4-hydroxy-2-nonenal has been researched along with Dehydration* in 1 studies
1 other study(ies) available for 4-hydroxy-2-nonenal and Dehydration
| Article | Year |
|---|---|
The protective effect of apelin against water-immersion and restraint stress-induced gastric damage.
The aim of the present study was to investigate the gastroprotective effect of apelin on water-immersion and restraint stress (WIRS)-induced gastric lesions. Male Wistar rats were divided into four groups: control, WIRS, F13A + WIRS and F13A. APJ receptor antagonist F13A was administered to rats to determine the influence of apelin on stress-induced gastric injury. WIRS administered for 6 h resulted in the development of gastric mucosal lesions accompanied by a significant increase in plasma corticosterone. WIRS increased the concentration of 4-hydroxynonenol (4-HNE) + malondialdehyde (MDA) and the expression of apelin and hypoxia inducible factor-1α (HIF-1α) in gastric mucosa. In addition, WIRS reduced the mucosal blood flow and gastric prostaglandin E(2) (PGE(2)) concentration. Plasma corticosterone, which was increased due to stress, was significantly decreased in the F13A + WIRS group. Gastric lesions and the 4-HNE + MDA concentration were also higher in the F13A + WIRS compared to the WIRS group. We conclude that apelin has a gastroprotective effect against stress-induced lesions possibly by reducing lipid peroxidation in gastric mucosa. Topics: Aldehydes; Animals; Apelin; Corticosterone; Dehydration; Dinoprostone; Gastric Mucosa; Hypoxia-Inducible Factor 1, alpha Subunit; Intercellular Signaling Peptides and Proteins; Male; Malondialdehyde; Rats, Wistar; Regional Blood Flow; Restraint, Physical; Stomach; Stomach Diseases; Stress, Physiological | 2014 |