Compounds > 4-isopropylbenzaldehyde-thiosemicarbazone

4-isopropylbenzaldehyde-thiosemicarbazone and Cell-Transformation--Neoplastic

4-isopropylbenzaldehyde-thiosemicarbazone has been researched along with Cell-Transformation--Neoplastic* in 1 studies

Other Studies

1 other study(ies) available for 4-isopropylbenzaldehyde-thiosemicarbazone and Cell-Transformation--Neoplastic

Article	Year
Synthesis and characterization of Pd(II) and Pt(II) complexes of p-isopropylbenzaldehyde N-protected thiosemicarbazones. Cytotoxic activity against ras-transformed cells. Journal of inorganic biochemistry, 1999, Jul-15, Volume: 75, Issue:4 Cytotoxicity tests in tumor cells sensitive to cis-DDP (HL-60, JURKAT, Hela and 3T3) and in tumor cells transformed by ras oncogenes and resistant to cis-DDP (Pam 212-ras) show that cyclometallated complexes 1a [Pd(p-is.TSCN-NHMe)]4, 2b [Pt(p-is.TSCN-NMe2)]4 and 4a [Pd(p-is.TSCN-NHex)]4 may be endowed with specific cytotoxic properties. In fact, these three novel metal-thiosemicarbazone compounds kill Pam 212-ras cells through apoptosis induction. These results, together with others recently published, indicate that the design and synthesis of metallated-thiosemicarbazone compounds may lead to the discovery of novel antitumor agents able to circumvent cis-DDP resistance, in particular tumor cell lines. Topics: Antineoplastic Agents; Apoptosis; Cell Transformation, Neoplastic; Genes, ras; Humans; Organometallic Compounds; Palladium; Platinum; Thiosemicarbazones	1999

Article

Year

Synthesis and characterization of Pd(II) and Pt(II) complexes of p-isopropylbenzaldehyde N-protected thiosemicarbazones. Cytotoxic activity against ras-transformed cells.

Journal of inorganic biochemistry, 1999, Jul-15, Volume: 75, Issue:4

Cytotoxicity tests in tumor cells sensitive to cis-DDP (HL-60, JURKAT, Hela and 3T3) and in tumor cells transformed by ras oncogenes and resistant to cis-DDP (Pam 212-ras) show that cyclometallated complexes 1a [Pd(p-is.TSCN-NHMe)]4, 2b [Pt(p-is.TSCN-NMe2)]4 and 4a [Pd(p-is.TSCN-NHex)]4 may be endowed with specific cytotoxic properties. In fact, these three novel metal-thiosemicarbazone compounds kill Pam 212-ras cells through apoptosis induction. These results, together with others recently published, indicate that the design and synthesis of metallated-thiosemicarbazone compounds may lead to the discovery of novel antitumor agents able to circumvent cis-DDP resistance, in particular tumor cell lines.

Topics: Antineoplastic Agents; Apoptosis; Cell Transformation, Neoplastic; Genes, ras; Humans; Organometallic Compounds; Palladium; Platinum; Thiosemicarbazones

1999