4-nitroquinoline-1-oxide has been researched along with Adult Premature Aging Syndrome in 16 studies
4-nitroquinoline N-oxide : A quinoline N-oxide carrying a nitro substituent at position 4.
| Excerpt | Relevance | Reference |
|---|---|---|
| " We show here that antisense suppression of WRN in two human glioma cell lines reproduces hallmarks of the drug cytotoxicity profile of WS cells, namely, hypersensitivity to 4-nitroquinoline 1-oxide, camptothecin and hydroxyurea." | 3.72 | The Werner syndrome protein confers resistance to the DNA lesions N3-methyladenine and O6-methylguanine: implications for WRN function. ( Blank, A; Bobola, MS; D Kolstoe, D; Gold, B; Loeb, LA; Meade, EH; Rabinovitch, PS; Silber, JR; Varadarajan, S, 2004) |
| "Werner's syndrome (WS) and Bloom's syndrome (BS) are rare autosomal genetic diseases that predispose to cancer and are associated with genomic instability." | 1.31 | Chromosomal instability in B-lymphoblasotoid cell lines from Werner and Bloom syndrome patients. ( Furuichi, Y; Goto, M; Hayashi, M; Honma, M; Sakamoto, H; Satoh, T; Sofuni, T; Sugimoto, M; Tadokoro, S; Tanabe, H, 2002) |
| "Werner syndrome is a genetic condition of young adults characterized by premature aging, limited replicative capacity of cells in vitro, and increased cancer risk." | 1.31 | WRN or telomerase constructs reverse 4-nitroquinoline 1-oxide sensitivity in transformed Werner syndrome fibroblasts. ( Chen, YH; Hisama, FM; Meyn, MS; Oshima, J; Weissman, SM, 2000) |
| "Chromosomal aberrations were also synergistically increased in WRN(-/-)/BLM(-/-) cells when irradiated with UV light in late S to G(2) phases." | 1.31 | Werner and Bloom helicases are involved in DNA repair in a complementary fashion. ( Fujita, K; Furuichi, Y; Imamura, O; Itoh, C; Matsumoto, T; Takeda, S, 2002) |
| "The clinical phenotype of Werner Syndrome (WRN) includes features reminiscent of accelerated aging and an increased incidence of sarcomas and other tumors of mesenchymal origin." | 1.31 | Werner syndrome diploid fibroblasts are sensitive to 4-nitroquinoline-N-oxide and 8-methoxypsoralen: implications for the disease phenotype. ( Emond, MJ; Gollahon, KA; Poot, M; Rabinovitch, PS; Silber, JR, 2002) |
| "Immortalized B lymphocytes from Werner syndrome subjects are shown to be hypersensitive to 4-nitroquinoline-1-oxide (4NQO), supporting earlier work on T lymphocytes." | 1.30 | An apoptosis-inducing genotoxin differentiates heterozygotic carriers for Werner helicase mutations from wild-type and homozygous mutants. ( Chen, R; Gollahon, KA; Hunt, KE; Martin, GM; Ogburn, CE; Oshima, J; Poot, M; Rabinovitch, PS, 1997) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (6.25) | 18.7374 |
| 1990's | 3 (18.75) | 18.2507 |
| 2000's | 12 (75.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Yamamoto, ML | 1 |
| Reliene, R | 1 |
| Oshima, J | 5 |
| Schiestl, RH | 1 |
| Ariyoshi, K | 1 |
| Suzuki, K | 2 |
| Goto, M | 3 |
| Oshimura, M | 2 |
| Ishizaki, K | 1 |
| Watanabe, M | 2 |
| Kodama, S | 2 |
| Poot, M | 3 |
| Silber, JR | 3 |
| Rabinovitch, PS | 4 |
| Honma, M | 1 |
| Tadokoro, S | 1 |
| Sakamoto, H | 1 |
| Tanabe, H | 1 |
| Sugimoto, M | 1 |
| Furuichi, Y | 3 |
| Satoh, T | 1 |
| Sofuni, T | 1 |
| Hayashi, M | 1 |
| Blank, A | 1 |
| Bobola, MS | 1 |
| Gold, B | 1 |
| Varadarajan, S | 1 |
| D Kolstoe, D | 1 |
| Meade, EH | 1 |
| Loeb, LA | 1 |
| Kyng, KJ | 1 |
| May, A | 1 |
| Stevnsner, T | 1 |
| Becker, KG | 1 |
| Kølvrå, S | 1 |
| Bohr, VA | 1 |
| Dong, YP | 1 |
| Seki, M | 1 |
| Yoshimura, A | 1 |
| Inoue, E | 1 |
| Furukawa, S | 1 |
| Tada, S | 1 |
| Enomoto, T | 1 |
| Ogburn, CE | 2 |
| Chen, R | 1 |
| Hunt, KE | 1 |
| Gollahon, KA | 2 |
| Martin, GM | 3 |
| Gray, MD | 1 |
| Wang, L | 2 |
| Youssoufian, H | 2 |
| Kashino, G | 1 |
| Takatsuji, T | 1 |
| Okumura, Y | 1 |
| Barrett, JC | 1 |
| Ware, CB | 1 |
| Ladiges, WC | 1 |
| Hisama, FM | 1 |
| Chen, YH | 1 |
| Meyn, MS | 1 |
| Weissman, SM | 1 |
| Sakamoto, S | 1 |
| Nishikawa, K | 1 |
| Heo, SJ | 1 |
| Shimamoto, A | 1 |
| Imamura, O | 1 |
| Fujita, K | 1 |
| Itoh, C | 1 |
| Takeda, S | 1 |
| Matsumoto, T | 1 |
| Emond, MJ | 1 |
| Gebhart, E | 1 |
| Bauer, R | 1 |
| Raub, U | 1 |
| Schinzel, M | 1 |
| Ruprecht, KW | 1 |
| Jonas, JB | 1 |
16 other studies available for 4-nitroquinoline-1-oxide and Adult Premature Aging Syndrome
| Article | Year |
|---|---|
Effects of human Werner helicase on intrachromosomal homologous recombination mediated DNA deletions in mice.
Topics: 4-Nitroquinoline-1-oxide; Animals; Buthionine Sulfoximine; Disease Models, Animal; DNA; DNA Damage; | 2008 |
Introduction of a normal human chromosome 8 corrects abnormal phenotypes of Werner syndrome cells immortalized by expressing an hTERT gene.
Topics: 4-Nitroquinoline-1-oxide; Animals; Blotting, Western; Cell Line, Transformed; Chromosomes, Human, Pa | 2009 |
A novel flow cytometric technique for drug cytotoxicity gives results comparable to colony-forming assays.
Topics: 4-Nitroquinoline-1-oxide; Antimetabolites; Antineoplastic Agents, Phytogenic; Benzimidazoles; Bromod | 2002 |
Chromosomal instability in B-lymphoblasotoid cell lines from Werner and Bloom syndrome patients.
Topics: 4-Nitroquinoline-1-oxide; B-Lymphocytes; Bloom Syndrome; Camptothecin; Carcinogens; Case-Control Stu | 2002 |
The Werner syndrome protein confers resistance to the DNA lesions N3-methyladenine and O6-methylguanine: implications for WRN function.
Topics: 4-Nitroquinoline-1-oxide; Adenine; Alkylating Agents; Antineoplastic Agents; Apoptosis; Camptothecin | 2004 |
Gene expression responses to DNA damage are altered in human aging and in Werner Syndrome.
Topics: 4-Nitroquinoline-1-oxide; Adult; Aged; Aging; Cell Line; DNA Damage; Fibroblasts; Gamma Rays; Gene E | 2005 |
WRN functions in a RAD18-dependent damage avoidance pathway.
Topics: 4-Nitroquinoline-1-oxide; Animals; Cell Line; Cell Proliferation; Chickens; Cisplatin; DNA Damage; D | 2007 |
An apoptosis-inducing genotoxin differentiates heterozygotic carriers for Werner helicase mutations from wild-type and homozygous mutants.
Topics: 4-Nitroquinoline-1-oxide; Apoptosis; B-Lymphocytes; Cell Line; DNA Helicases; Dose-Response Relation | 1997 |
Werner helicase is localized to transcriptionally active nucleoli of cycling cells.
Topics: 4-Nitroquinoline-1-oxide; Animals; Carcinogens; Cell Cycle; Cell Line, Transformed; Cell Nucleolus; | 1998 |
Failure to complement abnormal phenotypes of simian virus 40-transformed Werner syndrome cells by introduction of a normal human chromosome 8.
Topics: 4-Nitroquinoline-1-oxide; Animals; Carcinogens; Cell Fusion; Cell Line, Transformed; Cell Transforma | 1998 |
Cellular Werner phenotypes in mice expressing a putative dominant-negative human WRN gene.
Topics: 4-Nitroquinoline-1-oxide; Alleles; Animals; Cell Division; DNA Helicases; Down-Regulation; Exodeoxyr | 2000 |
WRN or telomerase constructs reverse 4-nitroquinoline 1-oxide sensitivity in transformed Werner syndrome fibroblasts.
Topics: 4-Nitroquinoline-1-oxide; Animals; Blotting, Western; Cell Line, Transformed; COS Cells; DNA Helicas | 2000 |
Werner helicase relocates into nuclear foci in response to DNA damaging agents and co-localizes with RPA and Rad51.
Topics: 4-Nitroquinoline-1-oxide; Aphidicolin; Bleomycin; Camptothecin; Cell Line; Cell Nucleus; DNA Damage; | 2001 |
Werner and Bloom helicases are involved in DNA repair in a complementary fashion.
Topics: 4-Nitroquinoline-1-oxide; Adenosine Triphosphatases; Amino Acid Sequence; Animals; B-Lymphocytes; Bl | 2002 |
Werner syndrome diploid fibroblasts are sensitive to 4-nitroquinoline-N-oxide and 8-methoxypsoralen: implications for the disease phenotype.
Topics: 4-Nitroquinoline-1-oxide; Apoptosis; Carcinogens; Cell Division; Cell Line; Cell Survival; Cells, Cu | 2002 |
Spontaneous and induced chromosomal instability in Werner syndrome.
Topics: 4-Nitroquinoline-1-oxide; Adult; Bleomycin; Cells, Cultured; Chromosome Aberrations; Epoxy Compounds | 1988 |