4-nitroquinoline-1-oxide has been researched along with Carcinoma, Squamous Cell of Head and Neck in 24 studies
4-nitroquinoline N-oxide : A quinoline N-oxide carrying a nitro substituent at position 4.
| Excerpt | Relevance | Reference |
|---|---|---|
| " One week after starting propranolol treatment, all rats were submitted to chemical induction of oral carcinogenesis with 4-nitroquinoline-1-oxide (4NQO)." | 3.96 | Beta-adrenergic blocker inhibits oral carcinogenesis and reduces tumor invasion. ( Bernabé, DG; Biasoli, ÉR; Cecilio, HP; Furuse, C; Kayahara, GM; Miyahara, GI; Oliveira, SHP; Pereira, KM; Valente, VB, 2020) |
| "Head and neck cancer is the sixth most common malignancy, and there is an urgent need to identify physiological processes contributing to tumorigenesis." | 1.91 | GPR68 limits the severity of chemical-induced oral epithelial dysplasia. ( Amin, ARMR; Graffeo, V; Griggs, N; McAleer, JP; Shore, D; Xu, Y; Zha, XM, 2023) |
| "Using two in vivo models of oral carcinogenesis with 4-nitroquinoline 1-oxide carcinogen on C57Bl/6 mice and F344 rats, we determined the effect of BRB on GC modulation during head and neck squamous cell carcinoma chemoprevention." | 1.72 | Modulation of the oral glucocorticoid system during black raspberry mediated oral cancer chemoprevention. ( Anderson, K; Iwenofu, H; Jordanides, PP; Lamenza, FF; Nedungadi, D; Oghumu, S; Rakotondraibe, L; Riedl, KM; Ryan, N; Swingler, MJ, 2022) |
| "Early diagnosis of oral squamous cell carcinoma (OSCC) remains an unmet clinical need." | 1.72 | Early antitumor activity of oral Langerhans cells is compromised by a carcinogen. ( Aizenbud, I; Amit, I; Barel, O; Capucha, T; Czerninski, R; David, E; Eli-Berchoer, L; Hovav, AH; Koren, N; Matanes, D; Saba, Y; Stoitzner, P; Wilensky, A; Yona, S; Zubeidat, K, 2022) |
| "Periodontitis was stimulated by placing a ligature subgingivally, while oral carcinogenesis was induced by systemic administration of 4NQO in the drinking water for 20 weeks." | 1.72 | Periodontal disease affects oral cancer progression in a surrogate animal model for tobacco exposure. ( Carrard, VC; Castilho, RM; Gaio, EJ; Nör, F; Rösing, CK; Spuldaro, TR; Squarize, CH; Wagner, VP, 2022) |
| "Oral squamous cell carcinoma (OSCC) is the most common subsite of head and neck cancer, with a 5-year survival rate of only 50%." | 1.62 | 4NQO induced carcinogenesis: A mouse model for oral squamous cell carcinoma. ( Curry, JM; Han, JYS; Martinez-Outschoorn, U; Philp, NJ; Sagheer, SH; Whitaker-Menezes, D, 2021) |
| "Tacrolimus (TAC, FK506) is a major calcineurin inhibitor and has been commonly used in treatments of patients with organ transplants and immune diseases." | 1.62 | Tacrolimus inhibits oral carcinogenesis through cell cycle control. ( Chen, W; Cheng, B; Hu, Q; Li, J; Li, Y; Ling, Z; Wang, Y; Wu, T; Xia, J; Zhang, L, 2021) |
| "Three HNSCC cell lines were then established, and one of these, termed JC1, was selected for further analysis due to its enhanced proliferative ability and tumorigenicity in immunodeficient nude mice." | 1.56 | An HNSCC syngeneic mouse model for tumor immunology research and preclinical evaluation. ( Fu, Y; Li, J; Tian, G; Xu, K; Zhang, Z, 2020) |
| "The role of CD44 in progression of head and neck squamous cell carcinoma (HNSCC) has been controversial." | 1.51 | CD44(+) tumor cells promote early angiogenesis in head and neck squamous cell carcinoma. ( Azambuja, JH; Dolg, L; Gellrich, NC; Gluszko, A; Kampmann, A; Ludwig, N; Szafarowski, T; Szczepanski, MJ; Whiteside, TL; Zimmerer, RM, 2019) |
| "Advanced oral squamous cell carcinomas (OSCC) have limited therapeutic options." | 1.51 | Impact of combination immunochemotherapies on progression of 4NQO-induced murine oral squamous cell carcinoma. ( Chelvanambi, M; Fabian, KPL; Hong, CS; Lang, S; Ludwig, S; Razzo, BM; Storkus, WJ; Whiteside, TL, 2019) |
| "Oral squamous cell carcinoma (OSCC) was induced by using 4- nitroquinoline-1-oxide (4NQO) as a carcinogen." | 1.46 | Comparison of injectable doxorubicin & its nanodrug complex chemotherapy for the treatment of 4-nitroquinoline-1-oxide induced oral squamous cell carcinoma in rats. ( Abbasi, MM; Abdal, K; Abdollahi, B; Aghbali, AA; Fotohi, S; Hamishehkar, H; Khiavi, MM; Salehi, R; Sina, M, 2017) |
| "Induction of oral carcinogenesis in transgenic mice using 4-nitroquinoline 1-oxide (4NQO) resulted in more extensive and severe tongue tumorigenesis compared with control animals." | 1.43 | MicroRNA-211 Enhances the Oncogenicity of Carcinogen-Induced Oral Carcinoma by Repressing TCF12 and Increasing Antioxidant Activity. ( Chang, KW; Chen, YF; Kao, SY; Lin, SC; Liu, CJ; Yang, CC, 2016) |
| "Head and neck squamous cell carcinoma (HNSCC) is a frequently fatal disease due, in large part, to a high rate of second primary tumor (SPT) formation." | 1.43 | STAT3 as a Chemoprevention Target in Carcinogen-Induced Head and Neck Squamous Cell Carcinoma. ( Acquafondata, M; Freilino, M; Gooding, WE; Grandis, JR; Johnson, DE; Li, H; Peyser, ND; Satake, M; Sen, M; Wang, L; Wang, Z; Zeng, Y, 2016) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 8 (33.33) | 24.3611 |
| 2020's | 16 (66.67) | 2.80 |
| Authors | Studies |
|---|---|
| Shishodia, G | 1 |
| Toledo, RRG | 1 |
| Rong, X | 1 |
| Zimmerman, E | 1 |
| Xiao, AY | 1 |
| Harrison, L | 1 |
| Nathan, CO | 1 |
| Nedungadi, D | 1 |
| Ryan, N | 1 |
| Anderson, K | 1 |
| Lamenza, FF | 1 |
| Jordanides, PP | 1 |
| Swingler, MJ | 1 |
| Rakotondraibe, L | 1 |
| Riedl, KM | 1 |
| Iwenofu, H | 1 |
| Oghumu, S | 1 |
| Saba, Y | 1 |
| Aizenbud, I | 1 |
| Matanes, D | 1 |
| Koren, N | 1 |
| Barel, O | 1 |
| Zubeidat, K | 1 |
| Capucha, T | 1 |
| David, E | 1 |
| Eli-Berchoer, L | 1 |
| Stoitzner, P | 1 |
| Wilensky, A | 1 |
| Amit, I | 1 |
| Czerninski, R | 1 |
| Yona, S | 1 |
| Hovav, AH | 1 |
| Michmerhuizen, NL | 1 |
| Heenan, C | 1 |
| Wang, J | 1 |
| Leonard, E | 1 |
| Bellile, E | 1 |
| Loganathan, SK | 1 |
| Wong, SY | 1 |
| Lei, YL | 1 |
| Brenner, JC | 1 |
| Spuldaro, TR | 1 |
| Wagner, VP | 1 |
| Nör, F | 1 |
| Gaio, EJ | 1 |
| Squarize, CH | 1 |
| Carrard, VC | 1 |
| Rösing, CK | 1 |
| Castilho, RM | 1 |
| Shore, D | 1 |
| Griggs, N | 1 |
| Graffeo, V | 1 |
| Amin, ARMR | 1 |
| Zha, XM | 1 |
| Xu, Y | 1 |
| McAleer, JP | 1 |
| Coeli-Lacchini, FB | 1 |
| da Silva, G | 1 |
| Belentani, M | 1 |
| Alves, JSF | 1 |
| Ushida, TR | 1 |
| Lunardelli, GT | 1 |
| Garcia, CB | 1 |
| Silva, TA | 1 |
| Lopes, NP | 1 |
| Leopoldino, AM | 1 |
| Sahu, SR | 1 |
| Thakur, S | 1 |
| Peroumal, D | 1 |
| Utkalaja, BG | 1 |
| Dutta, A | 1 |
| Kumari, P | 1 |
| Subhadarsini, I | 1 |
| Acharya, N | 1 |
| Ludwig, N | 1 |
| Szczepanski, MJ | 1 |
| Gluszko, A | 1 |
| Szafarowski, T | 1 |
| Azambuja, JH | 1 |
| Dolg, L | 1 |
| Gellrich, NC | 1 |
| Kampmann, A | 1 |
| Whiteside, TL | 2 |
| Zimmerer, RM | 1 |
| Kalish, JM | 1 |
| Tang, XH | 1 |
| Scognamiglio, T | 1 |
| Zhang, T | 1 |
| Gudas, LJ | 1 |
| Tan, MT | 1 |
| Wu, JG | 1 |
| Callejas-Valera, JL | 1 |
| Schwarz, RA | 1 |
| Gillenwater, AM | 1 |
| Richards-Kortum, RR | 1 |
| Vigneswaran, N | 1 |
| Fu, Y | 1 |
| Tian, G | 1 |
| Li, J | 2 |
| Zhang, Z | 1 |
| Xu, K | 1 |
| Cecilio, HP | 1 |
| Valente, VB | 2 |
| Pereira, KM | 1 |
| Kayahara, GM | 2 |
| Furuse, C | 2 |
| Biasoli, ÉR | 2 |
| Miyahara, GI | 2 |
| Oliveira, SHP | 2 |
| Bernabé, DG | 2 |
| Verza, FA | 1 |
| Oliveira, LK | 1 |
| Crivelini, MM | 1 |
| Sagheer, SH | 1 |
| Whitaker-Menezes, D | 1 |
| Han, JYS | 1 |
| Curry, JM | 1 |
| Martinez-Outschoorn, U | 1 |
| Philp, NJ | 1 |
| Li, Y | 1 |
| Wang, Y | 2 |
| Ling, Z | 1 |
| Chen, W | 1 |
| Zhang, L | 1 |
| Hu, Q | 1 |
| Wu, T | 1 |
| Cheng, B | 1 |
| Xia, J | 1 |
| Shi, Y | 1 |
| Xie, TX | 1 |
| Leach, DG | 1 |
| Wang, B | 1 |
| Young, S | 1 |
| Osman, AA | 1 |
| Sikora, AG | 1 |
| Ren, X | 1 |
| Hartgerink, JD | 1 |
| Myers, JN | 1 |
| Rangel, R | 1 |
| Khiavi, MM | 1 |
| Abdal, K | 1 |
| Abbasi, MM | 1 |
| Hamishehkar, H | 1 |
| Aghbali, AA | 1 |
| Salehi, R | 1 |
| Sina, M | 1 |
| Abdollahi, B | 1 |
| Fotohi, S | 1 |
| Ludwig, S | 1 |
| Hong, CS | 1 |
| Razzo, BM | 1 |
| Fabian, KPL | 1 |
| Chelvanambi, M | 1 |
| Lang, S | 1 |
| Storkus, WJ | 1 |
| Chen, YF | 2 |
| Chang, KW | 3 |
| Yang, IT | 1 |
| Tu, HF | 1 |
| Lin, SC | 3 |
| Chu, TH | 1 |
| Yang, CC | 2 |
| Liu, CJ | 2 |
| Lui, MT | 1 |
| Paparella, ML | 1 |
| Abrigo, M | 1 |
| Bal de Kier Joffe, E | 1 |
| Raimondi, AR | 1 |
| Kao, SY | 1 |
| Peyser, ND | 1 |
| Wang, L | 1 |
| Zeng, Y | 1 |
| Acquafondata, M | 1 |
| Freilino, M | 1 |
| Li, H | 1 |
| Sen, M | 1 |
| Gooding, WE | 1 |
| Satake, M | 1 |
| Wang, Z | 1 |
| Johnson, DE | 1 |
| Grandis, JR | 1 |
24 other studies available for 4-nitroquinoline-1-oxide and Carcinoma, Squamous Cell of Head and Neck
| Article | Year |
|---|---|
4NQO enhances differential activation of DNA repair proteins in HPV positive and HPV negative HNSCC cells.
Topics: 4-Nitroquinoline-1-oxide; Cells, Cultured; DNA Repair; Head and Neck Neoplasms; Humans; Keratinocyte | 2021 |
Modulation of the oral glucocorticoid system during black raspberry mediated oral cancer chemoprevention.
Topics: 4-Nitroquinoline-1-oxide; Animals; Carcinogenesis; Carcinogens; Carcinoma, Squamous Cell; Cell Line, | 2022 |
Early antitumor activity of oral Langerhans cells is compromised by a carcinogen.
Topics: 4-Nitroquinoline-1-oxide; Antineoplastic Agents; Carcinogens; Cell Line, Tumor; Dendritic Cells; Epi | 2022 |
Combined Pik3ca-H1047R and loss-of-function Notch1 alleles decrease survival time in a 4-nitroquinoline N-oxide-driven head and neck squamous cell carcinoma model.
Topics: 4-Nitroquinoline-1-oxide; Alleles; Class I Phosphatidylinositol 3-Kinases; Head and Neck Neoplasms; | 2022 |
Periodontal disease affects oral cancer progression in a surrogate animal model for tobacco exposure.
Topics: 4-Nitroquinoline-1-oxide; Animals; Carcinogenesis; Carcinoma, Squamous Cell; Disease Models, Animal; | 2022 |
GPR68 limits the severity of chemical-induced oral epithelial dysplasia.
Topics: 4-Nitroquinoline-1-oxide; Animals; Carcinogenesis; Carcinoma, Squamous Cell; Cell Transformation, Ne | 2023 |
Spermidine Suppresses Oral Carcinogenesis through Autophagy Induction, DNA Damage Repair, and Oxidative Stress Reduction.
Topics: 4-Nitroquinoline-1-oxide; Animals; Carcinogenesis; Carcinogens; Carcinoma, Squamous Cell; Ceramides; | 2023 |
4-nitroquinoline 1-oxide induces immune cells death to onset early immunosuppression during oral squamous cell carcinoma development.
Topics: 4-Nitroquinoline-1-oxide; Animals; Apoptosis; Carcinoma, Squamous Cell; Head and Neck Neoplasms; Hum | 2023 |
CD44(+) tumor cells promote early angiogenesis in head and neck squamous cell carcinoma.
Topics: 4-Nitroquinoline-1-oxide; Animals; Case-Control Studies; Cell Line, Tumor; Female; Gene Expression P | 2019 |
Doxycycline-induced exogenous Bmi-1 expression enhances tumor formation in a murine model of oral squamous cell carcinoma.
Topics: 4-Nitroquinoline-1-oxide; Animals; Anti-Bacterial Agents; Carcinogenesis; Carcinogens; Disease Model | 2020 |
A PIK3CA transgenic mouse model with chemical carcinogen exposure mimics human oral tongue tumorigenesis.
Topics: 4-Nitroquinoline-1-oxide; Animals; Cell Proliferation; Cell Transformation, Neoplastic; Class I Phos | 2020 |
An HNSCC syngeneic mouse model for tumor immunology research and preclinical evaluation.
Topics: 4-Nitroquinoline-1-oxide; Animals; Cell Line, Tumor; Coculture Techniques; DNA Mismatch Repair; Exom | 2020 |
Beta-adrenergic blocker inhibits oral carcinogenesis and reduces tumor invasion.
Topics: 4-Nitroquinoline-1-oxide; Adrenergic beta-Antagonists; Animals; Carcinogenesis; Carcinogens; Cytokin | 2020 |
Social isolation stress facilitates chemically induced oral carcinogenesis.
Topics: 4-Nitroquinoline-1-oxide; Animals; Behavior, Animal; Cytokines; Depression; Head and Neck Neoplasms; | 2021 |
4NQO induced carcinogenesis: A mouse model for oral squamous cell carcinoma.
Topics: 4-Nitroquinoline-1-oxide; Animals; Carcinogenesis; Carcinoma, Squamous Cell; Head and Neck Neoplasms | 2021 |
Tacrolimus inhibits oral carcinogenesis through cell cycle control.
Topics: 4-Nitroquinoline-1-oxide; Animals; Anticarcinogenic Agents; Carcinogens; Cell Cycle; Cellular Microe | 2021 |
Local Anti-PD-1 Delivery Prevents Progression of Premalignant Lesions in a 4NQO-Oral Carcinogenesis Mouse Model.
Topics: 4-Nitroquinoline-1-oxide; Animals; Antibodies, Monoclonal; Carcinogenesis; Disease Models, Animal; D | 2021 |
Comparison of injectable doxorubicin & its nanodrug complex chemotherapy for the treatment of 4-nitroquinoline-1-oxide induced oral squamous cell carcinoma in rats.
Topics: 4-Nitroquinoline-1-oxide; Animals; Carcinoma, Squamous Cell; Disease Models, Animal; Doxorubicin; Dr | 2017 |
Impact of combination immunochemotherapies on progression of 4NQO-induced murine oral squamous cell carcinoma.
Topics: 4-Nitroquinoline-1-oxide; Animals; Antineoplastic Combined Chemotherapy Protocols; Cancer Vaccines; | 2019 |
Establishment of syngeneic murine model for oral cancer therapy.
Topics: 4-Nitroquinoline-1-oxide; Animals; Antineoplastic Agents; B7-H1 Antigen; Carcinogenesis; Carcinogens | 2019 |
miR-211 promotes the progression of head and neck carcinomas by targeting TGFβRII.
Topics: 4-Nitroquinoline-1-oxide; Animals; Carcinoma, Squamous Cell; Disease Progression; Genes, myc; Head a | 2013 |
Oral-specific ablation of Klf4 disrupts epithelial terminal differentiation and increases premalignant lesions and carcinomas upon chemical carcinogenesis.
Topics: 4-Nitroquinoline-1-oxide; Animals; Carcinogenesis; Carcinogens; Carcinoma, Squamous Cell; Cell Diffe | 2015 |
MicroRNA-211 Enhances the Oncogenicity of Carcinogen-Induced Oral Carcinoma by Repressing TCF12 and Increasing Antioxidant Activity.
Topics: 4-Nitroquinoline-1-oxide; Animals; Basic Helix-Loop-Helix Transcription Factors; Blotting, Western; | 2016 |
STAT3 as a Chemoprevention Target in Carcinogen-Induced Head and Neck Squamous Cell Carcinoma.
Topics: 4-Nitroquinoline-1-oxide; Animals; Biomarkers; Carcinogens; Carcinoma, Squamous Cell; Chemopreventio | 2016 |