4-hydroxy-2-nonenal and Infertility--Female

To investigate the possible role of oxidative stress in the pathogenesis of female infertility, we examined the peritoneal fluid (PF) and plasma lipid peroxides levels in infertile women.. 4-hydroxynonenal (4-HNE) and malonyldialdehyde (MDA) concentrations were measured in peritoneal fluid and plasma samples obtained from: 10 infertile women with minimal and mild endometriosis, 24 patients with unexplained infertility, 11 women with PCOS and 14 patients with tubal infertility.. PF lipid peroxides level was significantly higher in women with idiopathic infertility compared to other groups. Plasma 4-HNE and MDA concentrations did not differ significantly between the infertile groups. No significant difference or relationship was observed between peritoneal fluid and plasma lipid peroxides levels.. Increased free radicals activity in the peritoneal fluid environment may be the factor responsible for some cases of "unexplained infertility".

Topics: Adult; Aldehydes; Ascitic Fluid; Biomarkers; Female; Humans; Infertility, Female; Lipid Peroxides; Malondialdehyde; Oxidative Stress