4-nitrobenzohydroxamic-acid and Tuberculosis

4-nitrobenzohydroxamic-acid has been researched along with Tuberculosis* in 1 studies

*Tuberculosis: Any of the infectious diseases of man and other animals caused by species of MYCOBACTERIUM TUBERCULOSIS. [MeSH]

Other Studies

1 other study(ies) available for 4-nitrobenzohydroxamic-acid and Tuberculosis

Article	Year
Syntheses and evaluation of substituted aromatic hydroxamates and hydroxamic acids that target Mycobacterium tuberculosis. Bioorganic & medicinal chemistry letters, 2015, Nov-01, Volume: 25, Issue:21 Tuberculosis (TB) continues to remain one of the most threatening diseases in the world. With the emergence of multi-drug resistant (MDR) and extensively drug resistant (XDR) strains, the need to develop new therapies is dire. The syntheses of a focused library of hydroxamates and hydroxamic acids is described, as well as anti-TB activity in the microplate alamar blue assay (MABA). A number of compounds exhibited good activity against Mtb, with notable compounds exhibiting MIC values in the range of 20-0.71 μM. This work suggests that both hydroxamates and their free acids may be incorporated into more complex scaffolds and serve as potential leads for the development of anti-TB agents. Topics: Antitubercular Agents; Dose-Response Relationship, Drug; Hydrocarbons, Aromatic; Hydroxamic Acids; Microbial Sensitivity Tests; Molecular Structure; Mycobacterium tuberculosis; Structure-Activity Relationship; Tuberculosis	2015

Article

Year

Syntheses and evaluation of substituted aromatic hydroxamates and hydroxamic acids that target Mycobacterium tuberculosis.

Bioorganic & medicinal chemistry letters, 2015, Nov-01, Volume: 25, Issue:21

Tuberculosis (TB) continues to remain one of the most threatening diseases in the world. With the emergence of multi-drug resistant (MDR) and extensively drug resistant (XDR) strains, the need to develop new therapies is dire. The syntheses of a focused library of hydroxamates and hydroxamic acids is described, as well as anti-TB activity in the microplate alamar blue assay (MABA). A number of compounds exhibited good activity against Mtb, with notable compounds exhibiting MIC values in the range of 20-0.71 μM. This work suggests that both hydroxamates and their free acids may be incorporated into more complex scaffolds and serve as potential leads for the development of anti-TB agents.

Topics: Antitubercular Agents; Dose-Response Relationship, Drug; Hydrocarbons, Aromatic; Hydroxamic Acids; Microbial Sensitivity Tests; Molecular Structure; Mycobacterium tuberculosis; Structure-Activity Relationship; Tuberculosis

2015