4-hydroxy-2-nonenal and Hearing-Loss--Sensorineural

We sought to determine the preventive effects of curcumin and its highly bioavailable preparation on noise-induced hearing loss in a novel murine model of permanent hearing loss developed by repeated exposure to noise. Upon exposure to noise (8-kHz octave band noise, 90 dB sound pressure level, 1 h), hearing ability was impaired in a temporary and reversible manner. During repeated noise exposure (1-h exposure per day, 5 days), there was a progressive increase in the auditory threshold shift at 12 and 20 kHz. The threshold shift persisted for at least 6 days after noise exposure. Oral administration of curcumin for 3 days before and each day during noise exposure significantly alleviated the hearing loss induced by repeated noise exposure. Curcumin abolished intranuclear translocation of nuclear factor-κB-p65 and generation of 4-hydroxynonenal-adducted proteins found in the cochlea after noise exposure. Theracurmin

Topics: Active Transport, Cell Nucleus; Administration, Ophthalmic; Aldehydes; Animals; Biological Availability; Cochlea; Curcumin; Differential Threshold; Disease Models, Animal; Dosage Forms; Environmental Exposure; Hearing; Hearing Loss, Sensorineural; Mice, Inbred Strains; Noise; Phytotherapy; Transcription Factor RelA