4-nitroquinoline-1-oxide has been researched along with Cancer of Esophagus in 33 studies
4-nitroquinoline N-oxide : A quinoline N-oxide carrying a nitro substituent at position 4.
| Excerpt | Relevance | Reference |
|---|---|---|
| " We used the 4-nitroquinoline-1-oxide (4-NQO) murine model of oral carcinogenesis and the Meadows-Cook model of alcohol abuse to assess changes in the expression of molecular markers during the initial stages of ESCC." | 7.81 | Initiation of esophageal squamous cell carcinoma (ESCC) in a murine 4-nitroquinoline-1-oxide and alcohol carcinogenesis model. ( Gudas, LJ; Osei-Sarfo, K; Scognamiglio, T; Tang, XH; Urvalek, AM, 2015) |
| "We investigated the effects of bexarotene (a retinoid X receptor agonist), CD1530 (a retinoic acid receptor γ selective agonist), and the combination of these two drugs for the prevention of oral carcinogenesis induced by the carcinogen 4-nitroquinoline 1-oxide (4-NQO) in a mouse model of human oral-cavity and esophageal squamous-cell carcinoma previously generated in our laboratory." | 7.80 | Combination of bexarotene and the retinoid CD1530 reduces murine oral-cavity carcinogenesis induced by the carcinogen 4-nitroquinoline 1-oxide. ( Gudas, LJ; Osei-Sarfo, K; Scognamiglio, T; Tang, XH; Urvalek, AM; Zhang, T, 2014) |
| " We used the 4-nitroquinoline-1-oxide (4-NQO) murine model of oral carcinogenesis and the Meadows-Cook model of alcohol abuse to assess changes in the expression of molecular markers during the initial stages of ESCC." | 3.81 | Initiation of esophageal squamous cell carcinoma (ESCC) in a murine 4-nitroquinoline-1-oxide and alcohol carcinogenesis model. ( Gudas, LJ; Osei-Sarfo, K; Scognamiglio, T; Tang, XH; Urvalek, AM, 2015) |
| "We investigated the effects of bexarotene (a retinoid X receptor agonist), CD1530 (a retinoic acid receptor γ selective agonist), and the combination of these two drugs for the prevention of oral carcinogenesis induced by the carcinogen 4-nitroquinoline 1-oxide (4-NQO) in a mouse model of human oral-cavity and esophageal squamous-cell carcinoma previously generated in our laboratory." | 3.80 | Combination of bexarotene and the retinoid CD1530 reduces murine oral-cavity carcinogenesis induced by the carcinogen 4-nitroquinoline 1-oxide. ( Gudas, LJ; Osei-Sarfo, K; Scognamiglio, T; Tang, XH; Urvalek, AM; Zhang, T, 2014) |
| "Esophageal cancer occurs as either squamous cell carcinoma (ESCC) or adenocarcinoma." | 1.48 | Dek overexpression in murine epithelia increases overt esophageal squamous cell carcinoma incidence. ( Cimperman, KA; Ehrman, LA; Guasch, G; Haas, SR; Komurov, K; Lane, A; Matrka, MC; Waclaw, RR; Wells, SI; Wikenheiser-Brokamp, KA, 2018) |
| "Esophageal and tongue cancers have both been associated with dietary zinc deficiency (ZD), and cyclooxygenase (COX-2) is often overexpressed in these cancers." | 1.33 | Dietary zinc modulation of COX-2 expression and lingual and esophageal carcinogenesis in rats. ( Farber, JL; Fong, LY; Jiang, Y; Zhang, L, 2005) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (6.06) | 18.7374 |
| 1990's | 1 (3.03) | 18.2507 |
| 2000's | 8 (24.24) | 29.6817 |
| 2010's | 17 (51.52) | 24.3611 |
| 2020's | 5 (15.15) | 2.80 |
| Authors | Studies |
|---|---|
| He, Y | 1 |
| Rivera, J | 1 |
| Diossy, M | 1 |
| Duan, H | 1 |
| Bowman-Colin, C | 1 |
| Reed, R | 1 |
| Jennings, R | 1 |
| Novak, J | 1 |
| Tran, SV | 1 |
| Cohen, EF | 1 |
| Szuts, D | 1 |
| Giobbie-Hurder, A | 1 |
| Bronson, RT | 1 |
| Bass, AJ | 1 |
| Signoretti, S | 1 |
| Szallasi, Z | 1 |
| Livingston, DM | 1 |
| Pathania, S | 1 |
| Luo, Y | 1 |
| Du, L | 1 |
| Yao, Z | 1 |
| Liu, F | 1 |
| Li, K | 1 |
| Li, F | 1 |
| Zhu, J | 1 |
| Coppes, RP | 1 |
| Zhang, D | 1 |
| Pan, Y | 1 |
| Gao, S | 1 |
| Zhang, H | 1 |
| Aziz, Z | 1 |
| Washington, MK | 1 |
| Jacobse, J | 1 |
| Choksi, Y | 1 |
| Han, L | 1 |
| Gao, QL | 1 |
| Zhou, XM | 1 |
| Shi, C | 1 |
| Chen, GY | 1 |
| Song, YP | 1 |
| Yao, YJ | 1 |
| Zhao, YM | 1 |
| Wen, XY | 1 |
| Liu, SL | 1 |
| Qi, YM | 1 |
| Gao, YF | 1 |
| Horiuchi, M | 1 |
| Taguchi, K | 1 |
| Hirose, W | 1 |
| Tsuchida, K | 1 |
| Suzuki, M | 1 |
| Taniyama, Y | 1 |
| Kamei, T | 1 |
| Yamamoto, M | 1 |
| Matrka, MC | 1 |
| Cimperman, KA | 1 |
| Haas, SR | 1 |
| Guasch, G | 1 |
| Ehrman, LA | 1 |
| Waclaw, RR | 1 |
| Komurov, K | 1 |
| Lane, A | 1 |
| Wikenheiser-Brokamp, KA | 1 |
| Wells, SI | 1 |
| Zhao, L | 1 |
| Ma, M | 1 |
| Wu, H | 1 |
| Zhang, C | 1 |
| Dai, S | 1 |
| Dong, P | 1 |
| Huo, B | 1 |
| Shan, B | 1 |
| Sawangarun, W | 1 |
| Mandasari, M | 1 |
| Aida, J | 1 |
| Morita, KI | 1 |
| Kayamori, K | 1 |
| Ikeda, T | 1 |
| Sakamoto, K | 1 |
| Zhou, YX | 1 |
| Fuentes-Creollo, G | 1 |
| Ponce, F | 1 |
| Langley, SA | 1 |
| Jen, KY | 1 |
| Celniker, SE | 1 |
| Mao, JH | 1 |
| Snijders, AM | 1 |
| Yue, GG | 1 |
| Li, L | 1 |
| Lee, JK | 1 |
| Kwok, HF | 1 |
| Wong, EC | 1 |
| Li, M | 1 |
| Fung, KP | 1 |
| Yu, J | 1 |
| Chan, AW | 1 |
| Chiu, PW | 1 |
| Lau, CB | 1 |
| Sarkar, J | 1 |
| Dominguez, E | 1 |
| Li, G | 1 |
| Kusewitt, DF | 1 |
| Johnson, DG | 1 |
| Tang, XH | 4 |
| Osei-Sarfo, K | 3 |
| Urvalek, AM | 3 |
| Zhang, T | 2 |
| Scognamiglio, T | 3 |
| Gudas, LJ | 4 |
| Tseng, SH | 1 |
| Yang, CC | 1 |
| Yu, EH | 1 |
| Chang, C | 1 |
| Lee, YS | 1 |
| Liu, CJ | 1 |
| Chang, KW | 1 |
| Lin, SC | 1 |
| Chen, MF | 2 |
| Kuan, FC | 1 |
| Yen, TC | 2 |
| Lu, MS | 1 |
| Lin, PY | 2 |
| Chung, YH | 1 |
| Chen, WC | 2 |
| Lee, KD | 1 |
| Wang, S | 2 |
| Du, Z | 1 |
| Luo, J | 1 |
| Wang, X | 1 |
| Li, H | 1 |
| Liu, Y | 1 |
| Zhang, Y | 1 |
| Ma, J | 1 |
| Xiao, W | 1 |
| Wang, Y | 1 |
| Zhong, X | 1 |
| Chen, PT | 1 |
| Hsieh, CC | 1 |
| Wu, CT | 1 |
| Wang, L | 1 |
| Cao, NN | 1 |
| Man, HW | 1 |
| Li, PF | 1 |
| Shan, BE | 1 |
| Chen, CH | 1 |
| Lu, HI | 1 |
| Wang, YM | 1 |
| Chen, YH | 1 |
| Lo, CM | 1 |
| Huang, WT | 1 |
| Li, SH | 1 |
| Morrison, BH | 1 |
| Haney, R | 1 |
| Lamarre, E | 1 |
| Drazba, J | 1 |
| Prestwich, GD | 1 |
| Lindner, DJ | 1 |
| Baba, S | 1 |
| Yamada, Y | 1 |
| Hatano, Y | 1 |
| Miyazaki, Y | 1 |
| Mori, H | 1 |
| Shibata, T | 1 |
| Hara, A | 1 |
| Wan, SG | 1 |
| Taccioli, C | 1 |
| Jiang, Y | 4 |
| Chen, H | 1 |
| Smalley, KJ | 1 |
| Huang, K | 1 |
| Liu, XP | 1 |
| Farber, JL | 3 |
| Croce, CM | 2 |
| Fong, LY | 5 |
| Feith, DJ | 1 |
| Pegg, AE | 1 |
| Knudsen, B | 1 |
| Bemis, D | 1 |
| Tickoo, S | 1 |
| Zhang, L | 2 |
| Liu, CG | 1 |
| Chatterjee, D | 1 |
| Huebner, K | 1 |
| Gunji, A | 1 |
| Uemura, A | 1 |
| Tsutsumi, M | 1 |
| Nozaki, T | 1 |
| Kusuoka, O | 1 |
| Omura, K | 1 |
| Suzuki, H | 1 |
| Nakagama, H | 1 |
| Sugimura, T | 1 |
| Masutani, M | 1 |
| Miyamoto, S | 1 |
| Yasui, Y | 1 |
| Kim, M | 1 |
| Sugie, S | 1 |
| Murakami, A | 1 |
| Ishigamori-Suzuki, R | 1 |
| Tanaka, T | 1 |
| Ito, N | 1 |
| Kitano, M | 1 |
| Hatano, H | 1 |
| Shisa, H | 1 |
| Johansson, SL | 1 |
| Hirsch, JM | 1 |
| Larsson, PA | 1 |
| Saidi, J | 1 |
| Osterdahl, BG | 1 |
1 review available for 4-nitroquinoline-1-oxide and Cancer of Esophagus
| Article | Year |
|---|---|
In vivo carcinogenesis of 4-nitroquinoline 1-oxide and related compounds.
Topics: 4-Nitroquinoline-1-oxide; Animals; Carcinogens; Esophageal Neoplasms; Intestinal Neoplasms; Liver Ne | 1981 |
32 other studies available for 4-nitroquinoline-1-oxide and Cancer of Esophagus
| Article | Year |
|---|---|
Topics: 4-Nitroquinoline-1-oxide; Animals; BRCA1 Protein; Cell Line, Tumor; Cell Transformation, Neoplastic; | 2021 |
Generation and Application of Inducible Chimeric RNA
Topics: 4-Nitroquinoline-1-oxide; Animals; Body Weight; Carcinogens; Disease Models, Animal; Esophageal Neop | 2022 |
A method for scoring 4-nitroquinoline 1-oxide-induced murine esophageal squamous neoplasia.
Topics: 4-Nitroquinoline-1-oxide; Animals; Carcinogens; Carcinoma; Esophageal Neoplasms; Esophageal Squamous | 2023 |
Characterization of CD103
Topics: 4-Nitroquinoline-1-oxide; Adult; Aged; Animals; Antibodies, Monoclonal; Antigens, CD; Biomarkers, Tu | 2020 |
Cellular Nrf2 Levels Determine Cell Fate during Chemical Carcinogenesis in Esophageal Epithelium.
Topics: 4-Nitroquinoline-1-oxide; Alleles; Animals; Carcinogenesis; Carcinogens; DNA Damage; Epithelium; Eso | 2021 |
Dek overexpression in murine epithelia increases overt esophageal squamous cell carcinoma incidence.
Topics: 4-Nitroquinoline-1-oxide; Animals; Carcinoma, Squamous Cell; DNA-Binding Proteins; Epithelium; Esoph | 2018 |
p-Hydroxylcinnamaldehyde slows the progression of 4NQO-induced oesophageal tumourigenesis via the RhoA-MAPK signaling pathway.
Topics: 4-Nitroquinoline-1-oxide; Animals; Carcinogenesis; Cinnamates; Disease Progression; Esophageal Neopl | 2018 |
Loss of Notch1 predisposes oro-esophageal epithelium to tumorigenesis.
Topics: 4-Nitroquinoline-1-oxide; Animals; Carcinogenesis; Disease Models, Animal; Epithelium; Esophageal Ne | 2018 |
No difference in 4-nitroquinoline induced tumorigenesis between germ-free and colonized mice.
Topics: 4-Nitroquinoline-1-oxide; Animals; Carcinogenesis; Carcinogens; Carcinoma, Squamous Cell; Cell Trans | 2019 |
Multiple modulatory activities of Andrographis paniculata on immune responses and xenograft growth in esophageal cancer preclinical models.
Topics: 4-Nitroquinoline-1-oxide; Administration, Oral; Andrographis; Animals; Apoptosis; Cell Line, Tumor; | 2019 |
Modeling gene-environment interactions in oral cavity and esophageal cancers demonstrates a role for the p53 R72P polymorphism in modulating susceptibility.
Topics: 4-Nitroquinoline-1-oxide; Animals; Blotting, Western; Carcinogens; Cells, Cultured; DNA, Viral; Esop | 2014 |
Combination of bexarotene and the retinoid CD1530 reduces murine oral-cavity carcinogenesis induced by the carcinogen 4-nitroquinoline 1-oxide.
Topics: 4-Nitroquinoline-1-oxide; Animals; Anticarcinogenic Agents; Benzoates; beta Catenin; Bexarotene; Car | 2014 |
K14-EGFP-miR-31 transgenic mice have high susceptibility to chemical-induced squamous cell tumorigenesis that is associating with Ku80 repression.
Topics: 4-Nitroquinoline-1-oxide; Animals; Antigens, Nuclear; Carcinoma, Squamous Cell; Cell Line, Tumor; DN | 2015 |
IL-6-stimulated CD11b+ CD14+ HLA-DR- myeloid-derived suppressor cells, are associated with progression and poor prognosis in squamous cell carcinoma of the esophagus.
Topics: 4-Nitroquinoline-1-oxide; Animals; Arginase; Carcinoma, Squamous Cell; Case-Control Studies; CD11b A | 2014 |
Inhibition of heat shock protein 90 suppresses squamous carcinogenic progression in a mouse model of esophageal cancer.
Topics: 4-Nitroquinoline-1-oxide; Animals; Carcinogens; Carcinoma, Squamous Cell; Cell Proliferation; Cell T | 2015 |
Initiation of esophageal squamous cell carcinoma (ESCC) in a murine 4-nitroquinoline-1-oxide and alcohol carcinogenesis model.
Topics: 4-Nitroquinoline-1-oxide; Animals; Carcinogenesis; Carcinogens; Carcinoma, Squamous Cell; Cell Proli | 2015 |
1α,25-Dihydroxyvitamin D3 Inhibits Esophageal Squamous Cell Carcinoma Progression by Reducing IL6 Signaling.
Topics: 4-Nitroquinoline-1-oxide; Animals; Calcitriol; Carcinoma, Squamous Cell; Cell Line, Tumor; Cell Prol | 2015 |
Gene expression profiling signatures for the diagnosis and prevention of oral cavity carcinogenesis-genome-wide analysis using RNA-seq technology.
Topics: 4-Nitroquinoline-1-oxide; Animals; Biomarkers, Tumor; Carcinogenesis; Carcinogens; Carcinoma, Squamo | 2015 |
Roles of coinhibitory molecules B7-H3 and B7-H4 in esophageal squamous cell carcinoma.
Topics: 4-Nitroquinoline-1-oxide; Adult; Aged; Animals; B7 Antigens; Carcinoma, Squamous Cell; Cell Line, Tu | 2016 |
Areca nut is associated with younger age of diagnosis, poor chemoradiotherapy response, and shorter overall survival in esophageal squamous cell carcinoma.
Topics: 4-Nitroquinoline-1-oxide; Adult; Aged; Aged, 80 and over; Animals; Antineoplastic Agents; Areca; Are | 2017 |
Gene deletion of inositol hexakisphosphate kinase 2 predisposes to aerodigestive tract carcinoma.
Topics: 4-Nitroquinoline-1-oxide; Animals; Apoptosis; Carcinogens; Carcinoma, Squamous Cell; Esophageal Neop | 2009 |
Global DNA hypomethylation suppresses squamous carcinogenesis in the tongue and esophagus.
Topics: 4-Nitroquinoline-1-oxide; Alleles; Animals; Carcinoma, Squamous Cell; Cell Line, Tumor; DNA (Cytosin | 2009 |
Zinc deficiency activates S100A8 inflammation in the absence of COX-2 and promotes murine oral-esophageal tumor progression.
Topics: 4-Nitroquinoline-1-oxide; Animals; Calgranulin A; Carcinogens; Cyclooxygenase 2; Dimethylnitrosamine | 2011 |
Targeted expression of ornithine decarboxylase antizyme prevents upper aerodigestive tract carcinogenesis in p53-deficient mice.
Topics: 4-Nitroquinoline-1-oxide; Animals; Carcinoma, Squamous Cell; Cell Proliferation; Cell Transformation | 2013 |
Oral cavity and esophageal carcinogenesis modeled in carcinogen-treated mice.
Topics: 4-Nitroquinoline-1-oxide; Animals; Bromodeoxyuridine; Carcinogens; Carcinoma, Papillary; Carcinoma, | 2004 |
Dietary zinc modulation of COX-2 expression and lingual and esophageal carcinogenesis in rats.
Topics: 4-Nitroquinoline-1-oxide; Animals; Apoptosis; Blotting, Western; Carcinogens; Carcinoma, Squamous Ce | 2005 |
Modulation of gene expression in precancerous rat esophagus by dietary zinc deficit and replenishment.
Topics: 4-Nitroquinoline-1-oxide; Animals; Carcinoma, Squamous Cell; Esophageal Neoplasms; Gene Expression R | 2005 |
Parp-1 deficiency does not increase the frequency of tumors in the oral cavity and esophagus of ICR/129Sv mice by 4-nitroquinoline 1-oxide, a carcinogen producing bulky adducts.
Topics: 4-Nitroquinoline-1-oxide; Animals; Carcinogens; Esophageal Neoplasms; Mice; Mice, Inbred ICR; Mice, | 2006 |
Zinc deficiency potentiates induction and progression of lingual and esophageal tumors in p53-deficient mice.
Topics: 4-Nitroquinoline-1-oxide; Animals; Biomarkers, Tumor; Carcinogens; Cyclooxygenase 2; Disease Models, | 2006 |
A novel rasH2 mouse carcinogenesis model that is highly susceptible to 4-NQO-induced tongue and esophageal carcinogenesis is useful for preclinical chemoprevention studies.
Topics: 4-Nitroquinoline-1-oxide; Animals; Anticarcinogenic Agents; Cell Proliferation; Dinoprostone; Esopha | 2008 |
Strain difference of susceptibility to 4-nitroquinoline 1-oxide-induced tongue carcinoma in rats.
Topics: 4-Nitroquinoline-1-oxide; Animals; Carcinogenicity Tests; Esophageal Neoplasms; Female; Male; Mouth | 1992 |
Snuff-induced carcinogenesis: effect of snuff in rats initiated with 4-nitroquinoline N-oxide.
Topics: 4-Nitroquinoline-1-oxide; Animals; Body Weight; Carcinoma, Squamous Cell; Esophageal Neoplasms; Lip | 1989 |