume: 237

    Topics: 4-Nitroquinoline-1-oxide; Animals; Carcinogens; Carcinoma, Squamous Cell; Female; Lasers, Semiconduc

2022
Laser photobiomodulation does not alter clinical and histological characteristics of 4-NQO-induced oral carcinomas and leukoplakia in mice.
    Journal of photochemistry and photobiology. B, Biology, 2022, Volume: 237

    Topics: 4-Nitroquinoline-1-oxide; Animals; Carcinogens; Carcinoma, Squamous Cell; Female; Lasers, Semiconduc

2022
Laser photobiomodulation does not alter clinical and histological characteristics of 4-NQO-induced oral carcinomas and leukoplakia in mice.
    Journal of photochemistry and photobiology. B, Biology, 2022, Volume: 237

    Topics: 4-Nitroquinoline-1-oxide; Animals; Carcinogens; Carcinoma, Squamous Cell; Female; Lasers, Semiconduc

2022
Laser photobiomodulation does not alter clinical and histological characteristics of 4-NQO-induced oral carcinomas and leukoplakia in mice.
    Journal of photochemistry and photobiology. B, Biology, 2022, Volume: 237

    Topics: 4-Nitroquinoline-1-oxide; Animals; Carcinogens; Carcinoma, Squamous Cell; Female; Lasers, Semiconduc

2022
Laser photobiomodulation does not alter clinical and histological characteristics of 4-NQO-induced oral carcinomas and leukoplakia in mice.
    Journal of photochemistry and photobiology. B, Biology, 2022, Volume: 237

    Topics: 4-Nitroquinoline-1-oxide; Animals; Carcinogens; Carcinoma, Squamous Cell; Female; Lasers, Semiconduc

2022
Laser photobiomodulation does not alter clinical and histological characteristics of 4-NQO-induced oral carcinomas and leukoplakia in mice.
    Journal of photochemistry and photobiology. B, Biology, 2022, Volume: 237

    Topics: 4-Nitroquinoline-1-oxide; Animals; Carcinogens; Carcinoma, Squamous Cell; Female; Lasers, Semiconduc

2022
Laser photobiomodulation does not alter clinical and histological characteristics of 4-NQO-induced oral carcinomas and leukoplakia in mice.
    Journal of photochemistry and photobiology. B, Biology, 2022, Volume: 237

    Topics: 4-Nitroquinoline-1-oxide; Animals; Carcinogens; Carcinoma, Squamous Cell; Female; Lasers, Semiconduc

2022
Laser photobiomodulation does not alter clinical and histological characteristics of 4-NQO-induced oral carcinomas and leukoplakia in mice.
    Journal of photochemistry and photobiology. B, Biology, 2022, Volume: 237

    Topics: 4-Nitroquinoline-1-oxide; Animals; Carcinogens; Carcinoma, Squamous Cell; Female; Lasers, Semiconduc

2022
GPR68 limits the severity of chemical-induced oral epithelial dysplasia.
    Scientific reports, 2023, 01-07, Volume: 13, Issue:1

    Topics: 4-Nitroquinoline-1-oxide; Animals; Carcinogenesis; Carcinoma, Squamous Cell; Cell Transformation, Ne

2023
Spermidine Suppresses Oral Carcinogenesis through Autophagy Induction, DNA Damage Repair, and Oxidative Stress Reduction.
    The American journal of pathology, 2023, Volume: 193, Issue:12

    Topics: 4-Nitroquinoline-1-oxide; Animals; Carcinogenesis; Carcinogens; Carcinoma, Squamous Cell; Ceramides;

2023
4-nitroquinoline 1-oxide induces immune cells death to onset early immunosuppression during oral squamous cell carcinoma development.
    Frontiers in immunology, 2023, Volume: 14

    Topics: 4-Nitroquinoline-1-oxide; Animals; Apoptosis; Carcinoma, Squamous Cell; Head and Neck Neoplasms; Hum

2023
Impact of dietary vitamin D on initiation and progression of oral cancer.
    The Journal of steroid biochemistry and molecular biology, 2020, Volume: 199

    Topics: 4-Nitroquinoline-1-oxide; Animals; Body Weight; Calcitriol; Carcinogenesis; Carcinoma, Squamous Cell

2020
Mutations in long-lived epithelial stem cells and their clonal progeny in pre-malignant lesions and in oral squamous cell carcinoma.
    Carcinogenesis, 2020, 11-13, Volume: 41, Issue:11

    Topics: 4-Nitroquinoline-1-oxide; Animals; Carcinogens; Carcinoma, Squamous Cell; Cell Lineage; Clone Cells;

2020
An Infection-Based Murine Model for Papillomavirus-Associated Head and Neck Cancer.
    mBio, 2020, 05-12, Volume: 11, Issue:3

    Topics: 4-Nitroquinoline-1-oxide; Animals; Carcinogens; Carcinoma, Squamous Cell; Disease Models, Animal; Fe

2020
The Histopathology of Oral Cancer Pain in a Mouse Model and a Human Cohort.
    Journal of dental research, 2021, Volume: 100, Issue:2

    Topics: 4-Nitroquinoline-1-oxide; Animals; Cancer Pain; Carcinoma, Squamous Cell; Humans; Mice; Mouth Neopla

2021
Can propranolol act as a chemopreventive agent during oral carcinogenesis? An experimental animal study.
    European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP), 2021, 07-01, Volume: 30, Issue:4

    Topics: 4-Nitroquinoline-1-oxide; Animals; Carcinogenesis; Carcinogens; Carcinoma, Squamous Cell; Disease Mo

2021
Genomic landscape and clonal architecture of mouse oral squamous cell carcinomas dictate tumour ecology.
    Nature communications, 2020, 11-09, Volume: 11, Issue:1

    Topics: 4-Nitroquinoline-1-oxide; Animals; Cadherins; Carcinogenesis; Carcinoma, Squamous Cell; Disease Mode

2020
Targeting of CD40 and PD-L1 Pathways Inhibits Progression of Oral Premalignant Lesions in a Carcinogen-induced Model of Oral Squamous Cell Carcinoma.
    Cancer prevention research (Philadelphia, Pa.), 2021, Volume: 14, Issue:3

    Topics: 4-Nitroquinoline-1-oxide; Animals; Antibodies, Monoclonal; B7-H1 Antigen; Carcinogens; Carcinoma, Sq

2021
4NQO induced carcinogenesis: A mouse model for oral squamous cell carcinoma.
    Methods in cell biology, 2021, Volume: 163

    Topics: 4-Nitroquinoline-1-oxide; Animals; Carcinogenesis; Carcinoma, Squamous Cell; Head and Neck Neoplasms

2021
Effectiveness of radiotherapy+ozone on tumoral tissue and survival in tongue cancer rat model.
    Auris, nasus, larynx, 2018, Volume: 45, Issue:1

    Topics: 4-Nitroquinoline-1-oxide; Animals; Carcinoma, Squamous Cell; Combined Modality Therapy; Disease Mode

2018
Comparison of injectable doxorubicin & its nanodrug complex chemotherapy for the treatment of 4-nitroquinoline-1-oxide induced oral squamous cell carcinoma in rats.
    The Indian journal of medical research, 2017, Volume: 145, Issue:1

    Topics: 4-Nitroquinoline-1-oxide; Animals; Carcinoma, Squamous Cell; Disease Models, Animal; Doxorubicin; Dr

2017
Curcumin and metformin-mediated chemoprevention of oral cancer is associated with inhibition of cancer stem cells.
    Molecular carcinogenesis, 2017, Volume: 56, Issue:11

    Topics: 4-Nitroquinoline-1-oxide; AC133 Antigen; Animals; Antineoplastic Agents; Carcinoma, Squamous Cell; C

2017
Tumor-Associated Macrophages in the Development of 4-Nitroquinoline-1-Oxide-Induced Tongue Squamous Cell Carcinoma in a Mouse Model.
    Oncology, 2017, Volume: 93, Issue:3

    Topics: 4-Nitroquinoline-1-oxide; Animals; Carcinogens; Carcinoma, Squamous Cell; Disease Models, Animal; Im

2017
Evaluation of ethyl gallate for its antioxidant and anticancer properties against chemical-induced tongue carcinogenesis in mice.
    The Biochemical journal, 2017, 08-22, Volume: 474, Issue:17

    Topics: 4-Nitroquinoline-1-oxide; Acacia; Animals; Antineoplastic Agents, Phytogenic; Antioxidants; Carcinom

2017
Early detection of squamous cell carcinoma in carcinogen induced oral cancer rodent model by ratiometric activatable cell penetrating peptides.
    Oral oncology, 2017, Volume: 71

    Topics: 4-Nitroquinoline-1-oxide; Animals; Carcinogens; Carcinoma, Squamous Cell; Cell-Penetrating Peptides;

2017
Tumor necrosis factor alpha secreted from oral squamous cell carcinoma contributes to cancer pain and associated inflammation.
    Pain, 2017, Volume: 158, Issue:12

    Topics: 4-Nitroquinoline-1-oxide; Animals; Cancer Pain; Carcinoma, Squamous Cell; Female; Inflammation; Mice

2017
Proteomics-based investigation of multiple stages of OSCC development indicates that the inhibition of Trx-1 delays oral malignant transformation.
    International journal of oncology, 2018, Volume: 52, Issue:3

    Topics: 4-Nitroquinoline-1-oxide; Adult; Aged; Animals; Apoptosis; Biomarkers, Tumor; Carcinogenesis; Carcin

2018
Dek overexpression in murine epithelia increases overt esophageal squamous cell carcinoma incidence.
    PLoS genetics, 2018, Volume: 14, Issue:3

    Topics: 4-Nitroquinoline-1-oxide; Animals; Carcinoma, Squamous Cell; DNA-Binding Proteins; Epithelium; Esoph

2018
Impact of Age on Disease Progression and Microenvironment in Oral Cancer.
    Journal of dental research, 2018, Volume: 97, Issue:11

    Topics: 4-Nitroquinoline-1-oxide; Age Factors; Animals; Carcinoma, Squamous Cell; Disease Progression; Femal

2018
Alterations of 63 hub genes during lingual carcinogenesis in C57BL/6J mice.
    Scientific reports, 2018, 08-22, Volume: 8, Issue:1

    Topics: 4-Nitroquinoline-1-oxide; Animals; Biomarkers, Tumor; Carcinogenesis; Carcinogens; Carcinoma, Squamo

2018
Immunohistochemistry profile of p75 neurotrophin receptor in oral epithelial dysplasia and oral squamous cell carcinoma induced by 4-nitroquinoline 1-oxide in rats.
    Archives of oral biology, 2018, Volume: 96

    Topics: 4-Nitroquinoline-1-oxide; Animals; Biomarkers, Tumor; Carcinoma, Squamous Cell; Disease Models, Anim

2018
No difference in 4-nitroquinoline induced tumorigenesis between germ-free and colonized mice.
    Molecular carcinogenesis, 2019, Volume: 58, Issue:5

    Topics: 4-Nitroquinoline-1-oxide; Animals; Carcinogenesis; Carcinogens; Carcinoma, Squamous Cell; Cell Trans

2019
Taiwanin C elicits apoptosis in arecoline and 4-nitroquinoline-1-oxide-induced oral squamous cell carcinoma cells and hinders proliferation via epidermal growth factor receptor/PI3K suppression.
    Environmental toxicology, 2019, Volume: 34, Issue:6

    Topics: 4-Nitroquinoline-1-oxide; Animals; Antineoplastic Agents, Phytogenic; Apoptosis; Arecoline; Carcinom

2019
Establishing of mouse oral carcinoma cell lines derived from transgenic mice and their use as syngeneic tumorigenesis models.
    BMC cancer, 2019, Mar-29, Volume: 19, Issue:1

    Topics: 4-Nitroquinoline-1-oxide; Animals; Carcinoma, Squamous Cell; Cell Culture Techniques; Cell Line, Tum

2019
Method for diagnosing neoplastic lesions by quantitative fluorescence value.
    Scientific reports, 2019, 05-24, Volume: 9, Issue:1

    Topics: 4-Nitroquinoline-1-oxide; Animals; Carcinogenesis; Carcinogens; Carcinoma, Squamous Cell; Disease Pr

2019
Tumor-derived exosomes promote carcinogenesis of murine oral squamous cell carcinoma.
    Carcinogenesis, 2020, 07-10, Volume: 41, Issue:5

    Topics: 4-Nitroquinoline-1-oxide; Animals; Apoptosis; B7-H1 Antigen; Carcinogenesis; Carcinogens; Carcinoma,

2020
Assessment of the Blood Parameters, Cardiac and Liver Enzymes in Oral Squamous Cell Carcinoma Following Treated with Injectable Doxorubicin-Loaded Nano-Particles.
    Asian Pacific journal of cancer prevention : APJCP, 2019, 07-01, Volume: 20, Issue:7

    Topics: 4-Nitroquinoline-1-oxide; Animals; Antibiotics, Antineoplastic; Carcinogens; Carcinoma, Squamous Cel

2019
[Expression of connexin 43 in tongue carcinogenesis].
    Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics, 2013, Volume: 30, Issue:2

    Topics: 4-Nitroquinoline-1-oxide; Animals; Carcinoma, Squamous Cell; Connexin 43; Male; Rats; Rats, Sprague-

2013
PTEN deficiency contributes to the development and progression of head and neck cancer.
    Neoplasia (New York, N.Y.), 2013, Volume: 15, Issue:5

    Topics: 4-Nitroquinoline-1-oxide; Animals; Carcinogenesis; Carcinoma, Squamous Cell; Cells, Cultured; Cycloo

2013
miR-211 promotes the progression of head and neck carcinomas by targeting TGFβRII.
    Cancer letters, 2013, Aug-28, Volume: 337, Issue:1

    Topics: 4-Nitroquinoline-1-oxide; Animals; Carcinoma, Squamous Cell; Disease Progression; Genes, myc; Head a

2013
The molecular features of tongue epithelium treated with the carcinogen 4-nitroquinoline-1-oxide and alcohol as a model for HNSCC.
    Carcinogenesis, 2013, Volume: 34, Issue:11

    Topics: 4-Nitroquinoline-1-oxide; Animals; beta Catenin; Blotting, Western; Carcinogens; Carcinoma, Squamous

2013
[Expression of cytokeratin 19 and connexin 43 in 4-nitroquinoline-l-oxide-induced rat tongue carcinogenesis].
    Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology, 2013, Volume: 31, Issue:3

    Topics: 4-Nitroquinoline-1-oxide; Animals; Carcinogenesis; Carcinoma, Squamous Cell; Connexin 43; Epithelial

2013
Eosinophil depletion protects mice from tongue squamous cell carcinoma induced by 4-nitroquinoline-1-oxide.
    Histology and histopathology, 2014, Volume: 29, Issue:3

    Topics: 4-Nitroquinoline-1-oxide; Animals; Carcinogens; Carcinoma, Squamous Cell; Disease Models, Animal; En

2014
Localization of liposomal mTHPC formulations within normal epithelium, dysplastic tissue, and carcinoma of oral epithelium in the 4NQO-carcinogenesis rat model.
    Lasers in surgery and medicine, 2013, Volume: 45, Issue:10

    Topics: 4-Nitroquinoline-1-oxide; Animals; Carcinogens; Carcinoma, Squamous Cell; Liposomes; Male; Mesoporph

2013
Grape seed extract and resveratrol prevent 4-nitroquinoline 1-oxide induced oral tumorigenesis in mice by modulating AMPK activation and associated biological responses.
    Molecular carcinogenesis, 2015, Volume: 54, Issue:4

    Topics: 4-Nitroquinoline-1-oxide; AMP-Activated Protein Kinases; Animals; Anticarcinogenic Agents; Apoptosis

2015
Increased frequency of CD4+ CD25+ FOXP3+ cells correlates with the progression of 4-nitroquinoline1-oxide-induced rat tongue carcinogenesis.
    Clinical oral investigations, 2014, Volume: 18, Issue:7

    Topics: 4-Nitroquinoline-1-oxide; Animals; Carcinoma, Squamous Cell; CD4 Antigens; Disease Progression; Flow

2014
Combination of telmisartan with cisplatin controls oral cancer cachexia in rats.
    BioMed research international, 2013, Volume: 2013

    Topics: 4-Nitroquinoline-1-oxide; Animals; Antineoplastic Combined Chemotherapy Protocols; Benzimidazoles; B

2013
Diffusion Reflection: A Novel Method for Detection of Oral Cancer.
    Journal of dental research, 2014, Volume: 93, Issue:6

    Topics: 4-Nitroquinoline-1-oxide; Animals; Carcinogens; Carcinoma in Situ; Carcinoma, Squamous Cell; Diffusi

2014
Chemopreventive activity of apple extract following medium-term oral carcinogenesis assay induced by 4-nitroquinoline-1-oxide.
    Archives of oral biology, 2014, Volume: 59, Issue:8

    Topics: 4-Nitroquinoline-1-oxide; Animals; Antineoplastic Agents; Apoptosis; Carcinogenesis; Carcinoma, Squa

2014
Expression of cancer stem cell marker during 4-nitroquinoline 1-oxide-induced rat tongue carcinogenesis.
    Journal of molecular histology, 2014, Volume: 45, Issue:6

    Topics: 4-Nitroquinoline-1-oxide; AC133 Antigen; Aldehyde Dehydrogenase 1 Family; Animals; Antigens, CD; Bio

2014
K14-EGFP-miR-31 transgenic mice have high susceptibility to chemical-induced squamous cell tumorigenesis that is associating with Ku80 repression.
    International journal of cancer, 2015, Mar-15, Volume: 136, Issue:6

    Topics: 4-Nitroquinoline-1-oxide; Animals; Antigens, Nuclear; Carcinoma, Squamous Cell; Cell Line, Tumor; DN

2015
Novel DOX-MTX nanoparticles improve oral SCC clinical outcome by down regulation of lymph dissemination factor VEGF-C expression in vivo: oral and IV modalities.
    Asian Pacific journal of cancer prevention : APJCP, 2014, Volume: 15, Issue:15

    Topics: 4-Nitroquinoline-1-oxide; Administration, Oral; Animals; Antineoplastic Combined Chemotherapy Protoc

2014
Methylation-associated gene silencing of RARB in areca carcinogens induced mouse oral squamous cell carcinoma.
    BioMed research international, 2014, Volume: 2014

    Topics: 4-Nitroquinoline-1-oxide; Animals; Areca; Arecoline; Carcinogens; Carcinoma, Squamous Cell; Cell Lin

2014
IL-6-stimulated CD11b+ CD14+ HLA-DR- myeloid-derived suppressor cells, are associated with progression and poor prognosis in squamous cell carcinoma of the esophagus.
    Oncotarget, 2014, Sep-30, Volume: 5, Issue:18

    Topics: 4-Nitroquinoline-1-oxide; Animals; Arginase; Carcinoma, Squamous Cell; Case-Control Studies; CD11b A

2014
Inhibition of heat shock protein 90 suppresses squamous carcinogenic progression in a mouse model of esophageal cancer.
    Journal of cancer research and clinical oncology, 2015, Volume: 141, Issue:8

    Topics: 4-Nitroquinoline-1-oxide; Animals; Carcinogens; Carcinoma, Squamous Cell; Cell Proliferation; Cell T

2015
Oral and IV dosages of doxorubicin-methotrexate loaded- nanoparticles inhibit progression of oral cancer by down- regulation of matrix Methaloproteinase 2 expression in vivo.
    Asian Pacific journal of cancer prevention : APJCP, 2014, Volume: 15, Issue:24

    Topics: 4-Nitroquinoline-1-oxide; Administration, Oral; Animals; Antineoplastic Combined Chemotherapy Protoc

2014
Oral-specific ablation of Klf4 disrupts epithelial terminal differentiation and increases premalignant lesions and carcinomas upon chemical carcinogenesis.
    Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology, 2015, Volume: 44, Issue:10

    Topics: 4-Nitroquinoline-1-oxide; Animals; Carcinogenesis; Carcinogens; Carcinoma, Squamous Cell; Cell Diffe

2015
Overexpression of lipocalins and pro-inflammatory chemokines and altered methylation of PTGS2 and APC2 in oral squamous cell carcinomas induced in rats by 4-nitroquinoline-1-oxide.
    PloS one, 2015, Volume: 10, Issue:1

    Topics: 4-Nitroquinoline-1-oxide; Animals; Carcinoma, Squamous Cell; Chemokines; Cyclooxygenase 1; Cyclooxyg

2015
Initiation of esophageal squamous cell carcinoma (ESCC) in a murine 4-nitroquinoline-1-oxide and alcohol carcinogenesis model.
    Oncotarget, 2015, Mar-20, Volume: 6, Issue:8

    Topics: 4-Nitroquinoline-1-oxide; Animals; Carcinogenesis; Carcinogens; Carcinoma, Squamous Cell; Cell Proli

2015
1α,25-Dihydroxyvitamin D3 Inhibits Esophageal Squamous Cell Carcinoma Progression by Reducing IL6 Signaling.
    Molecular cancer therapeutics, 2015, Volume: 14, Issue:6

    Topics: 4-Nitroquinoline-1-oxide; Animals; Calcitriol; Carcinoma, Squamous Cell; Cell Line, Tumor; Cell Prol

2015
Mcl-1 is an important therapeutic target for oral squamous cell carcinomas.
    Oncotarget, 2015, Jun-30, Volume: 6, Issue:18

    Topics: 4-Nitroquinoline-1-oxide; Animals; Apoptosis; Apoptosis Regulatory Proteins; Autophagy-Related Prote

2015
Impact of Short-term 1,25-Dihydroxyvitamin D3 on the Chemopreventive Efficacy of Erlotinib against Oral Cancer.
    Cancer prevention research (Philadelphia, Pa.), 2015, Volume: 8, Issue:9

    Topics: 4-Nitroquinoline-1-oxide; Animals; Anticarcinogenic Agents; Antineoplastic Agents; Calcitriol; Carci

2015
Gene expression profiling signatures for the diagnosis and prevention of oral cavity carcinogenesis-genome-wide analysis using RNA-seq technology.
    Oncotarget, 2015, Sep-15, Volume: 6, Issue:27

    Topics: 4-Nitroquinoline-1-oxide; Animals; Biomarkers, Tumor; Carcinogenesis; Carcinogens; Carcinoma, Squamo

2015
Inhibition of 4NQO-Induced Oral Carcinogenesis by Dietary Oyster Shell Calcium.
    Integrative cancer therapies, 2016, Volume: 15, Issue:1

    Topics: 4-Nitroquinoline-1-oxide; Animal Shells; Animals; Antineoplastic Agents; Calcium; Carcinogenesis; Ca

2016
Roles of coinhibitory molecules B7-H3 and B7-H4 in esophageal squamous cell carcinoma.
    Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine, 2016, Volume: 37, Issue:3

    Topics: 4-Nitroquinoline-1-oxide; Adult; Aged; Animals; B7 Antigens; Carcinoma, Squamous Cell; Cell Line, Tu

2016
Suppression of Rat Oral Carcinogenesis by Agonists of Peroxisome Proliferator Activated Receptor γ.
    PloS one, 2015, Volume: 10, Issue:10

    Topics: 4-Nitroquinoline-1-oxide; Animals; Antineoplastic Agents; Carcinoma, Squamous Cell; Male; Mouth Neop

2015
Establishment of a highly metastatic buccal squamous cell carcinoma cell line from a Sprague-Dawley Rat.
    Archives of oral biology, 2016, Volume: 62

    Topics: 4-Nitroquinoline-1-oxide; Animals; Carcinogenesis; Carcinoma, Squamous Cell; Cell Line, Tumor; Disea

2016
Modulation of IL-1β reprogrammes the tumor microenvironment to interrupt oral carcinogenesis.
    Scientific reports, 2016, Feb-01, Volume: 6

    Topics: 4-Nitroquinoline-1-oxide; Administration, Oral; Animals; Carcinoma, Squamous Cell; Cell Line, Tumor;

2016
The dynamics of gene expression changes in a mouse model of oral tumorigenesis may help refine prevention and treatment strategies in patients with oral cancer.
    Oncotarget, 2016, Jun-14, Volume: 7, Issue:24

    Topics: 4-Nitroquinoline-1-oxide; Animals; Antineoplastic Agents; Carcinogens; Carcinoma, Squamous Cell; Cel

2016
Cortactin is a prognostic marker for oral squamous cell carcinoma and its overexpression is involved in oral carcinogenesis.
    Environmental toxicology, 2017, Volume: 32, Issue:3

    Topics: 4-Nitroquinoline-1-oxide; Adult; Animals; Areca; Carcinogenesis; Carcinoma, Squamous Cell; Cortactin

2017
MicroRNA-211 Enhances the Oncogenicity of Carcinogen-Induced Oral Carcinoma by Repressing TCF12 and Increasing Antioxidant Activity.
    Cancer research, 2016, 08-15, Volume: 76, Issue:16

    Topics: 4-Nitroquinoline-1-oxide; Animals; Basic Helix-Loop-Helix Transcription Factors; Blotting, Western;

2016
STAT3 as a Chemoprevention Target in Carcinogen-Induced Head and Neck Squamous Cell Carcinoma.
    Cancer prevention research (Philadelphia, Pa.), 2016, Volume: 9, Issue:8

    Topics: 4-Nitroquinoline-1-oxide; Animals; Biomarkers; Carcinogens; Carcinoma, Squamous Cell; Chemopreventio

2016
Identification of reliable reference genes for quantitative gene expression studies in oral squamous cell carcinomas compared to adjacent normal tissues in the F344 rat model.
    Oncology reports, 2016, Volume: 36, Issue:2

    Topics: 4-Nitroquinoline-1-oxide; Animals; Carcinoma, Squamous Cell; Gene Expression; Gene Expression Profil

2016
Regulatory T cells function at the early stage of tumor progression in a mouse model of tongue squamous cell carcinoma.
    Cancer immunology, immunotherapy : CII, 2016, Volume: 65, Issue:11

    Topics: 4-Nitroquinoline-1-oxide; Animals; Carcinogenesis; Carcinoma, Squamous Cell; Cells, Cultured; Chemok

2016
p120-Catenin Is Required for Dietary Calcium Suppression of Oral Carcinogenesis in Mice.
    Journal of cellular physiology, 2017, Volume: 232, Issue:6

    Topics: 4-Nitroquinoline-1-oxide; Animals; Calcium; Calcium, Dietary; Carcinogenesis; Carcinoma, Squamous Ce

2017
Loss of NDRG2 Expression Confers Oral Squamous Cell Carcinoma with Enhanced Metastatic Potential.
    Cancer research, 2017, 05-01, Volume: 77, Issue:9

    Topics: 4-Nitroquinoline-1-oxide; Adaptor Proteins, Signal Transducing; Animals; Carcinoma, Squamous Cell; C

2017
Areca nut is associated with younger age of diagnosis, poor chemoradiotherapy response, and shorter overall survival in esophageal squamous cell carcinoma.
    PloS one, 2017, Volume: 12, Issue:2

    Topics: 4-Nitroquinoline-1-oxide; Adult; Aged; Aged, 80 and over; Animals; Antineoplastic Agents; Areca; Are

2017
Lack of promotion activity of diacylglycerol oil on 4-nitroquinoline 1-oxide induced carcinogenesis in the oral cavity of SD rats.
    Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 2008, Volume: 46, Issue:9

    Topics: 4-Nitroquinoline-1-oxide; Animals; Carcinogens; Carcinoma, Squamous Cell; Diet; Diglycerides; Fatty

2008
Apoptin induces apoptosis in an oral cancer mouse model.
    Cancer biology & therapy, 2008, Volume: 7, Issue:9

    Topics: 4-Nitroquinoline-1-oxide; Adenoviridae; Animals; Apoptosis; Capsid Proteins; Carcinogens; Carcinoma,

2008
Targeting mammalian target of rapamycin by rapamycin prevents tumor progression in an oral-specific chemical carcinogenesis model.
    Cancer prevention research (Philadelphia, Pa.), 2009, Volume: 2, Issue:1

    Topics: 4-Nitroquinoline-1-oxide; Animals; Antibiotics, Antineoplastic; Carcinogens; Carcinoma, Squamous Cel

2009
Increased expression of focal adhesion kinase correlates with cellular proliferation and apoptosis during 4-nitroquinoline-1-oxide-induced rat tongue carcinogenesis.
    Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology, 2009, Volume: 38, Issue:6

    Topics: 4-Nitroquinoline-1-oxide; Animals; Apoptosis; Biomarkers, Tumor; Carcinogens; Carcinoma, Squamous Ce

2009
Functional genomic analysis identified epidermal growth factor receptor activation as the most common genetic event in oral squamous cell carcinoma.
    Cancer research, 2009, Mar-15, Volume: 69, Issue:6

    Topics: 4-Nitroquinoline-1-oxide; Animals; Arecoline; Carcinogens; Carcinoma, Squamous Cell; Disease Models,

2009
Diabetes enhances the expression of H-ras and suppresses the expression of EGFR leading to increased cell proliferation.
    Histology and histopathology, 2009, Volume: 24, Issue:5

    Topics: 4-Nitroquinoline-1-oxide; Animals; Carcinogens; Carcinoma, Squamous Cell; Cell Proliferation; Diabet

2009
ABT-510 is an effective chemopreventive agent in the mouse 4-nitroquinoline 1-oxide model of oral carcinogenesis.
    Cancer prevention research (Philadelphia, Pa.), 2009, Volume: 2, Issue:4

    Topics: 4-Nitroquinoline-1-oxide; Angiogenesis Inhibitors; Animals; Carcinogens; Carcinoma, Squamous Cell; D

2009
Gene deletion of inositol hexakisphosphate kinase 2 predisposes to aerodigestive tract carcinoma.
    Oncogene, 2009, Jun-25, Volume: 28, Issue:25

    Topics: 4-Nitroquinoline-1-oxide; Animals; Apoptosis; Carcinogens; Carcinoma, Squamous Cell; Esophageal Neop

2009
Global DNA hypomethylation suppresses squamous carcinogenesis in the tongue and esophagus.
    Cancer science, 2009, Volume: 100, Issue:7

    Topics: 4-Nitroquinoline-1-oxide; Alleles; Animals; Carcinoma, Squamous Cell; Cell Line, Tumor; DNA (Cytosin

2009
A mouse model for oral squamous cell carcinoma.
    Journal of molecular histology, 2009, Volume: 40, Issue:3

    Topics: 4-Nitroquinoline-1-oxide; Animals; Biomarkers, Tumor; Cadherins; Carcinoma, Squamous Cell; Cyclin D1

2009
Wnt/beta-catenin signalling pathway following rat tongue carcinogenesis induced by 4-nitroquinoline 1-oxide.
    Experimental and molecular pathology, 2010, Volume: 88, Issue:1

    Topics: 4-Nitroquinoline-1-oxide; Animals; beta Catenin; Carcinogens; Carcinoma, Squamous Cell; Disease Mode

2010
A DNA methyltransferase inhibitor and all-trans retinoic acid reduce oral cavity carcinogenesis induced by the carcinogen 4-nitroquinoline 1-oxide.
    Cancer prevention research (Philadelphia, Pa.), 2009, Volume: 2, Issue:12

    Topics: 4-Nitroquinoline-1-oxide; Animals; Antineoplastic Combined Chemotherapy Protocols; Azacitidine; Carc

2009
Oral carcinogenesis induced by 4-nitroquinoline 1-oxide in lecithin:retinol acyltransferase gene knockout mice.
    The Journal of nutritional biochemistry, 2010, Volume: 21, Issue:10

    Topics: 4-Nitroquinoline-1-oxide; Acyltransferases; Animals; Base Sequence; Carcinogens; Carcinoma, Squamous

2010
Enhancement of tongue carcinogenesis in Hras128 transgenic rats treated with 4-nitroquinoline 1-oxide.
    Oncology reports, 2010, Volume: 23, Issue:2

    Topics: 4-Nitroquinoline-1-oxide; Animals; Carcinoma, Squamous Cell; Cell Transformation, Neoplastic; Drug S

2010
Deficiencies in the Fanconi anemia DNA damage response pathway increase sensitivity to HPV-associated head and neck cancer.
    Cancer research, 2010, Dec-01, Volume: 70, Issue:23

    Topics: 4-Nitroquinoline-1-oxide; Animals; Biomarkers, Tumor; Carcinoma, Squamous Cell; DNA Damage; Fanconi

2010
Fenofibrate exhibits a high potential to suppress the formation of squamous cell carcinoma in an oral-specific 4-nitroquinoline 1-oxide/arecoline mouse model.
    Biochimica et biophysica acta, 2011, Volume: 1812, Issue:4

    Topics: 4-Nitroquinoline-1-oxide; Acetyl-CoA Carboxylase; Animals; Anticarcinogenic Agents; Arecoline; Carci

2011
Inhibition of EGFR-STAT3 signaling with erlotinib prevents carcinogenesis in a chemically-induced mouse model of oral squamous cell carcinoma.
    Cancer prevention research (Philadelphia, Pa.), 2011, Volume: 4, Issue:2

    Topics: 4-Nitroquinoline-1-oxide; Animal Feed; Animals; Carcinogens; Carcinoma, Squamous Cell; Commiphora; D

2011
Histological and immunohistochemical evaluation of the chemopreventive role of lycopene in tongue carcinogenesis induced by 4-nitroquinoline-1-oxide.
    Archives of oral biology, 2011, Volume: 56, Issue:7

    Topics: 4-Nitroquinoline-1-oxide; Animals; Anticarcinogenic Agents; Antioxidants; Basement Membrane; beta Ca

2011
Zinc supplementation suppresses 4-nitroquinoline 1-oxide-induced rat oral carcinogenesis.
    Carcinogenesis, 2011, Volume: 32, Issue:4

    Topics: 4-Nitroquinoline-1-oxide; Animals; Apoptosis; Carcinoma, Squamous Cell; Cell Proliferation; Dietary

2011
Chronic restraint stress in oral squamous cell carcinoma.
    Journal of dental research, 2011, Volume: 90, Issue:6

    Topics: 4-Nitroquinoline-1-oxide; Animals; Carcinoma, Squamous Cell; Corticosterone; Immobilization; Kaplan-

2011
Oxidative DNA damage is a preliminary step during rat tongue carcinogenesis induced by 4-nitroquinoline 1-oxide.
    Journal of molecular histology, 2011, Volume: 42, Issue:2

    Topics: 4-Nitroquinoline-1-oxide; Animals; Carcinogens; Carcinoma, Squamous Cell; Comet Assay; DNA Damage; H

2011
Ethanol promotes chemically induced oral cancer in mice through activation of the 5-lipoxygenase pathway of arachidonic acid metabolism.
    Cancer prevention research (Philadelphia, Pa.), 2011, Volume: 4, Issue:11

    Topics: 4-Nitroquinoline-1-oxide; Animals; Anti-Infective Agents, Local; Arachidonate 5-Lipoxygenase; Arachi

2011
Myeloid-derived suppressor cells contribute to oral cancer progression in 4NQO-treated mice.
    Oral diseases, 2012, Volume: 18, Issue:1

    Topics: 4-Nitroquinoline-1-oxide; Animals; Arginase; Carcinoma, Squamous Cell; CD11b Antigen; Female; Flow C

2012
Chemopreventive effect of a mixture of Chinese Herbs (antitumor B) on chemically induced oral carcinogenesis.
    Molecular carcinogenesis, 2013, Volume: 52, Issue:1

    Topics: 4-Nitroquinoline-1-oxide; Alkaloids; Animals; Antineoplastic Agents, Phytogenic; Benzoxepins; Biomar

2013
Alkylation-induced genotoxicity as a predictor of DNA repair deficiency following experimental oral carcinogenesis.
    Journal of molecular histology, 2012, Volume: 43, Issue:2

    Topics: 4-Nitroquinoline-1-oxide; Administration, Oral; Alkylation; Animals; Carcinogens; Carcinoma, Squamou

2012
Homeobox C5 expression is associated with the progression of 4-nitroquinoline 1-oxide-induced rat tongue carcinogenesis.
    Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology, 2012, Volume: 41, Issue:6

    Topics: 4-Nitroquinoline-1-oxide; Animals; Biomarkers, Tumor; Carcinogens; Carcinoma, Squamous Cell; Cell Li

2012
Administration of a vaccine composed of dendritic cells pulsed with premalignant oral lesion lysate to mice bearing carcinogen-induced premalignant oral lesions stimulates a protective immune response.
    International immunopharmacology, 2012, Volume: 13, Issue:3

    Topics: 4-Nitroquinoline-1-oxide; Animals; Antigens, Neoplasm; Cancer Vaccines; Carcinogens; Carcinoma, Squa

2012
The inactive form of glycogen synthase kinase-3β is associated with the development of carcinomas in galectin-3 wild-type mice, but not in galectin-3-deficient mice.
    International journal of clinical and experimental pathology, 2012, Volume: 5, Issue:6

    Topics: 4-Nitroquinoline-1-oxide; Animals; Biomarkers, Tumor; Carcinogens; Carcinoma, Squamous Cell; Cell Nu

2012
Development of a 4-nitroquinoline-1-oxide model of lymph node metastasis in oral squamous cell carcinoma.
    Oral oncology, 2013, Volume: 49, Issue:4

    Topics: 4-Nitroquinoline-1-oxide; Animals; Carcinoma, Squamous Cell; Immunohistochemistry; Lymphatic Metasta

2013
Targeted expression of ornithine decarboxylase antizyme prevents upper aerodigestive tract carcinogenesis in p53-deficient mice.
    Carcinogenesis, 2013, Volume: 34, Issue:3

    Topics: 4-Nitroquinoline-1-oxide; Animals; Carcinoma, Squamous Cell; Cell Proliferation; Cell Transformation

2013
Basal stem cells contribute to squamous cell carcinomas in the oral cavity.
    Carcinogenesis, 2013, Volume: 34, Issue:5

    Topics: 4-Nitroquinoline-1-oxide; Animals; Carcinogens; Carcinoma, Squamous Cell; Cell Proliferation; Epithe

2013
The role of cellular trace elements in oral carcinogenesis induced by 4-nitroquinoline 1-oxide(4NQO).
    Hunan yi ke da xue xue bao = Hunan yike daxue xuebao = Bulletin of Hunan Medical University, 2000, Aug-28, Volume: 25, Issue:4

    Topics: 4-Nitroquinoline-1-oxide; Animals; Carcinoma, Squamous Cell; Copper; Electron Probe Microanalysis; F

2000
Skeletal muscle regeneration associated with the stroma reaction during tumor invasion in the rat tongue.
    Journal of submicroscopic cytology and pathology, 2002, Volume: 34, Issue:4

    Topics: 4-Nitroquinoline-1-oxide; Acetylcholinesterase; Animals; Biomarkers, Tumor; Bupivacaine; Carcinogens

2002
Histomorphologic and morphometric changes in minor salivary glands of the rat tongue during 4-nitroquinoline-1-oxide-induced carcinogenesis.
    Oral oncology, 2003, Volume: 39, Issue:5

    Topics: 4-Nitroquinoline-1-oxide; Analysis of Variance; Animals; Carcinogens; Carcinoma, Squamous Cell; Dise

2003
Changing expression of E- and P-cadherin during rat tongue carcinogenesis induced by 4-nitroquinoline 1-oxide.
    Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology, 2003, Volume: 32, Issue:9

    Topics: 4-Nitroquinoline-1-oxide; Animals; Cadherins; Carcinogens; Carcinoma, Squamous Cell; Cell Division;

2003
Inhibitory effects of selective cyclooxygenase-2 inhibitors, nimesulide and etodolac, on the development of squamous cell dysplasias and carcinomas of the tongue in rats initiated with 4-nitroquinoline 1-oxide.
    Cancer letters, 2003, Sep-25, Volume: 199, Issue:2

    Topics: 4-Nitroquinoline-1-oxide; Animals; Blotting, Western; Carcinogens; Carcinoma, Squamous Cell; Cell Di

2003
p53 haploinsufficiency profoundly accelerates the onset of tongue tumors in mice lacking the xeroderma pigmentosum group A gene.
    The American journal of pathology, 2003, Volume: 163, Issue:5

    Topics: 4-Nitroquinoline-1-oxide; Animals; Blotting, Southern; Carcinogens; Carcinoma, Squamous Cell; Diseas

2003
Expressions of junB and c-fos are enhanced in 4-nitroquinoline 1-oxide-induced rat tongue cancers.
    Pathology international, 2004, Volume: 54, Issue:1

    Topics: 4-Nitroquinoline-1-oxide; Animals; Biomarkers, Tumor; Carcinoma, Squamous Cell; Cell Nucleus; Diseas

2004
Oral cavity and esophageal carcinogenesis modeled in carcinogen-treated mice.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2004, Jan-01, Volume: 10, Issue:1 Pt 1

    Topics: 4-Nitroquinoline-1-oxide; Animals; Bromodeoxyuridine; Carcinogens; Carcinoma, Papillary; Carcinoma,

2004
Interaction between the immune system and tongue squamous cell carcinoma induced by 4-nitroquinoline N-oxide in mice.
    Oral oncology, 2004, Volume: 40, Issue:3

    Topics: 4-Nitroquinoline-1-oxide; Animals; Carcinogens; Carcinoma, Squamous Cell; Cell Division; Cytokines;

2004
High frequency methylation of p16INK4A gene during 4-nitroquinoline 1-oxide-induced rat tongue carcinogenesis.
    Oncology reports, 2004, Volume: 12, Issue:1

    Topics: 4-Nitroquinoline-1-oxide; Animals; Base Sequence; Carcinogens; Carcinoma, Squamous Cell; Cyclin-Depe

2004
Genomic instability in non-neoplastic oral mucosa cells can predict risk during 4-nitroquinoline 1-oxide-induced rat tongue carcinogenesis.
    Oral oncology, 2004, Volume: 40, Issue:9

    Topics: 4-Nitroquinoline-1-oxide; Animals; Carcinoma, Squamous Cell; Cell Transformation, Neoplastic; Comet

2004
Therapeutic efficacy of green tea polyphenols on cellular thiols in 4-Nitroquinoline 1-oxide-induced oral carcinogenesis.
    Chemico-biological interactions, 2004, Oct-15, Volume: 149, Issue:2-3

    Topics: 4-Nitroquinoline-1-oxide; Animals; Carcinogens; Carcinoma, Squamous Cell; Flavonoids; gamma-Glutamyl

2004
Suppressive effects of a selective cyclooxygenase-2 inhibitor, etodolac, on 4-nitroquinoline 1-oxide-induced rat tongue carcinogenesis.
    Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie, 2004, Volume: 56, Issue:3

    Topics: 4-Nitroquinoline-1-oxide; Administration, Oral; Animals; Anticarcinogenic Agents; Carcinogens; Carci

2004
Dietary zinc modulation of COX-2 expression and lingual and esophageal carcinogenesis in rats.
    Journal of the National Cancer Institute, 2005, Jan-05, Volume: 97, Issue:1

    Topics: 4-Nitroquinoline-1-oxide; Animals; Apoptosis; Blotting, Western; Carcinogens; Carcinoma, Squamous Ce

2005
4NQO oral carcinogenesis: animal models, molecular markers and future expectations.
    Oral oncology, 2005, Volume: 41, Issue:4

    Topics: 4-Nitroquinoline-1-oxide; Animals; Biomarkers, Tumor; Carcinogens; Carcinoma, Squamous Cell; Cell Tr

2005
Chemoprevention of 4-NQO-induced oral carcinogenesis by co-administration of all-trans retinoic acid loaded microspheres and celecoxib.
    Journal of controlled release : official journal of the Controlled Release Society, 2005, May-05, Volume: 104, Issue:1

    Topics: 4-Nitroquinoline-1-oxide; Animals; Anticarcinogenic Agents; Carcinoma, Squamous Cell; Celecoxib; Cyc

2005
A speed congenic rat strain bearing the tongue cancer susceptibility locus Tscc1 from Dark-Agouti rats.
    Cancer letters, 2006, Jan-18, Volume: 231, Issue:2

    Topics: 4-Nitroquinoline-1-oxide; Animals; Carcinogens; Carcinoma, Squamous Cell; Chromosomes; Female; Genet

2006
Modulation of gene expression in precancerous rat esophagus by dietary zinc deficit and replenishment.
    Cancer research, 2005, Sep-01, Volume: 65, Issue:17

    Topics: 4-Nitroquinoline-1-oxide; Animals; Carcinoma, Squamous Cell; Esophageal Neoplasms; Gene Expression R

2005
Head and neck cancer cell lines exhibit differential mitochondrial repair deficiency in response to 4NQO.
    Oral oncology, 2006, Volume: 42, Issue:2

    Topics: 4-Nitroquinoline-1-oxide; Carcinoma, Squamous Cell; DNA Adducts; DNA Damage; DNA Repair; DNA, Mitoch

2006
Abnormal expression of bcl-2 and bax in rat tongue mucosa during the development of squamous cell carcinoma induced by 4-nitroquinoline 1-oxide.
    International journal of experimental pathology, 2005, Volume: 86, Issue:6

    Topics: 4-Nitroquinoline-1-oxide; Animals; bcl-2-Associated X Protein; Biomarkers, Tumor; Carcinoma, Squamou

2005
Chemopreventive efficacy of all-trans-retinoic acid in biodegradable microspheres against epithelial cancers: results in a 4-nitroquinoline 1-oxide-induced oral carcinogenesis model.
    International journal of pharmaceutics, 2006, Aug-31, Volume: 320, Issue:1-2

    Topics: 4-Nitroquinoline-1-oxide; Animals; Antineoplastic Agents; Carcinoma, Squamous Cell; Cell Transformat

2006
p53 Transgenic mice are highly susceptible to 4-nitroquinoline-1-oxide-induced oral cancer.
    Molecular cancer research : MCR, 2006, Volume: 4, Issue:6

    Topics: 4-Nitroquinoline-1-oxide; Animals; Apoptosis; Carcinogens; Carcinoma, Squamous Cell; Cell Cycle; Dis

2006
4-Nitroquinoline-1-oxide-induced mutagen sensitivity and risk of nonmelanoma skin cancer: a case-control analysis.
    The Journal of investigative dermatology, 2007, Volume: 127, Issue:1

    Topics: 4-Nitroquinoline-1-oxide; Adult; Aged; Aged, 80 and over; Carcinoma, Basal Cell; Carcinoma, Squamous

2007
Identification of biomarkers that distinguish human papillomavirus (HPV)-positive versus HPV-negative head and neck cancers in a mouse model.
    Proceedings of the National Academy of Sciences of the United States of America, 2006, Sep-19, Volume: 103, Issue:38

    Topics: 4-Nitroquinoline-1-oxide; Animals; Biomarkers, Tumor; Carcinogens; Carcinoma, Squamous Cell; Cell Cy

2006
A prostaglandin E2 receptor subtype EP1-selective antagonist, ONO-8711, suppresses 4-nitroquinoline 1-oxide-induced rat tongue carcinogenesis.
    Carcinogenesis, 2007, Volume: 28, Issue:3

    Topics: 4-Nitroquinoline-1-oxide; Animal Feed; Animals; Bridged Bicyclo Compounds; Caproates; Carcinogens; C

2007
Stromal myofibroblasts and malignant transformation in a 4NQO rat tongue carcinogenesis model.
    Oral oncology, 2007, Volume: 43, Issue:10

    Topics: 4-Nitroquinoline-1-oxide; Animals; Carcinogens; Carcinoma, Squamous Cell; Cell Transformation, Neopl

2007
Possible enhancing activity of diacylglycerol on 4-nitroquinoline 1-oxide induced carcinogenesis of the tongue in human c-Ha-ras proto-oncogene transgenic rats.
    Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 2007, Volume: 45, Issue:6

    Topics: 4-Nitroquinoline-1-oxide; Alanine Transaminase; Animals; Animals, Genetically Modified; Aspartate Am

2007
Response of lymphocyte subsets and cytokines to Shenyang prescription in Sprague-Dawley rats with tongue squamous cell carcinomas induced by 4NQO.
    BMC cancer, 2007, Mar-05, Volume: 7

    Topics: 4-Nitroquinoline-1-oxide; Animals; Antineoplastic Agents; Carcinoma, Squamous Cell; Cell Count; Cyto

2007
Placental glutathione S-transferase correlates with cellular proliferation during rat tongue carcinogenesis induced by 4-nitroquinoline 1-oxide.
    Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie, 2007, Volume: 59, Issue:1

    Topics: 4-Nitroquinoline-1-oxide; Animals; Carcinogens; Carcinoma, Squamous Cell; Cell Proliferation; Fluore

2007
Effects of sex hormones on rat tongue carcinoma induced by 4-nitroquinoline 1-oxide (4NQO).
    The Bulletin of Tokyo Dental College, 2007, Volume: 48, Issue:1

    Topics: 4-Nitroquinoline-1-oxide; Animals; Carcinogens; Carcinoma, Squamous Cell; Estrogens; Female; Male; O

2007
[Establishment and identification of biological characteristics of rat monoclone cell line Rca-B].
    Zhonghua kou qiang yi xue za zhi = Zhonghua kouqiang yixue zazhi = Chinese journal of stomatology, 2007, Volume: 42, Issue:8

    Topics: 4-Nitroquinoline-1-oxide; Animals; Carcinoma, Squamous Cell; Cell Cycle; Cell Line, Tumor; Cell Prol

2007
Increased risk of oral cancer in diabetic animals is not associated with c-jun activation pathway.
    Journal of cranio-maxillo-facial surgery : official publication of the European Association for Cranio-Maxillo-Facial Surgery, 2007, Volume: 35, Issue:8

    Topics: 4-Nitroquinoline-1-oxide; Animals; Biopsy; Carcinogens; Carcinoma, Squamous Cell; Diabetes Mellitus,

2007
High interstitial fluid pressure in rat tongue cancer is related to increased lymph vessel area, tumor size, invasiveness and decreased body weight.
    Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology, 2008, Volume: 37, Issue:3

    Topics: 4-Nitroquinoline-1-oxide; Analysis of Variance; Animals; Body Weight; Carcinoma, Squamous Cell; Extr

2008
Collagenase-2 (matrix metalloproteinase-8) plays a protective role in tongue cancer.
    British journal of cancer, 2008, Feb-26, Volume: 98, Issue:4

    Topics: 4-Nitroquinoline-1-oxide; Adult; Aged; Aged, 80 and over; Animals; Biomarkers, Tumor; Blotting, West

2008
The effect of iron deficiency on experimental oral carcinogenesis in the rat.
    British journal of cancer, 1983, Volume: 47, Issue:3

    Topics: 4-Nitroquinoline-1-oxide; Anemia, Hypochromic; Animals; Body Weight; Carcinoma, Squamous Cell; Diet;

1983
Experimental induction of oral squamous cell carcinomas in mice with 4-nitroquinolone-1-oxide.
    Oral surgery, oral medicine, and oral pathology, 1984, Volume: 57, Issue:5

    Topics: 4-Nitroquinoline-1-oxide; Animals; Carcinoma, Squamous Cell; Male; Mice; Mice, Inbred CBA; Mouth Muc

1984
Verrucous hyperplasia and verrucous carcinoma of the rat oral mucosa. Experimental oral carcinogenesis using 4-nitroquinoline 1-oxide.
    Acta pathologica, microbiologica, et immunologica Scandinavica. Section A, Pathology, 1984, Volume: 92, Issue:6

    Topics: 4-Nitroquinoline-1-oxide; Animals; Carcinoma, Papillary; Carcinoma, Squamous Cell; Female; Gingival

1984
[Induction of squamous cell carcinoma of the oral cavity by administration of 4-nitroquinoline 1-oxide in the drinking water (author's transl)].
    Shika gakuho. Dental science reports, 1981, Volume: 81, Issue:3

    Topics: 4-Nitroquinoline-1-oxide; Animals; Carcinoma, Squamous Cell; Male; Mouth Neoplasms; Neoplasms, Exper

1981
Induction of squamous cell carcinoma in the oral cavity of rats by oral administration of 4-nitroquinoline-1-oxide (4NQO) in drinking water. A preliminary report.
    The Bulletin of Tokyo Dental College, 1981, Volume: 22, Issue:2

    Topics: 4-Nitroquinoline-1-oxide; Animals; Carcinoma, Squamous Cell; Male; Mouth Neoplasms; Neoplasms, Exper

1981
[Experimental lung cancer in rabbits, mice and rats induced by chemical carcinogens (author's transl)].
    Nihon Kyobu Shikkan Gakkai zasshi, 1981, Volume: 19, Issue:11

    Topics: 4-Nitroquinoline-1-oxide; Adenocarcinoma; Animals; Benzopyrenes; Carcinoma; Carcinoma, Squamous Cell

1981
Experimental induction of irreversible precancerous changes in the palatal epithelium of the rat.
    International journal of oral surgery, 1982, Volume: 11, Issue:1

    Topics: 4-Nitroquinoline-1-oxide; Animals; Carcinoma, Squamous Cell; Cell Transformation, Neoplastic; Female

1982
Nucleolar organizer regions in tongue carcinomas induced in rats: comparison with DNA cytofluorometric analysis.
    Acta oto-laryngologica, 1994, Volume: 114, Issue:4

    Topics: 4-Nitroquinoline-1-oxide; Aneuploidy; Animals; Bromodeoxyuridine; Carcinoma, Squamous Cell; Diploidy

1994
Inflammatory cell infiltrate associated with primary and transplanted tumours in an inbred model of oral carcinogenesis.
    Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology, 1995, Volume: 24, Issue:1

    Topics: 3T3 Cells; 4-Nitroquinoline-1-oxide; Animals; Antigens, CD; Carcinoma, Squamous Cell; CD5 Antigens;

1995
Characterization of a rat oral squamous cell carcinoma cell line UHG-RaC '93 induced by 4-nitroquinoline-1-oxide in vivo.
    Carcinogenesis, 1995, Volume: 16, Issue:11

    Topics: 4-Nitroquinoline-1-oxide; Animals; Carcinogens; Carcinoma, Squamous Cell; Cells, Cultured; Chromosom

1995
The cancer-promoting effect of N-nitrosonornicotine used in combination with a subcarcinogenic dose of 4-nitroquinoline-N-oxide and 7,12-dimethylbenz (A) anthracene.
    Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons, 1995, Volume: 53, Issue:8

    Topics: 4-Nitroquinoline-1-oxide; 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinogens; Carcinoma, Squamou

1995
Comparison of epithelial dysplasia--the 4NQO rat palate model and human oral mucosa.
    International journal of oral and maxillofacial surgery, 1995, Volume: 24, Issue:1 Pt 1

    Topics: 4-Nitroquinoline-1-oxide; Adult; Aged; Aged, 80 and over; Animals; Carcinoma, Squamous Cell; Chi-Squ

1995
Loss of expression of basement membrane proteins reflects anomalies of chromosomes 3 and 12 in the rat 4-nitroquinoline-N-oxide model of oral carcinogenesis.
    Carcinogenesis, 1995, Volume: 16, Issue:1

    Topics: 3T3 Cells; 4-Nitroquinoline-1-oxide; Animals; Basement Membrane; Carcinoma; Carcinoma, Squamous Cell

1995
Harvey ras (H-ras) point mutations are induced by 4-nitroquinoline-1-oxide in murine oral squamous epithelia, while squamous cell carcinomas and loss of heterozygosity occur without additional exposure.
    Cancer research, 1994, Oct-15, Volume: 54, Issue:20

    Topics: 4-Nitroquinoline-1-oxide; Animals; Base Sequence; Carcinoma, Squamous Cell; Codon; DNA Mutational An

1994
Distribution of basal lamina type IV collagen and laminin in normal rat tongue mucosa and experimental oral carcinoma: ultrastructural immunolocalization and immunogold quantitation.
    European journal of cancer. Part B, Oral oncology, 1994, Volume: 30B, Issue:4

    Topics: 4-Nitroquinoline-1-oxide; Animals; Basement Membrane; Carcinoma, Squamous Cell; Collagen; Female; La

1994
Chemoprevention of 4-nitroquinoline 1-oxide-induced oral carcinogenesis by dietary curcumin and hesperidin: comparison with the protective effect of beta-carotene.
    Cancer research, 1994, Sep-01, Volume: 54, Issue:17

    Topics: 4-Hydroxyaminoquinoline-1-oxide; 4-Nitroquinoline-1-oxide; Animals; beta Carotene; Carcinoma, Squamo

1994
Assessment of bromodeoxyuridine-labeled S-phase cells in experimentally induced precancerous lesions in the rat's tongue.
    European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery, 1994, Volume: 251, Issue:3

    Topics: 4-Nitroquinoline-1-oxide; Animals; Bromodeoxyuridine; Carcinoma in Situ; Carcinoma, Squamous Cell; C

1994
Chemoprevention of 4-nitroquinoline 1-oxide-induced oral carcinogenesis by dietary protocatechuic acid during initiation and postinitiation phases.
    Cancer research, 1994, May-01, Volume: 54, Issue:9

    Topics: 4-Nitroquinoline-1-oxide; Animals; Body Weight; Carcinoma, Squamous Cell; Hydroxybenzoates; Male; Nu

1994
Chemoprevention of tongue carcinogenesis in rats.
    Oral surgery, oral medicine, and oral pathology, 1993, Volume: 76, Issue:5

    Topics: 4-Nitroquinoline-1-oxide; Animals; Anticarcinogenic Agents; Butylated Hydroxytoluene; Carcinoma, Squ

1993
Laminin and type IV collagen in experimental rat oral carcinomas.
    Journal of comparative pathology, 1993, Volume: 108, Issue:4

    Topics: 4-Nitroquinoline-1-oxide; Animals; Basement Membrane; Carcinoma, Squamous Cell; Collagen; Female; La

1993
Ultrastructural features of normal epithelium and 4-nitroquinoline 1-oxide-induced carcinomas of the rat tongue.
    Journal of comparative pathology, 1993, Volume: 108, Issue:4

    Topics: 4-Nitroquinoline-1-oxide; Animals; Carcinoma, Squamous Cell; Cytoplasmic Granules; Epithelium; Femal

1993
Estimation of proliferative activity of experimental tongue carcinoma in rats. Immunohistochemical and DNA cytofluorometric analysis.
    Acta oto-laryngologica, 1993, Volume: 113, Issue:4

    Topics: 4-Nitroquinoline-1-oxide; Animals; Bromodeoxyuridine; Carcinoma, Squamous Cell; Cell Cycle; Cell Div

1993
Infrequent Ha-ras mutations and absence of Ki-ras, N-ras, and p53 mutations in 4-nitroquinoline 1-oxide-induced rat oral lesions.
    Molecular carcinogenesis, 1995, Volume: 14, Issue:4

    Topics: 4-Nitroquinoline-1-oxide; Animals; Base Sequence; Carcinoma, Squamous Cell; Exons; Gene Deletion; Ge

1995
In vivo fluorescence kinetics and localisation of aluminum phthalocyanine disulphonate in an autologous tumour model.
    British journal of cancer, 1996, Volume: 73, Issue:5

    Topics: 4-Nitroquinoline-1-oxide; Animals; Carcinoma, Squamous Cell; Fluorescence; Fluorescent Dyes; Indoles

1996
Stage-dependent genetically-based deformities of the regenerating newt limb from 4-nitroquinoline-N-oxide mutagenesis: potential embryonic regulation of cancer.
    Differentiation; research in biological diversity, 1996, Volume: 60, Issue:2

    Topics: 4-Nitroquinoline-1-oxide; Animals; Carcinogens; Carcinoma, Squamous Cell; Extremities; Female; Male;

1996
Chemoprevention of 4-nitroquinoline 1-oxide-induced oral carcinogenesis in rats by flavonoids diosmin and hesperidin, each alone and in combination.
    Cancer research, 1997, Jan-15, Volume: 57, Issue:2

    Topics: 4-Nitroquinoline-1-oxide; Animals; Anticarcinogenic Agents; Body Weight; Carcinogens; Carcinoma, Squ

1997
Photofrin-mediated photodynamic therapy of chemically-induced premalignant lesions and squamous cell carcinoma of the palatal mucosa in rats.
    International journal of oral and maxillofacial surgery, 1997, Volume: 26, Issue:3

    Topics: 4-Nitroquinoline-1-oxide; Animals; Antineoplastic Agents; Carcinogens; Carcinoma, Squamous Cell; Dis

1997
Consistent allelic loss on mouse chromosome 7 distal to tyrosinase in 4-nitroquinoline-1-oxide-induced oral cavity tumors with loss of heterozygosity at Ha-ras-1.
    Molecular carcinogenesis, 1997, Volume: 19, Issue:1

    Topics: 4-Nitroquinoline-1-oxide; Alleles; Animals; Base Sequence; Carcinogens; Carcinoma, Squamous Cell; Ch

1997
In vivo photo-detection of chemically induced premalignant lesions and squamous cell carcinoma of the rat palatal mucosa.
    Journal of photochemistry and photobiology. B, Biology, 1997, Volume: 39, Issue:2

    Topics: 4-Nitroquinoline-1-oxide; Animals; Carcinogens; Carcinoma, Squamous Cell; Hematoporphyrins; Image En

1997
Experimental tongue cancer in desalivated rats.
    Oral oncology, 1997, Volume: 33, Issue:2

    Topics: 4-Nitroquinoline-1-oxide; Animals; Body Weight; Carcinogens; Carcinoma, Squamous Cell; Male; Rats; R

1997
Glutathione S-transferase pi-class as a tumour marker in lingual preneoplastic and neoplastic lesions of rats and humans.
    Virchows Archiv : an international journal of pathology, 1997, Volume: 431, Issue:1

    Topics: 4-Nitroquinoline-1-oxide; Animals; Biomarkers, Tumor; Carcinogens; Carcinoma in Situ; Carcinoma, Squ

1997
1,4-phenylenebis(methylene)selenocyanate exerts exceptional chemopreventive activity in rat tongue carcinogenesis.
    Cancer research, 1997, Sep-01, Volume: 57, Issue:17

    Topics: 4-Nitroquinoline-1-oxide; Animals; Anticarcinogenic Agents; Biomarkers; Carcinogens; Carcinoma, Squa

1997
A region within murine chromosome 7F4, syntenic to the human 11q13 amplicon, is frequently amplified in 4NQO-induced oral cavity tumors.
    Oncogene, 1997, Sep-04, Volume: 15, Issue:10

    Topics: 4-Nitroquinoline-1-oxide; Animals; Base Sequence; Carcinoma, Squamous Cell; Chromosome Mapping; Chro

1997
p53 expression in various stages of 4-nitroquinoline 1-oxide induced carcinoma in the rat tongue.
    Journal of Osaka Dental University, 1996, Volume: 30, Issue:1-2

    Topics: 4-Nitroquinoline-1-oxide; Animals; Carcinogens; Carcinoma, Squamous Cell; Immunohistochemistry; Male

1996
Quantitative trait loci affecting 4-nitroquinoline 1-oxide-induced tongue carcinogenesis in the rat.
    Cancer research, 1998, Apr-15, Volume: 58, Issue:8

    Topics: 4-Nitroquinoline-1-oxide; Animals; Carcinoma, Squamous Cell; Disease Susceptibility; Genetic Linkage

1998
Detection of oral dysplasia in animals with fluorine-18-FDG and carbon-11-tyrosine.
    Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 1998, Volume: 39, Issue:8

    Topics: 4-Nitroquinoline-1-oxide; Animals; Carbon Radioisotopes; Carcinogens; Carcinoma, Squamous Cell; Fluo

1998
Decreased expression of CD80 is a marker for increased tumorigenicity in a new murine model of oral squamous-cell carcinoma.
    International journal of cancer, 1999, Jul-30, Volume: 82, Issue:3

    Topics: 4-Nitroquinoline-1-oxide; Animals; Animals, Congenic; B7-1 Antigen; Biomarkers, Tumor; Carcinoma, Sq

1999
Loss of differentiation of 4NQO-induced rat malignant oral keratinocytes correlates with metastatic dissemination and is associated with a reduced cellular response to TGF-beta1 and an altered receptor profile.
    Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology, 1999, Volume: 28, Issue:9

    Topics: 4-Nitroquinoline-1-oxide; Animals; Carcinoma; Carcinoma, Squamous Cell; Cell Differentiation; Cell T

1999
Altered placental glutathione S-transferase foci as a tumor marker during rat lingual carcinogenesis.
    The Chinese journal of dental research, 1999, Volume: 2, Issue:2

    Topics: 4-Nitroquinoline-1-oxide; Animals; Biomarkers, Tumor; Carcinoma, Squamous Cell; Glutathione Transfer

1999
Isolation of differentiated squamous and undifferentiated spindle carcinoma cell lines with differing metastatic potential from a 4-nitroquinoline N-Oxide-induced tongue carcinoma in a F344 rat.
    Japanese journal of cancer research : Gann, 2000, Volume: 91, Issue:12

    Topics: 4-Nitroquinoline-1-oxide; Animals; Carcinogens; Carcinoma; Carcinoma, Squamous Cell; Clone Cells; Ka

2000
Increased expression of cyclooxygenase-2 protein in 4-nitroquinoline-1-oxide-induced rat tongue carcinomas and chemopreventive efficacy of a specific inhibitor, nimesulide.
    Cancer research, 2001, Feb-15, Volume: 61, Issue:4

    Topics: 4-Nitroquinoline-1-oxide; Animals; Blotting, Western; Carcinogens; Carcinoma, Squamous Cell; Cycloox

2001
Xeroderma pigmentosum group A gene action as a protection factor against 4-nitroquinoline 1-oxide-induced tongue carcinogenesis.
    Carcinogenesis, 2001, Volume: 22, Issue:4

    Topics: 4-Nitroquinoline-1-oxide; Animals; Anticarcinogenic Agents; Carcinogens; Carcinoma, Squamous Cell; C

2001
Prevention of 4-nitroquinoline 1-oxide-induced rat tongue carcinogenesis by garlic.
    Fitoterapia, 2001, Volume: 72, Issue:5

    Topics: 4-Nitroquinoline-1-oxide; Animals; Antineoplastic Agents; Carcinoma, Squamous Cell; Garlic; Glutathi

2001
Alteration of pRb expression in the development of rat tongue carcinoma induced by 4-nitroquinoline 1-oxide.
    Oral oncology, 2001, Volume: 37, Issue:7

    Topics: 4-Nitroquinoline-1-oxide; Animals; Blotting, Western; Carcinogens; Carcinoma, Squamous Cell; Cyclin

2001
[A rat model of tongue mucosa squamous cell carcinoma induced by oral administration of 4NQO in drinking water].
    Zhonghua kou qiang yi xue za zhi = Zhonghua kouqiang yixue zazhi = Chinese journal of stomatology, 1999, Volume: 34, Issue:6

    Topics: 4-Nitroquinoline-1-oxide; Animals; Carcinogens; Carcinoma, Squamous Cell; Disease Models, Animal; Dr

1999
[The expression of RAR beta mRNA in rat tongue carcinogenesis].
    Zhonghua kou qiang yi xue za zhi = Zhonghua kouqiang yixue zazhi = Chinese journal of stomatology, 2000, Volume: 35, Issue:5

    Topics: 4-Nitroquinoline-1-oxide; Animals; Carcinoma, Squamous Cell; Disease Models, Animal; Down-Regulation

2000
On the significance of sex hormones in producing experimental prostate tumor in the rat.
    Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer, 1977, Issue:60

    Topics: 4-Nitroquinoline-1-oxide; Animals; Carcinoma, Squamous Cell; Male; Methylcholanthrene; Neoplasm Meta

1977
Effect of oil-attached BCG cell-wall skeleton and thymectomy on the incidence of lung cancer and amyloidosis induced by chemical carcinogens in rabbits.
    Gan, 1978, Volume: 69, Issue:4

    Topics: 4-Nitroquinoline-1-oxide; Adenocarcinoma; Amyloidosis; Animals; BCG Vaccine; Carcinoma, Squamous Cel

1978
Histological changes in the submandibular glands of rats after intraductal injection of chemical carcinogens.
    Acta pathologica japonica, 1975, Volume: 25, Issue:1

    Topics: 4-Nitroquinoline-1-oxide; 9,10-Dimethyl-1,2-benzanthracene; Adenoma, Pleomorphic; Animals; Carcinoge

1975
Alterations in the lipid content of rat palatal epithelium during carcinogenesis.
    Histochemistry, 1975, Jul-30, Volume: 44, Issue:2

    Topics: 4-Nitroquinoline-1-oxide; 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinoma in Situ; Carcinoma, S

1975
Effects in rats of sodium chloride on experimental gastric cancers induced by N-methyl-N-nitro-N-nitrosoguanidine or 4-nitroquinoline-1-oxide.
    Journal of the National Cancer Institute, 1975, Volume: 55, Issue:1

    Topics: 4-Nitroquinoline-1-oxide; Adenocarcinoma; Animals; Carcinoma, Squamous Cell; Drug Synergism; Gastric

1975
Cytogenetic analysis of oral and cutaneous squamous cell carcinomas in the rat.
    Odontologisk revy, 1975, Volume: 26, Issue:3

    Topics: 4-Nitroquinoline-1-oxide; 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinoma, Squamous Cell; Cell

1975
Electron microscopic studies of placental and uterine tumors induced in rats.
    Acta pathologica japonica, 1976, Volume: 26, Issue:6

    Topics: 4-Nitroquinoline-1-oxide; 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinoma, Squamous Cell; Chori

1976
Inhibitory effects of the natural products indole-3-carbinol and sinigrin during initiation and promotion phases of 4-nitroquinoline 1-oxide-induced rat tongue carcinogenesis.
    Japanese journal of cancer research : Gann, 1992, Volume: 83, Issue:8

    Topics: 4-Nitroquinoline-1-oxide; Animals; Anticarcinogenic Agents; Antioxidants; Body Weight; Carcinoma, Sq

1992
Candida albicans as a promoter of oral mucosal neoplasia.
    Carcinogenesis, 1992, Volume: 13, Issue:5

    Topics: 4-Nitroquinoline-1-oxide; Animals; Candida albicans; Carcinogens; Carcinoma, Squamous Cell; Male; Pa

1992
Changes in EGF and TGE-beta receptor expression reflects differentiation of rat malignant oral keratinocytes.
    Biochemical Society transactions, 1991, Volume: 19, Issue:2

    Topics: 4-Nitroquinoline-1-oxide; Animals; Carcinoma, Squamous Cell; Cell Differentiation; Cell Division; Ce

1991
Alterations of the nucleolar organizer regions during 4-nitroquinoline 1-oxide-induced tongue carcinogenesis in rats.
    Carcinogenesis, 1991, Volume: 12, Issue:2

    Topics: 4-Nitroquinoline-1-oxide; Animals; Carcinoma, Squamous Cell; Cell Division; Epithelial Cells; Hyperp

1991
Temporal alterations in cytokeratin expression during experimental oral mucosal carcinogenesis.
    Carcinogenesis, 1991, Volume: 12, Issue:10

    Topics: 4-Nitroquinoline-1-oxide; Animals; Biomarkers, Tumor; Carcinoma, Squamous Cell; Electrophoresis, Gel

1991
4-Nitroquinoline 1-oxide.
    Japanese journal of cancer research : Gann, 1991, Volume: 82, Issue:12

    Topics: 4-Nitroquinoline-1-oxide; Animals; Carcinoma, Squamous Cell; Humans; Mutagens; Skin Neoplasms

1991
Malignant conversion, the first stage in progression, is distinct from phorbol ester promotion in mouse skin.
    Basic life sciences, 1991, Volume: 57

    Topics: 4-Nitroquinoline-1-oxide; 9,10-Dimethyl-1,2-benzanthracene; Acetone; Animals; Carcinoma, Squamous Ce

1991
The effect of topical vitamin C on palatal oral mucosal carcinogenesis using 4-nitroquinoline-1-oxide.
    Journal de biologie buccale, 1991, Volume: 19, Issue:3

    Topics: 4-Nitroquinoline-1-oxide; Administration, Topical; Animals; Ascorbic Acid; Carcinoma, Squamous Cell;

1991
A relationship found between intra-oral sites of 4NQO reductase activity and chemical carcinogenesis.
    Cell and tissue kinetics, 1990, Volume: 23, Issue:4

    Topics: 4-Nitroquinoline-1-oxide; Animals; Carcinoma, Squamous Cell; Cheek; Dihydrolipoamide Dehydrogenase;

1990
Blood group antigen staining pattern during experimental carcinogenesis in rat palate.
    APMIS : acta pathologica, microbiologica, et immunologica Scandinavica, 1988, Volume: 96, Issue:2

    Topics: 4-Nitroquinoline-1-oxide; Animals; Blood Group Antigens; Carcinoma, Squamous Cell; Epithelium; Femal

1988
Ia+ epithelial dendritic cells during oral carcinogenesis in the rat.
    Journal of oral pathology, 1988, Volume: 17, Issue:3

    Topics: 4-Nitroquinoline-1-oxide; Animals; Carcinoma, Squamous Cell; Dendritic Cells; Epithelium; Histocompa

1988
Snuff-induced carcinogenesis: effect of snuff in rats initiated with 4-nitroquinoline N-oxide.
    Cancer research, 1989, Jun-01, Volume: 49, Issue:11

    Topics: 4-Nitroquinoline-1-oxide; Animals; Body Weight; Carcinoma, Squamous Cell; Esophageal Neoplasms; Lip

1989
Snuff tumorigenesis: effects of long-term snuff administration after initiation with 4-nitroquinoline-N-oxide and herpes simplex virus type 1.
    Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology, 1989, Volume: 18, Issue:4

    Topics: 4-Nitroquinoline-1-oxide; Animals; Carcinogens; Carcinoma, Squamous Cell; Cocarcinogenesis; Ear Neop

1989
Initiation and promotion of experimental oral mucosal carcinogenesis in mice.
    Journal of oral pathology, 1986, Volume: 15, Issue:1

    Topics: 4-Nitroquinoline-1-oxide; Animals; Carcinoma, Squamous Cell; Epithelium; Male; Mice; Mice, Inbred CB

1986
The effect of iron deficiency on early oral carcinogenesis in the rat.
    Journal of oral pathology, 1986, Volume: 15, Issue:5

    Topics: 4-Nitroquinoline-1-oxide; Animals; Body Weight; Carcinoma, Squamous Cell; Cocarcinogenesis; Hyperpla

1986
Oral epithelial atypia and acantholytic dyskeratosis in rats painted with 4-nitroquinoline N-oxide.
    Journal of oral pathology, 1986, Volume: 15, Issue:5

    Topics: 4-Nitroquinoline-1-oxide; Acantholysis; Animals; Carcinoma, Squamous Cell; Leukoplakia, Oral; Male;

1986
[Cell proliferation in the carcinogenic process of tongue carcinoma in rats induced by 4-nitroquinoline-1-oxide. 2. Relation between morphology, microvascular architecture and cell proliferation in keratinized lesions and squamous cell carcinoma].
    Shika gakuho. Dental science reports, 1986, Volume: 86, Issue:5

    Topics: 4-Nitroquinoline-1-oxide; Animals; Carcinoma, Squamous Cell; Cell Division; Leukoplakia, Oral; Male;

1986
The distribution of blood group antigens in experimentally produced carcinomas of rat palate.
    Journal of oral pathology, 1986, Volume: 15, Issue:10

    Topics: 4-Nitroquinoline-1-oxide; ABO Blood-Group System; Animals; Carcinoma, Papillary; Carcinoma, Squamous

1986
Loss of epithelial cell surface carbohydrates during experimental oral carcinogenesis in the rat.
    British journal of cancer, 1987, Volume: 55, Issue:6

    Topics: 4-Nitroquinoline-1-oxide; Animals; Carbohydrate Metabolism; Carcinoma, Squamous Cell; Cell Membrane;

1987
Dose-response relationship in complete oral 4NQO-carcinogenesis in rats.
    Acta pathologica, microbiologica, et immunologica Scandinavica. Section A, Pathology, 1987, Volume: 95, Issue:5

    Topics: 4-Nitroquinoline-1-oxide; Animals; Carcinoma, Squamous Cell; Dose-Response Relationship, Drug; Femal

1987
The relationship between epithelial Ia expression and the inflammatory cell infiltrate during experimental oral carcinogenesis.
    Virchows Archiv. A, Pathological anatomy and histopathology, 1988, Volume: 413, Issue:6

    Topics: 4-Nitroquinoline-1-oxide; Animals; Carcinoma, Squamous Cell; Disease Models, Animal; Epithelium; His

1988
Histomorphometric analysis of epithelial changes in chemically induced oral mucosal carcinogenesis in rats.
    Journal of oral pathology, 1988, Volume: 17, Issue:9-10

    Topics: 4-Nitroquinoline-1-oxide; Animals; Carcinoma, Squamous Cell; Cell Count; Epithelium; Male; Mouth Muc

1988
Experimental induction of preneoplastic and neoplastic changes in the lingual mucosa of rats.
    Journal de biologie buccale, 1985, Volume: 13, Issue:4

    Topics: 4-Nitroquinoline-1-oxide; Animals; Carcinoma, Squamous Cell; Epithelium; Male; Mouth Mucosa; Precanc

1985