4-iodo-2,5-dimethoxyphenylisopropylamine has been researched along with Neuroblastoma in 2 studies
4-iodo-2,5-dimethoxyphenylisopropylamine: RN given refers to unlabeled parent cpd without isomeric designation; a serotonin agonist
2-(4-iodo-2,5-dimethoxyphenyl)-1-methylethylamine : An organoiodine compound that is amphetamine bearing two methoxy substituents at positions 2 and 5 as well as an iodo substituent at position 4.
Neuroblastoma: A common neoplasm of early childhood arising from neural crest cells in the sympathetic nervous system, and characterized by diverse clinical behavior, ranging from spontaneous remission to rapid metastatic progression and death. This tumor is the most common intraabdominal malignancy of childhood, but it may also arise from thorax, neck, or rarely occur in the central nervous system. Histologic features include uniform round cells with hyperchromatic nuclei arranged in nests and separated by fibrovascular septa. Neuroblastomas may be associated with the opsoclonus-myoclonus syndrome. (From DeVita et al., Cancer: Principles and Practice of Oncology, 5th ed, pp2099-2101; Curr Opin Oncol 1998 Jan;10(1):43-51)
| Excerpt | Relevance | Reference |
|---|---|---|
| " In a dose-response study the 5-HT2A agonist (±)-2,5-dimethoxy-4-iodoamphetamine hydrochloride (DOI) (25 nM to 5 μM) protected against serum deprivation cytotoxicity." | 1.39 | 5-HT2A serotonin receptor agonist DOI alleviates cytotoxicity in neuroblastoma cells: role of the ERK pathway. ( Grünblatt, E; Marinova, Z; Walitza, S, 2013) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (50.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (50.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Marinova, Z | 1 |
| Walitza, S | 1 |
| Grünblatt, E | 1 |
| Newton, RA | 1 |
| Phipps, SL | 1 |
| Flanigan, TP | 1 |
| Newberry, NR | 1 |
| Carey, JE | 1 |
| Kumar, C | 1 |
| McDonald, B | 1 |
| Chen, C | 1 |
| Elliott, JM | 1 |
2 other studies available for 4-iodo-2,5-dimethoxyphenylisopropylamine and Neuroblastoma
| Article | Year |
|---|---|
5-HT2A serotonin receptor agonist DOI alleviates cytotoxicity in neuroblastoma cells: role of the ERK pathway.
Topics: Amphetamines; Cell Line, Tumor; Cell Proliferation; Culture Media, Serum-Free; Dose-Response Relatio | 2013 |
Characterisation of human 5-hydroxytryptamine2A and 5-hydroxytryptamine2C receptors expressed in the human neuroblastoma cell line SH-SY5Y: comparative stimulation by hallucinogenic drugs.
Topics: Adrenergic alpha-Agonists; Amphetamines; Antiparkinson Agents; Calcium; Choroid Plexus; Electrophysi | 1996 |