4-nitroquinoline-1-oxide has been researched along with Cancer of the Tongue in 190 studies
4-nitroquinoline N-oxide : A quinoline N-oxide carrying a nitro substituent at position 4.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Based on a critical review of published studies, we aimed to develop a good practice guide for using 4-nitroquinoline-1-oxide (4NQO) as an inducer of oral carcinogenesis in Wistar rats." | 9.22 | 4-nitroquinoline-1-oxide (4NQO) induced oral carcinogenesis: A systematic literature review. ( Carrard, VC; Martins, MAT; Martins, MD; Schmidt, TR; Schuch, LF; Silveira, FM; Wagner, VP; Zigmundo, GCO, 2022) |
| "An important rat model using the chemical carcinogen 4-nitroquinoline-1-oxide (4NQO) has been described for the study of the process of oral carcinogenesis." | 8.31 | Proposal of a secure and efficient protocol for a murine oral carcinogenesis model induced by 4-nitroquinoline-1-oxide (4NQO). ( Campagnol, D; Castilho, RM; Danilevicz, CK; Garcez, TNA; Martins, MAT; Martins, MD; Michel, CHT; Schmidt, TR; Schuch, LF; Vargas, PA, 2023) |
| "The multistep process of oral carcinogenesis provides a biological rationale for the use of chemoprevention in individuals at increased risk of developing oral cancer." | 5.62 | Can propranolol act as a chemopreventive agent during oral carcinogenesis? An experimental animal study. ( Carrard, VC; Castilho, RM; Gaio, EJ; Nör, F; Rösing, CK; Spuldaro, TR; Wagner, VP, 2021) |
| "Based on a critical review of published studies, we aimed to develop a good practice guide for using 4-nitroquinoline-1-oxide (4NQO) as an inducer of oral carcinogenesis in Wistar rats." | 5.22 | 4-nitroquinoline-1-oxide (4NQO) induced oral carcinogenesis: A systematic literature review. ( Carrard, VC; Martins, MAT; Martins, MD; Schmidt, TR; Schuch, LF; Silveira, FM; Wagner, VP; Zigmundo, GCO, 2022) |
| "An important rat model using the chemical carcinogen 4-nitroquinoline-1-oxide (4NQO) has been described for the study of the process of oral carcinogenesis." | 4.31 | Proposal of a secure and efficient protocol for a murine oral carcinogenesis model induced by 4-nitroquinoline-1-oxide (4NQO). ( Campagnol, D; Castilho, RM; Danilevicz, CK; Garcez, TNA; Martins, MAT; Martins, MD; Michel, CHT; Schmidt, TR; Schuch, LF; Vargas, PA, 2023) |
| "4-nitroquinoline-1-oxide(4NQO) was used to induce oral carcinogenesis in the mucosa of SD rats and immunohistoche-mical technique was used to study the expression of CK19 and Cx43 in various stages of oral carcinogenesis." | 3.79 | [Expression of cytokeratin 19 and connexin 43 in 4-nitroquinoline-l-oxide-induced rat tongue carcinogenesis]. ( Feng, Y; Kang, X; Li, C; Nie, M, 2013) |
| " At the termination of the experiment (32 weeks), the incidences of tongue neoplasms and preneoplastic lesions, polyamine levels in the tongue tissue, and cell proliferation activity estimated in terms of 5-bromodeoxyuridine (BrdU)-labeling index and by morphometric analysis of silver-stained nucleolar organizer regions' protein (AgNORs) were compared among the groups." | 3.69 | Chemopreventive effect of a xanthine oxidase inhibitor, 1'-acetoxychavicol acetate, on rat oral carcinogenesis. ( Hara, A; Kawamori, T; Koshimizu, K; Makita, H; Mori, H; Murakami, A; Ohigashi, H; Ohnishi, M; Satoh, K; Tanaka, T, 1996) |
| "Oral cancer pain is initiated and maintained in the cancer microenvironment and attributed to release of mediators that sensitize primary sensory nerves." | 1.62 | The Histopathology of Oral Cancer Pain in a Mouse Model and a Human Cohort. ( Albertson, DG; Bandary, D; Bhattacharya, A; Brar, B; Chen, J; Dolan, JC; Janal, MN; Naik, K; Schmidt, BL; Zhang, S, 2021) |
| "The multistep process of oral carcinogenesis provides a biological rationale for the use of chemoprevention in individuals at increased risk of developing oral cancer." | 1.62 | Can propranolol act as a chemopreventive agent during oral carcinogenesis? An experimental animal study. ( Carrard, VC; Castilho, RM; Gaio, EJ; Nör, F; Rösing, CK; Spuldaro, TR; Wagner, VP, 2021) |
| "Oral carcinogenesis involves the progression of the normal mucosa into potentially malignant disorders and finally into cancer." | 1.56 | Single-Cell Analysis of Different Stages of Oral Cancer Carcinogenesis in a Mouse Model. ( Chiang, WF; Hsieh, YP; Huang, LY; Huang, TT; Huang, WT; Hwang, DY; Jiang, SS; Liu, KJ; Wang, YY, 2020) |
| "Pyrrolidine dithiocarbamate (PDTC) is a powerful antioxidant and antitumoral agent." | 1.56 | Protective and therapeutic effects of pyrrolidine dithiocarbamate in a rat tongue cancer model created experimentally using 4-nitroquinoline 1-oxide. ( Doğan, R; Gucin, Z; Hafız, AM; Ozer, OF; Ozturan, O; Yenigun, A, 2020) |
| "This carcinogenesis model was quantitatively evaluated by FI." | 1.51 | Method for diagnosing neoplastic lesions by quantitative fluorescence value. ( Kasahara, M; Kosugi, A; Mori, T; Nakamura-Takahashi, A; Shibahara, T; Yang, L, 2019) |
| "Moreover, chemical carcinogenesis can promote stressor-like effects with hormonal changes in the tissue microenvironment, which may be associated to tumor progression." | 1.48 | Stress hormones concentrations in the normal microenvironment predict risk for chemically induced cancer in rats. ( Bernabé, DG; Biasoli, ÉR; de Andrade, M; de Oliveira, SHP; Dos Santos, PSP; Ferreira, JZ; Lopes, FYK; Miyahara, GI; Soubhia, AMP; Sundefeld, MLMM; Valente, VB; Verza, FA, 2018) |
| "Patients with oral cancer report severe pain during function." | 1.46 | Tumor necrosis factor alpha secreted from oral squamous cell carcinoma contributes to cancer pain and associated inflammation. ( Bhattacharya, A; Dolan, JC; Hickman, DN; MacRae, J; Scheff, NN; Schmidt, BL; Sharma, AK; Ye, Y, 2017) |
| "The typical progression of oral cancer is from hyperplastic epithelial lesions through dysplasia to invasive carcinoma." | 1.43 | Dynamic changes in the gene expression profile during rat oral carcinogenesis induced by 4-nitroquinoline 1-oxide. ( Du, Y; Ge, S; Hu, B; Lou, J; Zhang, J; Zhou, Z, 2016) |
| "Preventive measures against oral carcinogenesis are urgently warranted to lower the high morbidity and mortality associated with this malignancy worldwide." | 1.42 | Grape seed extract and resveratrol prevent 4-nitroquinoline 1-oxide induced oral tumorigenesis in mice by modulating AMPK activation and associated biological responses. ( Agarwal, C; Agarwal, R; Deep, G; Orlicky, DJ; Sclafani, RA; Shrotriya, S; Tyagi, A; Wang, XJ; Wisell, J, 2015) |
| "Susceptibly to the induction of rat tongue cancer (TC) by oral 4-nitroquinoline 1-oxide (4NQO) exposure is a polygenic trait." | 1.40 | Pthlh, a promising cancer modifier gene in rat tongue carcinogenesis. ( Ehara, M; Hiai, H; Hirano, M; Kawarada, K; Kitano, M; Muraki, T; Nagayama, M; Shisa, H; Sugimoto, M; Sugiyama, A; Suwa, H; Tanuma, J, 2014) |
| "One of the theories regarding oral carcinogenesis is that the tumor growth is initiated from cancer stem cells (CSCs) that self-renew and give rise to differentiated tumor cells, like stem cells do in normal tissues." | 1.40 | Expression of cancer stem cell marker during 4-nitroquinoline 1-oxide-induced rat tongue carcinogenesis. ( Choi, H; Im, Y; Jeon, S; Kim, J; Kim, O; Kim, S; Lee, G; Lee, JY; Lim, W; Moon, YL; Ni, K; Oh, HK; Song, SY; You, JW, 2014) |
| "Head and neck squamous cell carcinoma (HNSCC) is the sixth most common type of cancer affecting humans worldwide." | 1.39 | The molecular features of tongue epithelium treated with the carcinogen 4-nitroquinoline-1-oxide and alcohol as a model for HNSCC. ( Gudas, LJ; Osei-Sarfo, K; Scognamiglio, T; Tang, XH; Urvalek, AM, 2013) |
| "The cells of origin of oral cavity squamous cell carcinoma (OCSCC) are unknown." | 1.39 | Basal stem cells contribute to squamous cell carcinomas in the oral cavity. ( Gudas, LJ; Scognamiglio, T; Tang, XH, 2013) |
| "Lycopene treatment significantly decreased the incidence of 4-NQO induced tongue carcinogenesis." | 1.37 | Histological and immunohistochemical evaluation of the chemopreventive role of lycopene in tongue carcinogenesis induced by 4-nitroquinoline-1-oxide. ( El-Rouby, DH, 2011) |
| "In pre-neoplastic lesions and squamous cell carcinomas induced after 12 and 20 weeks following carcinogen exposure, respectively, oxidative DNA damage was also increased (P < 0." | 1.37 | Oxidative DNA damage is a preliminary step during rat tongue carcinogenesis induced by 4-nitroquinoline 1-oxide. ( Carvalho, JG; Miranda, SR; Noguti, J; Oshima, CT; Ribeiro, DA, 2011) |
| "The incidence of squamous cell carcinoma (SCC) increased from 20% (8/41) to 43% (17/40; P < 0." | 1.37 | Ethanol promotes chemically induced oral cancer in mice through activation of the 5-lipoxygenase pathway of arachidonic acid metabolism. ( Chen, X; Guo, Y; Sun, Z; Wang, X; Zhang, X, 2011) |
| "In well-differentiated squamous cell carcinoma induced after 20 weeks of treatment with 4NQO, Wnt1 was expressed in the majority of the dysplasic cells and tumor cells." | 1.36 | Wnt/beta-catenin signalling pathway following rat tongue carcinogenesis induced by 4-nitroquinoline 1-oxide. ( Fracalossi, AC; Oshima, CT; Ribeiro, DA; Silva, Mde S, 2010) |
| "In the present study, tongue squamous cell carcinoma (SCC) was induced by adding the carcinogen 4-nitroquinoline oxide in drinking water for 19 weeks." | 1.35 | High interstitial fluid pressure in rat tongue cancer is related to increased lymph vessel area, tumor size, invasiveness and decreased body weight. ( Haug, SR; Heyeraas, KJ; Ibrahim, SO; Raju, B, 2008) |
| "The incidence of tongue squamous cell carcinomas (SCC) in the 4-NQO-treated rats was 64%, while that in the rats given ONO-8711 after 4-NQO exposure was 29 (P<0." | 1.34 | A prostaglandin E2 receptor subtype EP1-selective antagonist, ONO-8711, suppresses 4-nitroquinoline 1-oxide-induced rat tongue carcinogenesis. ( Fujitsuka, H; Kobayashi, A; Makita, H; Maruyama, T; Miyamoto, S; Mutoh, M; Shibata, T; Suzuki, R; Tanaka, T; Toida, M; Wakabayashi, K; Yasui, Y; Yonemoto, K, 2007) |
| "Tongue squamous cell carcinoma (SCC) was confirmed by pathological examination in 61 rats." | 1.34 | Response of lymphocyte subsets and cytokines to Shenyang prescription in Sprague-Dawley rats with tongue squamous cell carcinomas induced by 4NQO. ( Chen, W; He, D; Jiang, C; Qiu, W; Ye, D; Zhang, P; Zhang, X; Zhang, Z, 2007) |
| "Esophageal and tongue cancers have both been associated with dietary zinc deficiency (ZD), and cyclooxygenase (COX-2) is often overexpressed in these cancers." | 1.33 | Dietary zinc modulation of COX-2 expression and lingual and esophageal carcinogenesis in rats. ( Farber, JL; Fong, LY; Jiang, Y; Zhang, L, 2005) |
| "In well-differentiated squamous cell carcinoma induced after 20 weeks of treatment with 4NQO, bcl-2 was expressed in some cells of tumour islands." | 1.33 | Abnormal expression of bcl-2 and bax in rat tongue mucosa during the development of squamous cell carcinoma induced by 4-nitroquinoline 1-oxide. ( Marques, ME; Ribeiro, DA; Salvadori, DM, 2005) |
| "Oral squamous cell carcinoma (SCC) develops from pre-malignant lesions, but the role of cell adhesion molecules such as E-cadherin (E-CD) and P-cadherin (P-CD) in the pre-malignant stage has not been elucidated." | 1.32 | Changing expression of E- and P-cadherin during rat tongue carcinogenesis induced by 4-nitroquinoline 1-oxide. ( Kadota, H; Kakudo, K; Sakaki, T; Tamura, I, 2003) |
| "One differentiated squamous cell carcinoma (SCC) cell line (RSC3-E2) and two undifferentiated tumor cell lines (RSC3-LM and RSC3-E2R) with different metastatic potential were established from a 4-nitroquinoline N-oxide (4NQO)-induced differentiated SCC in F344 rat tongue." | 1.31 | Isolation of differentiated squamous and undifferentiated spindle carcinoma cell lines with differing metastatic potential from a 4-nitroquinoline N-Oxide-induced tongue carcinoma in a F344 rat. ( Fukushima, S; Kurita, K; Moriuchi, T; Nakanishi, H; Takeuchi, S; Tatematsu, M; Tonoki, H; Tsukamoto, T; Yamamoto, S; Yoshida, K, 2000) |
| "After 50 weeks of 4NQO exposure, tongue squamous cell carcinomas (SCCs) occurred in XPA(-/-) mice only, no tumors being observed in XPA(+/-) and XPA(+/+) animals." | 1.31 | Xeroderma pigmentosum group A gene action as a protection factor against 4-nitroquinoline 1-oxide-induced tongue carcinogenesis. ( Ide, F; Ishikawa, T; Kusama, K; Nakatsuru, Y; Oda, H; Sakashita, H; Tanaka, K, 2001) |
| "The incidence of tongue cancer in rats treated with 4NQO for 9 weeks, 13 weeks, 16 weeks and then observed for 32 weeks was 50." | 1.30 | [A rat model of tongue mucosa squamous cell carcinoma induced by oral administration of 4NQO in drinking water]. ( Chen, W; He, R; Liu, X, 1999) |
| "Eighteen (72%) of 25 squamous cell carcinomas showed a diploid pattern, while 7 (28%) showed a diploid plus tetraploid pattern." | 1.29 | Nucleolar organizer regions in tongue carcinomas induced in rats: comparison with DNA cytofluorometric analysis. ( Itoh, T; Takahashi, H; Yamamoto, Y, 1994) |
| "The incidence of animals developing squamous cell carcinomas was similar in both groups, but tumour development was significantly earlier in iron-deficient animals (mean 183 days) compared to controls (mean 229 days)." | 1.27 | The effect of iron deficiency on experimental oral carcinogenesis in the rat. ( MacDonald, DG; Prime, SS; Rennie, JS, 1983) |
| "Oral epithelial atypia and squamous cell carcinoma were observed with increasing prevalence as the period of carcinogen exposure was increased." | 1.27 | Experimental induction of oral squamous cell carcinomas in mice with 4-nitroquinolone-1-oxide. ( Reade, PC; Steidler, NE, 1984) |
| "Invasive carcinomas were either endophytic or exophytic." | 1.27 | Experimental tongue carcinoma of rats induced by oral administration of 4-nitroquinoline 1-oxide (4NQO) in drinking water. ( Ohne, M; Satoh, T; Takai, H; Yamada, S, 1985) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 17 (8.95) | 18.7374 |
| 1990's | 34 (17.89) | 18.2507 |
| 2000's | 67 (35.26) | 29.6817 |
| 2010's | 62 (32.63) | 24.3611 |
| 2020's | 10 (5.26) | 2.80 |
| Authors | Studies |
|---|---|
| Zigmundo, GCO | 1 |
| Schuch, LF | 2 |
| Schmidt, TR | 2 |
| Silveira, FM | 1 |
| Martins, MAT | 2 |
| Carrard, VC | 2 |
| Martins, MD | 2 |
| Wagner, VP | 2 |
| da Silva, RCB | 1 |
| de Barros Viana, M | 1 |
| Ribeiro, DA | 18 |
| Neto, JNC | 1 |
| Sorbo, JM | 1 |
| Filho, CAA | 1 |
| Sabino, TFM | 1 |
| Brunetti, IL | 1 |
| de Andrade, CR | 1 |
| Campagnol, D | 1 |
| Michel, CHT | 1 |
| Garcez, TNA | 1 |
| Danilevicz, CK | 1 |
| Castilho, RM | 2 |
| Vargas, PA | 1 |
| Coeli-Lacchini, FB | 1 |
| da Silva, G | 1 |
| Belentani, M | 1 |
| Alves, JSF | 1 |
| Ushida, TR | 1 |
| Lunardelli, GT | 1 |
| Garcia, CB | 1 |
| Silva, TA | 1 |
| Lopes, NP | 1 |
| Leopoldino, AM | 1 |
| Tan, MT | 1 |
| Wu, JG | 1 |
| Callejas-Valera, JL | 1 |
| Schwarz, RA | 1 |
| Gillenwater, AM | 1 |
| Richards-Kortum, RR | 1 |
| Vigneswaran, N | 2 |
| Naik, K | 1 |
| Janal, MN | 1 |
| Chen, J | 2 |
| Bandary, D | 1 |
| Brar, B | 1 |
| Zhang, S | 1 |
| Dolan, JC | 2 |
| Schmidt, BL | 2 |
| Albertson, DG | 1 |
| Bhattacharya, A | 2 |
| Spuldaro, TR | 1 |
| Nör, F | 1 |
| Gaio, EJ | 1 |
| Rösing, CK | 1 |
| Huang, LY | 1 |
| Hsieh, YP | 1 |
| Wang, YY | 1 |
| Hwang, DY | 1 |
| Jiang, SS | 1 |
| Huang, WT | 1 |
| Chiang, WF | 1 |
| Liu, KJ | 1 |
| Huang, TT | 1 |
| Hafız, AM | 2 |
| Doğan, R | 2 |
| Gucin, Z | 1 |
| Ozer, OF | 1 |
| Yenigun, A | 2 |
| Ozturan, O | 2 |
| Kiziltan, HS | 1 |
| Buyukpinarbaslili, N | 1 |
| Eris, AH | 1 |
| Madankumar, A | 2 |
| Tamilarasi, S | 1 |
| Premkumar, T | 1 |
| Gopikrishnan, M | 1 |
| Nagabhishek, N | 1 |
| Devaki, T | 2 |
| Miki, K | 2 |
| Orita, Y | 2 |
| Gion, Y | 2 |
| Takao, S | 2 |
| Ohno, K | 2 |
| Takeuchi, M | 2 |
| Ito, T | 3 |
| Minoura, A | 2 |
| Tachibana, T | 2 |
| Marunaka, H | 2 |
| Makino, T | 2 |
| Matsukawa, A | 2 |
| Nishizaki, K | 2 |
| Yoshino, T | 2 |
| Sato, Y | 2 |
| Mohan, S | 1 |
| Thiagarajan, K | 1 |
| Chandrasekaran, R | 1 |
| Scheff, NN | 1 |
| Ye, Y | 1 |
| MacRae, J | 1 |
| Hickman, DN | 1 |
| Sharma, AK | 1 |
| Valente, VB | 1 |
| Verza, FA | 1 |
| Lopes, FYK | 1 |
| Ferreira, JZ | 1 |
| Dos Santos, PSP | 1 |
| Sundefeld, MLMM | 1 |
| Biasoli, ÉR | 1 |
| Miyahara, GI | 1 |
| Soubhia, AMP | 1 |
| de Andrade, M | 1 |
| de Oliveira, SHP | 1 |
| Bernabé, DG | 1 |
| Soares, GR | 1 |
| de Moura, CFG | 1 |
| Silva, MJD | 1 |
| Vilegas, W | 1 |
| Santamarina, AB | 1 |
| Pisani, LP | 1 |
| Estadella, D | 1 |
| Liu, H | 1 |
| Li, J | 2 |
| Yang, Y | 1 |
| Liu, L | 1 |
| Yu, L | 1 |
| Tu, M | 1 |
| Yuan, R | 1 |
| Yue, W | 1 |
| Luo, Q | 1 |
| Ruan, Y | 1 |
| Dai, X | 1 |
| Sawangarun, W | 1 |
| Mandasari, M | 1 |
| Aida, J | 1 |
| Morita, KI | 1 |
| Kayamori, K | 1 |
| Ikeda, T | 1 |
| Sakamoto, K | 1 |
| Zhou, YX | 1 |
| Fuentes-Creollo, G | 1 |
| Ponce, F | 1 |
| Langley, SA | 1 |
| Jen, KY | 1 |
| Celniker, SE | 1 |
| Mao, JH | 1 |
| Snijders, AM | 1 |
| Chen, YF | 2 |
| Liu, CJ | 1 |
| Lin, LH | 1 |
| Chou, CH | 1 |
| Yeh, LY | 1 |
| Lin, SC | 2 |
| Chang, KW | 2 |
| Kosugi, A | 1 |
| Kasahara, M | 1 |
| Yang, L | 2 |
| Nakamura-Takahashi, A | 1 |
| Shibahara, T | 2 |
| Mori, T | 1 |
| Yang, IT | 1 |
| Tu, HF | 1 |
| Jayakumar, S | 1 |
| Gokuladhas, K | 1 |
| Rajan, B | 1 |
| Raghunandhakumar, S | 1 |
| Asokkumar, S | 1 |
| Feng, Y | 2 |
| Kang, XJ | 1 |
| Li, CH | 1 |
| Nie, MH | 1 |
| Osei-Sarfo, K | 2 |
| Tang, XH | 4 |
| Urvalek, AM | 2 |
| Scognamiglio, T | 3 |
| Gudas, LJ | 4 |
| Kang, X | 1 |
| Li, C | 4 |
| Nie, M | 1 |
| da Silva, JM | 1 |
| Queiroz-Junior, CM | 1 |
| Batista, AC | 1 |
| Rachid, MA | 1 |
| Teixeira, MM | 1 |
| da Silva, TA | 1 |
| Shrotriya, S | 1 |
| Tyagi, A | 1 |
| Deep, G | 1 |
| Orlicky, DJ | 1 |
| Wisell, J | 1 |
| Wang, XJ | 1 |
| Sclafani, RA | 1 |
| Agarwal, R | 1 |
| Agarwal, C | 1 |
| Suwa, H | 1 |
| Hirano, M | 6 |
| Kawarada, K | 1 |
| Nagayama, M | 1 |
| Ehara, M | 1 |
| Muraki, T | 1 |
| Shisa, H | 9 |
| Sugiyama, A | 1 |
| Sugimoto, M | 1 |
| Hiai, H | 6 |
| Kitano, M | 11 |
| Tanuma, J | 7 |
| Zhao, J | 1 |
| Wang, Z | 1 |
| Han, J | 1 |
| Qiu, X | 1 |
| Pan, J | 1 |
| Hellebust, A | 1 |
| Rosbach, K | 1 |
| Wu, JK | 1 |
| Nguyen, J | 1 |
| Gillenwater, A | 1 |
| Richards-Kortum, R | 1 |
| de Jesus, GP | 1 |
| Ribeiro, FA | 2 |
| de Moura, CF | 1 |
| Gollucke, AP | 1 |
| Oshima, CT | 7 |
| Fixler, D | 1 |
| Ankri, R | 1 |
| Kaplan, I | 3 |
| Novikov, I | 1 |
| Hirshberg, A | 3 |
| Barcessat, AR | 2 |
| Huang, I | 1 |
| Rabelo, GD | 1 |
| Rosin, FC | 2 |
| Ferreira, LG | 1 |
| de Cerqueira Luz, JG | 1 |
| Corrêa, L | 2 |
| Lim, W | 1 |
| Choi, H | 1 |
| Kim, J | 1 |
| Kim, S | 1 |
| Jeon, S | 1 |
| Ni, K | 1 |
| Song, SY | 1 |
| Oh, HK | 1 |
| Im, Y | 1 |
| Lee, G | 1 |
| Lee, JY | 1 |
| Moon, YL | 1 |
| You, JW | 1 |
| Kim, O | 1 |
| de Souza, MV | 1 |
| Servato, JP | 1 |
| Loyola, AM | 2 |
| Cardoso, SV | 2 |
| Chammas, R | 2 |
| Liu, FT | 2 |
| Silva, MJ | 1 |
| de Faria, PR | 2 |
| Noguti, J | 3 |
| Alvarenga, TA | 1 |
| Marchi, P | 1 |
| Andersen, ML | 1 |
| Paparella, ML | 1 |
| Abrigo, M | 1 |
| Bal de Kier Joffe, E | 1 |
| Raimondi, AR | 1 |
| Abbasi, MM | 2 |
| Helli, S | 1 |
| Monfaredan, A | 1 |
| Jahanban-Esfahlan, R | 1 |
| Peres, RC | 1 |
| Spolidorio, LC | 1 |
| Maluf, Lle S | 1 |
| Zhang, T | 1 |
| Borges, GG | 1 |
| Ge, S | 1 |
| Zhang, J | 1 |
| Du, Y | 1 |
| Hu, B | 1 |
| Zhou, Z | 2 |
| Lou, J | 1 |
| Mei, C | 1 |
| Guiqing, L | 1 |
| Wen, T | 1 |
| Yuan, Z | 1 |
| Yuxiong, S | 1 |
| Yujie, L | 1 |
| Liu, YC | 2 |
| Ho, HC | 2 |
| Lee, MR | 3 |
| Yeh, CM | 2 |
| Tseng, HC | 2 |
| Lin, YC | 1 |
| Chung, JG | 2 |
| Hanakawa, H | 1 |
| Tanaka, T | 26 |
| Atsumi, N | 1 |
| Nakamura, N | 1 |
| Yanai, H | 1 |
| Komai, Y | 1 |
| Omachi, T | 1 |
| Tanaka, K | 3 |
| Ishigaki, K | 1 |
| Saiga, K | 1 |
| Ohsugi, H | 1 |
| Tokuyama, Y | 1 |
| Imahashi, Y | 1 |
| Hisha, H | 1 |
| Yoshida, N | 1 |
| Kumano, K | 1 |
| Okazaki, K | 1 |
| Ueno, H | 1 |
| Saitoh, T | 1 |
| Sato, K | 2 |
| Tonogi, M | 5 |
| Tanaka, Y | 3 |
| Yamane, GY | 2 |
| Grilli, DG | 1 |
| Salvadori, DM | 5 |
| Umemura, T | 1 |
| Maeda, M | 3 |
| Kijima, A | 1 |
| Ishii, Y | 1 |
| Tasaki, M | 1 |
| Okamura, T | 1 |
| Inoue, T | 1 |
| Hirose, M | 1 |
| Nishikawa, A | 2 |
| Hong, Y | 4 |
| Xia, J | 3 |
| Rhodus, NL | 2 |
| Cheng, B | 4 |
| Lv, N | 1 |
| Tao, X | 2 |
| Chen, X | 3 |
| Minicucci, EM | 2 |
| da Silva, GN | 2 |
| Favero Salvadori, DM | 2 |
| Baba, S | 1 |
| Yamada, Y | 5 |
| Hatano, Y | 1 |
| Miyazaki, Y | 1 |
| Mori, H | 20 |
| Shibata, T | 4 |
| Hara, A | 9 |
| Zheng, YF | 1 |
| Chen, ZL | 1 |
| Chen, HB | 1 |
| Cheng, J | 1 |
| Liu, X | 4 |
| Dai, Y | 1 |
| Huang, Y | 1 |
| Chang, NW | 1 |
| Pei, RJ | 1 |
| Yeh, KT | 1 |
| Chan, HC | 1 |
| Lin, C | 1 |
| Hsieh, WT | 1 |
| Kao, MC | 1 |
| Tsai, MH | 1 |
| Lin, CF | 1 |
| Fracalossi, AC | 3 |
| Silva, Mde S | 1 |
| Naoi, K | 1 |
| Sunagawa, N | 1 |
| Yoshida, I | 1 |
| Morioka, T | 1 |
| Nakashima, M | 1 |
| Ishihara, M | 1 |
| Fukamachi, K | 2 |
| Itoh, Y | 1 |
| Tsuda, H | 6 |
| Yoshimi, N | 4 |
| Suzui, M | 4 |
| Farahati, B | 1 |
| Stachs, O | 1 |
| Prall, F | 1 |
| Stave, J | 1 |
| Guthoff, R | 1 |
| Pau, HW | 1 |
| Just, T | 1 |
| Miranda, SR | 2 |
| Franco, M | 2 |
| Vered, M | 3 |
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| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Observational Study on the Carcinogenesis of SOX-9 in Oral Cancer, and Chemopreventive Possibility for the Treatment of Oral Cancer Using SOX-9 Inhibitor.[NCT01919567] | 255 participants (Anticipated) | Observational | 2011-11-30 | Recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for 4-nitroquinoline-1-oxide and Cancer of the Tongue
| Article | Year |
|---|---|
4-nitroquinoline-1-oxide (4NQO) induced oral carcinogenesis: A systematic literature review.
Topics: 4-Nitroquinoline-1-oxide; Animals; Carcinogenesis; Carcinoma, Squamous Cell; Rats; Rats, Wistar; Ton | 2022 |
Host genes controlling the susceptibility and resistance to squamous cell carcinoma of the tongue in a rat model.
Topics: 4-Nitroquinoline-1-oxide; Animals; Carcinogens; Carcinoma, Squamous Cell; Chromosome Mapping; Geneti | 2000 |
188 other studies available for 4-nitroquinoline-1-oxide and Cancer of the Tongue
| Article | Year |
|---|---|
The impact of stress on rat tongue carcinogenesis induced by 4-nitroquinoline 1-oxide: some theoretical concepts for scientific debate.
Topics: 4-Nitroquinoline-1-oxide; Animals; Carcinogenesis; Carcinogens; Oxides; Rats; Tongue; Tongue Neoplas | 2023 |
Negative terpinen-4-ol modulate potentially malignant and malignant lingual lesions induced by 4-nitroquinoline-1-oxide in rat model.
Topics: 4-Nitroquinoline-1-oxide; Alanine Transaminase; Alkaline Phosphatase; Animals; Aspartate Aminotransf | 2022 |
Proposal of a secure and efficient protocol for a murine oral carcinogenesis model induced by 4-nitroquinoline-1-oxide (4NQO).
Topics: 4-Nitroquinoline-1-oxide; Animals; Carcinogenesis; Carcinogens; Carcinoma; Male; Mice; Rats; Rats, W | 2023 |
Spermidine Suppresses Oral Carcinogenesis through Autophagy Induction, DNA Damage Repair, and Oxidative Stress Reduction.
Topics: 4-Nitroquinoline-1-oxide; Animals; Carcinogenesis; Carcinogens; Carcinoma, Squamous Cell; Ceramides; | 2023 |
A PIK3CA transgenic mouse model with chemical carcinogen exposure mimics human oral tongue tumorigenesis.
Topics: 4-Nitroquinoline-1-oxide; Animals; Cell Proliferation; Cell Transformation, Neoplastic; Class I Phos | 2020 |
The Histopathology of Oral Cancer Pain in a Mouse Model and a Human Cohort.
Topics: 4-Nitroquinoline-1-oxide; Animals; Cancer Pain; Carcinoma, Squamous Cell; Humans; Mice; Mouth Neopla | 2021 |
Can propranolol act as a chemopreventive agent during oral carcinogenesis? An experimental animal study.
Topics: 4-Nitroquinoline-1-oxide; Animals; Carcinogenesis; Carcinogens; Carcinoma, Squamous Cell; Disease Mo | 2021 |
Single-Cell Analysis of Different Stages of Oral Cancer Carcinogenesis in a Mouse Model.
Topics: 4-Nitroquinoline-1-oxide; Animals; Arecoline; Biomarkers, Tumor; Carcinogenesis; Carcinogens; Cell L | 2020 |
Protective and therapeutic effects of pyrrolidine dithiocarbamate in a rat tongue cancer model created experimentally using 4-nitroquinoline 1-oxide.
Topics: 4-Nitroquinoline-1-oxide; Animals; Pyrrolidines; Rats; Thiocarbamates; Tongue Neoplasms | 2020 |
Effectiveness of radiotherapy+ozone on tumoral tissue and survival in tongue cancer rat model.
Topics: 4-Nitroquinoline-1-oxide; Animals; Carcinoma, Squamous Cell; Combined Modality Therapy; Disease Mode | 2018 |
Geraniol attenuates 4NQO-induced tongue carcinogenesis through downregulating the activation of NF-κB in rats.
Topics: 4-Nitroquinoline-1-oxide; Acyclic Monoterpenes; Animals; Anticarcinogenic Agents; Blood Cell Count; | 2017 |
Tumor-Associated Macrophages in the Development of 4-Nitroquinoline-1-Oxide-Induced Tongue Squamous Cell Carcinoma in a Mouse Model.
Topics: 4-Nitroquinoline-1-oxide; Animals; Carcinogens; Carcinoma, Squamous Cell; Disease Models, Animal; Im | 2017 |
Evaluation of ethyl gallate for its antioxidant and anticancer properties against chemical-induced tongue carcinogenesis in mice.
Topics: 4-Nitroquinoline-1-oxide; Acacia; Animals; Antineoplastic Agents, Phytogenic; Antioxidants; Carcinom | 2017 |
Tumor necrosis factor alpha secreted from oral squamous cell carcinoma contributes to cancer pain and associated inflammation.
Topics: 4-Nitroquinoline-1-oxide; Animals; Cancer Pain; Carcinoma, Squamous Cell; Female; Inflammation; Mice | 2017 |
Stress hormones concentrations in the normal microenvironment predict risk for chemically induced cancer in rats.
Topics: 4-Nitroquinoline-1-oxide; Adrenocorticotropic Hormone; Animals; Biomarkers, Tumor; Brain-Derived Neu | 2018 |
Protective effects of purple carrot extract (Daucus carota) against rat tongue carcinogenesis induced by 4-nitroquinoline 1-oxide.
Topics: 4-Nitroquinoline-1-oxide; Animals; Carcinogens; Cell Proliferation; Daucus carota; Male; Plant Extra | 2018 |
Alterations of 63 hub genes during lingual carcinogenesis in C57BL/6J mice.
Topics: 4-Nitroquinoline-1-oxide; Animals; Biomarkers, Tumor; Carcinogenesis; Carcinogens; Carcinoma, Squamo | 2018 |
Loss of Notch1 predisposes oro-esophageal epithelium to tumorigenesis.
Topics: 4-Nitroquinoline-1-oxide; Animals; Carcinogenesis; Disease Models, Animal; Epithelium; Esophageal Ne | 2018 |
No difference in 4-nitroquinoline induced tumorigenesis between germ-free and colonized mice.
Topics: 4-Nitroquinoline-1-oxide; Animals; Carcinogenesis; Carcinogens; Carcinoma, Squamous Cell; Cell Trans | 2019 |
Establishing of mouse oral carcinoma cell lines derived from transgenic mice and their use as syngeneic tumorigenesis models.
Topics: 4-Nitroquinoline-1-oxide; Animals; Carcinoma, Squamous Cell; Cell Culture Techniques; Cell Line, Tum | 2019 |
Method for diagnosing neoplastic lesions by quantitative fluorescence value.
Topics: 4-Nitroquinoline-1-oxide; Animals; Carcinogenesis; Carcinogens; Carcinoma, Squamous Cell; Disease Pr | 2019 |
Establishment of syngeneic murine model for oral cancer therapy.
Topics: 4-Nitroquinoline-1-oxide; Animals; Antineoplastic Agents; B7-H1 Antigen; Carcinogenesis; Carcinogens | 2019 |
Geraniol modulates tongue and hepatic phase I and phase II conjugation activities and may contribute directly to the chemopreventive activity against experimental oral carcinogenesis.
Topics: 4-Nitroquinoline-1-oxide; Acyclic Monoterpenes; Animals; Anticarcinogenic Agents; Carcinogens; Cytoc | 2013 |
[Expression of connexin 43 in tongue carcinogenesis].
Topics: 4-Nitroquinoline-1-oxide; Animals; Carcinoma, Squamous Cell; Connexin 43; Male; Rats; Rats, Sprague- | 2013 |
The molecular features of tongue epithelium treated with the carcinogen 4-nitroquinoline-1-oxide and alcohol as a model for HNSCC.
Topics: 4-Nitroquinoline-1-oxide; Animals; beta Catenin; Blotting, Western; Carcinogens; Carcinoma, Squamous | 2013 |
[Expression of cytokeratin 19 and connexin 43 in 4-nitroquinoline-l-oxide-induced rat tongue carcinogenesis].
Topics: 4-Nitroquinoline-1-oxide; Animals; Carcinogenesis; Carcinoma, Squamous Cell; Connexin 43; Epithelial | 2013 |
Eosinophil depletion protects mice from tongue squamous cell carcinoma induced by 4-nitroquinoline-1-oxide.
Topics: 4-Nitroquinoline-1-oxide; Animals; Carcinogens; Carcinoma, Squamous Cell; Disease Models, Animal; En | 2014 |
Grape seed extract and resveratrol prevent 4-nitroquinoline 1-oxide induced oral tumorigenesis in mice by modulating AMPK activation and associated biological responses.
Topics: 4-Nitroquinoline-1-oxide; AMP-Activated Protein Kinases; Animals; Anticarcinogenic Agents; Apoptosis | 2015 |
Pthlh, a promising cancer modifier gene in rat tongue carcinogenesis.
Topics: 4-Nitroquinoline-1-oxide; Animals; Base Sequence; Carcinogens; Cell Transformation, Neoplastic; Gene | 2014 |
Increased frequency of CD4+ CD25+ FOXP3+ cells correlates with the progression of 4-nitroquinoline1-oxide-induced rat tongue carcinogenesis.
Topics: 4-Nitroquinoline-1-oxide; Animals; Carcinoma, Squamous Cell; CD4 Antigens; Disease Progression; Flow | 2014 |
Vital-dye-enhanced multimodal imaging of neoplastic progression in a mouse model of oral carcinogenesis.
Topics: 4-Chloro-7-nitrobenzofurazan; 4-Nitroquinoline-1-oxide; Algorithms; Animals; Deoxyglucose; Discrimin | 2013 |
Anti-tumor activity of grape juice concentrate in the rat tongue two-stage initiation-promotion protocol induced by 4-nitroquinoline 1-oxide.
Topics: 4-Nitroquinoline-1-oxide; Animals; Anticarcinogenic Agents; Base Sequence; Beverages; Comet Assay; C | 2014 |
Diffusion Reflection: A Novel Method for Detection of Oral Cancer.
Topics: 4-Nitroquinoline-1-oxide; Animals; Carcinogens; Carcinoma in Situ; Carcinoma, Squamous Cell; Diffusi | 2014 |
Systemic toxic effects during early phases of topical 4-NQO-induced oral carcinogenesis in rats.
Topics: 4-Nitroquinoline-1-oxide; Administration, Topical; Alanine Transaminase; Animals; Aspartate Aminotra | 2014 |
Expression of cancer stem cell marker during 4-nitroquinoline 1-oxide-induced rat tongue carcinogenesis.
Topics: 4-Nitroquinoline-1-oxide; AC133 Antigen; Aldehyde Dehydrogenase 1 Family; Animals; Antigens, CD; Bio | 2014 |
Expression of APC protein during tongue malignant transformation in galectin-3-deficient mice challenged by the carcinogen 4-nitroquniline-n-oxide.
Topics: 4-Nitroquinoline-1-oxide; Adenomatous Polyposis Coli Protein; Animals; Carcinogens; Carcinoma; Cell | 2014 |
The influence of sleep restriction on expression of apoptosis regulatory proteins p53, Bcl-2 and Bax following rat tongue carcinogenesis induced by 4-nitroquinoline 1-oxide.
Topics: 4-Nitroquinoline-1-oxide; Animals; Apoptosis; Apoptosis Regulatory Proteins; bcl-2-Associated X Prot | 2015 |
Oral-specific ablation of Klf4 disrupts epithelial terminal differentiation and increases premalignant lesions and carcinomas upon chemical carcinogenesis.
Topics: 4-Nitroquinoline-1-oxide; Animals; Carcinogenesis; Carcinogens; Carcinoma, Squamous Cell; Cell Diffe | 2015 |
Hesa-A Improves Clinical Outcome of Oral Carcinoma by Affecting p53 Gene Expression in vivo.
Topics: 4-Nitroquinoline-1-oxide; Animals; Carcinoma; Gene Expression; Genes, p53; Male; Phytotherapy; Plant | 2015 |
Antioxidant activity of apple extract protects against rat tongue carcinogenesis induced by 4-nitroquinoline 1-oxide.
Topics: 4-Nitroquinoline-1-oxide; Animals; Anticarcinogenic Agents; Antioxidants; Carcinogens; Drinking Wate | 2015 |
Gene expression profiling signatures for the diagnosis and prevention of oral cavity carcinogenesis-genome-wide analysis using RNA-seq technology.
Topics: 4-Nitroquinoline-1-oxide; Animals; Biomarkers, Tumor; Carcinogenesis; Carcinogens; Carcinoma, Squamo | 2015 |
Effect of 5-ALA-mediated photodynamic therapy on mast cell and microvessels densities present in oral premalignant lesions induced in rats.
Topics: 4-Nitroquinoline-1-oxide; Aminolevulinic Acid; Animals; Antigens, CD34; Cell Degranulation; Female; | 2015 |
Dynamic changes in the gene expression profile during rat oral carcinogenesis induced by 4-nitroquinoline 1-oxide.
Topics: 4-Nitroquinoline-1-oxide; Animals; Carcinogenesis; Cyclin D1; Disease Models, Animal; Gene Expressio | 2016 |
[Myeloid-derived suppressor cell expression and significance in peripheral blood and tongue lesions of mouse].
Topics: 4-Nitroquinoline-1-oxide; Animals; Arginase; Cell Count; Flow Cytometry; Mice; Models, Animal; Myelo | 2015 |
Cortactin is a prognostic marker for oral squamous cell carcinoma and its overexpression is involved in oral carcinogenesis.
Topics: 4-Nitroquinoline-1-oxide; Adult; Animals; Areca; Carcinogenesis; Carcinoma, Squamous Cell; Cortactin | 2017 |
Regulatory T cells function at the early stage of tumor progression in a mouse model of tongue squamous cell carcinoma.
Topics: 4-Nitroquinoline-1-oxide; Animals; Carcinogenesis; Carcinoma, Squamous Cell; Cells, Cultured; Chemok | 2016 |
Bmi1-positive cells in the lingual epithelium could serve as cancer stem cells in tongue cancer.
Topics: 4-Nitroquinoline-1-oxide; Animals; Cell Lineage; Cell Proliferation; Epithelium; Mice; Mice, Inbred | 2016 |
Expression of Cytokeratin 13, 14, 17, and 19 in 4-nitroquinoline-1-oxide-induced Oral Carcinogenesis in Rat.
Topics: 4-Nitroquinoline-1-oxide; Animals; Epithelial Cells; Immunohistochemistry; Keratins, Type I; Precanc | 2016 |
Genomic instability in blood cells is able to predict the oral cancer risk: an experimental study in rats.
Topics: 4-Nitroquinoline-1-oxide; Animals; Carcinogens; Comet Assay; Erythroblasts; Erythrocytes, Abnormal; | 2008 |
Lack of promotion activity of diacylglycerol oil on 4-nitroquinoline 1-oxide induced carcinogenesis in the oral cavity of SD rats.
Topics: 4-Nitroquinoline-1-oxide; Animals; Carcinogens; Carcinoma, Squamous Cell; Diet; Diglycerides; Fatty | 2008 |
p16(CDKN2A) expression during rat tongue carcinogenesis induced by 4-nitroquinoline-1-oxide.
Topics: 4-Nitroquinoline-1-oxide; Animals; Carcinogens; Cyclin-Dependent Kinase Inhibitor p16; Disease Model | 2009 |
Increased expression of focal adhesion kinase correlates with cellular proliferation and apoptosis during 4-nitroquinoline-1-oxide-induced rat tongue carcinogenesis.
Topics: 4-Nitroquinoline-1-oxide; Animals; Apoptosis; Biomarkers, Tumor; Carcinogens; Carcinoma, Squamous Ce | 2009 |
No mutations found in exon 2 of gene p16CDKN2A during rat tongue carcinogenesis induced by 4-nitroquinoline-1-oxide.
Topics: 4-Nitroquinoline-1-oxide; Animals; Base Sequence; Cyclin-Dependent Kinase Inhibitor p16; DNA Mutatio | 2009 |
Global DNA hypomethylation suppresses squamous carcinogenesis in the tongue and esophagus.
Topics: 4-Nitroquinoline-1-oxide; Alleles; Animals; Carcinoma, Squamous Cell; Cell Line, Tumor; DNA (Cytosin | 2009 |
[Expression of survivin, Bcl-2 and p53 during 4-nitro-quinoline 1-oxide-induced rat tongue carcinogenesis].
Topics: 4-Nitroquinoline-1-oxide; Animals; Apoptosis; Cell Transformation, Neoplastic; Genes, bcl-2; Male; M | 2009 |
Expression of gap junctional protein connexin43 during 4-nitroquinoline-1-oxide-induced rat tongue carcinogenesis.
Topics: 4-Nitroquinoline-1-oxide; Animals; Connexin 43; Epithelium; Gap Junctions; Gene Expression Regulatio | 2009 |
Co-treating with arecoline and 4-nitroquinoline 1-oxide to establish a mouse model mimicking oral tumorigenesis.
Topics: 4-Nitroquinoline-1-oxide; alpha-Crystallin B Chain; Animals; Arecoline; Carcinogens; Disease Models, | 2010 |
Wnt/beta-catenin signalling pathway following rat tongue carcinogenesis induced by 4-nitroquinoline 1-oxide.
Topics: 4-Nitroquinoline-1-oxide; Animals; beta Catenin; Carcinogens; Carcinoma, Squamous Cell; Disease Mode | 2010 |
Enhancement of tongue carcinogenesis in Hras128 transgenic rats treated with 4-nitroquinoline 1-oxide.
Topics: 4-Nitroquinoline-1-oxide; Animals; Carcinoma, Squamous Cell; Cell Transformation, Neoplastic; Drug S | 2010 |
Rigid confocal endoscopy for in vivo imaging of experimental oral squamous intra-epithelial lesions.
Topics: 4-Nitroquinoline-1-oxide; Animals; Carcinogens; Carcinoma in Situ; Cell Membrane; Cell Nucleus; Dise | 2010 |
The role of matrix metalloproteinases 2 and 9 during rat tongue carcinogenesis induced by 4-nitroquinoline 1-oxide.
Topics: 4-Nitroquinoline-1-oxide; Animals; Cytoplasm; Immunochemistry; Male; Matrix Metalloproteinase 2; Mat | 2010 |
The effect of desalivation on the malignant transformation of the tongue epithelium and associated stromal myofibroblasts in a rat 4-nitroquinoline 1-oxide-induced carcinogenesis model.
Topics: 4-Nitroquinoline-1-oxide; Actins; Animals; Carcinoma; Cell Proliferation; Cell Transformation, Neopl | 2010 |
The effect of dietary and topical celecoxib on 4-nitroquinoline-1-oxide-induced lingual epithelium alternations in rat.
Topics: 4-Nitroquinoline-1-oxide; Administration, Topical; Analysis of Variance; Animals; Celecoxib; Cycloox | 2009 |
The role of the TP53 gene during rat tongue carcinogenesis induced by 4-nitroquinoline 1-oxide.
Topics: 4-Nitroquinoline-1-oxide; Animals; Carcinogenicity Tests; Genes, p53; Immunohistochemistry; Male; Mu | 2011 |
Inhibition of 4-NQO-induced F433 rat tongue carcinogenesis by oleuropein-rich extract.
Topics: 4-Nitroquinoline-1-oxide; Animals; Anticarcinogenic Agents; Antioxidants; Carcinogens; Immunohistoch | 2011 |
Zinc deficiency activates S100A8 inflammation in the absence of COX-2 and promotes murine oral-esophageal tumor progression.
Topics: 4-Nitroquinoline-1-oxide; Animals; Calgranulin A; Carcinogens; Cyclooxygenase 2; Dimethylnitrosamine | 2011 |
Histological and immunohistochemical evaluation of the chemopreventive role of lycopene in tongue carcinogenesis induced by 4-nitroquinoline-1-oxide.
Topics: 4-Nitroquinoline-1-oxide; Animals; Anticarcinogenic Agents; Antioxidants; Basement Membrane; beta Ca | 2011 |
Ras gene mutation is not related to tumour invasion during rat tongue carcinogenesis induced by 4-nitroquinoline 1-oxide.
Topics: 4-Nitroquinoline-1-oxide; Actins; Animals; Cell Transformation, Neoplastic; Genes, ras; Ki-67 Antige | 2011 |
Zinc supplementation suppresses 4-nitroquinoline 1-oxide-induced rat oral carcinogenesis.
Topics: 4-Nitroquinoline-1-oxide; Animals; Apoptosis; Carcinoma, Squamous Cell; Cell Proliferation; Dietary | 2011 |
Chronic restraint stress in oral squamous cell carcinoma.
Topics: 4-Nitroquinoline-1-oxide; Animals; Carcinoma, Squamous Cell; Corticosterone; Immobilization; Kaplan- | 2011 |
Oxidative DNA damage is a preliminary step during rat tongue carcinogenesis induced by 4-nitroquinoline 1-oxide.
Topics: 4-Nitroquinoline-1-oxide; Animals; Carcinogens; Carcinoma, Squamous Cell; Comet Assay; DNA Damage; H | 2011 |
Ethanol promotes chemically induced oral cancer in mice through activation of the 5-lipoxygenase pathway of arachidonic acid metabolism.
Topics: 4-Nitroquinoline-1-oxide; Animals; Anti-Infective Agents, Local; Arachidonate 5-Lipoxygenase; Arachi | 2011 |
Myeloid-derived suppressor cells contribute to oral cancer progression in 4NQO-treated mice.
Topics: 4-Nitroquinoline-1-oxide; Animals; Arginase; Carcinoma, Squamous Cell; CD11b Antigen; Female; Flow C | 2012 |
Alkylation-induced genotoxicity as a predictor of DNA repair deficiency following experimental oral carcinogenesis.
Topics: 4-Nitroquinoline-1-oxide; Administration, Oral; Alkylation; Animals; Carcinogens; Carcinoma, Squamou | 2012 |
Homeobox C5 expression is associated with the progression of 4-nitroquinoline 1-oxide-induced rat tongue carcinogenesis.
Topics: 4-Nitroquinoline-1-oxide; Animals; Biomarkers, Tumor; Carcinogens; Carcinoma, Squamous Cell; Cell Li | 2012 |
Early induction of cytokines/cytokine receptors and Cox2, and activation of NF-κB in 4-nitroquinoline 1-oxide-induced murine oral cancer model.
Topics: 4-Nitroquinoline-1-oxide; Animals; Carcinogens; Cyclooxygenase 2; Cytokines; Enzyme Induction; Femal | 2012 |
The inactive form of glycogen synthase kinase-3β is associated with the development of carcinomas in galectin-3 wild-type mice, but not in galectin-3-deficient mice.
Topics: 4-Nitroquinoline-1-oxide; Animals; Biomarkers, Tumor; Carcinogens; Carcinoma, Squamous Cell; Cell Nu | 2012 |
Targeted expression of ornithine decarboxylase antizyme prevents upper aerodigestive tract carcinogenesis in p53-deficient mice.
Topics: 4-Nitroquinoline-1-oxide; Animals; Carcinoma, Squamous Cell; Cell Proliferation; Cell Transformation | 2013 |
Roles of Keap1-Nrf2 system in upper aerodigestive tract carcinogenesis.
Topics: 4-Nitroquinoline-1-oxide; Adaptor Proteins, Signal Transducing; Animals; Cell Transformation, Neopla | 2013 |
Basal stem cells contribute to squamous cell carcinomas in the oral cavity.
Topics: 4-Nitroquinoline-1-oxide; Animals; Carcinogens; Carcinoma, Squamous Cell; Cell Proliferation; Epithe | 2013 |
Modifying effects of dietary capsaicin and rotenone on 4-nitroquinoline 1-oxide-induced rat tongue carcinogenesis.
Topics: 4-Nitroquinoline-1-oxide; Animals; Anticarcinogenic Agents; Biogenic Polyamines; Capsaicin; Carcinog | 2002 |
Investigation of environmental factors for diagnosing malignant potential in oral epithelial dysplasia.
Topics: 4-Nitroquinoline-1-oxide; Animals; Apoptosis; Base Sequence; Biomarkers, Tumor; Carcinogens; Disease | 2002 |
Carcinogenesis modifier loci in rat tongue are subject to frequent loss of heterozygosity.
Topics: 4-Nitroquinoline-1-oxide; Animals; Chromosome Mapping; Female; Genes, p53; Genes, ras; Loss of Heter | 2002 |
A COX-2 inhibitor, nimesulide, inhibits chemically-induced rat tongue carcinogenesis through suppression of cell proliferation activity and COX-2 and iNOS expression.
Topics: 4-Nitroquinoline-1-oxide; Animals; Anticarcinogenic Agents; Apoptosis; Carcinogens; Cell Division; C | 2003 |
A novel geranylated derivative, ethyl 3-(4'-geranyloxy-3'-methoxyphenyl)-2-propenoate, synthesized from ferulic acid suppresses carcinogenesis and inducible nitric oxide synthase in rat tongue.
Topics: 4-Nitroquinoline-1-oxide; Animals; Biomarkers, Tumor; Carcinogens; Cell Division; Coumaric Acids; Fr | 2003 |
Expression of beta-catenin in rat oral epithelial dysplasia induced by 4-nitroquinoline 1-oxide.
Topics: 4-Nitroquinoline-1-oxide; Animals; beta Catenin; Biomarkers, Tumor; Carcinogens; Cytoskeletal Protei | 2002 |
Skeletal muscle regeneration associated with the stroma reaction during tumor invasion in the rat tongue.
Topics: 4-Nitroquinoline-1-oxide; Acetylcholinesterase; Animals; Biomarkers, Tumor; Bupivacaine; Carcinogens | 2002 |
Histomorphologic and morphometric changes in minor salivary glands of the rat tongue during 4-nitroquinoline-1-oxide-induced carcinogenesis.
Topics: 4-Nitroquinoline-1-oxide; Analysis of Variance; Animals; Carcinogens; Carcinoma, Squamous Cell; Dise | 2003 |
Correlation of P-cadherin and beta-catenin expression and phosphorylation with carcinogenesis in rat tongue cancer induced with 4-nitroquinoline 1-oxide.
Topics: 4-Nitroquinoline-1-oxide; Animals; beta Catenin; Blotting, Western; Cadherins; Carcinogens; Cytoskel | 2003 |
Inhibitory effects of troglitazone, a peroxisome proliferator-activated receptor gamma ligand, in rat tongue carcinogenesis initiated with 4-nitroquinoline 1-oxide.
Topics: 4-Nitroquinoline-1-oxide; Animals; Antineoplastic Agents; Bromodeoxyuridine; Carcinogens; Chromans; | 2003 |
Changing expression of E- and P-cadherin during rat tongue carcinogenesis induced by 4-nitroquinoline 1-oxide.
Topics: 4-Nitroquinoline-1-oxide; Animals; Cadherins; Carcinogens; Carcinoma, Squamous Cell; Cell Division; | 2003 |
Inhibitory effects of selective cyclooxygenase-2 inhibitors, nimesulide and etodolac, on the development of squamous cell dysplasias and carcinomas of the tongue in rats initiated with 4-nitroquinoline 1-oxide.
Topics: 4-Nitroquinoline-1-oxide; Animals; Blotting, Western; Carcinogens; Carcinoma, Squamous Cell; Cell Di | 2003 |
[Experimental production of labial and lingual carcinoma by local application of 4-nitroquinoline N-oxide].
Topics: 4-Nitroquinoline-1-oxide; Humans; Lip Neoplasms; Oxides; Quinolines; Tongue Neoplasms | 1962 |
p53 haploinsufficiency profoundly accelerates the onset of tongue tumors in mice lacking the xeroderma pigmentosum group A gene.
Topics: 4-Nitroquinoline-1-oxide; Animals; Blotting, Southern; Carcinogens; Carcinoma, Squamous Cell; Diseas | 2003 |
Expressions of junB and c-fos are enhanced in 4-nitroquinoline 1-oxide-induced rat tongue cancers.
Topics: 4-Nitroquinoline-1-oxide; Animals; Biomarkers, Tumor; Carcinoma, Squamous Cell; Cell Nucleus; Diseas | 2004 |
Oral cavity and esophageal carcinogenesis modeled in carcinogen-treated mice.
Topics: 4-Nitroquinoline-1-oxide; Animals; Bromodeoxyuridine; Carcinogens; Carcinoma, Papillary; Carcinoma, | 2004 |
Interaction between the immune system and tongue squamous cell carcinoma induced by 4-nitroquinoline N-oxide in mice.
Topics: 4-Nitroquinoline-1-oxide; Animals; Carcinogens; Carcinoma, Squamous Cell; Cell Division; Cytokines; | 2004 |
High frequency methylation of p16INK4A gene during 4-nitroquinoline 1-oxide-induced rat tongue carcinogenesis.
Topics: 4-Nitroquinoline-1-oxide; Animals; Base Sequence; Carcinogens; Carcinoma, Squamous Cell; Cyclin-Depe | 2004 |
Genomic instability in non-neoplastic oral mucosa cells can predict risk during 4-nitroquinoline 1-oxide-induced rat tongue carcinogenesis.
Topics: 4-Nitroquinoline-1-oxide; Animals; Carcinoma, Squamous Cell; Cell Transformation, Neoplastic; Comet | 2004 |
Suppressive effects of a selective cyclooxygenase-2 inhibitor, etodolac, on 4-nitroquinoline 1-oxide-induced rat tongue carcinogenesis.
Topics: 4-Nitroquinoline-1-oxide; Administration, Oral; Animals; Anticarcinogenic Agents; Carcinogens; Carci | 2004 |
Dietary zinc modulation of COX-2 expression and lingual and esophageal carcinogenesis in rats.
Topics: 4-Nitroquinoline-1-oxide; Animals; Apoptosis; Blotting, Western; Carcinogens; Carcinoma, Squamous Ce | 2005 |
Dietary garcinol inhibits 4-nitroquinoline 1-oxide-induced tongue carcinogenesis in rats.
Topics: 4-Nitroquinoline-1-oxide; Animals; Anticarcinogenic Agents; Carcinogens; Cyclin D1; Cyclooxygenase 2 | 2005 |
Chemoprevention of 4-NQO-induced oral carcinogenesis by co-administration of all-trans retinoic acid loaded microspheres and celecoxib.
Topics: 4-Nitroquinoline-1-oxide; Animals; Anticarcinogenic Agents; Carcinoma, Squamous Cell; Celecoxib; Cyc | 2005 |
A speed congenic rat strain bearing the tongue cancer susceptibility locus Tscc1 from Dark-Agouti rats.
Topics: 4-Nitroquinoline-1-oxide; Animals; Carcinogens; Carcinoma, Squamous Cell; Chromosomes; Female; Genet | 2006 |
An animal model for the rapid induction of tongue neoplasms in human c-Ha-ras proto-oncogene transgenic rats by 4-nitroquinoline 1-oxide: its potential use for preclinical chemoprevention studies.
Topics: 4-Nitroquinoline-1-oxide; Administration, Oral; Animals; Animals, Genetically Modified; beta Catenin | 2006 |
Abnormal expression of bcl-2 and bax in rat tongue mucosa during the development of squamous cell carcinoma induced by 4-nitroquinoline 1-oxide.
Topics: 4-Nitroquinoline-1-oxide; Animals; bcl-2-Associated X Protein; Biomarkers, Tumor; Carcinoma, Squamou | 2005 |
Selective loss of resistant alleles at p15INK4B and p16INK4A genes in chemically-induced rat tongue cancers.
Topics: 4-Nitroquinoline-1-oxide; Animals; Carcinogens; Cyclin-Dependent Kinase Inhibitor p15; DNA Methylati | 2006 |
Zinc deficiency potentiates induction and progression of lingual and esophageal tumors in p53-deficient mice.
Topics: 4-Nitroquinoline-1-oxide; Animals; Biomarkers, Tumor; Carcinogens; Cyclooxygenase 2; Disease Models, | 2006 |
Chemopreventive efficacy of all-trans-retinoic acid in biodegradable microspheres against epithelial cancers: results in a 4-nitroquinoline 1-oxide-induced oral carcinogenesis model.
Topics: 4-Nitroquinoline-1-oxide; Animals; Antineoplastic Agents; Carcinoma, Squamous Cell; Cell Transformat | 2006 |
p53 Transgenic mice are highly susceptible to 4-nitroquinoline-1-oxide-induced oral cancer.
Topics: 4-Nitroquinoline-1-oxide; Animals; Apoptosis; Carcinogens; Carcinoma, Squamous Cell; Cell Cycle; Dis | 2006 |
Modulatory efficacy of green tea polyphenols on glycoconjugates and immunological markers in 4-Nitroquinoline 1-oxide-induced oral carcinogenesis-A therapeutic approach.
Topics: 4-Nitroquinoline-1-oxide; Acid Phosphatase; Animals; Antineoplastic Agents, Phytogenic; beta-Galacto | 2006 |
A prostaglandin E2 receptor subtype EP1-selective antagonist, ONO-8711, suppresses 4-nitroquinoline 1-oxide-induced rat tongue carcinogenesis.
Topics: 4-Nitroquinoline-1-oxide; Animal Feed; Animals; Bridged Bicyclo Compounds; Caproates; Carcinogens; C | 2007 |
Frequent mutation of p16(CDKN2A) exon 1 during rat tongue carcinogenesis induced by 4-nitroquinoline-1-oxide.
Topics: 4-Nitroquinoline-1-oxide; Animals; Base Sequence; Carcinogens; Cell Transformation, Neoplastic; DNA; | 2007 |
Enhanced levels of glutathione and protein glutathiolation in rat tongue epithelium during 4-NQO-induced carcinogenesis.
Topics: 4-Nitroquinoline-1-oxide; Animals; Carcinogens; Carcinoma in Situ; Epithelium; Focal Epithelial Hype | 2007 |
Stromal myofibroblasts and malignant transformation in a 4NQO rat tongue carcinogenesis model.
Topics: 4-Nitroquinoline-1-oxide; Animals; Carcinogens; Carcinoma, Squamous Cell; Cell Transformation, Neopl | 2007 |
Possible enhancing activity of diacylglycerol on 4-nitroquinoline 1-oxide induced carcinogenesis of the tongue in human c-Ha-ras proto-oncogene transgenic rats.
Topics: 4-Nitroquinoline-1-oxide; Alanine Transaminase; Animals; Animals, Genetically Modified; Aspartate Am | 2007 |
Response of lymphocyte subsets and cytokines to Shenyang prescription in Sprague-Dawley rats with tongue squamous cell carcinomas induced by 4NQO.
Topics: 4-Nitroquinoline-1-oxide; Animals; Antineoplastic Agents; Carcinoma, Squamous Cell; Cell Count; Cyto | 2007 |
Expression of receptor for advanced glycation end products during rat tongue carcinogenesis by 4-nitroquinoline 1-oxide and effect of a selective cyclooxygenase-2 inhibitor, etodolac.
Topics: 4-Nitroquinoline-1-oxide; Animals; Anticarcinogenic Agents; Cell Transformation, Neoplastic; Cycloox | 2006 |
Survivin and inducible nitric oxide synthase production during 4NQO-induced rat tongue carcinogenesis: a possible relationship.
Topics: 4-Nitroquinoline-1-oxide; Animals; Cell Transformation, Neoplastic; Immunohistochemistry; Male; Micr | 2007 |
Placental glutathione S-transferase correlates with cellular proliferation during rat tongue carcinogenesis induced by 4-nitroquinoline 1-oxide.
Topics: 4-Nitroquinoline-1-oxide; Animals; Carcinogens; Carcinoma, Squamous Cell; Cell Proliferation; Fluore | 2007 |
Effects of 1,4-phenylenebis(methylene)selenocyanate on mutagenesis and p53 protein expression in the tongue of lacI rats treated with 4-nitroquinoline-N-oxide.
Topics: 4-Nitroquinoline-1-oxide; Animals; Animals, Genetically Modified; Anticarcinogenic Agents; Carcinoge | 2007 |
Effects of sex hormones on rat tongue carcinoma induced by 4-nitroquinoline 1-oxide (4NQO).
Topics: 4-Nitroquinoline-1-oxide; Animals; Carcinogens; Carcinoma, Squamous Cell; Estrogens; Female; Male; O | 2007 |
Sympathectomy decreases size and invasiveness of tongue cancer in rats.
Topics: 4-Nitroquinoline-1-oxide; Animals; Body Weight; Carcinogens; Cell Proliferation; Extracellular Fluid | 2007 |
A novel rasH2 mouse carcinogenesis model that is highly susceptible to 4-NQO-induced tongue and esophageal carcinogenesis is useful for preclinical chemoprevention studies.
Topics: 4-Nitroquinoline-1-oxide; Animals; Anticarcinogenic Agents; Cell Proliferation; Dinoprostone; Esopha | 2008 |
High interstitial fluid pressure in rat tongue cancer is related to increased lymph vessel area, tumor size, invasiveness and decreased body weight.
Topics: 4-Nitroquinoline-1-oxide; Analysis of Variance; Animals; Body Weight; Carcinoma, Squamous Cell; Extr | 2008 |
Collagenase-2 (matrix metalloproteinase-8) plays a protective role in tongue cancer.
Topics: 4-Nitroquinoline-1-oxide; Adult; Aged; Aged, 80 and over; Animals; Biomarkers, Tumor; Blotting, West | 2008 |
The effect of iron deficiency on experimental oral carcinogenesis in the rat.
Topics: 4-Nitroquinoline-1-oxide; Anemia, Hypochromic; Animals; Body Weight; Carcinoma, Squamous Cell; Diet; | 1983 |
[Microangioarchitecture of 4-nitroquinoline 1-oxide (4NQO)-induced tongue carcinoma in rats].
Topics: 4-Nitroquinoline-1-oxide; Animals; Autoradiography; Carcinoma; Carcinoma in Situ; Male; Microcircula | 1983 |
Experimental induction of oral squamous cell carcinomas in mice with 4-nitroquinolone-1-oxide.
Topics: 4-Nitroquinoline-1-oxide; Animals; Carcinoma, Squamous Cell; Male; Mice; Mice, Inbred CBA; Mouth Muc | 1984 |
Verrucous hyperplasia and verrucous carcinoma of the rat oral mucosa. Experimental oral carcinogenesis using 4-nitroquinoline 1-oxide.
Topics: 4-Nitroquinoline-1-oxide; Animals; Carcinoma, Papillary; Carcinoma, Squamous Cell; Female; Gingival | 1984 |
Nucleolar organizer regions in tongue carcinomas induced in rats: comparison with DNA cytofluorometric analysis.
Topics: 4-Nitroquinoline-1-oxide; Aneuploidy; Animals; Bromodeoxyuridine; Carcinoma, Squamous Cell; Diploidy | 1994 |
Proteoglycan changes in carcinogen (4NQO)-treated rat tongue mucosa.
Topics: 4-Nitroquinoline-1-oxide; Administration, Topical; Animals; Body Water; Carcinoma; Connective Tissue | 1995 |
Distribution of basal lamina type IV collagen and laminin in normal rat tongue mucosa and experimental oral carcinoma: ultrastructural immunolocalization and immunogold quantitation.
Topics: 4-Nitroquinoline-1-oxide; Animals; Basement Membrane; Carcinoma, Squamous Cell; Collagen; Female; La | 1994 |
Chemoprevention of 4-nitroquinoline 1-oxide-induced oral carcinogenesis by dietary curcumin and hesperidin: comparison with the protective effect of beta-carotene.
Topics: 4-Hydroxyaminoquinoline-1-oxide; 4-Nitroquinoline-1-oxide; Animals; beta Carotene; Carcinoma, Squamo | 1994 |
Assessment of bromodeoxyuridine-labeled S-phase cells in experimentally induced precancerous lesions in the rat's tongue.
Topics: 4-Nitroquinoline-1-oxide; Animals; Bromodeoxyuridine; Carcinoma in Situ; Carcinoma, Squamous Cell; C | 1994 |
Chemoprevention of 4-nitroquinoline 1-oxide-induced oral carcinogenesis by dietary protocatechuic acid during initiation and postinitiation phases.
Topics: 4-Nitroquinoline-1-oxide; Animals; Body Weight; Carcinoma, Squamous Cell; Hydroxybenzoates; Male; Nu | 1994 |
Chemoprevention of tongue carcinogenesis in rats.
Topics: 4-Nitroquinoline-1-oxide; Animals; Anticarcinogenic Agents; Butylated Hydroxytoluene; Carcinoma, Squ | 1993 |
Inhibition of 4-nitroquinoline-1-oxide-induced rat tongue carcinogenesis by the naturally occurring plant phenolics caffeic, ellagic, chlorogenic and ferulic acids.
Topics: 4-Nitroquinoline-1-oxide; Animals; Anticarcinogenic Agents; Antioxidants; Caffeic Acids; Chlorogenic | 1993 |
Laminin and type IV collagen in experimental rat oral carcinomas.
Topics: 4-Nitroquinoline-1-oxide; Animals; Basement Membrane; Carcinoma, Squamous Cell; Collagen; Female; La | 1993 |
Ultrastructural features of normal epithelium and 4-nitroquinoline 1-oxide-induced carcinomas of the rat tongue.
Topics: 4-Nitroquinoline-1-oxide; Animals; Carcinoma, Squamous Cell; Cytoplasmic Granules; Epithelium; Femal | 1993 |
Estimation of proliferative activity of experimental tongue carcinoma in rats. Immunohistochemical and DNA cytofluorometric analysis.
Topics: 4-Nitroquinoline-1-oxide; Animals; Bromodeoxyuridine; Carcinoma, Squamous Cell; Cell Cycle; Cell Div | 1993 |
Chemoprevention of oral carcinogenesis by DL-alpha-difluoromethylornithine, an ornithine decarboxylase inhibitor: dose-dependent reduction in 4-nitroquinoline 1-oxide-induced tongue neoplasms in rats.
Topics: 4-Nitroquinoline-1-oxide; Animals; Carcinoma; Dose-Response Relationship, Drug; Drug Screening Assay | 1993 |
Infrequent Ha-ras mutations and absence of Ki-ras, N-ras, and p53 mutations in 4-nitroquinoline 1-oxide-induced rat oral lesions.
Topics: 4-Nitroquinoline-1-oxide; Animals; Base Sequence; Carcinoma, Squamous Cell; Exons; Gene Deletion; Ge | 1995 |
Chemopreventive effect of a xanthine oxidase inhibitor, 1'-acetoxychavicol acetate, on rat oral carcinogenesis.
Topics: 4-Nitroquinoline-1-oxide; Animals; Anticarcinogenic Agents; Benzyl Alcohols; Biogenic Polyamines; Br | 1996 |
Chemoprevention of 4-nitroquinoline 1-oxide-induced oral carcinogenesis in rats by flavonoids diosmin and hesperidin, each alone and in combination.
Topics: 4-Nitroquinoline-1-oxide; Animals; Anticarcinogenic Agents; Body Weight; Carcinogens; Carcinoma, Squ | 1997 |
Genetic controls of susceptibility and resistance to 4-nitroquinoline 1-oxide-induced tongue carcinomas in rats.
Topics: 4-Nitroquinoline-1-oxide; Animals; Carcinogens; Cocarcinogenesis; Disease Susceptibility; Drug Resis | 1996 |
Experimental tongue cancer in desalivated rats.
Topics: 4-Nitroquinoline-1-oxide; Animals; Body Weight; Carcinogens; Carcinoma, Squamous Cell; Male; Rats; R | 1997 |
Glutathione S-transferase pi-class as a tumour marker in lingual preneoplastic and neoplastic lesions of rats and humans.
Topics: 4-Nitroquinoline-1-oxide; Animals; Biomarkers, Tumor; Carcinogens; Carcinoma in Situ; Carcinoma, Squ | 1997 |
1,4-phenylenebis(methylene)selenocyanate exerts exceptional chemopreventive activity in rat tongue carcinogenesis.
Topics: 4-Nitroquinoline-1-oxide; Animals; Anticarcinogenic Agents; Biomarkers; Carcinogens; Carcinoma, Squa | 1997 |
p53 expression in various stages of 4-nitroquinoline 1-oxide induced carcinoma in the rat tongue.
Topics: 4-Nitroquinoline-1-oxide; Animals; Carcinogens; Carcinoma, Squamous Cell; Immunohistochemistry; Male | 1996 |
Chemoprevention of 4-nitroquinoline 1-oxide-induced oral carcinogenesis by citrus auraptene in rats.
Topics: 4-Nitroquinoline-1-oxide; Animals; Anticarcinogenic Agents; Bromodeoxyuridine; Carcinogens; Coumarin | 1998 |
Quantitative trait loci affecting 4-nitroquinoline 1-oxide-induced tongue carcinogenesis in the rat.
Topics: 4-Nitroquinoline-1-oxide; Animals; Carcinoma, Squamous Cell; Disease Susceptibility; Genetic Linkage | 1998 |
Effect of photodynamic therapy using 5-aminolevulinic acid on 4-nitroquinoline-1-oxide-induced premalignant and malignant lesions of mouse tongue.
Topics: 4-Nitroquinoline-1-oxide; Aminolevulinic Acid; Animals; Carcinogens; Fluorescent Antibody Technique; | 1999 |
Changes in Bcl-2 and Bax expression in rat tongue during 4-nitroquinoline 1-oxide-induced carcinogenesis.
Topics: 4-Nitroquinoline-1-oxide; Animals; Apoptosis; bcl-2-Associated X Protein; Carcinogens; Carcinoma; Ce | 1999 |
Oral cancer: role of the basement membrane in invasion.
Topics: 4-Nitroquinoline-1-oxide; Animals; Basement Membrane; Carcinogens; Carcinoma; Cell Movement; Collage | 1999 |
Promotional effects of CO(2) laser and scalpel incision on 4-NQO-induced premalignant lesions of mouse tongue.
Topics: 4-Nitroquinoline-1-oxide; Animals; Biomarkers, Tumor; Carcinogens; ErbB Receptors; Immunohistochemis | 1999 |
Chemopreventive effect of dietary flavonoid morin on chemically induced rat tongue carcinogenesis.
Topics: 4-Nitroquinoline-1-oxide; Animals; Anticarcinogenic Agents; Biogenic Polyamines; Diet; Flavonoids; G | 1999 |
Chemopreventive effect of bovine lactoferrin on 4-nitroquinoline 1-oxide-induced tongue carcinogenesis in male F344 rats.
Topics: 4-Nitroquinoline-1-oxide; Animals; Body Weight; Carcinogens; Cattle; Epithelium; Glutathione Transfe | 2000 |
Altered placental glutathione S-transferase foci as a tumor marker during rat lingual carcinogenesis.
Topics: 4-Nitroquinoline-1-oxide; Animals; Biomarkers, Tumor; Carcinoma, Squamous Cell; Glutathione Transfer | 1999 |
Isolation of differentiated squamous and undifferentiated spindle carcinoma cell lines with differing metastatic potential from a 4-nitroquinoline N-Oxide-induced tongue carcinoma in a F344 rat.
Topics: 4-Nitroquinoline-1-oxide; Animals; Carcinogens; Carcinoma; Carcinoma, Squamous Cell; Clone Cells; Ka | 2000 |
The effect of desalivation on 4-nitroquinoline-1-oxide-induced tongue carcinogenesis: a morphometric study of nucleolar organizer regions.
Topics: 4-Nitroquinoline-1-oxide; Analysis of Variance; Animals; Carcinogens; Cell Transformation, Neoplasti | 2001 |
Increased expression of cyclooxygenase-2 protein in 4-nitroquinoline-1-oxide-induced rat tongue carcinomas and chemopreventive efficacy of a specific inhibitor, nimesulide.
Topics: 4-Nitroquinoline-1-oxide; Animals; Blotting, Western; Carcinogens; Carcinoma, Squamous Cell; Cycloox | 2001 |
Xeroderma pigmentosum group A gene action as a protection factor against 4-nitroquinoline 1-oxide-induced tongue carcinogenesis.
Topics: 4-Nitroquinoline-1-oxide; Animals; Anticarcinogenic Agents; Carcinogens; Carcinoma, Squamous Cell; C | 2001 |
Five quantitative trait loci affecting 4-nitroquinoline 1-oxide-induced tongue cancer in the rat.
Topics: 4-Nitroquinoline-1-oxide; Alleles; Animals; Carcinogens; Chromosome Mapping; Female; Genetic Predisp | 2001 |
Prevention of 4-nitroquinoline 1-oxide-induced rat tongue carcinogenesis by garlic.
Topics: 4-Nitroquinoline-1-oxide; Animals; Antineoplastic Agents; Carcinoma, Squamous Cell; Garlic; Glutathi | 2001 |
Alteration of pRb expression in the development of rat tongue carcinoma induced by 4-nitroquinoline 1-oxide.
Topics: 4-Nitroquinoline-1-oxide; Animals; Blotting, Western; Carcinogens; Carcinoma, Squamous Cell; Cyclin | 2001 |
[A rat model of tongue mucosa squamous cell carcinoma induced by oral administration of 4NQO in drinking water].
Topics: 4-Nitroquinoline-1-oxide; Animals; Carcinogens; Carcinoma, Squamous Cell; Disease Models, Animal; Dr | 1999 |
[The expression of RAR beta mRNA in rat tongue carcinogenesis].
Topics: 4-Nitroquinoline-1-oxide; Animals; Carcinoma, Squamous Cell; Disease Models, Animal; Down-Regulation | 2000 |
[Expression of p53 protein during 4NQO-induced lingual carcinogenesis in two strains of rats].
Topics: 4-Nitroquinoline-1-oxide; Animals; Immunohistochemistry; Rats; Rats, Inbred Strains; Species Specifi | 2000 |
[Telomerase activity in rat tongue carcinogenesis].
Topics: 4-Nitroquinoline-1-oxide; Animals; Biomarkers, Tumor; Disease Models, Animal; Quinolones; Rats; Rats | 2000 |
Dietary silymarin suppresses 4-nitroquinoline 1-oxide-induced tongue carcinogenesis in male F344 rats.
Topics: 4-Nitroquinoline-1-oxide; Animals; Anticarcinogenic Agents; Apoptosis; Carcinogens; Diet; Dinoprosto | 2002 |
Inhibitory effects of the natural products indole-3-carbinol and sinigrin during initiation and promotion phases of 4-nitroquinoline 1-oxide-induced rat tongue carcinogenesis.
Topics: 4-Nitroquinoline-1-oxide; Animals; Anticarcinogenic Agents; Antioxidants; Body Weight; Carcinoma, Sq | 1992 |
Strain difference of susceptibility to 4-nitroquinoline 1-oxide-induced tongue carcinoma in rats.
Topics: 4-Nitroquinoline-1-oxide; Animals; Carcinogenicity Tests; Esophageal Neoplasms; Female; Male; Mouth | 1992 |
Candida albicans as a promoter of oral mucosal neoplasia.
Topics: 4-Nitroquinoline-1-oxide; Animals; Candida albicans; Carcinogens; Carcinoma, Squamous Cell; Male; Pa | 1992 |
Alterations of the nucleolar organizer regions during 4-nitroquinoline 1-oxide-induced tongue carcinogenesis in rats.
Topics: 4-Nitroquinoline-1-oxide; Animals; Carcinoma, Squamous Cell; Cell Division; Epithelial Cells; Hyperp | 1991 |
A relationship found between intra-oral sites of 4NQO reductase activity and chemical carcinogenesis.
Topics: 4-Nitroquinoline-1-oxide; Animals; Carcinoma, Squamous Cell; Cheek; Dihydrolipoamide Dehydrogenase; | 1990 |
[Experimental study on the effects of peplomycin on tongue carcinoma induced by 4-nitroquinoline 1-oxide (4 NQO) in rats. Part 2. Effects of peplomycin on tongue-epithelium lesions induced by 4NQO in rats].
Topics: 4-Nitroquinoline-1-oxide; Animals; Bleomycin; Carcinoma; Peplomycin; Rats; Rats, Inbred Strains; Ton | 1988 |
[Experimental study on the effects of peplomycin on tongue carcinoma induced by 4-nitroquinoline 1-oxide (4NQO) in rats. Part 1. Effects of peplomycin on the tongue epithelium of normal rats].
Topics: 4-Nitroquinoline-1-oxide; Animals; Bleomycin; Epithelium; Peplomycin; Rats; Rats, Inbred Strains; To | 1988 |
Snuff-induced carcinogenesis: effect of snuff in rats initiated with 4-nitroquinoline N-oxide.
Topics: 4-Nitroquinoline-1-oxide; Animals; Body Weight; Carcinoma, Squamous Cell; Esophageal Neoplasms; Lip | 1989 |
Inhibitory effects of non-steroidal anti-inflammatory drugs, piroxicam and indomethacin on 4-nitroquinoline 1-oxide-induced tongue carcinogenesis in male ACI/N rats.
Topics: 4-Nitroquinoline-1-oxide; Animals; Indomethacin; Male; Nitroquinolines; Ornithine Decarboxylase Inhi | 1989 |
[Cell proliferation in the carcinogenetic processes of tongue carcinoma induced by 4-nitroquinoline-1-oxide in rats. 1. Relation between morphology and microvascular architecture of the filiform papillae of dorsal surface of the tongue in normal albino ra
Topics: 4-Nitroquinoline-1-oxide; Animals; Arterioles; Carcinoma; Cell Division; Cell Transformation, Neopla | 1986 |
Carcinogenicity of betel quid. III. Enhancement of 4-nitroquinoline-1-oxide- and N-2-fluorenylacetamide-induced carcinogenesis in rats by subsequent administration of betel nut.
Topics: 2-Acetylaminofluorene; 4-Nitroquinoline-1-oxide; Animals; Areca; Chromosome Aberrations; Cocarcinoge | 1986 |
[Cell proliferation in the carcinogenic process of tongue carcinoma in rats induced by 4-nitroquinoline-1-oxide. 2. Relation between morphology, microvascular architecture and cell proliferation in keratinized lesions and squamous cell carcinoma].
Topics: 4-Nitroquinoline-1-oxide; Animals; Carcinoma, Squamous Cell; Cell Division; Leukoplakia, Oral; Male; | 1986 |
[The developmental process of tongue carcinoma induced by 4-nitroquinoline 1-oxide (4NQO)in rats].
Topics: 4-Nitroquinoline-1-oxide; Animals; Carcinoma; Male; Rats; Tongue Neoplasms | 1987 |
[Induction of tongue carcinoma in the rats by oral administration of 4-nitroquinoline 1-oxide (4NQO) solution. The incidence and morphological characteristics].
Topics: 4-Nitroquinoline-1-oxide; Animals; Carcinoma; Male; Rats; Rats, Inbred Strains; Tongue Neoplasms | 1987 |
Experimental tongue carcinoma of rats induced by oral administration of 4-nitroquinoline 1-oxide (4NQO) in drinking water.
Topics: 4-Nitroquinoline-1-oxide; Administration, Oral; Animals; Carcinoma; Carcinoma in Situ; Male; Neoplas | 1985 |
[Histological and vascular changes in rat tongue and tongue carcinoma after cryosurgery].
Topics: 4-Nitroquinoline-1-oxide; Animals; Carcinoma; Cryosurgery; Male; Necrosis; Rats; Rats, Inbred Strain | 1985 |
Experimental induction of preneoplastic and neoplastic changes in the lingual mucosa of rats.
Topics: 4-Nitroquinoline-1-oxide; Animals; Carcinoma, Squamous Cell; Epithelium; Male; Mouth Mucosa; Precanc | 1985 |