4-nitroquinoline-1-oxide has been researched along with Cancer of Mouth in 167 studies
4-nitroquinoline N-oxide : A quinoline N-oxide carrying a nitro substituent at position 4.
| Excerpt | Relevance | Reference |
|---|---|---|
| " In this study we aimed to examine whether a chemical activator of NRF2, sulforaphane (SFN), may have chemopreventive effects on oxidative stress-associated oral carcinogenesis." | 7.83 | Chemoprevention of oxidative stress-associated oral carcinogenesis by sulforaphane depends on NRF2 and the isothiocyanate moiety. ( Chen, H; Chen, X; Chen, XL; Kapita, M; Lan, A; Li, W; Liu, Y; Palko, O; Prigge, JR; Schmidt, EE; Sun, Z; Xiong, Z; Zhang, X; Zhou, S, 2016) |
| "We combined the 4-nitroquinoline-1-oxide (4-NQO) oral carcinogenesis and Meadows-Cook alcohol mouse models to elucidate the molecular events and to identify the novel biomarkers associated with oral cancer development." | 7.81 | Identification of Ethanol and 4-Nitroquinoline-1-Oxide Induced Epigenetic and Oxidative Stress Markers During Oral Cavity Carcinogenesis. ( Gudas, LJ; Osei-Sarfo, K; Scognamiglio, T; Tang, XH; Urvalek, AM; Zhang, T, 2015) |
| "We investigated the effects of bexarotene (a retinoid X receptor agonist), CD1530 (a retinoic acid receptor γ selective agonist), and the combination of these two drugs for the prevention of oral carcinogenesis induced by the carcinogen 4-nitroquinoline 1-oxide (4-NQO) in a mouse model of human oral-cavity and esophageal squamous-cell carcinoma previously generated in our laboratory." | 7.80 | Combination of bexarotene and the retinoid CD1530 reduces murine oral-cavity carcinogenesis induced by the carcinogen 4-nitroquinoline 1-oxide. ( Gudas, LJ; Osei-Sarfo, K; Scognamiglio, T; Tang, XH; Urvalek, AM; Zhang, T, 2014) |
| "The aim of this study was to evaluate the chemopreventive activity of an apple extract following medium-term oral carcinogenesis assay induced by 4-nitroquinoline-1-oxide (4NQO)." | 7.80 | Chemopreventive activity of apple extract following medium-term oral carcinogenesis assay induced by 4-nitroquinoline-1-oxide. ( Aguiar, O; Barbisan, LF; Catharino, RR; de Moura, CF; Ferreira, MS; Gollucke, AP; Ribeiro, DA; Ribeiro, FA; Spadari, RC, 2014) |
| "The objective of the present investigation was to study the effect of combination of telmisartan with cisplatin in oral cancer cachexia induced by applying 0." | 7.79 | Combination of telmisartan with cisplatin controls oral cancer cachexia in rats. ( Damle, D; Patel, BM, 2013) |
| " The lipid changes were induced either through essential fatty acid (EFA) deficiency or through carbon tetrachloride-induced liver cirrhosis." | 7.65 | Effects of essential fatty acid deficiency and of carbon tetrachloride-induced liver cirrhosis on oral carcinogenesis in the rat. ( Lekholm, U; Wallenius, K, 1976) |
| "The multistep process of oral carcinogenesis provides a biological rationale for the use of chemoprevention in individuals at increased risk of developing oral cancer." | 5.62 | Can propranolol act as a chemopreventive agent during oral carcinogenesis? An experimental animal study. ( Carrard, VC; Castilho, RM; Gaio, EJ; Nör, F; Rösing, CK; Spuldaro, TR; Wagner, VP, 2021) |
| "Lymph node metastasis is one of the most important prognostic factors in oral squamous cell carcinoma." | 5.39 | Development of a 4-nitroquinoline-1-oxide model of lymph node metastasis in oral squamous cell carcinoma. ( Li, J; Liang, F; Qing, H; Yang, Y; Yu, D, 2013) |
| " To address this gap in knowledge, we conducted preclinical trials using the 4-nitroquinoline-1-oxide 4NQO carcinogen model of oral carcinogenesis." | 3.96 | Impact of dietary vitamin D on initiation and progression of oral cancer. ( DeJong, H; Hershberger, PA; Seshadri, M; Verma, A; Vincent-Chong, VK, 2020) |
| " One week after starting propranolol treatment, all rats were submitted to chemical induction of oral carcinogenesis with 4-nitroquinoline-1-oxide (4NQO)." | 3.96 | Beta-adrenergic blocker inhibits oral carcinogenesis and reduces tumor invasion. ( Bernabé, DG; Biasoli, ÉR; Cecilio, HP; Furuse, C; Kayahara, GM; Miyahara, GI; Oliveira, SHP; Pereira, KM; Valente, VB, 2020) |
| " In this study we aimed to examine whether a chemical activator of NRF2, sulforaphane (SFN), may have chemopreventive effects on oxidative stress-associated oral carcinogenesis." | 3.83 | Chemoprevention of oxidative stress-associated oral carcinogenesis by sulforaphane depends on NRF2 and the isothiocyanate moiety. ( Chen, H; Chen, X; Chen, XL; Kapita, M; Lan, A; Li, W; Liu, Y; Palko, O; Prigge, JR; Schmidt, EE; Sun, Z; Xiong, Z; Zhang, X; Zhou, S, 2016) |
| "We combined the 4-nitroquinoline-1-oxide (4-NQO) oral carcinogenesis and Meadows-Cook alcohol mouse models to elucidate the molecular events and to identify the novel biomarkers associated with oral cancer development." | 3.81 | Identification of Ethanol and 4-Nitroquinoline-1-Oxide Induced Epigenetic and Oxidative Stress Markers During Oral Cavity Carcinogenesis. ( Gudas, LJ; Osei-Sarfo, K; Scognamiglio, T; Tang, XH; Urvalek, AM; Zhang, T, 2015) |
| "We investigated the effects of bexarotene (a retinoid X receptor agonist), CD1530 (a retinoic acid receptor γ selective agonist), and the combination of these two drugs for the prevention of oral carcinogenesis induced by the carcinogen 4-nitroquinoline 1-oxide (4-NQO) in a mouse model of human oral-cavity and esophageal squamous-cell carcinoma previously generated in our laboratory." | 3.80 | Combination of bexarotene and the retinoid CD1530 reduces murine oral-cavity carcinogenesis induced by the carcinogen 4-nitroquinoline 1-oxide. ( Gudas, LJ; Osei-Sarfo, K; Scognamiglio, T; Tang, XH; Urvalek, AM; Zhang, T, 2014) |
| "The aim of this study was to evaluate the chemopreventive activity of an apple extract following medium-term oral carcinogenesis assay induced by 4-nitroquinoline-1-oxide (4NQO)." | 3.80 | Chemopreventive activity of apple extract following medium-term oral carcinogenesis assay induced by 4-nitroquinoline-1-oxide. ( Aguiar, O; Barbisan, LF; Catharino, RR; de Moura, CF; Ferreira, MS; Gollucke, AP; Ribeiro, DA; Ribeiro, FA; Spadari, RC, 2014) |
| "The objective of the present investigation was to study the effect of combination of telmisartan with cisplatin in oral cancer cachexia induced by applying 0." | 3.79 | Combination of telmisartan with cisplatin controls oral cancer cachexia in rats. ( Damle, D; Patel, BM, 2013) |
| "4-nitroquinoline-1-oxide(4NQO) was used to induce oral carcinogenesis in the mucosa of SD rats and immunohistoche-mical technique was used to study the expression of CK19 and Cx43 in various stages of oral carcinogenesis." | 3.79 | [Expression of cytokeratin 19 and connexin 43 in 4-nitroquinoline-l-oxide-induced rat tongue carcinogenesis]. ( Feng, Y; Kang, X; Li, C; Nie, M, 2013) |
| " The lipid changes were induced either through essential fatty acid (EFA) deficiency or through carbon tetrachloride-induced liver cirrhosis." | 3.65 | Effects of essential fatty acid deficiency and of carbon tetrachloride-induced liver cirrhosis on oral carcinogenesis in the rat. ( Lekholm, U; Wallenius, K, 1976) |
| "In the 4-NQO model, squamous cell carcinoma, dysplasia, and hyperkeratosis were observed in 75." | 2.87 | Met Receptor Tyrosine Kinase and Chemoprevention of Oral Cancer. ( El-Naggar, AK; Fan, YH; Feng, L; Foy, JP; Hong, WK; Kim, ES; Lang, W; Lee, JJ; Lingen, MW; Lippman, SM; Mao, L; Papadimitrakopoulou, V; Saintigny, P; William, WN; Zhang, L, 2018) |
| "In summary, the 4-NQO-induced murine oral cancer model is relevant for investigating human oral carcinogenesis, including the immune microenvironment, and for evaluating therapeutic and chemoprevention agents." | 2.72 | The 4-NQO mouse model: An update on a well-established in vivo model of oral carcinogenesis. ( Bertolus, C; Bouaoud, J; Darido, C; De Souza, G; Elkabets, M; Saintigny, P; Tortereau, A, 2021) |
| "Human oral cancer is the sixth largest group of malignancies worldwide and single largest group of malignancies in the Indian subcontinent." | 2.43 | 4-nitroquinoline-1-oxide induced experimental oral carcinogenesis. ( Kanojia, D; Vaidya, MM, 2006) |
| "Knockdown of HSD11B2 in oral cancer cells promotes cellular proliferation, invasion and expression of angiogenic biomarkers EGFR and VEGFA." | 1.72 | Modulation of the oral glucocorticoid system during black raspberry mediated oral cancer chemoprevention. ( Anderson, K; Iwenofu, H; Jordanides, PP; Lamenza, FF; Nedungadi, D; Oghumu, S; Rakotondraibe, L; Riedl, KM; Ryan, N; Swingler, MJ, 2022) |
| "Periodontitis was stimulated by placing a ligature subgingivally, while oral carcinogenesis was induced by systemic administration of 4NQO in the drinking water for 20 weeks." | 1.72 | Periodontal disease affects oral cancer progression in a surrogate animal model for tobacco exposure. ( Carrard, VC; Castilho, RM; Gaio, EJ; Nör, F; Rösing, CK; Spuldaro, TR; Squarize, CH; Wagner, VP, 2022) |
| "Oral cancer was induced on the tongue by nitroquinoline oxide (4-NQO), diluted in the water for 16 weeks." | 1.72 | Laser photobiomodulation does not alter clinical and histological characteristics of 4-NQO-induced oral carcinomas and leukoplakia in mice. ( Cherubini, K; Estrázulas, M; Koth, VS; Neculqueo, GW; Salum, FG, 2022) |
| "The multistep process of oral carcinogenesis provides a biological rationale for the use of chemoprevention in individuals at increased risk of developing oral cancer." | 1.62 | Can propranolol act as a chemopreventive agent during oral carcinogenesis? An experimental animal study. ( Carrard, VC; Castilho, RM; Gaio, EJ; Nör, F; Rösing, CK; Spuldaro, TR; Wagner, VP, 2021) |
| "Two histologic subtypes of squamous cell carcinomas (SCCs) were identified-SCCs with exophytic and invasive components associated with papillary lesions (pSCCs) and invasive SCCs without exophytic histology (iSCCs)." | 1.62 | The Histopathology of Oral Cancer Pain in a Mouse Model and a Human Cohort. ( Albertson, DG; Bandary, D; Bhattacharya, A; Brar, B; Chen, J; Dolan, JC; Janal, MN; Naik, K; Schmidt, BL; Zhang, S, 2021) |
| "Tacrolimus (TAC, FK506) is a major calcineurin inhibitor and has been commonly used in treatments of patients with organ transplants and immune diseases." | 1.62 | Tacrolimus inhibits oral carcinogenesis through cell cycle control. ( Chen, W; Cheng, B; Hu, Q; Li, J; Li, Y; Ling, Z; Wang, Y; Wu, T; Xia, J; Zhang, L, 2021) |
| "Oral squamous cell carcinoma (OSCC) is the most common subsite of head and neck cancer, with a 5-year survival rate of only 50%." | 1.62 | 4NQO induced carcinogenesis: A mouse model for oral squamous cell carcinoma. ( Curry, JM; Han, JYS; Martinez-Outschoorn, U; Philp, NJ; Sagheer, SH; Whitaker-Menezes, D, 2021) |
| "Oral carcinogenesis involves the progression of the normal mucosa into potentially malignant disorders and finally into cancer." | 1.56 | Single-Cell Analysis of Different Stages of Oral Cancer Carcinogenesis in a Mouse Model. ( Chiang, WF; Hsieh, YP; Huang, LY; Huang, TT; Huang, WT; Hwang, DY; Jiang, SS; Liu, KJ; Wang, YY, 2020) |
| "Oral squamous cell carcinomas (OSCCs) are the most common cancers of the oral cavity, but the molecular mechanisms driving OSCC carcinogenesis remain unclear." | 1.56 | Mutations in long-lived epithelial stem cells and their clonal progeny in pre-malignant lesions and in oral squamous cell carcinoma. ( Gudas, LJ; Melis, M; Scognamiglio, T; Zhang, T, 2020) |
| "Advanced oral squamous cell carcinomas (OSCC) have limited therapeutic options." | 1.51 | Impact of combination immunochemotherapies on progression of 4NQO-induced murine oral squamous cell carcinoma. ( Chelvanambi, M; Fabian, KPL; Hong, CS; Lang, S; Ludwig, S; Razzo, BM; Storkus, WJ; Whiteside, TL, 2019) |
| "The incidence of extraoral neoplasms was significantly lower (16%) in the younger cohort." | 1.48 | Impact of Age on Disease Progression and Microenvironment in Oral Cancer. ( DeJong, H; Hershberger, PA; Merzianu, M; Patti, A; Rich, LJ; Seshadri, M; Vincent-Chong, VK, 2018) |
| "The majority of cases of oral squamous cell carcinoma (OSCC) develop from oral potentially malignant disorders, which have been confirmed to be involved in chronic oxidative stimulation." | 1.48 | Proteomics-based investigation of multiple stages of OSCC development indicates that the inhibition of Trx-1 delays oral malignant transformation. ( Chen, X; Cheng, B; Hu, Q; Wang, C; Wu, T; Xia, J; Yang, L, 2018) |
| "All mice were exposed to a low dose of oral cancer carcinogen 4-nitroquinoline 1-oxide and rates of oral squamous cell carcinoma (OSCC) and proliferation and differentiation in the cancerous and non-cancerous oral epithelium of these mice were examined." | 1.46 | p120-Catenin Is Required for Dietary Calcium Suppression of Oral Carcinogenesis in Mice. ( Bikle, DD; Chen, Y; Deng, X; Ji, S; Jiang, Y; Liao, E; Liao, L; Shrestha, C; Xie, Z; Yuan, Y, 2017) |
| "Patients with oral cancer report severe pain during function." | 1.46 | Tumor necrosis factor alpha secreted from oral squamous cell carcinoma contributes to cancer pain and associated inflammation. ( Bhattacharya, A; Dolan, JC; Hickman, DN; MacRae, J; Scheff, NN; Schmidt, BL; Sharma, AK; Ye, Y, 2017) |
| "The TGS was able to discriminate oral squamous cell carcinoma (OSCC) from normal oral mucosa in 3 independent datasets." | 1.43 | The dynamics of gene expression changes in a mouse model of oral tumorigenesis may help refine prevention and treatment strategies in patients with oral cancer. ( Bertolus, C; Caulin, C; Chabaud, S; Foy, JP; Goudot, P; Hong, WK; Lachuer, J; Lang, W; Lavergne, E; Le Texier, V; Lippman, SM; Perol, D; Saintigny, P; Thomas, E; Tortereau, A, 2016) |
| "Head and neck squamous cell carcinoma (HNSCC) is a frequently fatal disease due, in large part, to a high rate of second primary tumor (SPT) formation." | 1.43 | STAT3 as a Chemoprevention Target in Carcinogen-Induced Head and Neck Squamous Cell Carcinoma. ( Acquafondata, M; Freilino, M; Gooding, WE; Grandis, JR; Johnson, DE; Li, H; Peyser, ND; Satake, M; Sen, M; Wang, L; Wang, Z; Zeng, Y, 2016) |
| "Oral squamous cell carcinomas (OSCCs) induced in F344 rats by 4-nitroquinoline-1-oxide (4-NQO) demonstrate considerable phenotypic similarity to human oral cancers and the model has been widely used for carcinogenesis and chemoprevention studies." | 1.43 | Identification of reliable reference genes for quantitative gene expression studies in oral squamous cell carcinomas compared to adjacent normal tissues in the F344 rat model. ( McCormick, DL; Peng, X, 2016) |
| "Induction of oral carcinogenesis in transgenic mice using 4-nitroquinoline 1-oxide (4NQO) resulted in more extensive and severe tongue tumorigenesis compared with control animals." | 1.43 | MicroRNA-211 Enhances the Oncogenicity of Carcinogen-Induced Oral Carcinoma by Repressing TCF12 and Increasing Antioxidant Activity. ( Chang, KW; Chen, YF; Kao, SY; Lin, SC; Liu, CJ; Yang, CC, 2016) |
| "The incidence of buccal squamous cell carcinoma (buccal SCC) is considered to be the second highest out of all oral cancers, but the unsatisfactory in vivo tumorigenicity and metastatic potential of the widely used cell lines have greatly delayed studies on the mechanisms of tumor progression." | 1.43 | Establishment of a highly metastatic buccal squamous cell carcinoma cell line from a Sprague-Dawley Rat. ( Chen, W; Lv, Z; Qin, X; Xu, Q; Yan, M; Zhang, J, 2016) |
| "The typical progression of oral cancer is from hyperplastic epithelial lesions through dysplasia to invasive carcinoma." | 1.43 | Dynamic changes in the gene expression profile during rat oral carcinogenesis induced by 4-nitroquinoline 1-oxide. ( Du, Y; Ge, S; Hu, B; Lou, J; Zhang, J; Zhou, Z, 2016) |
| "Curcumin has therapeutic potential in preventing several types of cancer, including colon, liver, prostate, and breast." | 1.42 | Chemopreventive activity of systemically administered curcumin on oral cancer in the 4-nitroquinoline 1-oxide model. ( Curylofo, FA; Gonçalves, Vde P; Guimarães, MR; Ortega, AA; Ribeiro, DA; Rossa Junior, C; Spolidorio, LC, 2015) |
| "Oral squamous cell carcinomas (OSCC) were induced in male F344 rats by 4-nitroquinoline-1-oxide (NQO; 20 ppm in the drinking water for 10 weeks)." | 1.42 | Suppression of Rat Oral Carcinogenesis by Agonists of Peroxisome Proliferator Activated Receptor γ. ( Horn, TL; Johnson, WD; Lubet, RA; McCormick, DL; Peng, X; Steele, VE, 2015) |
| "Despite intensive investigation, oral squamous cell carcinomas (OSCC) represent a clinical challenge resulting in significant morbidity and mortality." | 1.42 | Mcl-1 is an important therapeutic target for oral squamous cell carcinomas. ( Das, SK; Dash, R; Fisher, PB; Maji, S; Panda, S; Pattanaik, L; Pellecchia, M; Quinn, BA; Samal, SK; Sarkar, D, 2015) |
| "Oral squamous cell carcinomas (OSCC) induced in F344 rats by 4-nitroquinoline-1-oxide (4-NQO) demonstrate considerable phenotypic similarity to human oral cancers." | 1.42 | Overexpression of lipocalins and pro-inflammatory chemokines and altered methylation of PTGS2 and APC2 in oral squamous cell carcinomas induced in rats by 4-nitroquinoline-1-oxide. ( Johnson, WD; Li, W; McCormick, DL; Peng, X; Torres, KE, 2015) |
| "Oral cancer is one of the most common and lethal cancers in the world." | 1.40 | Oral and IV dosages of doxorubicin-methotrexate loaded- nanoparticles inhibit progression of oral cancer by down- regulation of matrix Methaloproteinase 2 expression in vivo. ( Abbasi, MM; Hamishehkar, H; Jahanban-Esfahlan, R; Khiavi, MM; Monfaredan, A; Seidi, K, 2014) |
| "Regarding oral squamous cell carcinoma (OSCC) development, chewing areca is known to be a strong risk factor in many Asian cultures." | 1.40 | Methylation-associated gene silencing of RARB in areca carcinogens induced mouse oral squamous cell carcinoma. ( Chang, NW; Chen, CM; Chen, HL; Cheng, JC; Fan, SR; Lai, ZL; Tsai, MH; Tsou, YA, 2014) |
| "Oral squamous cell carcinoma (OSCC) remains as one of the most difficult malignancies to control because of its high propensity for local invasion and cervical lymph node dissemination." | 1.40 | Novel DOX-MTX nanoparticles improve oral SCC clinical outcome by down regulation of lymph dissemination factor VEGF-C expression in vivo: oral and IV modalities. ( Abbasi, MM; Hamishehkar, H; Jahanban- Esfahlan, R; Monfaredan, A; Seidi, K, 2014) |
| "Lymph node metastasis is one of the most important prognostic factors in oral squamous cell carcinoma." | 1.39 | Development of a 4-nitroquinoline-1-oxide model of lymph node metastasis in oral squamous cell carcinoma. ( Li, J; Liang, F; Qing, H; Yang, Y; Yu, D, 2013) |
| "4-nitroquioline 1-oxide (4NQO)-induced oral cancer model was introduced to study the anticancer activity of L." | 1.39 | Lactobacillus salivarius REN inhibits rat oral cancer induced by 4-nitroquioline 1-oxide. ( Fang, B; Guo, H; Jiang, J; Jiang, L; Lei, X; Li, J; Liu, R; Ren, F; Wang, F; Zhang, L; Zhang, M; Zhao, L, 2013) |
| "The cells of origin of oral cavity squamous cell carcinoma (OCSCC) are unknown." | 1.39 | Basal stem cells contribute to squamous cell carcinomas in the oral cavity. ( Gudas, LJ; Scognamiglio, T; Tang, XH, 2013) |
| "0." | 1.37 | Fenofibrate exhibits a high potential to suppress the formation of squamous cell carcinoma in an oral-specific 4-nitroquinoline 1-oxide/arecoline mouse model. ( Chang, NW; Chiu, CF; Chu, PY; Hsu, HT; Lin, C; Tsai, MH; Yeh, CM; Yeh, KT, 2011) |
| "Chemoprevention of head and neck squamous cell carcinoma (HNSCC), a disease associated with high mortality rates and frequent occurrence of second primary tumor (SPT), is an important clinical goal." | 1.37 | Inhibition of EGFR-STAT3 signaling with erlotinib prevents carcinogenesis in a chemically-induced mouse model of oral squamous cell carcinoma. ( Bednash, JS; Freilino, ML; Gooding, WE; Grandis, JR; Joyce, SC; Leeman-Neill, RJ; Lingen, MW; Neill, DB; Panahandeh, MC; Seethala, RR; Singh, SV; Thomas, SM, 2011) |
| "The incidence of squamous cell carcinoma (SCC) increased from 20% (8/41) to 43% (17/40; P < 0." | 1.37 | Ethanol promotes chemically induced oral cancer in mice through activation of the 5-lipoxygenase pathway of arachidonic acid metabolism. ( Chen, X; Guo, Y; Sun, Z; Wang, X; Zhang, X, 2011) |
| " We determined that 8 weeks of 100 microg/mL 4-NQO in the drinking water was the optimal dosage and duration to cause a sufficient incidence of hyperkeratoses, dysplasias, and HNSCC over a period of 32 weeks with minimal morbidity and mortality." | 1.35 | ABT-510 is an effective chemopreventive agent in the mouse 4-nitroquinoline 1-oxide model of oral carcinogenesis. ( Hasina, R; Jalil, A; Jones, CL; Kasza, K; Lingen, MW; Martin, LE, 2009) |
| "Oral cancer is one of the most common cancers in the world." | 1.35 | Chemopreventive and therapeutic modulation of green tea polyphenols on drug metabolizing enzymes in 4-Nitroquinoline 1-oxide induced oral cancer. ( Babu, PV; Devi, RS; Narayan, S; Sabitha, KE; Shyamala Devi, CS; Srinivasan, P; Suchalatha, S, 2008) |
| "To establish a monoclone cell line of squamous cell carcinoma (SCC) in rat buccal mucosa and to study its biological characteristics." | 1.34 | [Establishment and identification of biological characteristics of rat monoclone cell line Rca-B]. ( Chen, WT; Feng, YY; Jiang, CH; Li, NY; Ye, DX; Zhou, XJ, 2007) |
| "The results of this study indicate that NNN, when combined with subcarcinogenic doses of other strong carcinogens, is a promoter in the development of squamous cell carcinoma and that 4NQO in 0." | 1.29 | The cancer-promoting effect of N-nitrosonornicotine used in combination with a subcarcinogenic dose of 4-nitroquinoline-N-oxide and 7,12-dimethylbenz (A) anthracene. ( Altuwairgi, OS; Doku, HC; Papageorge, MB, 1995) |
| "Larger invasive squamous cell carcinomas consistently lost the wild-type allele, whereas preneoplastic lesions and small tumors were heterozygous for ras." | 1.29 | Harvey ras (H-ras) point mutations are induced by 4-nitroquinoline-1-oxide in murine oral squamous epithelia, while squamous cell carcinomas and loss of heterozygosity occur without additional exposure. ( Ackermann, DM; Hawkins, BL; Hendler, FJ; Heniford, BW; Yuan, B, 1994) |
| "Precancerous lesions and squamous cell carcinomas (SCCs) were induced in the oral mucosa of outbred male Sprague-Dawley rats by repeated application of the carcinogen 4-nitroquinoline-1-oxide." | 1.28 | Temporal alterations in cytokeratin expression during experimental oral mucosal carcinogenesis. ( Boyd, NM; Reade, PC, 1991) |
| "Oral epithelial atypia and squamous cell carcinoma were observed with increasing prevalence as the period of carcinogen exposure was increased." | 1.27 | Experimental induction of oral squamous cell carcinomas in mice with 4-nitroquinolone-1-oxide. ( Reade, PC; Steidler, NE, 1984) |
| "The incidence of animals developing squamous cell carcinomas was similar in both groups, but tumour development was significantly earlier in iron-deficient animals (mean 183 days) compared to controls (mean 229 days)." | 1.27 | The effect of iron deficiency on experimental oral carcinogenesis in the rat. ( MacDonald, DG; Prime, SS; Rennie, JS, 1983) |
| "The clinical development of oral cancer differed significantly among the three groups (P less than 0." | 1.26 | Effect of different levels of dietary zinc on development of chemically induced oral cancer in rats. ( Abdulla, M; Mathur, A; Wallenius, K, 1979) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 26 (15.57) | 18.7374 |
| 1990's | 29 (17.37) | 18.2507 |
| 2000's | 28 (16.77) | 29.6817 |
| 2010's | 64 (38.32) | 24.3611 |
| 2020's | 20 (11.98) | 2.80 |
| Authors | Studies |
|---|---|
| Chao, JL | 1 |
| Korzinkin, M | 1 |
| Zhavoronkov, A | 1 |
| Ozerov, IV | 1 |
| Walker, MT | 1 |
| Higgins, K | 1 |
| Lingen, MW | 6 |
| Izumchenko, E | 1 |
| Savage, PA | 1 |
| Nedungadi, D | 1 |
| Ryan, N | 1 |
| Anderson, K | 1 |
| Lamenza, FF | 1 |
| Jordanides, PP | 1 |
| Swingler, MJ | 1 |
| Rakotondraibe, L | 1 |
| Riedl, KM | 1 |
| Iwenofu, H | 1 |
| Oghumu, S | 1 |
| Spuldaro, TR | 2 |
| Wagner, VP | 2 |
| Nör, F | 2 |
| Gaio, EJ | 3 |
| Squarize, CH | 1 |
| Carrard, VC | 3 |
| Rösing, CK | 3 |
| Castilho, RM | 2 |
| Yin, P | 1 |
| Chen, J | 2 |
| Wu, Y | 1 |
| Gao, F | 1 |
| Wen, J | 1 |
| Zhang, W | 1 |
| Su, Y | 1 |
| Zhang, X | 3 |
| Neculqueo, GW | 3 |
| Estrázulas, M | 3 |
| Cherubini, K | 3 |
| Koth, VS | 3 |
| Salum, FG | 3 |
| Coeli-Lacchini, FB | 1 |
| da Silva, G | 1 |
| Belentani, M | 1 |
| Alves, JSF | 1 |
| Ushida, TR | 1 |
| Lunardelli, GT | 1 |
| Garcia, CB | 1 |
| Silva, TA | 1 |
| Lopes, NP | 1 |
| Leopoldino, AM | 1 |
| Sahu, SR | 1 |
| Thakur, S | 1 |
| Peroumal, D | 1 |
| Utkalaja, BG | 1 |
| Dutta, A | 1 |
| Kumari, P | 1 |
| Subhadarsini, I | 1 |
| Acharya, N | 1 |
| Verma, A | 1 |
| Vincent-Chong, VK | 2 |
| DeJong, H | 2 |
| Hershberger, PA | 3 |
| Seshadri, M | 4 |
| Melis, M | 1 |
| Zhang, T | 4 |
| Scognamiglio, T | 7 |
| Gudas, LJ | 8 |
| Cecilio, HP | 1 |
| Valente, VB | 1 |
| Pereira, KM | 1 |
| Kayahara, GM | 1 |
| Furuse, C | 1 |
| Biasoli, ÉR | 1 |
| Miyahara, GI | 1 |
| Oliveira, SHP | 1 |
| Bernabé, DG | 1 |
| Naik, K | 1 |
| Janal, MN | 1 |
| Bandary, D | 1 |
| Brar, B | 1 |
| Zhang, S | 1 |
| Dolan, JC | 2 |
| Schmidt, BL | 2 |
| Albertson, DG | 1 |
| Bhattacharya, A | 2 |
| Huang, LY | 1 |
| Hsieh, YP | 1 |
| Wang, YY | 1 |
| Hwang, DY | 1 |
| Jiang, SS | 1 |
| Huang, WT | 1 |
| Chiang, WF | 1 |
| Liu, KJ | 1 |
| Huang, TT | 1 |
| Sequeira, I | 1 |
| Rashid, M | 1 |
| Tomás, IM | 1 |
| Williams, MJ | 1 |
| Graham, TA | 1 |
| Adams, DJ | 1 |
| Vigilante, A | 1 |
| Watt, FM | 1 |
| Monteiro de Oliveira Novaes, JA | 1 |
| Hirz, T | 1 |
| Guijarro, I | 1 |
| Nilsson, M | 1 |
| Pisegna, MA | 1 |
| Poteete, A | 1 |
| Barsoumian, HB | 1 |
| Fradette, JJ | 1 |
| Chen, LN | 1 |
| Gibbons, DL | 1 |
| Tian, X | 1 |
| Wang, J | 2 |
| Myers, JN | 3 |
| McArthur, MJ | 1 |
| Bell, D | 1 |
| William, WN | 3 |
| Heymach, JV | 2 |
| Bouaoud, J | 1 |
| De Souza, G | 1 |
| Darido, C | 1 |
| Tortereau, A | 2 |
| Elkabets, M | 1 |
| Bertolus, C | 2 |
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| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Pharmacokinetics Study of Antitumor B in Healthy Volunteers[NCT04230057] | 12 participants (Actual) | Observational | 2019-12-12 | Active, not recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
5 reviews available for 4-nitroquinoline-1-oxide and Cancer of Mouth
| Article | Year |
|---|---|
The 4-NQO mouse model: An update on a well-established in vivo model of oral carcinogenesis.
Topics: 4-Nitroquinoline-1-oxide; Animals; Carcinogenesis; Carcinogens; Carcinoma, Squamous Cell; Mice; Mout | 2021 |
4-nitroquinoline-1-oxide induced experimental oral carcinogenesis.
Topics: 4-Nitroquinoline-1-oxide; Animals; Biomarkers, Tumor; Carcinogens; Carcinoma, Squamous Cell; Cell Tr | 2006 |
In vivo carcinogenesis of 4-nitroquinoline 1-oxide and related compounds.
Topics: 4-Nitroquinoline-1-oxide; Animals; Carcinogens; Esophageal Neoplasms; Intestinal Neoplasms; Liver Ne | 1981 |
Animal models of intra-oral chemical carcinogenesis: a review.
Topics: 4-Nitroquinoline-1-oxide; 9,10-Dimethyl-1,2-benzanthracene; Animal Nutritional Physiological Phenome | 1981 |
Experimental oral carcinogenesis. A basic rat model for the study of oral carcinogenesis using the carcinogen 4-nitroquinoline 1-oxide.
Topics: 4-Nitroquinoline-1-oxide; 9,10-Dimethyl-1,2-benzanthracene; Animals; Disease Models, Animal; Dose-Re | 1990 |
2 trials available for 4-nitroquinoline-1-oxide and Cancer of Mouth
| Article | Year |
|---|---|
Spontaneous alveolar bone loss after 4NQO exposure in Wistar rats.
Topics: 4-Nitroquinoline-1-oxide; Alveolar Bone Loss; Animals; Carcinogenesis; Carcinogens; Carcinoma, Squam | 2018 |
Met Receptor Tyrosine Kinase and Chemoprevention of Oral Cancer.
Topics: 4-Nitroquinoline-1-oxide; Animals; Antineoplastic Agents; Biomarkers, Tumor; Carcinoma, Squamous Cel | 2018 |
160 other studies available for 4-nitroquinoline-1-oxide and Cancer of Mouth
| Article | Year |
|---|---|
Effector T cell responses unleashed by regulatory T cell ablation exacerbate oral squamous cell carcinoma.
Topics: 4-Nitroquinoline-1-oxide; Amino Acid Sequence; Animals; Antigens, Neoplasm; Carcinogens; Carcinoma, | 2021 |
Modulation of the oral glucocorticoid system during black raspberry mediated oral cancer chemoprevention.
Topics: 4-Nitroquinoline-1-oxide; Animals; Carcinogenesis; Carcinogens; Carcinoma, Squamous Cell; Cell Line, | 2022 |
Periodontal disease affects oral cancer progression in a surrogate animal model for tobacco exposure.
Topics: 4-Nitroquinoline-1-oxide; Animals; Carcinogenesis; Carcinoma, Squamous Cell; Disease Models, Animal; | 2022 |
Chemoprevention of 4NQO-Induced Mouse Tongue Carcinogenesis by AKT Inhibitor through the MMP-9/RhoC Signaling Pathway and Autophagy.
Topics: 4-Nitroquinoline-1-oxide; Animals; Autophagy; Carcinogenesis; Carcinoma, Squamous Cell; Chemoprevent | 2022 |
Laser photobiomodulation does not alter clinical and histological characteristics of 4-NQO-induced oral carcinomas and leukoplakia in mice.
Topics: 4-Nitroquinoline-1-oxide; Animals; Carcinogens; Carcinoma, Squamous Cell; Female; Lasers, Semiconduc | 2022 |
Laser photobiomodulation does not alter clinical and histological characteristics of 4-NQO-induced oral carcinomas and leukoplakia in mice.
Topics: 4-Nitroquinoline-1-oxide; Animals; Carcinogens; Carcinoma, Squamous Cell; Female; Lasers, Semiconduc | 2022 |
Laser photobiomodulation does not alter clinical and histological characteristics of 4-NQO-induced oral carcinomas and leukoplakia in mice.
Topics: 4-Nitroquinoline-1-oxide; Animals; Carcinogens; Carcinoma, Squamous Cell; Female; Lasers, Semiconduc | 2022 |
Laser photobiomodulation does not alter clinical and histological characteristics of 4-NQO-induced oral carcinomas and leukoplakia in mice.
Topics: 4-Nitroquinoline-1-oxide; Animals; Carcinogens; Carcinoma, Squamous Cell; Female; Lasers, Semiconduc | 2022 |
Laser photobiomodulation does not alter clinical and histological characteristics of 4-NQO-induced oral carcinomas and leukoplakia in mice.
Topics: 4-Nitroquinoline-1-oxide; Animals; Carcinogens; Carcinoma, Squamous Cell; Female; Lasers, Semiconduc | 2022 |
Laser photobiomodulation does not alter clinical and histological characteristics of 4-NQO-induced oral carcinomas and leukoplakia in mice.
Topics: 4-Nitroquinoline-1-oxide; Animals; Carcinogens; Carcinoma, Squamous Cell; Female; Lasers, Semiconduc | 2022 |
Laser photobiomodulation does not alter clinical and histological characteristics of 4-NQO-induced oral carcinomas and leukoplakia in mice.
Topics: 4-Nitroquinoline-1-oxide; Animals; Carcinogens; Carcinoma, Squamous Cell; Female; Lasers, Semiconduc | 2022 |
Laser photobiomodulation does not alter clinical and histological characteristics of 4-NQO-induced oral carcinomas and leukoplakia in mice.
Topics: 4-Nitroquinoline-1-oxide; Animals; Carcinogens; Carcinoma, Squamous Cell; Female; Lasers, Semiconduc | 2022 |
Laser photobiomodulation does not alter clinical and histological characteristics of 4-NQO-induced oral carcinomas and leukoplakia in mice.
Topics: 4-Nitroquinoline-1-oxide; Animals; Carcinogens; Carcinoma, Squamous Cell; Female; Lasers, Semiconduc | 2022 |
Spermidine Suppresses Oral Carcinogenesis through Autophagy Induction, DNA Damage Repair, and Oxidative Stress Reduction.
Topics: 4-Nitroquinoline-1-oxide; Animals; Carcinogenesis; Carcinogens; Carcinoma, Squamous Cell; Ceramides; | 2023 |
4-nitroquinoline 1-oxide induces immune cells death to onset early immunosuppression during oral squamous cell carcinoma development.
Topics: 4-Nitroquinoline-1-oxide; Animals; Apoptosis; Carcinoma, Squamous Cell; Head and Neck Neoplasms; Hum | 2023 |
Impact of dietary vitamin D on initiation and progression of oral cancer.
Topics: 4-Nitroquinoline-1-oxide; Animals; Body Weight; Calcitriol; Carcinogenesis; Carcinoma, Squamous Cell | 2020 |
Mutations in long-lived epithelial stem cells and their clonal progeny in pre-malignant lesions and in oral squamous cell carcinoma.
Topics: 4-Nitroquinoline-1-oxide; Animals; Carcinogens; Carcinoma, Squamous Cell; Cell Lineage; Clone Cells; | 2020 |
Beta-adrenergic blocker inhibits oral carcinogenesis and reduces tumor invasion.
Topics: 4-Nitroquinoline-1-oxide; Adrenergic beta-Antagonists; Animals; Carcinogenesis; Carcinogens; Cytokin | 2020 |
The Histopathology of Oral Cancer Pain in a Mouse Model and a Human Cohort.
Topics: 4-Nitroquinoline-1-oxide; Animals; Cancer Pain; Carcinoma, Squamous Cell; Humans; Mice; Mouth Neopla | 2021 |
Can propranolol act as a chemopreventive agent during oral carcinogenesis? An experimental animal study.
Topics: 4-Nitroquinoline-1-oxide; Animals; Carcinogenesis; Carcinogens; Carcinoma, Squamous Cell; Disease Mo | 2021 |
Single-Cell Analysis of Different Stages of Oral Cancer Carcinogenesis in a Mouse Model.
Topics: 4-Nitroquinoline-1-oxide; Animals; Arecoline; Biomarkers, Tumor; Carcinogenesis; Carcinogens; Cell L | 2020 |
Genomic landscape and clonal architecture of mouse oral squamous cell carcinomas dictate tumour ecology.
Topics: 4-Nitroquinoline-1-oxide; Animals; Cadherins; Carcinogenesis; Carcinoma, Squamous Cell; Disease Mode | 2020 |
Targeting of CD40 and PD-L1 Pathways Inhibits Progression of Oral Premalignant Lesions in a Carcinogen-induced Model of Oral Squamous Cell Carcinoma.
Topics: 4-Nitroquinoline-1-oxide; Animals; Antibodies, Monoclonal; B7-H1 Antigen; Carcinogens; Carcinoma, Sq | 2021 |
4NQO induced carcinogenesis: A mouse model for oral squamous cell carcinoma.
Topics: 4-Nitroquinoline-1-oxide; Animals; Carcinogenesis; Carcinoma, Squamous Cell; Head and Neck Neoplasms | 2021 |
Tacrolimus inhibits oral carcinogenesis through cell cycle control.
Topics: 4-Nitroquinoline-1-oxide; Animals; Anticarcinogenic Agents; Carcinogens; Cell Cycle; Cellular Microe | 2021 |
Local Anti-PD-1 Delivery Prevents Progression of Premalignant Lesions in a 4NQO-Oral Carcinogenesis Mouse Model.
Topics: 4-Nitroquinoline-1-oxide; Animals; Antibodies, Monoclonal; Carcinogenesis; Disease Models, Animal; D | 2021 |
Curcumin and metformin-mediated chemoprevention of oral cancer is associated with inhibition of cancer stem cells.
Topics: 4-Nitroquinoline-1-oxide; AC133 Antigen; Animals; Antineoplastic Agents; Carcinoma, Squamous Cell; C | 2017 |
Early detection of squamous cell carcinoma in carcinogen induced oral cancer rodent model by ratiometric activatable cell penetrating peptides.
Topics: 4-Nitroquinoline-1-oxide; Animals; Carcinogens; Carcinoma, Squamous Cell; Cell-Penetrating Peptides; | 2017 |
Tumor necrosis factor alpha secreted from oral squamous cell carcinoma contributes to cancer pain and associated inflammation.
Topics: 4-Nitroquinoline-1-oxide; Animals; Cancer Pain; Carcinoma, Squamous Cell; Female; Inflammation; Mice | 2017 |
PD-1 Blockade Prevents the Development and Progression of Carcinogen-Induced Oral Premalignant Lesions.
Topics: 4-Nitroquinoline-1-oxide; Animals; Antibodies, Monoclonal; Apoptosis; Carcinogens; CD4-Positive T-Ly | 2017 |
Proteomics-based investigation of multiple stages of OSCC development indicates that the inhibition of Trx-1 delays oral malignant transformation.
Topics: 4-Nitroquinoline-1-oxide; Adult; Aged; Animals; Apoptosis; Biomarkers, Tumor; Carcinogenesis; Carcin | 2018 |
Impact of Age on Disease Progression and Microenvironment in Oral Cancer.
Topics: 4-Nitroquinoline-1-oxide; Age Factors; Animals; Carcinoma, Squamous Cell; Disease Progression; Femal | 2018 |
Alterations of 63 hub genes during lingual carcinogenesis in C57BL/6J mice.
Topics: 4-Nitroquinoline-1-oxide; Animals; Biomarkers, Tumor; Carcinogenesis; Carcinogens; Carcinoma, Squamo | 2018 |
Immunohistochemistry profile of p75 neurotrophin receptor in oral epithelial dysplasia and oral squamous cell carcinoma induced by 4-nitroquinoline 1-oxide in rats.
Topics: 4-Nitroquinoline-1-oxide; Animals; Biomarkers, Tumor; Carcinoma, Squamous Cell; Disease Models, Anim | 2018 |
Autophagy is positively associated with the accumulation of myeloid‑derived suppressor cells in 4‑nitroquinoline‑1‑oxide‑induced oral cancer.
Topics: 4-Nitroquinoline-1-oxide; Adult; Aged; Aged, 80 and over; Animals; Beclin-1; Female; Gene Expression | 2018 |
Prevention of oral carcinogenesis in rats by Dracaena cinnabari resin extracts.
Topics: 4-Nitroquinoline-1-oxide; Animals; Carcinogenesis; Dracaena; Female; Male; Mouth Neoplasms; Plant Ex | 2019 |
Evaluation of the Chemopreventive Activity of Grape Skin Extract Using Medium-term Oral Carcinogenesis Assay Induced by 4-Nitroquinoline 1-Oxide.
Topics: 4-Nitroquinoline-1-oxide; Animals; Antioxidants; Carcinogenesis; Catalase; Gene Expression Regulatio | 2019 |
No difference in 4-nitroquinoline induced tumorigenesis between germ-free and colonized mice.
Topics: 4-Nitroquinoline-1-oxide; Animals; Carcinogenesis; Carcinogens; Carcinoma, Squamous Cell; Cell Trans | 2019 |
Role of Electron Microscopy in Early Detection of Altered Epithelium During Experimental Oral Carcinogenesis.
Topics: 4-Nitroquinoline-1-oxide; Animals; Carcinogens; Carcinoma; Disease Models, Animal; Early Diagnosis; | 2019 |
Taiwanin C elicits apoptosis in arecoline and 4-nitroquinoline-1-oxide-induced oral squamous cell carcinoma cells and hinders proliferation via epidermal growth factor receptor/PI3K suppression.
Topics: 4-Nitroquinoline-1-oxide; Animals; Antineoplastic Agents, Phytogenic; Apoptosis; Arecoline; Carcinom | 2019 |
Impact of combination immunochemotherapies on progression of 4NQO-induced murine oral squamous cell carcinoma.
Topics: 4-Nitroquinoline-1-oxide; Animals; Antineoplastic Combined Chemotherapy Protocols; Cancer Vaccines; | 2019 |
Tumor-derived exosomes promote carcinogenesis of murine oral squamous cell carcinoma.
Topics: 4-Nitroquinoline-1-oxide; Animals; Apoptosis; B7-H1 Antigen; Carcinogenesis; Carcinogens; Carcinoma, | 2020 |
Assessment of the Blood Parameters, Cardiac and Liver Enzymes in Oral Squamous Cell Carcinoma Following Treated with Injectable Doxorubicin-Loaded Nano-Particles.
Topics: 4-Nitroquinoline-1-oxide; Animals; Antibiotics, Antineoplastic; Carcinogens; Carcinoma, Squamous Cel | 2019 |
Modeling gene-environment interactions in oral cavity and esophageal cancers demonstrates a role for the p53 R72P polymorphism in modulating susceptibility.
Topics: 4-Nitroquinoline-1-oxide; Animals; Blotting, Western; Carcinogens; Cells, Cultured; DNA, Viral; Esop | 2014 |
Lactobacillus salivarius REN inhibits rat oral cancer induced by 4-nitroquioline 1-oxide.
Topics: 4-Nitroquinoline-1-oxide; Animals; Apoptosis; Blotting, Western; Carcinogens; Cell Proliferation; Cy | 2013 |
[Expression of cytokeratin 19 and connexin 43 in 4-nitroquinoline-l-oxide-induced rat tongue carcinogenesis].
Topics: 4-Nitroquinoline-1-oxide; Animals; Carcinogenesis; Carcinoma, Squamous Cell; Connexin 43; Epithelial | 2013 |
Effect of topical 5-ALA mediated photodynamic therapy on proliferation index of keratinocytes in 4-NQO-induced potentially malignant oral lesions.
Topics: 4-Nitroquinoline-1-oxide; Administration, Topical; Aminolevulinic Acid; Animals; Apoptosis; Cell Pro | 2013 |
Localization of liposomal mTHPC formulations within normal epithelium, dysplastic tissue, and carcinoma of oral epithelium in the 4NQO-carcinogenesis rat model.
Topics: 4-Nitroquinoline-1-oxide; Animals; Carcinogens; Carcinoma, Squamous Cell; Liposomes; Male; Mesoporph | 2013 |
Combination of telmisartan with cisplatin controls oral cancer cachexia in rats.
Topics: 4-Nitroquinoline-1-oxide; Animals; Antineoplastic Combined Chemotherapy Protocols; Benzimidazoles; B | 2013 |
Chemopreventive activity of apple extract following medium-term oral carcinogenesis assay induced by 4-nitroquinoline-1-oxide.
Topics: 4-Nitroquinoline-1-oxide; Animals; Antineoplastic Agents; Apoptosis; Carcinogenesis; Carcinoma, Squa | 2014 |
Combination of bexarotene and the retinoid CD1530 reduces murine oral-cavity carcinogenesis induced by the carcinogen 4-nitroquinoline 1-oxide.
Topics: 4-Nitroquinoline-1-oxide; Animals; Anticarcinogenic Agents; Benzoates; beta Catenin; Bexarotene; Car | 2014 |
K14-EGFP-miR-31 transgenic mice have high susceptibility to chemical-induced squamous cell tumorigenesis that is associating with Ku80 repression.
Topics: 4-Nitroquinoline-1-oxide; Animals; Antigens, Nuclear; Carcinoma, Squamous Cell; Cell Line, Tumor; DN | 2015 |
Novel DOX-MTX nanoparticles improve oral SCC clinical outcome by down regulation of lymph dissemination factor VEGF-C expression in vivo: oral and IV modalities.
Topics: 4-Nitroquinoline-1-oxide; Administration, Oral; Animals; Antineoplastic Combined Chemotherapy Protoc | 2014 |
Methylation-associated gene silencing of RARB in areca carcinogens induced mouse oral squamous cell carcinoma.
Topics: 4-Nitroquinoline-1-oxide; Animals; Areca; Arecoline; Carcinogens; Carcinoma, Squamous Cell; Cell Lin | 2014 |
Chemopreventive activity of systemically administered curcumin on oral cancer in the 4-nitroquinoline 1-oxide model.
Topics: 4-Nitroquinoline-1-oxide; Animals; Antineoplastic Agents; Biomarkers, Tumor; Carcinogens; Corn Oil; | 2015 |
Oral and IV dosages of doxorubicin-methotrexate loaded- nanoparticles inhibit progression of oral cancer by down- regulation of matrix Methaloproteinase 2 expression in vivo.
Topics: 4-Nitroquinoline-1-oxide; Administration, Oral; Animals; Antineoplastic Combined Chemotherapy Protoc | 2014 |
Oral-specific ablation of Klf4 disrupts epithelial terminal differentiation and increases premalignant lesions and carcinomas upon chemical carcinogenesis.
Topics: 4-Nitroquinoline-1-oxide; Animals; Carcinogenesis; Carcinogens; Carcinoma, Squamous Cell; Cell Diffe | 2015 |
Overexpression of lipocalins and pro-inflammatory chemokines and altered methylation of PTGS2 and APC2 in oral squamous cell carcinomas induced in rats by 4-nitroquinoline-1-oxide.
Topics: 4-Nitroquinoline-1-oxide; Animals; Carcinoma, Squamous Cell; Chemokines; Cyclooxygenase 1; Cyclooxyg | 2015 |
A robust method for assessing chemically induced mutagenic effects in the oral cavity of transgenic Big Blue® rats.
Topics: 4-Nitroquinoline-1-oxide; Animals; DNA Mutational Analysis; Gene Frequency; Male; Mouth; Mouth Neopl | 2015 |
Mcl-1 is an important therapeutic target for oral squamous cell carcinomas.
Topics: 4-Nitroquinoline-1-oxide; Animals; Apoptosis; Apoptosis Regulatory Proteins; Autophagy-Related Prote | 2015 |
Inhibition of 4-nitroquinoline-1-oxide-induced oral carcinogenesis by dietary calcium.
Topics: 4-Nitroquinoline-1-oxide; Animals; Biomarkers; Calcium, Dietary; Carcinogenesis; Cell Differentiatio | 2015 |
Impact of Short-term 1,25-Dihydroxyvitamin D3 on the Chemopreventive Efficacy of Erlotinib against Oral Cancer.
Topics: 4-Nitroquinoline-1-oxide; Animals; Anticarcinogenic Agents; Antineoplastic Agents; Calcitriol; Carci | 2015 |
Gene expression profiling signatures for the diagnosis and prevention of oral cavity carcinogenesis-genome-wide analysis using RNA-seq technology.
Topics: 4-Nitroquinoline-1-oxide; Animals; Biomarkers, Tumor; Carcinogenesis; Carcinogens; Carcinoma, Squamo | 2015 |
Identification of Ethanol and 4-Nitroquinoline-1-Oxide Induced Epigenetic and Oxidative Stress Markers During Oral Cavity Carcinogenesis.
Topics: 4-Nitroquinoline-1-oxide; Animals; Biomarkers, Tumor; Carcinogenesis; Carcinogens; Epigenesis, Genet | 2015 |
Inhibition of 4NQO-Induced Oral Carcinogenesis by Dietary Oyster Shell Calcium.
Topics: 4-Nitroquinoline-1-oxide; Animal Shells; Animals; Antineoplastic Agents; Calcium; Carcinogenesis; Ca | 2016 |
Notch1 Activation or Loss Promotes HPV-Induced Oral Tumorigenesis.
Topics: 4-Nitroquinoline-1-oxide; 9,10-Dimethyl-1,2-benzanthracene; Animals; Breast Neoplasms; Carcinogens; | 2015 |
Suppression of Rat Oral Carcinogenesis by Agonists of Peroxisome Proliferator Activated Receptor γ.
Topics: 4-Nitroquinoline-1-oxide; Animals; Antineoplastic Agents; Carcinoma, Squamous Cell; Male; Mouth Neop | 2015 |
Taiwanin C selectively inhibits arecoline and 4-NQO-induced oral cancer cell proliferation via ERK1/2 inactivation.
Topics: 4-Nitroquinoline-1-oxide; Animals; Antineoplastic Agents, Phytogenic; Arecoline; Cell Cycle Proteins | 2017 |
Establishment of a highly metastatic buccal squamous cell carcinoma cell line from a Sprague-Dawley Rat.
Topics: 4-Nitroquinoline-1-oxide; Animals; Carcinogenesis; Carcinoma, Squamous Cell; Cell Line, Tumor; Disea | 2016 |
Overexpression of Bcl-2, SOCS 1, 3 and Cdh 1, 2 are associated with the early neoplasic changes in modified 4-nitroquinoline 1-oxide-induced murine oral cancer model.
Topics: 4-Nitroquinoline-1-oxide; Animals; Biomarkers, Tumor; Cadherins; Carcinogens; Disease Models, Animal | 2016 |
Dynamic changes in the gene expression profile during rat oral carcinogenesis induced by 4-nitroquinoline 1-oxide.
Topics: 4-Nitroquinoline-1-oxide; Animals; Carcinogenesis; Cyclin D1; Disease Models, Animal; Gene Expressio | 2016 |
The dynamics of gene expression changes in a mouse model of oral tumorigenesis may help refine prevention and treatment strategies in patients with oral cancer.
Topics: 4-Nitroquinoline-1-oxide; Animals; Antineoplastic Agents; Carcinogens; Carcinoma, Squamous Cell; Cel | 2016 |
Cortactin is a prognostic marker for oral squamous cell carcinoma and its overexpression is involved in oral carcinogenesis.
Topics: 4-Nitroquinoline-1-oxide; Adult; Animals; Areca; Carcinogenesis; Carcinoma, Squamous Cell; Cortactin | 2017 |
MicroRNA-211 Enhances the Oncogenicity of Carcinogen-Induced Oral Carcinoma by Repressing TCF12 and Increasing Antioxidant Activity.
Topics: 4-Nitroquinoline-1-oxide; Animals; Basic Helix-Loop-Helix Transcription Factors; Blotting, Western; | 2016 |
STAT3 as a Chemoprevention Target in Carcinogen-Induced Head and Neck Squamous Cell Carcinoma.
Topics: 4-Nitroquinoline-1-oxide; Animals; Biomarkers; Carcinogens; Carcinoma, Squamous Cell; Chemopreventio | 2016 |
Identification of reliable reference genes for quantitative gene expression studies in oral squamous cell carcinomas compared to adjacent normal tissues in the F344 rat model.
Topics: 4-Nitroquinoline-1-oxide; Animals; Carcinoma, Squamous Cell; Gene Expression; Gene Expression Profil | 2016 |
Chemoprevention of oxidative stress-associated oral carcinogenesis by sulforaphane depends on NRF2 and the isothiocyanate moiety.
Topics: 4-Nitroquinoline-1-oxide; Animals; Anticarcinogenic Agents; Carcinogenesis; Carcinogens; Chemopreven | 2016 |
Down-regulation of β-catenin and the associated migration ability by Taiwanin C in arecoline and 4-NQO-induced oral cancer cells via GSK-3β activation.
Topics: 4-Nitroquinoline-1-oxide; Animals; Arecoline; beta Catenin; Cell Line, Tumor; Cell Movement; Cell Pr | 2017 |
p120-Catenin Is Required for Dietary Calcium Suppression of Oral Carcinogenesis in Mice.
Topics: 4-Nitroquinoline-1-oxide; Animals; Calcium; Calcium, Dietary; Carcinogenesis; Carcinoma, Squamous Ce | 2017 |
Loss of NDRG2 Expression Confers Oral Squamous Cell Carcinoma with Enhanced Metastatic Potential.
Topics: 4-Nitroquinoline-1-oxide; Adaptor Proteins, Signal Transducing; Animals; Carcinoma, Squamous Cell; C | 2017 |
A novel immunocompetent murine model for Candida albicans-promoted oral epithelial dysplasia.
Topics: 4-Nitroquinoline-1-oxide; Animals; Candida albicans; Candidiasis, Oral; Carcinogens; Disease Models, | 2009 |
Lack of promotion activity of diacylglycerol oil on 4-nitroquinoline 1-oxide induced carcinogenesis in the oral cavity of SD rats.
Topics: 4-Nitroquinoline-1-oxide; Animals; Carcinogens; Carcinoma, Squamous Cell; Diet; Diglycerides; Fatty | 2008 |
Apoptin induces apoptosis in an oral cancer mouse model.
Topics: 4-Nitroquinoline-1-oxide; Adenoviridae; Animals; Apoptosis; Capsid Proteins; Carcinogens; Carcinoma, | 2008 |
Cyclin D1 overexpression increases susceptibility to 4-nitroquinoline-1-oxide-induced dysplasia and neoplasia in murine squamous oral epithelium.
Topics: 4-Nitroquinoline-1-oxide; Animals; Blotting, Northern; Carcinogens; Cell Differentiation; Cell Proli | 2009 |
Functional genomic analysis identified epidermal growth factor receptor activation as the most common genetic event in oral squamous cell carcinoma.
Topics: 4-Nitroquinoline-1-oxide; Animals; Arecoline; Carcinogens; Carcinoma, Squamous Cell; Disease Models, | 2009 |
Diabetes enhances the expression of H-ras and suppresses the expression of EGFR leading to increased cell proliferation.
Topics: 4-Nitroquinoline-1-oxide; Animals; Carcinogens; Carcinoma, Squamous Cell; Cell Proliferation; Diabet | 2009 |
ABT-510 is an effective chemopreventive agent in the mouse 4-nitroquinoline 1-oxide model of oral carcinogenesis.
Topics: 4-Nitroquinoline-1-oxide; Angiogenesis Inhibitors; Animals; Carcinogens; Carcinoma, Squamous Cell; D | 2009 |
Gene deletion of inositol hexakisphosphate kinase 2 predisposes to aerodigestive tract carcinoma.
Topics: 4-Nitroquinoline-1-oxide; Animals; Apoptosis; Carcinogens; Carcinoma, Squamous Cell; Esophageal Neop | 2009 |
A mouse model for oral squamous cell carcinoma.
Topics: 4-Nitroquinoline-1-oxide; Animals; Biomarkers, Tumor; Cadherins; Carcinoma, Squamous Cell; Cyclin D1 | 2009 |
A DNA methyltransferase inhibitor and all-trans retinoic acid reduce oral cavity carcinogenesis induced by the carcinogen 4-nitroquinoline 1-oxide.
Topics: 4-Nitroquinoline-1-oxide; Animals; Antineoplastic Combined Chemotherapy Protocols; Azacitidine; Carc | 2009 |
Oral carcinogenesis induced by 4-nitroquinoline 1-oxide in lecithin:retinol acyltransferase gene knockout mice.
Topics: 4-Nitroquinoline-1-oxide; Acyltransferases; Animals; Base Sequence; Carcinogens; Carcinoma, Squamous | 2010 |
Dual inhibition of vascular endothelial growth factor receptor and epidermal growth factor receptor is an effective chemopreventive strategy in the mouse 4-NQO model of oral carcinogenesis.
Topics: 4-Nitroquinoline-1-oxide; Animals; Antineoplastic Agents; Carcinogens; Disease Models, Animal; Drug | 2010 |
Fenofibrate exhibits a high potential to suppress the formation of squamous cell carcinoma in an oral-specific 4-nitroquinoline 1-oxide/arecoline mouse model.
Topics: 4-Nitroquinoline-1-oxide; Acetyl-CoA Carboxylase; Animals; Anticarcinogenic Agents; Arecoline; Carci | 2011 |
Inhibition of EGFR-STAT3 signaling with erlotinib prevents carcinogenesis in a chemically-induced mouse model of oral squamous cell carcinoma.
Topics: 4-Nitroquinoline-1-oxide; Animal Feed; Animals; Carcinogens; Carcinoma, Squamous Cell; Commiphora; D | 2011 |
Ethanol promotes chemically induced oral cancer in mice through activation of the 5-lipoxygenase pathway of arachidonic acid metabolism.
Topics: 4-Nitroquinoline-1-oxide; Animals; Anti-Infective Agents, Local; Arachidonate 5-Lipoxygenase; Arachi | 2011 |
Chemopreventive effect of a mixture of Chinese Herbs (antitumor B) on chemically induced oral carcinogenesis.
Topics: 4-Nitroquinoline-1-oxide; Alkaloids; Animals; Antineoplastic Agents, Phytogenic; Benzoxepins; Biomar | 2013 |
Topical polyethylene glycol as a novel chemopreventive agent for oral cancer via targeting of epidermal growth factor response.
Topics: 4-Nitroquinoline-1-oxide; Administration, Oral; Administration, Topical; Animals; Antineoplastic Age | 2012 |
Development of a 4-nitroquinoline-1-oxide model of lymph node metastasis in oral squamous cell carcinoma.
Topics: 4-Nitroquinoline-1-oxide; Animals; Carcinoma, Squamous Cell; Immunohistochemistry; Lymphatic Metasta | 2013 |
Basal stem cells contribute to squamous cell carcinomas in the oral cavity.
Topics: 4-Nitroquinoline-1-oxide; Animals; Carcinogens; Carcinoma, Squamous Cell; Cell Proliferation; Epithe | 2013 |
The role of cellular trace elements in oral carcinogenesis induced by 4-nitroquinoline 1-oxide(4NQO).
Topics: 4-Nitroquinoline-1-oxide; Animals; Carcinoma, Squamous Cell; Copper; Electron Probe Microanalysis; F | 2000 |
[The electron probe microanalysis on oral precancer treated by garlic].
Topics: 4-Nitroquinoline-1-oxide; Animals; Copper; Drugs, Chinese Herbal; Electron Probe Microanalysis; Epit | 2000 |
[Study on trace elements in epithelial cells during oral carcinogenesis prevented by garlic].
Topics: 4-Nitroquinoline-1-oxide; Animals; Copper; Drugs, Chinese Herbal; Epithelial Cells; Female; Garlic; | 2000 |
Oral cavity and esophageal carcinogenesis modeled in carcinogen-treated mice.
Topics: 4-Nitroquinoline-1-oxide; Animals; Bromodeoxyuridine; Carcinogens; Carcinoma, Papillary; Carcinoma, | 2004 |
Therapeutic efficacy of green tea polyphenols on cellular thiols in 4-Nitroquinoline 1-oxide-induced oral carcinogenesis.
Topics: 4-Nitroquinoline-1-oxide; Animals; Carcinogens; Carcinoma, Squamous Cell; Flavonoids; gamma-Glutamyl | 2004 |
4NQO oral carcinogenesis: animal models, molecular markers and future expectations.
Topics: 4-Nitroquinoline-1-oxide; Animals; Biomarkers, Tumor; Carcinogens; Carcinoma, Squamous Cell; Cell Tr | 2005 |
Parp-1 deficiency does not increase the frequency of tumors in the oral cavity and esophagus of ICR/129Sv mice by 4-nitroquinoline 1-oxide, a carcinogen producing bulky adducts.
Topics: 4-Nitroquinoline-1-oxide; Animals; Carcinogens; Esophageal Neoplasms; Mice; Mice, Inbred ICR; Mice, | 2006 |
Chemopreventive efficacy of all-trans-retinoic acid in biodegradable microspheres against epithelial cancers: results in a 4-nitroquinoline 1-oxide-induced oral carcinogenesis model.
Topics: 4-Nitroquinoline-1-oxide; Animals; Antineoplastic Agents; Carcinoma, Squamous Cell; Cell Transformat | 2006 |
p53 Transgenic mice are highly susceptible to 4-nitroquinoline-1-oxide-induced oral cancer.
Topics: 4-Nitroquinoline-1-oxide; Animals; Apoptosis; Carcinogens; Carcinoma, Squamous Cell; Cell Cycle; Dis | 2006 |
Modulatory efficacy of green tea polyphenols on glycoconjugates and immunological markers in 4-Nitroquinoline 1-oxide-induced oral carcinogenesis-A therapeutic approach.
Topics: 4-Nitroquinoline-1-oxide; Acid Phosphatase; Animals; Antineoplastic Agents, Phytogenic; beta-Galacto | 2006 |
[Establishment and identification of biological characteristics of rat monoclone cell line Rca-B].
Topics: 4-Nitroquinoline-1-oxide; Animals; Carcinoma, Squamous Cell; Cell Cycle; Cell Line, Tumor; Cell Prol | 2007 |
Increased risk of oral cancer in diabetic animals is not associated with c-jun activation pathway.
Topics: 4-Nitroquinoline-1-oxide; Animals; Biopsy; Carcinogens; Carcinoma, Squamous Cell; Diabetes Mellitus, | 2007 |
Collagenase-2 (matrix metalloproteinase-8) plays a protective role in tongue cancer.
Topics: 4-Nitroquinoline-1-oxide; Adult; Aged; Aged, 80 and over; Animals; Biomarkers, Tumor; Blotting, West | 2008 |
Chemopreventive and therapeutic modulation of green tea polyphenols on drug metabolizing enzymes in 4-Nitroquinoline 1-oxide induced oral cancer.
Topics: 4-Nitroquinoline-1-oxide; Animals; Antineoplastic Agents; Antioxidants; Aryl Hydrocarbon Hydroxylase | 2008 |
The effect of iron deficiency on experimental oral carcinogenesis in the rat.
Topics: 4-Nitroquinoline-1-oxide; Anemia, Hypochromic; Animals; Body Weight; Carcinoma, Squamous Cell; Diet; | 1983 |
Focal acantholytic dyskeratosis in experimental oral carcinogenesis in rats.
Topics: 4-Nitroquinoline-1-oxide; Acantholysis; Animals; Keratosis; Leukoplakia, Oral; Mouth Diseases; Mouth | 1983 |
Experimental induction of oral squamous cell carcinomas in mice with 4-nitroquinolone-1-oxide.
Topics: 4-Nitroquinoline-1-oxide; Animals; Carcinoma, Squamous Cell; Male; Mice; Mice, Inbred CBA; Mouth Muc | 1984 |
Verrucous hyperplasia and verrucous carcinoma of the rat oral mucosa. Experimental oral carcinogenesis using 4-nitroquinoline 1-oxide.
Topics: 4-Nitroquinoline-1-oxide; Animals; Carcinoma, Papillary; Carcinoma, Squamous Cell; Female; Gingival | 1984 |
[Induction of squamous cell carcinoma of the oral cavity by administration of 4-nitroquinoline 1-oxide in the drinking water (author's transl)].
Topics: 4-Nitroquinoline-1-oxide; Animals; Carcinoma, Squamous Cell; Male; Mouth Neoplasms; Neoplasms, Exper | 1981 |
Induction of squamous cell carcinoma in the oral cavity of rats by oral administration of 4-nitroquinoline-1-oxide (4NQO) in drinking water. A preliminary report.
Topics: 4-Nitroquinoline-1-oxide; Animals; Carcinoma, Squamous Cell; Male; Mouth Neoplasms; Neoplasms, Exper | 1981 |
Inflammatory cell infiltrate associated with primary and transplanted tumours in an inbred model of oral carcinogenesis.
Topics: 3T3 Cells; 4-Nitroquinoline-1-oxide; Animals; Antigens, CD; Carcinoma, Squamous Cell; CD5 Antigens; | 1995 |
Inhibition of 4-nitroquinoline-1-oxide-induced rat oral carcinogenesis by dietary exposure of a new retinoidal butenolide, KYN-54, during the initiation and post-initiation phases.
Topics: 4-Butyrolactone; 4-Nitroquinoline-1-oxide; Animals; Anticarcinogenic Agents; Biogenic Polyamines; Br | 1995 |
Characterization of a rat oral squamous cell carcinoma cell line UHG-RaC '93 induced by 4-nitroquinoline-1-oxide in vivo.
Topics: 4-Nitroquinoline-1-oxide; Animals; Carcinogens; Carcinoma, Squamous Cell; Cells, Cultured; Chromosom | 1995 |
The cancer-promoting effect of N-nitrosonornicotine used in combination with a subcarcinogenic dose of 4-nitroquinoline-N-oxide and 7,12-dimethylbenz (A) anthracene.
Topics: 4-Nitroquinoline-1-oxide; 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinogens; Carcinoma, Squamou | 1995 |
Comparison of epithelial dysplasia--the 4NQO rat palate model and human oral mucosa.
Topics: 4-Nitroquinoline-1-oxide; Adult; Aged; Aged, 80 and over; Animals; Carcinoma, Squamous Cell; Chi-Squ | 1995 |
Loss of expression of basement membrane proteins reflects anomalies of chromosomes 3 and 12 in the rat 4-nitroquinoline-N-oxide model of oral carcinogenesis.
Topics: 3T3 Cells; 4-Nitroquinoline-1-oxide; Animals; Basement Membrane; Carcinoma; Carcinoma, Squamous Cell | 1995 |
Chemoprevention of digestive organs carcinogenesis by natural product protocatechuic acid.
Topics: 4-Nitroquinoline-1-oxide; Animals; Azoxymethane; Colonic Neoplasms; Diethylnitrosamine; Digestive Sy | 1995 |
Harvey ras (H-ras) point mutations are induced by 4-nitroquinoline-1-oxide in murine oral squamous epithelia, while squamous cell carcinomas and loss of heterozygosity occur without additional exposure.
Topics: 4-Nitroquinoline-1-oxide; Animals; Base Sequence; Carcinoma, Squamous Cell; Codon; DNA Mutational An | 1994 |
Chemoprevention of 4-nitroquinoline 1-oxide-induced oral carcinogenesis by dietary curcumin and hesperidin: comparison with the protective effect of beta-carotene.
Topics: 4-Hydroxyaminoquinoline-1-oxide; 4-Nitroquinoline-1-oxide; Animals; beta Carotene; Carcinoma, Squamo | 1994 |
Identification of basal lamina acidic glycoconjugates, particularly heparan sulphate proteoglycans, using a poly-L-lysine-gold probe in induced oral carcinomas.
Topics: 4-Nitroquinoline-1-oxide; Animals; Basement Membrane; Carcinogens; Female; Glycoconjugates; Gold; He | 1996 |
[The effect of topically garlic solution painting on experimental oral precancer and oral cancer in rats].
Topics: 4-Nitroquinoline-1-oxide; Animals; Antineoplastic Agents, Phytogenic; Female; Garlic; Male; Mouth Mu | 1995 |
Nuclear morphometry in experimental oral mucosal carcinogenesis.
Topics: 4-Nitroquinoline-1-oxide; Animals; Carcinogens; Cell Nucleus; Cell Transformation, Neoplastic; Disea | 1996 |
The effect of vitamin C on the hamster cheek pouch treated with the water soluble carcinogen 4-nitroquinoline-1-oxide (4NQO).
Topics: 4-Nitroquinoline-1-oxide; Animals; Ascorbic Acid; Carcinogens; Cell Transformation, Neoplastic; Chee | 1996 |
Induction by 4-nitroquinoline-1-oxide of oral epithelial dysplasia and neoplasia in scurvy-prone osteogenic disorder Shionogi (ODS) rats.
Topics: 4-Nitroquinoline-1-oxide; Animals; Epithelium; Male; Mouth Mucosa; Mouth Neoplasms; Osteochondrodysp | 1996 |
Chemoprevention of 4-nitroquinoline 1-oxide-induced rat oral carcinogenesis by the dietary flavonoids chalcone, 2-hydroxychalcone, and quercetin.
Topics: 4-Nitroquinoline-1-oxide; Animals; Anticarcinogenic Agents; Biogenic Polyamines; Body Weight; Bromod | 1996 |
Consistent allelic loss on mouse chromosome 7 distal to tyrosinase in 4-nitroquinoline-1-oxide-induced oral cavity tumors with loss of heterozygosity at Ha-ras-1.
Topics: 4-Nitroquinoline-1-oxide; Alleles; Animals; Base Sequence; Carcinogens; Carcinoma, Squamous Cell; Ch | 1997 |
A region within murine chromosome 7F4, syntenic to the human 11q13 amplicon, is frequently amplified in 4NQO-induced oral cavity tumors.
Topics: 4-Nitroquinoline-1-oxide; Animals; Base Sequence; Carcinoma, Squamous Cell; Chromosome Mapping; Chro | 1997 |
Overexpression of autocrine TGF-beta 1 suppresses the growth of spindle epithelial cells in vitro and in vivo in the rat 4NQO model of oral carcinogenesis.
Topics: 4-Nitroquinoline-1-oxide; Animals; Cell Division; Keratinocytes; Mice; Mice, Nude; Mouth Neoplasms; | 1997 |
Detection of oral dysplasia in animals with fluorine-18-FDG and carbon-11-tyrosine.
Topics: 4-Nitroquinoline-1-oxide; Animals; Carbon Radioisotopes; Carcinogens; Carcinoma, Squamous Cell; Fluo | 1998 |
Decreased expression of CD80 is a marker for increased tumorigenicity in a new murine model of oral squamous-cell carcinoma.
Topics: 4-Nitroquinoline-1-oxide; Animals; Animals, Congenic; B7-1 Antigen; Biomarkers, Tumor; Carcinoma, Sq | 1999 |
Loss of differentiation of 4NQO-induced rat malignant oral keratinocytes correlates with metastatic dissemination and is associated with a reduced cellular response to TGF-beta1 and an altered receptor profile.
Topics: 4-Nitroquinoline-1-oxide; Animals; Carcinoma; Carcinoma, Squamous Cell; Cell Differentiation; Cell T | 1999 |
Overexpression of JunB in undifferentiated malignant rat oral keratinocytes enhances the malignant phenotype in vitro without altering cellular differentiation.
Topics: 3T3 Cells; 4-Nitroquinoline-1-oxide; Animals; Bacterial Proteins; Blotting, Northern; Blotting, West | 2001 |
Epithelial-mesenchymal interactions in experimental oral mucosal carcinogenesis.
Topics: 4-Nitroquinoline-1-oxide; Animals; Carcinogens; Connective Tissue; Disease Models, Animal; Epitheliu | 2001 |
Different mutation status of the beta-catenin gene in carcinogen-induced colon, brain, and oral tumors in rats.
Topics: 4-Nitroquinoline-1-oxide; Animals; Anthraquinones; beta Catenin; Brain Neoplasms; Carcinogens; Colon | 2001 |
Effect of different levels of dietary zinc on development of chemically induced oral cancer in rats.
Topics: 4-Nitroquinoline-1-oxide; Animals; Female; Mouth Neoplasms; Neoplasms, Experimental; Rats; Zinc | 1979 |
Influence of zinc on onset and progression of oral carcinogenesis in rats.
Topics: 4-Nitroquinoline-1-oxide; Animals; Copper; Female; Male; Mouth Mucosa; Mouth Neoplasms; Neoplasms, E | 1979 |
Cytogenetic analysis of oral and cutaneous squamous cell carcinomas in the rat.
Topics: 4-Nitroquinoline-1-oxide; 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinoma, Squamous Cell; Cell | 1975 |
Effects of essential fatty acid deficiency and of carbon tetrachloride-induced liver cirrhosis on oral carcinogenesis in the rat.
Topics: 4-Nitroquinoline-1-oxide; Animals; Carbon Tetrachloride; Carcinogens; Diet; Fatty Acids, Essential; | 1976 |
Strain difference of susceptibility to 4-nitroquinoline 1-oxide-induced tongue carcinoma in rats.
Topics: 4-Nitroquinoline-1-oxide; Animals; Carcinogenicity Tests; Esophageal Neoplasms; Female; Male; Mouth | 1992 |
Epithelial-mesenchymal interactions in experimental oral mucosal carcinogenesis: establishing a technique.
Topics: 4-Nitroquinoline-1-oxide; Animals; Cell Communication; Connective Tissue; Epithelium; Male; Mouth Mu | 1992 |
Changes in EGF and TGE-beta receptor expression reflects differentiation of rat malignant oral keratinocytes.
Topics: 4-Nitroquinoline-1-oxide; Animals; Carcinoma, Squamous Cell; Cell Differentiation; Cell Division; Ce | 1991 |
Temporal alterations in cytokeratin expression during experimental oral mucosal carcinogenesis.
Topics: 4-Nitroquinoline-1-oxide; Animals; Biomarkers, Tumor; Carcinoma, Squamous Cell; Electrophoresis, Gel | 1991 |
Basal cell nuclear size in experimental oral mucosal carcinogenesis.
Topics: 4-Nitroquinoline-1-oxide; Animals; Cell Nucleus; Cell Transformation, Neoplastic; Male; Mouth Mucosa | 1991 |
The effect of topical vitamin C on palatal oral mucosal carcinogenesis using 4-nitroquinoline-1-oxide.
Topics: 4-Nitroquinoline-1-oxide; Administration, Topical; Animals; Ascorbic Acid; Carcinoma, Squamous Cell; | 1991 |
Tumour progression in experimental oral carcinogenesis is associated with changes in EGF and TGF-beta receptor expression and altered responses to these growth factors.
Topics: 4-Nitroquinoline-1-oxide; Animals; Cell Division; Cell Line; Cell Transformation, Neoplastic; Cells, | 1990 |
Ia+ epithelial dendritic cells during oral carcinogenesis in the rat.
Topics: 4-Nitroquinoline-1-oxide; Animals; Carcinoma, Squamous Cell; Dendritic Cells; Epithelium; Histocompa | 1988 |
Transformation of oral keratinocytes in vitro by 4-nitroquinoline N-oxide.
Topics: 4-Nitroquinoline-1-oxide; Animals; Cell Transformation, Neoplastic; Cells, Cultured; Epidermal Cells | 1988 |
Epithelial dendritic cells and connective tissue macrophages in oral carcinogenesis and the effects of systemic Corynebacterium parvum.
Topics: 4-Nitroquinoline-1-oxide; Animals; Antibodies, Monoclonal; Connective Tissue; Dendritic Cells; Epide | 1989 |
Snuff-induced carcinogenesis: effect of snuff in rats initiated with 4-nitroquinoline N-oxide.
Topics: 4-Nitroquinoline-1-oxide; Animals; Body Weight; Carcinoma, Squamous Cell; Esophageal Neoplasms; Lip | 1989 |
Development of aneuploidy in experimental oral carcinogenesis.
Topics: 4-Nitroquinoline-1-oxide; Aneuploidy; Animals; Cell Line; Cells, Cultured; Colony-Forming Units Assa | 1989 |
Snuff tumorigenesis: effects of long-term snuff administration after initiation with 4-nitroquinoline-N-oxide and herpes simplex virus type 1.
Topics: 4-Nitroquinoline-1-oxide; Animals; Carcinogens; Carcinoma, Squamous Cell; Cocarcinogenesis; Ear Neop | 1989 |
Initiation and promotion of experimental oral mucosal carcinogenesis in mice.
Topics: 4-Nitroquinoline-1-oxide; Animals; Carcinoma, Squamous Cell; Epithelium; Male; Mice; Mice, Inbred CB | 1986 |
The effect of iron deficiency on early oral carcinogenesis in the rat.
Topics: 4-Nitroquinoline-1-oxide; Animals; Body Weight; Carcinoma, Squamous Cell; Cocarcinogenesis; Hyperpla | 1986 |
Oral epithelial atypia and acantholytic dyskeratosis in rats painted with 4-nitroquinoline N-oxide.
Topics: 4-Nitroquinoline-1-oxide; Acantholysis; Animals; Carcinoma, Squamous Cell; Leukoplakia, Oral; Male; | 1986 |
Carcinogenicity of betel quid. III. Enhancement of 4-nitroquinoline-1-oxide- and N-2-fluorenylacetamide-induced carcinogenesis in rats by subsequent administration of betel nut.
Topics: 2-Acetylaminofluorene; 4-Nitroquinoline-1-oxide; Animals; Areca; Chromosome Aberrations; Cocarcinoge | 1986 |
Loss of epithelial cell surface carbohydrates during experimental oral carcinogenesis in the rat.
Topics: 4-Nitroquinoline-1-oxide; Animals; Carbohydrate Metabolism; Carcinoma, Squamous Cell; Cell Membrane; | 1987 |
Dose-response relationship in complete oral 4NQO-carcinogenesis in rats.
Topics: 4-Nitroquinoline-1-oxide; Animals; Carcinoma, Squamous Cell; Dose-Response Relationship, Drug; Femal | 1987 |
The relationship between epithelial Ia expression and the inflammatory cell infiltrate during experimental oral carcinogenesis.
Topics: 4-Nitroquinoline-1-oxide; Animals; Carcinoma, Squamous Cell; Disease Models, Animal; Epithelium; His | 1988 |
Histomorphometric analysis of epithelial changes in chemically induced oral mucosal carcinogenesis in rats.
Topics: 4-Nitroquinoline-1-oxide; Animals; Carcinoma, Squamous Cell; Cell Count; Epithelium; Male; Mouth Muc | 1988 |