4-iodo-2,5-dimethoxyphenylisopropylamine has been researched along with Muscle Contraction in 17 studies
4-iodo-2,5-dimethoxyphenylisopropylamine: RN given refers to unlabeled parent cpd without isomeric designation; a serotonin agonist
2-(4-iodo-2,5-dimethoxyphenyl)-1-methylethylamine : An organoiodine compound that is amphetamine bearing two methoxy substituents at positions 2 and 5 as well as an iodo substituent at position 4.
Muscle Contraction: A process leading to shortening and/or development of tension in muscle tissue. Muscle contraction occurs by a sliding filament mechanism whereby actin filaments slide inward among the myosin filaments.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Intrathecal injection of 5-methoxy-N,N'-dimethyltryptamine (5-MeODMT), (+/-)-1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane hydrochloride (DOI) or 2,5-dimethoxy-alpha,4-dimethylbenzene ethamine hydrochloride (DOM) produced dose-related back muscle contractions (BMC) and wet dog shakes (WDS) which were both markedly attenuated by intraperitoneal pretreatment with either ritanserin (1 mg kg-1), ketanserin (0." | 3.68 | Characterization of the 5-HT receptor subtypes involved in the motor behaviours produced by intrathecal administration of 5-HT agonists in rats. ( Fone, KC; Marsden, CA; Robinson, AJ, 1991) |
| "Pretreatment with dantrolene completely abolished serotonin-induced MH." | 1.30 | Attenuation of serotonin-induced contractures in skeletal muscle from malignant hyperthermia-susceptible patients with dantrolene. ( Fiege, M; Köchling, A; Lambrecht, W; Scholz, J; Schulte am Esch, J; von Richthofen, V; Wappler, F, 1997) |
| "In pigs genetically susceptible to malignant hyperthermia (MH), it has been shown that serotonin (5-HT2) receptor agonists can induce MH and "psychotic" behaviour." | 1.29 | [Effects of serotonin 2 receptor agonists on skeletal muscle preparations in patients with a disposition toward malignant hyperthermia]. ( Köchling, A; Löscher, W; Roewer, N; Rumberger, E; Scholz, J; Schulte am Esch, J; Steinfath, M; Wappler, F, 1995) |
| "Tianeptine is a novel antidepressant which uniquely facilitates 5-hydroxytryptamine (5-HT) uptake." | 1.28 | The effects of tianeptine on wet-dog shakes, fore-paw treading and a flexor reflex in rats are consistent with enhancement of 5-hydroxytryptamine uptake. ( Koshikawa, N; Mocaër, E; Stephenson, JD, 1991) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 16 (94.12) | 18.2507 |
| 2000's | 1 (5.88) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Wainscott, DB | 2 |
| Cohen, ML | 3 |
| Schenck, KW | 2 |
| Audia, JE | 1 |
| Nissen, JS | 1 |
| Baez, M | 1 |
| Kursar, JD | 1 |
| Lucaites, VL | 1 |
| Nelson, DL | 2 |
| Enguix, MJ | 1 |
| Sánchez, L | 1 |
| Villazón, M | 1 |
| Brea, J | 1 |
| Tristán, H | 1 |
| Caruncho, HJ | 1 |
| Cadavid, MI | 1 |
| Loza, MI | 1 |
| Sikorski, BW | 1 |
| James, GM | 1 |
| Glance, SD | 1 |
| Hodgson, WC | 1 |
| King, RG | 1 |
| Wappler, F | 4 |
| Roewer, N | 2 |
| Köchling, A | 3 |
| Scholz, J | 4 |
| Steinfath, M | 3 |
| Rumberger, E | 1 |
| Löscher, W | 2 |
| Schulte am Esch, J | 3 |
| Messori, E | 1 |
| Rizzi, CA | 1 |
| Candura, SM | 1 |
| Lucchelli, A | 1 |
| Balestra, B | 1 |
| Tonini, M | 1 |
| Johnson, MP | 1 |
| Susemichel, A | 1 |
| Robertson, DW | 1 |
| Oppermann, S | 1 |
| von Richthofen, V | 2 |
| Fiege, M | 1 |
| Lambrecht, W | 1 |
| Darmani, NA | 1 |
| Ahmad, B | 1 |
| Cheer, JF | 1 |
| Cadogan, AK | 1 |
| Marsden, CA | 3 |
| Fone, KC | 2 |
| Kendall, DA | 1 |
| O'Gara, BA | 1 |
| Illuzzi, FA | 1 |
| Chung, M | 1 |
| Portnoy, AD | 1 |
| Fraga, K | 1 |
| Frieman, VB | 1 |
| Javid, FA | 1 |
| Naylor, RJ | 1 |
| Watts, SW | 1 |
| Robinson, AJ | 1 |
| Wright, IK | 1 |
| Ismail, H | 1 |
| Upton, N | 1 |
| Koshikawa, N | 1 |
| Mocaër, E | 1 |
| Stephenson, JD | 1 |
1 trial available for 4-iodo-2,5-dimethoxyphenylisopropylamine and Muscle Contraction
| Article | Year |
|---|---|
Ritanserin attenuates the in vitro effects of the 5-HT2 receptor agonist DOI on skeletal muscles from malignant hyperthermia-susceptible patients.
Topics: Adolescent; Adult; Amphetamines; Female; Humans; In Vitro Techniques; Male; Malignant Hyperthermia; | 1997 |
16 other studies available for 4-iodo-2,5-dimethoxyphenylisopropylamine and Muscle Contraction
| Article | Year |
|---|---|
Pharmacological characteristics of the newly cloned rat 5-hydroxytryptamine2F receptor.
Topics: Animals; Binding Sites; Cell Line; Cloning, Molecular; Gastric Fundus; Inositol 1,4,5-Trisphosphate; | 1993 |
Differential regulation of rat peripheral 5-HT(2A) and 5-HT(2B) receptor systems: influence of drug treatment.
Topics: Amphetamines; Animals; Antipsychotic Agents; Aorta, Thoracic; Clozapine; Cyproheptadine; Gastric Fun | 2003 |
Effect of endothelium on diabetes-induced changes in constrictor responses mediated by 5-hydroxytryptamine in rat aorta.
Topics: Amphetamines; Animals; Aorta; Arginine; Body Weight; Diabetes Mellitus, Experimental; Endothelium; I | 1993 |
[Effects of serotonin 2 receptor agonists on skeletal muscle preparations in patients with a disposition toward malignant hyperthermia].
Topics: Adolescent; Adult; Aged; Amphetamines; Child; Female; Humans; In Vitro Techniques; Male; Malignant H | 1995 |
5-Hydroxytryptamine receptors that facilitate excitatory neuromuscular transmission in the guinea-pig isolated detrusor muscle.
Topics: Acetylcholine; Adenosine Triphosphate; Amphetamines; Animals; Dose-Response Relationship, Drug; Elec | 1995 |
DOI and alpha-methylserotonin: comparative vascular and nonvascular smooth muscle effects and central 5-hydroxytryptamine2 receptor affinities.
Topics: Amphetamines; Animals; Brain; Muscle Contraction; Muscle, Smooth; Muscle, Smooth, Vascular; Rats; Re | 1993 |
Effects of the serotonin2 receptor agonist DOI on skeletal muscle specimens from malignant hyperthermia-susceptible patients.
Topics: Adolescent; Adult; Aged; Amphetamines; Animals; Cattle; Child; Child, Preschool; Halothane; Humans; | 1996 |
Attenuation of serotonin-induced contractures in skeletal muscle from malignant hyperthermia-susceptible patients with dantrolene.
Topics: Adolescent; Adult; Amphetamines; Child; Child, Preschool; Dantrolene; Humans; Malignant Hyperthermia | 1997 |
Long-term sequential determination of behavioral ontogeny of 5-HT1A and 5-HT2 receptor functions in the rat.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Amphetamines; Animals; Body Temperature; Female; Head Moveme | 1999 |
Modification of 5-HT2 receptor mediated behaviour in the rat by oleamide and the role of cannabinoid receptors.
Topics: Amphetamines; Animals; Behavior, Animal; Cannabinoids; Cerebral Cortex; Cyclohexanols; Dronabinol; E | 1999 |
Serotonin induces four pharmacologically separable contractile responses in the pharynx of the leech Hirudo medicinalis.
Topics: 5-Methoxytryptamine; 8-Hydroxy-2-(di-n-propylamino)tetralin; Amphetamines; Animals; Dose-Response Re | 1999 |
Characterisation of 5-HT2 receptor subtypes in the Suncus murinus intestine.
Topics: Amphetamines; Animals; Female; In Vitro Techniques; Indoles; Intestines; Male; Muscle Contraction; P | 1999 |
Characterization of the contractile serotonergic receptor in guinea pig trachea with agonists and antagonists.
Topics: Amphetamines; Animals; Guinea Pigs; In Vitro Techniques; Male; Muscle Contraction; Phosphatidylinosi | 1992 |
Characterization of the 5-HT receptor subtypes involved in the motor behaviours produced by intrathecal administration of 5-HT agonists in rats.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Amphetamines; Animals; Clorgyline; Fluoxetine; Injections, S | 1991 |
Effect of isolation rearing on 5-HT agonist-induced responses in the rat.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Amphetamines; Animals; Behavior, Animal; Male; Methoxydimeth | 1991 |
The effects of tianeptine on wet-dog shakes, fore-paw treading and a flexor reflex in rats are consistent with enhancement of 5-hydroxytryptamine uptake.
Topics: Amphetamines; Animals; Antidepressive Agents, Tricyclic; Behavior, Animal; Carbidopa; Decerebrate St | 1991 |