4-hydroxyisoleucine has been researched along with Diabetes-Mellitus* in 2 studies
1 review(s) available for 4-hydroxyisoleucine and Diabetes-Mellitus
| Article | Year |
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New legume sources as therapeutic agents.
This review evaluates the potential health benefits of three legume sources that rarely appear in Western diets and are often overlooked as functional foods. Fenugreek (Trigonella foenum graecum) and isolated fenugreek fractions have been shown to act as hypoglycaemic and hypocholesterolaemic agents in both animal and human studies. The unique dietary fibre composition and high saponin content in fenugreek appears to be responsible for these therapeutic properties. Faba beans (Vicia faba) have lipid-lowering effects and may also be a good source of antioxidants and chemopreventive factors. Mung beans (Phaseolus aureus, Vigna radiatus) are thought to be beneficial as an antidiabetic, low glycaemic index food, rich in antioxidants. Evidence suggests that these three novel sources of legumes may provide health benefits when included in the daily diet. Topics: Animals; Anticholesteremic Agents; Antioxidants; Cell Differentiation; Diabetes Mellitus; Dietary Fiber; Dietary Supplements; Dogs; Fabaceae; Favism; Glucose; Humans; Hypoglycemic Agents; Isoleucine; Lipid Metabolism; Lipid Peroxidation; Minerals; Plant Proteins; Rats; Trigonella; Vicia faba | 2002 |
1 other study(ies) available for 4-hydroxyisoleucine and Diabetes-Mellitus
| Article | Year |
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Antihyperglycaemic effect of an unusual amino acid (4-hydroxyisoleucine) in C57BL/KsJ-db/db mice.
The present report confirms the anti-hyperglycaemic and anti-dyslipidemic properties of 4-hydroxyisoleucine, an unusual amino acid isolated from Trigonella foenum-graecum seeds, for the first time in a well-characterised model of type II diabetes, i.e. db/db mice. 4-Hydroxyisoleucine, when given orally to these mice at 50 mg kg(-1) dose level, significantly (p < 0.05) declined their elevated blood glucose, plasma insulin, triglycerides, total cholesterol, low-density lipoprotein-cholesterol levels and raised their declined plasma high-density lipoprotein-cholesterol level. These results indicate that 4-hydroxyisoleucine exhibits significant potential as an anti-diabetic agent by suppressing progression of type II diabetic states that is suggested by enhancement of insulin sensitivity and glucose uptake in peripheral tissue. Topics: Animals; Blood Glucose; Body Weight; Diabetes Mellitus; Hypoglycemic Agents; Isoleucine; Mice; Mice, Inbred Strains; Molecular Structure; Seeds; Trigonella | 2010 |