4-nitrobenzohydroxamic-acid and Hepatitis-C

4-nitrobenzohydroxamic-acid has been researched along with Hepatitis-C* in 1 studies

Other Studies

1 other study(ies) available for 4-nitrobenzohydroxamic-acid and Hepatitis-C

Article	Year
Benzohydroxamic acids as potent and selective anti-HCV agents. Bioorganic & medicinal chemistry letters, 2013, Nov-01, Volume: 23, Issue:21 A diverse collection of 40 derivatives of benzohydroxamic acid (BHAs) of various structural groups were synthesized and tested against hepatitis C virus (HCV) in full-genome replicon assay. Some of these compounds demonstrated an exceptional activity, suppressing viral replication at sub-micromolar concentrations. The compounds were inactive against key viral enzymes NS3, and NS5B in vitro assays, suggesting host cell inhibition target(s). The testing results were consistent with metal coordination by the BHAs hydroxamic group in complex with a target(s). Remarkably, this class of compounds did not suppress poliomyelitis virus (PV) propagation in RD cells indicating a specific antiviral activity of BHAs against HCV. Topics: Animals; Antiviral Agents; Cell Line; Genome, Viral; Hepacivirus; Hepatitis C; Humans; Hydroxamic Acids; Poliovirus; Replicon	2013

Article

Year

Benzohydroxamic acids as potent and selective anti-HCV agents.

Bioorganic & medicinal chemistry letters, 2013, Nov-01, Volume: 23, Issue:21

A diverse collection of 40 derivatives of benzohydroxamic acid (BHAs) of various structural groups were synthesized and tested against hepatitis C virus (HCV) in full-genome replicon assay. Some of these compounds demonstrated an exceptional activity, suppressing viral replication at sub-micromolar concentrations. The compounds were inactive against key viral enzymes NS3, and NS5B in vitro assays, suggesting host cell inhibition target(s). The testing results were consistent with metal coordination by the BHAs hydroxamic group in complex with a target(s). Remarkably, this class of compounds did not suppress poliomyelitis virus (PV) propagation in RD cells indicating a specific antiviral activity of BHAs against HCV.

Topics: Animals; Antiviral Agents; Cell Line; Genome, Viral; Hepacivirus; Hepatitis C; Humans; Hydroxamic Acids; Poliovirus; Replicon

2013