4-iodo-2,5-dimethoxyphenylisopropylamine has been researched along with Seizures in 6 studies
4-iodo-2,5-dimethoxyphenylisopropylamine: RN given refers to unlabeled parent cpd without isomeric designation; a serotonin agonist
2-(4-iodo-2,5-dimethoxyphenyl)-1-methylethylamine : An organoiodine compound that is amphetamine bearing two methoxy substituents at positions 2 and 5 as well as an iodo substituent at position 4.
Seizures: Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of brain cells. Clinical manifestations include abnormal motor, sensory and psychic phenomena. Recurrent seizures are usually referred to as EPILEPSY or seizure disorder.
| Excerpt | Relevance | Reference |
|---|---|---|
| " In order to clarify the role of 5-HT2 receptors in epilepsy, the present study examined the effects of a 5-HT2 receptor agonist 1-(2,5-dimethoxy-4-iodophenyl)-2-amino-propane(DOI) and a 5-HT2 receptor antagonist ketanserin on HIP-kindled seizures." | 7.68 | [Serotonergic mechanisms of hippocampal kindled seizures in cats--effects of 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane and ketanserin]. ( Hasegawa, H; Nakamura, M; Wada, Y; Yamaguchi, N, 1993) |
| "This was surprising since seizures induced by acute lithium plus DOI were less severe than those after acute lithium plus pilocarpine, but myo-inositol was more effective in blocking the latter." | 5.29 | Modulation by inositol of cholinergic- and serotonergic-induced seizures in lithium-treated rats. ( Jope, RS; Williams, MB, 1995) |
| " In order to clarify the role of 5-HT2 receptors in epilepsy, the present study examined the effects of a 5-HT2 receptor agonist 1-(2,5-dimethoxy-4-iodophenyl)-2-amino-propane(DOI) and a 5-HT2 receptor antagonist ketanserin on HIP-kindled seizures." | 3.68 | [Serotonergic mechanisms of hippocampal kindled seizures in cats--effects of 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane and ketanserin]. ( Hasegawa, H; Nakamura, M; Wada, Y; Yamaguchi, N, 1993) |
| "This study assessed the effects of a serotonin (5-HT)1A agonist 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT), a 5-HT2 agonist 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI) and a 5-HT2 antagonist ketanserin on fully kindled seizures from the hippocampus." | 3.68 | Role of serotonin receptor subtype in seizures kindled from the feline hippocampus. ( Hasegawa, H; Nakamura, M; Wada, Y; Yamaguchi, N, 1992) |
| "This was surprising since seizures induced by acute lithium plus DOI were less severe than those after acute lithium plus pilocarpine, but myo-inositol was more effective in blocking the latter." | 1.29 | Modulation by inositol of cholinergic- and serotonergic-induced seizures in lithium-treated rats. ( Jope, RS; Williams, MB, 1995) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 4 (66.67) | 18.2507 |
| 2000's | 1 (16.67) | 29.6817 |
| 2010's | 1 (16.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Gunia-Krzyżak, A | 1 |
| Żelaszczyk, D | 1 |
| Rapacz, A | 1 |
| Żesławska, E | 1 |
| Waszkielewicz, AM | 1 |
| Pańczyk, K | 1 |
| Słoczyńska, K | 1 |
| Pękala, E | 1 |
| Nitek, W | 1 |
| Filipek, B | 1 |
| Marona, H | 1 |
| Pericić, D | 1 |
| Lazić, J | 1 |
| Jazvinsćak Jembrek, M | 1 |
| Svob Strac, D | 1 |
| Williams, MB | 2 |
| Jope, RS | 2 |
| Nakamura, M | 2 |
| Wada, Y | 2 |
| Hasegawa, H | 2 |
| Yamaguchi, N | 2 |
6 other studies available for 4-iodo-2,5-dimethoxyphenylisopropylamine and Seizures
| Article | Year |
|---|---|
Structure-anticonvulsant activity studies in the group of (E)-N-cinnamoyl aminoalkanols derivatives monosubstituted in phenyl ring with 4-Cl, 4-CH
Topics: Amino Alcohols; Animals; Anticonvulsants; Crystallography, X-Ray; Disease Models, Animal; Dose-Respo | 2017 |
Stimulation of 5-HT 1A receptors increases the seizure threshold for picrotoxin in mice.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Amphetamines; Animals; Drug Administration Schedule; Drug Th | 2005 |
Modulation by inositol of cholinergic- and serotonergic-induced seizures in lithium-treated rats.
Topics: Amphetamines; Animals; Cholinergic Agents; Drug Synergism; Inositol; Lithium; Male; Pilocarpine; Rat | 1995 |
Lithium potentiates phosphoinositide-linked 5-HT receptor stimulation in vivo.
Topics: Amphetamines; Animals; Drug Synergism; Genes, fos; Lithium; Male; Phosphatidylinositols; Rats; Rats, | 1994 |
[Serotonergic mechanisms of hippocampal kindled seizures in cats--effects of 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane and ketanserin].
Topics: Amphetamines; Animals; Cats; Epilepsy; Hippocampus; Ketanserin; Kindling, Neurologic; Receptors, Ser | 1993 |
Role of serotonin receptor subtype in seizures kindled from the feline hippocampus.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Amphetamines; Animals; Anticonvulsants; Cats; Electric Stimu | 1992 |