4-hydroxy-2-nonenal and Ototoxicity

4-hydroxy-2-nonenal has been researched along with Ototoxicity* in 1 studies

Other Studies

1 other study(ies) available for 4-hydroxy-2-nonenal and Ototoxicity

Article	Year
Inhibition of ferroptosis protects House Ear Institute-Organ of Corti 1 cells and cochlear hair cells from cisplatin-induced ototoxicity. Journal of cellular and molecular medicine, 2020, Volume: 24, Issue:20 Ferroptosis is a recently recognized form of non-apoptotic cell death caused by an iron-dependent accumulation of lipid hydroperoxides, which plays important roles in a wide spectrum of pathological conditions. The present study was aimed to investigate the impact of ferroptosis on cisplatin-induced sensory hair cell damage. Cell viability was determined by Cell Counting Kit-8 and lactase dehydrogenase assays. The reactive oxygen species (ROS) levels were evaluated by 2,7-Dichlorodi-hydrofluorescein diacetate (DCFH-DA) and MitoSox-Red staining. Mitochondrial membrane potential (MMP) was measured by tetramethylrhodamine methyl ester (TMRM) staining. Lipid peroxidation, intracellular and mitochondrial iron were detected by Liperfluo, C11-BODIPY Topics: Aldehydes; Animals; Carbolines; Cell Line; Cell Survival; Cisplatin; Cyclohexylamines; Cytoprotection; Ferroptosis; Hair Cells, Auditory; Iron; Iron Overload; Membrane Potential, Mitochondrial; Mice, Inbred C57BL; Ototoxicity; Phenylenediamines; Reactive Oxygen Species	2020

Article

Year

Inhibition of ferroptosis protects House Ear Institute-Organ of Corti 1 cells and cochlear hair cells from cisplatin-induced ototoxicity.

Journal of cellular and molecular medicine, 2020, Volume: 24, Issue:20

Ferroptosis is a recently recognized form of non-apoptotic cell death caused by an iron-dependent accumulation of lipid hydroperoxides, which plays important roles in a wide spectrum of pathological conditions. The present study was aimed to investigate the impact of ferroptosis on cisplatin-induced sensory hair cell damage. Cell viability was determined by Cell Counting Kit-8 and lactase dehydrogenase assays. The reactive oxygen species (ROS) levels were evaluated by 2,7-Dichlorodi-hydrofluorescein diacetate (DCFH-DA) and MitoSox-Red staining. Mitochondrial membrane potential (MMP) was measured by tetramethylrhodamine methyl ester (TMRM) staining. Lipid peroxidation, intracellular and mitochondrial iron were detected by Liperfluo, C11-BODIPY

Topics: Aldehydes; Animals; Carbolines; Cell Line; Cell Survival; Cisplatin; Cyclohexylamines; Cytoprotection; Ferroptosis; Hair Cells, Auditory; Iron; Iron Overload; Membrane Potential, Mitochondrial; Mice, Inbred C57BL; Ototoxicity; Phenylenediamines; Reactive Oxygen Species

2020