4-iodo-2,5-dimethoxyphenylisopropylamine has been researched along with Tics in 4 studies
4-iodo-2,5-dimethoxyphenylisopropylamine: RN given refers to unlabeled parent cpd without isomeric designation; a serotonin agonist
2-(4-iodo-2,5-dimethoxyphenyl)-1-methylethylamine : An organoiodine compound that is amphetamine bearing two methoxy substituents at positions 2 and 5 as well as an iodo substituent at position 4.
Tics: Habitual, repeated, rapid contraction of certain muscles, resulting in stereotyped individualized actions that can be voluntarily suppressed for only brief periods. They often involve the face, vocal cords, neck, and less often the extremities. Examples include repetitive throat clearing, vocalizations, sniffing, pursing the lips, and excessive blinking. Tics tend to be aggravated by emotional stress. When frequent they may interfere with speech and INTERPERSONAL RELATIONS. Conditions which feature frequent and prominent tics as a primary manifestation of disease are referred to as TIC DISORDERS. (From Adams et al., Principles of Neurology, 6th ed, pp109-10)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Donepezil is an acetylcholinesterase inhibitor approved for use in mild to moderate Alzheimer's disease." | 5.32 | Effects of donepezil on DOI-induced head twitch response in mice: implications for Tourette syndrome. ( Hayslett, RL; Tizabi, Y, 2003) |
| "We previously reported a novel psychobiotic strain of Lactobacillus plantarum PS128 (PS128) which could ameliorate anxiety-like& depression-like behaviors and modulate cerebral dopamine (DA) and serotonin (5-HT) in mice." | 1.51 | Lactobacillus plantarum PS128 ameliorates 2,5-Dimethoxy-4-iodoamphetamine-induced tic-like behaviors via its influences on the microbiota-gut-brain-axis. ( Cheng, YF; Hsu, CC; Jeng, OJ; Lee, WT; Li, SW; Liao, JF; Tsai, YC; Wang, S; Wu, CC, 2019) |
| "Thus, mouse strains selected for a particular trait may be leveraged to generate hypothesis-driven studies aimed at clarifying the potential role played by the environment in modulating the exhibition of the symptoms of interest." | 1.40 | A behavioural test battery to investigate tic-like symptoms, stereotypies, attentional capabilities, and spontaneous locomotion in different mouse strains. ( Ceci, C; Laviola, G; Macrì, S; Proietti Onori, M, 2014) |
| "Donepezil is an acetylcholinesterase inhibitor approved for use in mild to moderate Alzheimer's disease." | 1.32 | Effects of donepezil on DOI-induced head twitch response in mice: implications for Tourette syndrome. ( Hayslett, RL; Tizabi, Y, 2003) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (25.00) | 29.6817 |
| 2010's | 3 (75.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Liao, JF | 1 |
| Cheng, YF | 1 |
| Li, SW | 1 |
| Lee, WT | 1 |
| Hsu, CC | 1 |
| Wu, CC | 1 |
| Jeng, OJ | 1 |
| Wang, S | 1 |
| Tsai, YC | 1 |
| Proietti Onori, M | 1 |
| Ceci, C | 1 |
| Laviola, G | 1 |
| Macrì, S | 1 |
| Canal, CE | 1 |
| Booth, RG | 1 |
| Morgan, D | 1 |
| Hayslett, RL | 1 |
| Tizabi, Y | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Pilot Examination of Galantamine in the Management of Tic Disorders[NCT00226824] | Phase 4 | 1 participants (Actual) | Interventional | 2005-09-30 | Terminated (stopped due to Unable to recruit subjects into the trial.) | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
4 other studies available for 4-iodo-2,5-dimethoxyphenylisopropylamine and Tics
| Article | Year |
|---|---|
Lactobacillus plantarum PS128 ameliorates 2,5-Dimethoxy-4-iodoamphetamine-induced tic-like behaviors via its influences on the microbiota-gut-brain-axis.
Topics: Amphetamines; Animals; Brain; Corpus Striatum; Dopamine; Gastrointestinal Microbiome; Haloperidol; L | 2019 |
A behavioural test battery to investigate tic-like symptoms, stereotypies, attentional capabilities, and spontaneous locomotion in different mouse strains.
Topics: Amphetamine; Amphetamines; Animals; Attention; Central Nervous System Stimulants; Circadian Rhythm; | 2014 |
Support for 5-HT2C receptor functional selectivity in vivo utilizing structurally diverse, selective 5-HT2C receptor ligands and the 2,5-dimethoxy-4-iodoamphetamine elicited head-twitch response model.
Topics: Amphetamines; Animals; Dose-Response Relationship, Drug; Drug Interactions; Dyskinesia, Drug-Induced | 2013 |
Effects of donepezil on DOI-induced head twitch response in mice: implications for Tourette syndrome.
Topics: Amphetamines; Animals; Donepezil; Drug Synergism; Head Movements; Indans; Male; Mecamylamine; Mice; | 2003 |