4-hydroxyquinazoline and Colorectal-Neoplasms

The pathogenesis of colorectal cancer is a multifactorial process. Dysbiosis and the overexpression of COX-2 and LDHA are important effectors in the initiation and development of the disease through chromosomal instability, PGE2 biosynthesis, and induction of the Warburg effect, respectively. Herein, we report the in vitro testing of some new quinoxalinone and quinazolinone Schiff's bases as: antibacterial, COX-2 and LDHA inhibitors, and anticolorectal agents on HCT-116 and LoVo cells. Moreover, molecular docking and SAR analyses were performed to identify the structural features contributing to the biological activities. Among the synthesized molecules, the most active cytotoxic agent, (

Topics: Anti-Bacterial Agents; Antineoplastic Agents; Caco-2 Cells; Cell Proliferation; Colorectal Neoplasms; Cyclooxygenase 2 Inhibitors; Drug Design; Drug Resistance, Multiple; Humans; L-Lactate Dehydrogenase; Molecular Docking Simulation; Molecular Structure; Quinazolinones; Quinoxalines; Structure-Activity Relationship