4-nitroquinoline-1-oxide has been researched along with Cancer of Head in 37 studies
4-nitroquinoline N-oxide : A quinoline N-oxide carrying a nitro substituent at position 4.
| Excerpt | Relevance | Reference |
|---|---|---|
| " In this study, we performed both assays in 16 established lymphoblastoid cell lines derived from patients with xeroderma pigmentosum (n = 3), ataxia telangiectasia (n = 2), head and neck cancer (n = 3), and melanoma (n = 2), and from normal human subjects (n = 6) using UV light, 4-nitroquinoline-1-oxide (4-NQO; an UV-mimetic agent), and gamma-irradiation as the test agents." | 3.69 | DNA repair capacity correlates with mutagen sensitivity in lymphoblastoid cell lines. ( Cheng, L; Gu, J; Hsu, TC; Kripke, ML; Spitz, MR; Strom, SS; Wei, Q; Xu, X, 1996) |
| "In the 4-NQO model, squamous cell carcinoma, dysplasia, and hyperkeratosis were observed in 75." | 2.87 | Met Receptor Tyrosine Kinase and Chemoprevention of Oral Cancer. ( El-Naggar, AK; Fan, YH; Feng, L; Foy, JP; Hong, WK; Kim, ES; Lang, W; Lee, JJ; Lingen, MW; Lippman, SM; Mao, L; Papadimitrakopoulou, V; Saintigny, P; William, WN; Zhang, L, 2018) |
| "Head and neck cancer is the sixth most common malignancy, and there is an urgent need to identify physiological processes contributing to tumorigenesis." | 1.91 | GPR68 limits the severity of chemical-induced oral epithelial dysplasia. ( Amin, ARMR; Graffeo, V; Griggs, N; McAleer, JP; Shore, D; Xu, Y; Zha, XM, 2023) |
| "Using two in vivo models of oral carcinogenesis with 4-nitroquinoline 1-oxide carcinogen on C57Bl/6 mice and F344 rats, we determined the effect of BRB on GC modulation during head and neck squamous cell carcinoma chemoprevention." | 1.72 | Modulation of the oral glucocorticoid system during black raspberry mediated oral cancer chemoprevention. ( Anderson, K; Iwenofu, H; Jordanides, PP; Lamenza, FF; Nedungadi, D; Oghumu, S; Rakotondraibe, L; Riedl, KM; Ryan, N; Swingler, MJ, 2022) |
| "Early diagnosis of oral squamous cell carcinoma (OSCC) remains an unmet clinical need." | 1.72 | Early antitumor activity of oral Langerhans cells is compromised by a carcinogen. ( Aizenbud, I; Amit, I; Barel, O; Capucha, T; Czerninski, R; David, E; Eli-Berchoer, L; Hovav, AH; Koren, N; Matanes, D; Saba, Y; Stoitzner, P; Wilensky, A; Yona, S; Zubeidat, K, 2022) |
| "Periodontitis was stimulated by placing a ligature subgingivally, while oral carcinogenesis was induced by systemic administration of 4NQO in the drinking water for 20 weeks." | 1.72 | Periodontal disease affects oral cancer progression in a surrogate animal model for tobacco exposure. ( Carrard, VC; Castilho, RM; Gaio, EJ; Nör, F; Rösing, CK; Spuldaro, TR; Squarize, CH; Wagner, VP, 2022) |
| "Oral squamous cell carcinoma (OSCC) is the most common subsite of head and neck cancer, with a 5-year survival rate of only 50%." | 1.62 | 4NQO induced carcinogenesis: A mouse model for oral squamous cell carcinoma. ( Curry, JM; Han, JYS; Martinez-Outschoorn, U; Philp, NJ; Sagheer, SH; Whitaker-Menezes, D, 2021) |
| "Three HNSCC cell lines were then established, and one of these, termed JC1, was selected for further analysis due to its enhanced proliferative ability and tumorigenicity in immunodeficient nude mice." | 1.56 | An HNSCC syngeneic mouse model for tumor immunology research and preclinical evaluation. ( Fu, Y; Li, J; Tian, G; Xu, K; Zhang, Z, 2020) |
| "The role of CD44 in progression of head and neck squamous cell carcinoma (HNSCC) has been controversial." | 1.51 | CD44(+) tumor cells promote early angiogenesis in head and neck squamous cell carcinoma. ( Azambuja, JH; Dolg, L; Gellrich, NC; Gluszko, A; Kampmann, A; Ludwig, N; Szafarowski, T; Szczepanski, MJ; Whiteside, TL; Zimmerer, RM, 2019) |
| "The incidence of extraoral neoplasms was significantly lower (16%) in the younger cohort." | 1.48 | Impact of Age on Disease Progression and Microenvironment in Oral Cancer. ( DeJong, H; Hershberger, PA; Merzianu, M; Patti, A; Rich, LJ; Seshadri, M; Vincent-Chong, VK, 2018) |
| "Oral squamous cell carcinoma (OSCC) was induced by using 4- nitroquinoline-1-oxide (4NQO) as a carcinogen." | 1.46 | Comparison of injectable doxorubicin & its nanodrug complex chemotherapy for the treatment of 4-nitroquinoline-1-oxide induced oral squamous cell carcinoma in rats. ( Abbasi, MM; Abdal, K; Abdollahi, B; Aghbali, AA; Fotohi, S; Hamishehkar, H; Khiavi, MM; Salehi, R; Sina, M, 2017) |
| "Induction of oral carcinogenesis in transgenic mice using 4-nitroquinoline 1-oxide (4NQO) resulted in more extensive and severe tongue tumorigenesis compared with control animals." | 1.43 | MicroRNA-211 Enhances the Oncogenicity of Carcinogen-Induced Oral Carcinoma by Repressing TCF12 and Increasing Antioxidant Activity. ( Chang, KW; Chen, YF; Kao, SY; Lin, SC; Liu, CJ; Yang, CC, 2016) |
| "Head and neck squamous cell carcinoma (HNSCC) is a frequently fatal disease due, in large part, to a high rate of second primary tumor (SPT) formation." | 1.43 | STAT3 as a Chemoprevention Target in Carcinogen-Induced Head and Neck Squamous Cell Carcinoma. ( Acquafondata, M; Freilino, M; Gooding, WE; Grandis, JR; Johnson, DE; Li, H; Peyser, ND; Satake, M; Sen, M; Wang, L; Wang, Z; Zeng, Y, 2016) |
| "The sequencing of the head and neck cancer has provided a blueprint of the most frequent genetic alterations in this cancer type." | 1.39 | PTEN deficiency contributes to the development and progression of head and neck cancer. ( Abrahao, AC; Castilho, RM; Gutkind, JS; Lingen, MW; Molinolo, A; Squarize, CH, 2013) |
| "Head and neck squamous cell carcinoma (HNSCC) is the sixth most common type of cancer affecting humans worldwide." | 1.39 | The molecular features of tongue epithelium treated with the carcinogen 4-nitroquinoline-1-oxide and alcohol as a model for HNSCC. ( Gudas, LJ; Osei-Sarfo, K; Scognamiglio, T; Tang, XH; Urvalek, AM, 2013) |
| " Furthermore, we show that the inhibition of mTOR by the chronic administration of rapamycin halts the malignant conversion of precancerous lesions and promotes the regression of advanced carcinogen-induced SCCs." | 1.35 | Targeting mammalian target of rapamycin by rapamycin prevents tumor progression in an oral-specific chemical carcinogenesis model. ( Amornphimoltham, P; Czerninski, R; Gutkind, JS; Molinolo, AA; Patel, V, 2009) |
| "Head and neck squamous cell carcinoma (HNSCC) is a leading cause of cancer mortality worldwide." | 1.33 | Identification of biomarkers that distinguish human papillomavirus (HPV)-positive versus HPV-negative head and neck cancers in a mouse model. ( Lambert, PF; Pitot, HC; Strati, K, 2006) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (5.41) | 18.2507 |
| 2000's | 3 (8.11) | 29.6817 |
| 2010's | 17 (45.95) | 24.3611 |
| 2020's | 15 (40.54) | 2.80 |
| Authors | Studies |
|---|---|
| Shishodia, G | 1 |
| Toledo, RRG | 1 |
| Rong, X | 1 |
| Zimmerman, E | 1 |
| Xiao, AY | 1 |
| Harrison, L | 1 |
| Nathan, CO | 1 |
| Nedungadi, D | 1 |
| Ryan, N | 1 |
| Anderson, K | 1 |
| Lamenza, FF | 1 |
| Jordanides, PP | 1 |
| Swingler, MJ | 1 |
| Rakotondraibe, L | 1 |
| Riedl, KM | 1 |
| Iwenofu, H | 1 |
| Oghumu, S | 1 |
| Li, JH | 1 |
| Forghani, R | 1 |
| Bure, L | 1 |
| Wojtkiewicz, GR | 1 |
| Wu, Y | 1 |
| Iwamoto, Y | 1 |
| Ali, M | 1 |
| Li, A | 1 |
| Wang, C | 1 |
| Jalali Motlagh, N | 1 |
| Papadakis, AI | 1 |
| Pusztaszeri, MP | 1 |
| Spatz, A | 1 |
| Curtin, H | 1 |
| Cheng, YS | 1 |
| Chen, JW | 1 |
| Saba, Y | 1 |
| Aizenbud, I | 1 |
| Matanes, D | 1 |
| Koren, N | 1 |
| Barel, O | 1 |
| Zubeidat, K | 1 |
| Capucha, T | 1 |
| David, E | 1 |
| Eli-Berchoer, L | 1 |
| Stoitzner, P | 1 |
| Wilensky, A | 1 |
| Amit, I | 1 |
| Czerninski, R | 2 |
| Yona, S | 1 |
| Hovav, AH | 1 |
| Michmerhuizen, NL | 1 |
| Heenan, C | 1 |
| Wang, J | 1 |
| Leonard, E | 1 |
| Bellile, E | 1 |
| Loganathan, SK | 1 |
| Wong, SY | 1 |
| Lei, YL | 1 |
| Brenner, JC | 1 |
| Spuldaro, TR | 1 |
| Wagner, VP | 1 |
| Nör, F | 1 |
| Gaio, EJ | 1 |
| Squarize, CH | 2 |
| Carrard, VC | 1 |
| Rösing, CK | 1 |
| Castilho, RM | 2 |
| Shore, D | 1 |
| Griggs, N | 1 |
| Graffeo, V | 1 |
| Amin, ARMR | 1 |
| Zha, XM | 1 |
| Xu, Y | 1 |
| McAleer, JP | 1 |
| Coeli-Lacchini, FB | 1 |
| da Silva, G | 1 |
| Belentani, M | 1 |
| Alves, JSF | 1 |
| Ushida, TR | 1 |
| Lunardelli, GT | 1 |
| Garcia, CB | 1 |
| Silva, TA | 1 |
| Lopes, NP | 1 |
| Leopoldino, AM | 1 |
| Sahu, SR | 1 |
| Thakur, S | 1 |
| Peroumal, D | 1 |
| Utkalaja, BG | 1 |
| Dutta, A | 1 |
| Kumari, P | 1 |
| Subhadarsini, I | 1 |
| Acharya, N | 1 |
| Ludwig, N | 1 |
| Szczepanski, MJ | 1 |
| Gluszko, A | 1 |
| Szafarowski, T | 1 |
| Azambuja, JH | 1 |
| Dolg, L | 1 |
| Gellrich, NC | 1 |
| Kampmann, A | 1 |
| Whiteside, TL | 1 |
| Zimmerer, RM | 1 |
| Kalish, JM | 1 |
| Tang, XH | 2 |
| Scognamiglio, T | 2 |
| Zhang, T | 1 |
| Gudas, LJ | 2 |
| Wei, T | 1 |
| Buehler, D | 1 |
| Ward-Shaw, E | 1 |
| Lambert, PF | 4 |
| Fu, Y | 1 |
| Tian, G | 1 |
| Li, J | 1 |
| Zhang, Z | 1 |
| Xu, K | 1 |
| Verza, FA | 1 |
| Valente, VB | 1 |
| Oliveira, LK | 1 |
| Kayahara, GM | 1 |
| Crivelini, MM | 1 |
| Furuse, C | 1 |
| Biasoli, ÉR | 1 |
| Miyahara, GI | 1 |
| Oliveira, SHP | 1 |
| Bernabé, DG | 1 |
| Sagheer, SH | 1 |
| Whitaker-Menezes, D | 1 |
| Han, JYS | 1 |
| Curry, JM | 1 |
| Martinez-Outschoorn, U | 1 |
| Philp, NJ | 1 |
| Shi, Y | 1 |
| Xie, TX | 1 |
| Leach, DG | 1 |
| Wang, B | 1 |
| Young, S | 1 |
| Osman, AA | 1 |
| Sikora, AG | 1 |
| Ren, X | 1 |
| Hartgerink, JD | 1 |
| Myers, JN | 1 |
| Rangel, R | 1 |
| Khiavi, MM | 1 |
| Abdal, K | 1 |
| Abbasi, MM | 1 |
| Hamishehkar, H | 1 |
| Aghbali, AA | 1 |
| Salehi, R | 1 |
| Sina, M | 1 |
| Abdollahi, B | 1 |
| Fotohi, S | 1 |
| Saintigny, P | 1 |
| William, WN | 1 |
| Foy, JP | 1 |
| Papadimitrakopoulou, V | 1 |
| Lang, W | 1 |
| Zhang, L | 1 |
| Fan, YH | 1 |
| Feng, L | 1 |
| Kim, ES | 1 |
| El-Naggar, AK | 1 |
| Lee, JJ | 1 |
| Mao, L | 1 |
| Hong, WK | 1 |
| Lingen, MW | 2 |
| Lippman, SM | 1 |
| Vincent-Chong, VK | 1 |
| DeJong, H | 1 |
| Rich, LJ | 1 |
| Patti, A | 1 |
| Merzianu, M | 2 |
| Hershberger, PA | 2 |
| Seshadri, M | 2 |
| Abrahao, AC | 1 |
| Molinolo, A | 1 |
| Gutkind, JS | 2 |
| Chu, TH | 1 |
| Yang, CC | 2 |
| Liu, CJ | 2 |
| Lui, MT | 1 |
| Lin, SC | 2 |
| Chang, KW | 2 |
| Osei-Sarfo, K | 1 |
| Urvalek, AM | 1 |
| Paparella, ML | 1 |
| Abrigo, M | 1 |
| Bal de Kier Joffe, E | 1 |
| Raimondi, AR | 1 |
| Bothwell, KD | 1 |
| Shaurova, T | 1 |
| Suresh, A | 1 |
| Kuriakose, MA | 1 |
| Johnson, CS | 1 |
| Jadav, RS | 1 |
| Kumar, D | 1 |
| Buwa, N | 1 |
| Ganguli, S | 1 |
| Thampatty, SR | 1 |
| Balasubramanian, N | 1 |
| Bhandari, R | 1 |
| Chen, YF | 1 |
| Kao, SY | 1 |
| Peyser, ND | 1 |
| Wang, L | 1 |
| Zeng, Y | 1 |
| Acquafondata, M | 1 |
| Freilino, M | 1 |
| Li, H | 1 |
| Sen, M | 1 |
| Gooding, WE | 1 |
| Satake, M | 1 |
| Wang, Z | 1 |
| Johnson, DE | 1 |
| Grandis, JR | 1 |
| Amornphimoltham, P | 1 |
| Patel, V | 1 |
| Molinolo, AA | 1 |
| Jabbar, S | 1 |
| Strati, K | 3 |
| Shin, MK | 1 |
| Pitot, HC | 3 |
| Park, JW | 1 |
| Spardy, N | 1 |
| Duensing, S | 1 |
| Grompe, M | 1 |
| De Costa, AM | 1 |
| Justis, DN | 1 |
| Schuyler, CA | 1 |
| Young, MR | 1 |
| Feith, DJ | 1 |
| Pegg, AE | 1 |
| Fong, LY | 1 |
| Ohkoshi, A | 1 |
| Suzuki, T | 1 |
| Ono, M | 1 |
| Kobayashi, T | 1 |
| Yamamoto, M | 1 |
| Kim, MM | 1 |
| Glazer, CA | 1 |
| Mambo, E | 1 |
| Chatterjee, A | 1 |
| Zhao, M | 1 |
| Sidransky, D | 1 |
| Califano, JA | 1 |
| Wei, Q | 1 |
| Spitz, MR | 1 |
| Gu, J | 1 |
| Cheng, L | 1 |
| Xu, X | 1 |
| Strom, SS | 1 |
| Kripke, ML | 1 |
| Hsu, TC | 1 |
| Johansson, SL | 1 |
| Saidi, J | 1 |
| Osterdahl, BG | 1 |
| Smith, RA | 1 |
1 trial available for 4-nitroquinoline-1-oxide and Cancer of Head
| Article | Year |
|---|---|
Met Receptor Tyrosine Kinase and Chemoprevention of Oral Cancer.
Topics: 4-Nitroquinoline-1-oxide; Animals; Antineoplastic Agents; Biomarkers, Tumor; Carcinoma, Squamous Cel | 2018 |
36 other studies available for 4-nitroquinoline-1-oxide and Cancer of Head
| Article | Year |
|---|---|
4NQO enhances differential activation of DNA repair proteins in HPV positive and HPV negative HNSCC cells.
Topics: 4-Nitroquinoline-1-oxide; Cells, Cultured; DNA Repair; Head and Neck Neoplasms; Humans; Keratinocyte | 2021 |
Modulation of the oral glucocorticoid system during black raspberry mediated oral cancer chemoprevention.
Topics: 4-Nitroquinoline-1-oxide; Animals; Carcinogenesis; Carcinogens; Carcinoma, Squamous Cell; Cell Line, | 2022 |
Molecular immuno-imaging improves tumor detection in head and neck cancer.
Topics: 4-Nitroquinoline-1-oxide; Animals; Biomarkers, Tumor; Cell Line, Tumor; Female; Head and Neck Neopla | 2022 |
Early antitumor activity of oral Langerhans cells is compromised by a carcinogen.
Topics: 4-Nitroquinoline-1-oxide; Antineoplastic Agents; Carcinogens; Cell Line, Tumor; Dendritic Cells; Epi | 2022 |
Combined Pik3ca-H1047R and loss-of-function Notch1 alleles decrease survival time in a 4-nitroquinoline N-oxide-driven head and neck squamous cell carcinoma model.
Topics: 4-Nitroquinoline-1-oxide; Alleles; Class I Phosphatidylinositol 3-Kinases; Head and Neck Neoplasms; | 2022 |
Periodontal disease affects oral cancer progression in a surrogate animal model for tobacco exposure.
Topics: 4-Nitroquinoline-1-oxide; Animals; Carcinogenesis; Carcinoma, Squamous Cell; Disease Models, Animal; | 2022 |
GPR68 limits the severity of chemical-induced oral epithelial dysplasia.
Topics: 4-Nitroquinoline-1-oxide; Animals; Carcinogenesis; Carcinoma, Squamous Cell; Cell Transformation, Ne | 2023 |
Spermidine Suppresses Oral Carcinogenesis through Autophagy Induction, DNA Damage Repair, and Oxidative Stress Reduction.
Topics: 4-Nitroquinoline-1-oxide; Animals; Carcinogenesis; Carcinogens; Carcinoma, Squamous Cell; Ceramides; | 2023 |
4-nitroquinoline 1-oxide induces immune cells death to onset early immunosuppression during oral squamous cell carcinoma development.
Topics: 4-Nitroquinoline-1-oxide; Animals; Apoptosis; Carcinoma, Squamous Cell; Head and Neck Neoplasms; Hum | 2023 |
CD44(+) tumor cells promote early angiogenesis in head and neck squamous cell carcinoma.
Topics: 4-Nitroquinoline-1-oxide; Animals; Case-Control Studies; Cell Line, Tumor; Female; Gene Expression P | 2019 |
Doxycycline-induced exogenous Bmi-1 expression enhances tumor formation in a murine model of oral squamous cell carcinoma.
Topics: 4-Nitroquinoline-1-oxide; Animals; Anti-Bacterial Agents; Carcinogenesis; Carcinogens; Disease Model | 2020 |
An Infection-Based Murine Model for Papillomavirus-Associated Head and Neck Cancer.
Topics: 4-Nitroquinoline-1-oxide; Animals; Carcinogens; Carcinoma, Squamous Cell; Disease Models, Animal; Fe | 2020 |
An HNSCC syngeneic mouse model for tumor immunology research and preclinical evaluation.
Topics: 4-Nitroquinoline-1-oxide; Animals; Cell Line, Tumor; Coculture Techniques; DNA Mismatch Repair; Exom | 2020 |
Social isolation stress facilitates chemically induced oral carcinogenesis.
Topics: 4-Nitroquinoline-1-oxide; Animals; Behavior, Animal; Cytokines; Depression; Head and Neck Neoplasms; | 2021 |
4NQO induced carcinogenesis: A mouse model for oral squamous cell carcinoma.
Topics: 4-Nitroquinoline-1-oxide; Animals; Carcinogenesis; Carcinoma, Squamous Cell; Head and Neck Neoplasms | 2021 |
Local Anti-PD-1 Delivery Prevents Progression of Premalignant Lesions in a 4NQO-Oral Carcinogenesis Mouse Model.
Topics: 4-Nitroquinoline-1-oxide; Animals; Antibodies, Monoclonal; Carcinogenesis; Disease Models, Animal; D | 2021 |
Comparison of injectable doxorubicin & its nanodrug complex chemotherapy for the treatment of 4-nitroquinoline-1-oxide induced oral squamous cell carcinoma in rats.
Topics: 4-Nitroquinoline-1-oxide; Animals; Carcinoma, Squamous Cell; Disease Models, Animal; Doxorubicin; Dr | 2017 |
Impact of Age on Disease Progression and Microenvironment in Oral Cancer.
Topics: 4-Nitroquinoline-1-oxide; Age Factors; Animals; Carcinoma, Squamous Cell; Disease Progression; Femal | 2018 |
PTEN deficiency contributes to the development and progression of head and neck cancer.
Topics: 4-Nitroquinoline-1-oxide; Animals; Carcinogenesis; Carcinoma, Squamous Cell; Cells, Cultured; Cycloo | 2013 |
miR-211 promotes the progression of head and neck carcinomas by targeting TGFβRII.
Topics: 4-Nitroquinoline-1-oxide; Animals; Carcinoma, Squamous Cell; Disease Progression; Genes, myc; Head a | 2013 |
The molecular features of tongue epithelium treated with the carcinogen 4-nitroquinoline-1-oxide and alcohol as a model for HNSCC.
Topics: 4-Nitroquinoline-1-oxide; Animals; beta Catenin; Blotting, Western; Carcinogens; Carcinoma, Squamous | 2013 |
Oral-specific ablation of Klf4 disrupts epithelial terminal differentiation and increases premalignant lesions and carcinomas upon chemical carcinogenesis.
Topics: 4-Nitroquinoline-1-oxide; Animals; Carcinogenesis; Carcinogens; Carcinoma, Squamous Cell; Cell Diffe | 2015 |
Impact of Short-term 1,25-Dihydroxyvitamin D3 on the Chemopreventive Efficacy of Erlotinib against Oral Cancer.
Topics: 4-Nitroquinoline-1-oxide; Animals; Anticarcinogenic Agents; Antineoplastic Agents; Calcitriol; Carci | 2015 |
Deletion of inositol hexakisphosphate kinase 1 (IP6K1) reduces cell migration and invasion, conferring protection from aerodigestive tract carcinoma in mice.
Topics: 4-Nitroquinoline-1-oxide; Animals; Cell Adhesion; Cell Movement; Extracellular Space; Fibroblasts; F | 2016 |
MicroRNA-211 Enhances the Oncogenicity of Carcinogen-Induced Oral Carcinoma by Repressing TCF12 and Increasing Antioxidant Activity.
Topics: 4-Nitroquinoline-1-oxide; Animals; Basic Helix-Loop-Helix Transcription Factors; Blotting, Western; | 2016 |
STAT3 as a Chemoprevention Target in Carcinogen-Induced Head and Neck Squamous Cell Carcinoma.
Topics: 4-Nitroquinoline-1-oxide; Animals; Biomarkers; Carcinogens; Carcinoma, Squamous Cell; Chemopreventio | 2016 |
Targeting mammalian target of rapamycin by rapamycin prevents tumor progression in an oral-specific chemical carcinogenesis model.
Topics: 4-Nitroquinoline-1-oxide; Animals; Antibiotics, Antineoplastic; Carcinogens; Carcinoma, Squamous Cel | 2009 |
Human papillomavirus type 16 E6 and E7 oncoproteins act synergistically to cause head and neck cancer in mice.
Topics: 4-Nitroquinoline-1-oxide; Animals; Carcinogens; Disease Models, Animal; Head and Neck Neoplasms; Hum | 2010 |
Deficiencies in the Fanconi anemia DNA damage response pathway increase sensitivity to HPV-associated head and neck cancer.
Topics: 4-Nitroquinoline-1-oxide; Animals; Biomarkers, Tumor; Carcinoma, Squamous Cell; DNA Damage; Fanconi | 2010 |
Administration of a vaccine composed of dendritic cells pulsed with premalignant oral lesion lysate to mice bearing carcinogen-induced premalignant oral lesions stimulates a protective immune response.
Topics: 4-Nitroquinoline-1-oxide; Animals; Antigens, Neoplasm; Cancer Vaccines; Carcinogens; Carcinoma, Squa | 2012 |
Targeted expression of ornithine decarboxylase antizyme prevents upper aerodigestive tract carcinogenesis in p53-deficient mice.
Topics: 4-Nitroquinoline-1-oxide; Animals; Carcinoma, Squamous Cell; Cell Proliferation; Cell Transformation | 2013 |
Roles of Keap1-Nrf2 system in upper aerodigestive tract carcinogenesis.
Topics: 4-Nitroquinoline-1-oxide; Adaptor Proteins, Signal Transducing; Animals; Cell Transformation, Neopla | 2013 |
Head and neck cancer cell lines exhibit differential mitochondrial repair deficiency in response to 4NQO.
Topics: 4-Nitroquinoline-1-oxide; Carcinoma, Squamous Cell; DNA Adducts; DNA Damage; DNA Repair; DNA, Mitoch | 2006 |
Identification of biomarkers that distinguish human papillomavirus (HPV)-positive versus HPV-negative head and neck cancers in a mouse model.
Topics: 4-Nitroquinoline-1-oxide; Animals; Biomarkers, Tumor; Carcinogens; Carcinoma, Squamous Cell; Cell Cy | 2006 |
DNA repair capacity correlates with mutagen sensitivity in lymphoblastoid cell lines.
Topics: 4-Nitroquinoline-1-oxide; Ataxia Telangiectasia; Biomarkers; Carcinogens; Cell Line; Chromatids; Chr | 1996 |
Promoting effect of snuff in rats initiated by 4-nitroquinoline-N-oxide or 7,12-dimethylbenz(a)anthracene.
Topics: 4-Nitroquinoline-1-oxide; 9,10-Dimethyl-1,2-benzanthracene; Animals; Body Weight; Carcinogens; Drug | 1991 |