4-nitroquinoline-1-oxide has been researched along with Ataxia Telangiectasia in 12 studies
4-nitroquinoline N-oxide : A quinoline N-oxide carrying a nitro substituent at position 4.
Ataxia Telangiectasia: An autosomal recessive inherited disorder characterized by choreoathetosis beginning in childhood, progressive CEREBELLAR ATAXIA; TELANGIECTASIS of CONJUNCTIVA and SKIN; DYSARTHRIA; B- and T-cell immunodeficiency, and RADIOSENSITIVITY to IONIZING RADIATION. Affected individuals are prone to recurrent sinobronchopulmonary infections, lymphoreticular neoplasms, and other malignancies. Serum ALPHA-FETOPROTEINS are usually elevated. (Menkes, Textbook of Child Neurology, 5th ed, p688) The gene for this disorder (ATM) encodes a cell cycle checkpoint protein kinase and has been mapped to chromosome 11 (11q22-q23).
| Excerpt | Relevance | Reference |
|---|---|---|
| " In this study, we performed both assays in 16 established lymphoblastoid cell lines derived from patients with xeroderma pigmentosum (n = 3), ataxia telangiectasia (n = 2), head and neck cancer (n = 3), and melanoma (n = 2), and from normal human subjects (n = 6) using UV light, 4-nitroquinoline-1-oxide (4-NQO; an UV-mimetic agent), and gamma-irradiation as the test agents." | 3.69 | DNA repair capacity correlates with mutagen sensitivity in lymphoblastoid cell lines. ( Cheng, L; Gu, J; Hsu, TC; Kripke, ML; Spitz, MR; Strom, SS; Wei, Q; Xu, X, 1996) |
| " The 4NQO-hypersensitive AT3BI cells exhibited normal inhibition of DNA synthesis when treated with the chemical, as manifested by both dose-response and time-course measurements." | 1.28 | Lack of correlation between hypersensitivity to cell killing and impaired inhibition of DNA synthesis in ataxia telangiectasia fibroblasts treated with 4-nitroquinoline 1-oxide. ( Mirzayans, R; Paterson, MC, 1991) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 8 (66.67) | 18.7374 |
| 1990's | 4 (33.33) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Smith, PJ | 2 |
| Paterson, MC | 5 |
| Jaspers, NG | 1 |
| de Wit, J | 1 |
| Regulski, MR | 1 |
| Bootsma, D | 1 |
| Le François-Chabas, D | 1 |
| Montagnier, L | 2 |
| Barfknecht, TR | 1 |
| Little, JB | 1 |
| Jones, NJ | 1 |
| Ellard, S | 1 |
| Waters, R | 1 |
| Parry, EM | 1 |
| Wei, Q | 1 |
| Spitz, MR | 1 |
| Gu, J | 1 |
| Cheng, L | 1 |
| Xu, X | 1 |
| Strom, SS | 1 |
| Kripke, ML | 1 |
| Hsu, TC | 1 |
| Lefrançois, D | 1 |
| Kokalj, N | 1 |
| Viegas-Péquignot, E | 1 |
| Dutrillaux, B | 1 |
| Mirzayans, R | 3 |
| Inoue, T | 1 |
| Aikawa, K | 1 |
| Tezuka, H | 1 |
| Kada, T | 1 |
| Shultz, LD | 1 |
| Smith, BP | 1 |
| Sabour, M | 1 |
12 other studies available for 4-nitroquinoline-1-oxide and Ataxia Telangiectasia
| Article | Year |
|---|---|
Gamma-ray induced inhibition of DNA synthesis in ataxia telangiectasia fibroblasts is a function of excision repair capacity.
Topics: 4-Nitroquinoline-1-oxide; Ataxia Telangiectasia; Bleomycin; Cells, Cultured; DNA; DNA Repair; Gamma | 1980 |
Abnormal regulation of DNA replication and increased lethality in ataxia telangiectasia cells exposed to carcinogenic agents.
Topics: 4-Nitroquinoline-1-oxide; Alkylating Agents; Ataxia Telangiectasia; Bleomycin; Carcinogens; Cell Sur | 1982 |
[Supertransformation of a human lymphoblastoid cell line by chemical carcinogens].
Topics: 4-Nitroquinoline-1-oxide; Animals; Ataxia Telangiectasia; Burkitt Lymphoma; Carcinogens; Cell Line; | 1983 |
Defective DNA repair and increased lethality in ataxia telangiectasia cells exposed to 4-nitroquinoline-1-oxide.
Topics: 4-Nitroquinoline-1-oxide; Ataxia Telangiectasia; Cell Line; Cell Survival; Child; Child, Preschool; | 1980 |
Hypersensitivity of ataxia telangiectasia skin fibroblasts to DNA alkylating agents.
Topics: 4-Nitroquinoline-1-oxide; Alkylating Agents; Ataxia Telangiectasia; Cell Line; Cell Survival; Ethyl | 1982 |
Cellular and chromosomal hypersensitivity to DNA crosslinking agents and topoisomerase inhibitors in the radiosensitive Chinese hamster irs mutants: phenotypic similarities to ataxia telangiectasia and Fanconi's anaemia cells.
Topics: 4-Nitroquinoline-1-oxide; Alkylating Agents; Animals; Ataxia Telangiectasia; Cell Line; Cell Surviva | 1993 |
DNA repair capacity correlates with mutagen sensitivity in lymphoblastoid cell lines.
Topics: 4-Nitroquinoline-1-oxide; Ataxia Telangiectasia; Biomarkers; Carcinogens; Cell Line; Chromatids; Chr | 1996 |
High recurrence of rearrangements involving chromosome 14 in an ataxia telangiectasia lymphoblastoid cell line and in its mutagen-treated derivatives.
Topics: 4-Nitroquinoline-1-oxide; Adult; Antigens, Viral; Ataxia Telangiectasia; Cell Line, Transformed; Cel | 1991 |
Lack of correlation between hypersensitivity to cell killing and impaired inhibition of DNA synthesis in ataxia telangiectasia fibroblasts treated with 4-nitroquinoline 1-oxide.
Topics: 4-Nitroquinoline-1-oxide; Ataxia Telangiectasia; Cell Survival; Cells, Cultured; DNA; DNA Damage; Fi | 1991 |
Effect of DNA-damaging agents on isolated spleen cells and lung fibroblasts from the mouse mutant "wasted," a putative animal model for ataxia-telangiectasia.
Topics: 4-Nitroquinoline-1-oxide; Animals; Ataxia Telangiectasia; Bleomycin; Disease Models, Animal; DNA; DN | 1986 |
Hypersensitivity to cell killing and faulty repair of 1-beta-D-arabinofuranosylcytosine-detectable sites in human (ataxia-telangiectasia) fibroblasts treated with 4-nitroquinoline 1-oxide.
Topics: 4-Nitroquinoline-1-oxide; Ataxia Telangiectasia; Cell Survival; Cytarabine; DNA; DNA Damage; DNA Rep | 1989 |
Enhanced bioreduction of 4-nitroquinoline 1-oxide by cultured ataxia telangiectasia cells.
Topics: 4-Nitroquinoline-1-oxide; Ataxia Telangiectasia; Biotransformation; Cells, Cultured; DNA Damage; DNA | 1988 |