4-hydroxyretinoic-acid has been researched along with Vitamin-A-Deficiency* in 1 studies
1 other study(ies) available for 4-hydroxyretinoic-acid and Vitamin-A-Deficiency
| Article | Year |
|---|---|
Isolation and identification of 4-hydroxy- and 4-oxoretinoic acid. In vitro metabolites of all-trans-retinoic acid in hamster trachea and liver.
Incubation of [3H]retinoic acid in the presence of hamster liver 10000g supernatant produces several metabolites that are more polar than the parent compound. Two of these metabolites are identical with synthetic all-trans-4-hydroxyretinoic acid and all-trans-4-oxoretinoic acid both in ultraviolet absorption and mass spectral characteristics and in migration rates on two different reverse-phase high-pressure liquid chromatographic systems. The metabolites produced in a cell-free liver incubation reaction also migrate on a high-pressure liquid chromatography column together with metabolites isolated from a tracheal organ culture system. Both the metabolites and the synthetic standards show less biological activity than the parent all-trans-retinoic acid in a tracheal organ culture assay. Topics: Animals; Biological Assay; Chromatography, High Pressure Liquid; Cricetinae; Female; Liver; Male; Mass Spectrometry; Spectrophotometry, Ultraviolet; Trachea; Tretinoin; Vitamin A; Vitamin A Deficiency | 1979 |