Page last updated: 2024-10-19

4-hydroxyphenylpyruvic acid and Alcaptonuria

4-hydroxyphenylpyruvic acid has been researched along with Alcaptonuria in 3 studies

4-hydroxyphenylpyruvic acid: RN given refers to parent cpd
4-hydroxyphenylpyruvic acid : A 2-oxo monocarboxylic acid that is pyruvic acid in which one of the methyl hydrogens is substituted by a 4-hydroxyphenyl group.

Research Excerpts

ExcerptRelevanceReference
"We have assessed the effect of elevated concentrations of hydroxyphenylpyruvic acid (HPPA), hydroxyphenyllactic acid (HPLA) and tyrosine, on a range of chemistry tests in serum and urine to explore the potential for chemical interference on routine laboratory analyses in patients with alkaptonuria (AKU) treated with nitisinone and similarly implications for patients with hereditary tyrosinemia type 1 (HT-1)."7.91Interference of hydroxyphenylpyruvic acid, hydroxyphenyllactic acid and tyrosine on routine serum and urine clinical chemistry assays; implications for biochemical monitoring of patients with alkaptonuria treated with nitisinone. ( Curtis, SL; Gallagher, JA; Milan, AM; Norman, BP; Olsson, B; Ranganath, LR; Roberts, NB, 2019)
"We have assessed the effect of elevated concentrations of hydroxyphenylpyruvic acid (HPPA), hydroxyphenyllactic acid (HPLA) and tyrosine, on a range of chemistry tests in serum and urine to explore the potential for chemical interference on routine laboratory analyses in patients with alkaptonuria (AKU) treated with nitisinone and similarly implications for patients with hereditary tyrosinemia type 1 (HT-1)."3.91Interference of hydroxyphenylpyruvic acid, hydroxyphenyllactic acid and tyrosine on routine serum and urine clinical chemistry assays; implications for biochemical monitoring of patients with alkaptonuria treated with nitisinone. ( Curtis, SL; Gallagher, JA; Milan, AM; Norman, BP; Olsson, B; Ranganath, LR; Roberts, NB, 2019)
"The drug nitisinone (NTBC) is used to treat tyrosinemia type I, and more recently has been also used for the treatment of another disorder of tyrosine metabolism, alkaptonuria."3.81Perturbations of tyrosine metabolism promote the indolepyruvate pathway via tryptophan in host and microbiome. ( Barshop, BA; Gangoiti, JA; Gertsman, I; Nyhan, WL, 2015)

Research

Studies (3)

TimeframeStudies, this research(%)All Research%
pre-19901 (33.33)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's2 (66.67)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Curtis, SL1
Norman, BP1
Milan, AM1
Gallagher, JA1
Olsson, B1
Ranganath, LR1
Roberts, NB1
Gertsman, I1
Gangoiti, JA1
Nyhan, WL1
Barshop, BA1
Nordlinger, BM1
Fulenwider, JT1
Faraj, BA1
Bethel, RA1
Rudman, D1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Nitisinone (NTBC) In Different Age Groups Of Patients With Alkaptonuria[NCT01390077]Phase 2/Phase 38 participants (Actual)Interventional2011-01-31Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Homogentisic Acid Excretion

Urine homogentisic acid (umol/mmol creatinine) (NCT01390077)
Timeframe: 3-6 months

InterventionuM (Mean)
HGA, Baseline1425.9
HGA, 2 mg/d Nitisinone113.1
HGA, 4 mg Nitisinone34.0

Tyrosine Levels

Plasma tyrosine (uM) (NCT01390077)
Timeframe: 3-6 months

InterventionuM (Mean)
Tyrosine, Baseline53.1
Tyrosine, 2 mg/d Nitisinone668.7
Tyrosine, 4 mg Nitisinone703.7

Other Studies

3 other studies available for 4-hydroxyphenylpyruvic acid and Alcaptonuria

ArticleYear
Interference of hydroxyphenylpyruvic acid, hydroxyphenyllactic acid and tyrosine on routine serum and urine clinical chemistry assays; implications for biochemical monitoring of patients with alkaptonuria treated with nitisinone.
    Clinical biochemistry, 2019, Volume: 71

    Topics: 4-Hydroxyphenylpyruvate Dioxygenase; Alkaptonuria; Cyclohexanones; Enzyme Inhibitors; Humans; Nitrob

2019
Perturbations of tyrosine metabolism promote the indolepyruvate pathway via tryptophan in host and microbiome.
    Molecular genetics and metabolism, 2015, Volume: 114, Issue:3

    Topics: Aldehydes; Alkaptonuria; Cell Line, Tumor; Cyclohexanones; Gastrointestinal Microbiome; Humans; Indo

2015
Tyrosine metabolism in cirrhosis: acquired alkaptonuria.
    Surgical forum, 1978, Volume: 29

    Topics: Alkaptonuria; Homogentisic Acid; Humans; Liver Cirrhosis; Liver Function Tests; Phenylpyruvic Acids;

1978