4-hydroxyisoleucine and Disease-Models--Animal

4-hydroxyisoleucine has been researched along with Disease-Models--Animal* in 1 studies

Other Studies

1 other study(ies) available for 4-hydroxyisoleucine and Disease-Models--Animal

Article	Year
4-hydroxyisoleucine an unusual amino acid as antidyslipidemic and antihyperglycemic agent. Bioorganic & medicinal chemistry letters, 2006, Jan-15, Volume: 16, Issue:2 Trigonella foenum-graecum, commonly known as fenugreek, is an annual herbaceous plant. From the seeds of T. foenum-graecum an unusual amino acid, 4-hydroxyisoleucine 5, has been isolated, which significantly decreased the plasma triglyceride levels by 33% (P<0.002), total cholesterol (TC) by 22% (P<0.02), and free fatty acids by 14%, accompanied by an increase in HDL-C/TC ratio by 39% in the dyslipidemic hamster model. Topics: Administration, Oral; Animals; Cholesterol; Cholesterol, HDL; Cricetinae; Diabetes Mellitus, Type 2; Dietary Fats; Disease Models, Animal; Drug Evaluation, Preclinical; Fatty Acids; Hypoglycemic Agents; Hypolipidemic Agents; Isoleucine; Male; Molecular Structure; Seeds; Structure-Activity Relationship; Triglycerides; Trigonella	2006

Article

Year

4-hydroxyisoleucine an unusual amino acid as antidyslipidemic and antihyperglycemic agent.

Bioorganic & medicinal chemistry letters, 2006, Jan-15, Volume: 16, Issue:2

Trigonella foenum-graecum, commonly known as fenugreek, is an annual herbaceous plant. From the seeds of T. foenum-graecum an unusual amino acid, 4-hydroxyisoleucine 5, has been isolated, which significantly decreased the plasma triglyceride levels by 33% (P<0.002), total cholesterol (TC) by 22% (P<0.02), and free fatty acids by 14%, accompanied by an increase in HDL-C/TC ratio by 39% in the dyslipidemic hamster model.

Topics: Administration, Oral; Animals; Cholesterol; Cholesterol, HDL; Cricetinae; Diabetes Mellitus, Type 2; Dietary Fats; Disease Models, Animal; Drug Evaluation, Preclinical; Fatty Acids; Hypoglycemic Agents; Hypolipidemic Agents; Isoleucine; Male; Molecular Structure; Seeds; Structure-Activity Relationship; Triglycerides; Trigonella

2006