4-hydroxy-3-methoxymethamphetamine has been researched along with Amphetamine-Related-Disorders* in 1 studies
1 other study(ies) available for 4-hydroxy-3-methoxymethamphetamine and Amphetamine-Related-Disorders
| Article | Year |
|---|---|
Direct determination of glucuronide and sulfate of 4-hydroxy-3-methoxymethamphetamine, the main metabolite of MDMA, in human urine.
A sensitive and reliable LC-ESI-MS procedure for the simultaneous determination of MDMA and its five metabolites including 4-hydroxy-3-methoxymethamphetamine (HMMA) conjugates has been established following the synthesis of two HMMA conjugates, 4-hydroxy-3-methoxymethamphetamine-glucuronide (HMMA-Glu) and 4-hydroxy-3-methoxymethamphetamine-sulfate (HMMA-Sul). Pretreatment of urine samples with methanol and LC-MS employing a C(18) semi-micro column with a gradient elution program provided the successful separations and MS determinations of these analytes within 20 min. Upon applying the method to MDMA users' urine specimens, HMMA-Glu and HMMA-Sul have been directly determined, suggesting the superiority of sulfation to glucuronidation in the HMMA phase II metabolism. Topics: 3,4-Methylenedioxyamphetamine; Amphetamine-Related Disorders; Calibration; Designer Drugs; Gas Chromatography-Mass Spectrometry; Glucuronides; Hallucinogens; Humans; Methamphetamine; N-Methyl-3,4-methylenedioxyamphetamine; Reference Standards; Reproducibility of Results; Sensitivity and Specificity; Substance Abuse Detection; Sulfates | 2007 |