4-hydroxy-2-nonenal and Nasal-Polyps

Nicotinamide adenine dinucleotide phosphate (NADPH) oxidase produces reactive oxygen species (ROS) involved in oxidative stress and signal transduction. Recent studies have suggested that NADPH oxidase is associated with the pathogenesis of chronic rhinosinusitis with nasal polyps (CRSwNP). The aim of this study was to detect the expression of NADPH oxidase subunits and 4-hydroxynonenal (4-HNE) in nasal polyp tissue and normal nasal mucosa, in order to explore the possible role played by NADPH oxidase in the pathogenesis of CRSwNP.. Thirteen patients with CRSwNP and 9 normal control subjects were selected to participate in this study, in which we evaluated the expression of different NADPH oxidase subunits (gp91. Western blot and real-time PCR results showed that p67. The levels of p67

Topics: Adult; Aged; Aldehydes; Chronic Disease; Eosinophils; Female; Humans; Male; Middle Aged; NADPH Oxidases; Nasal Mucosa; Nasal Polyps; Neutrophils; Oxidative Stress; Phosphoproteins; Rhinitis; Sinusitis