4-diphenylacetoxy-1,1-dimethylpiperidinium and Reperfusion Injury studies

4-diphenylacetoxy-1,1-dimethylpiperidinium and Reperfusion Injury

4-diphenylacetoxy-1,1-dimethylpiperidinium: muscarinic receptor antagonist; RN given refers to parent cpd; do not confuse abbreviation 4-DAMP with a similar cpd which does not contain dimethyl groups
4-DAMP(1+) : A quaternary ammonium salt obtained by formal methylation of the tertiary amino function of 4-diphenylacetoxy-N-methylpiperidine.

Reperfusion Injury: Adverse functional, metabolic, or structural changes in tissues that result from the restoration of blood flow to the tissue (REPERFUSION) following ISCHEMIA.

Research Excerpts

Excerpt	Relevance	Reference
"Choline treatment attenuated I/R-induced vascular dysfunction, blocked elevations in the levels of reactive oxygen species (ROS) and decreased the up-regulated expression of oxidised CaMKII and phosphorylated CaMKII."	1.42	Activation of M3 cholinoceptors attenuates vascular injury after ischaemia/reperfusion by inhibiting the Ca2+/calmodulin-dependent protein kinase II pathway. ( Bi, XY; He, X; Lu, XZ; Xu, M; Yu, XJ; Zang, WJ; Zhao, M; Zhao, ZH, 2015)

Research

Studies (2)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	0 (0.00)	29.6817
2010's	2 (100.00)	24.3611
2020's	0 (0.00)	2.80

Timeframe

Studies, this research(%)

All Research%

pre-1990

0 (0.00)

18.7374

1990's

0 (0.00)

18.2507

2000's

0 (0.00)

29.6817

2010's

2 (100.00)

24.3611

2020's

0 (0.00)

2.80

Authors

Authors	Studies
Lu, XZ	1
Bi, XY	1
He, X	2
Zhao, M	2
Xu, M	2
Yu, XJ	1
Zhao, ZH	1
Zang, WJ	1
Bi, X	1
Yu, X	1
Lu, X	1
Zang, W	1

Studies

Lu, XZ

Bi, XY

He, X

Zhao, M

Xu, M

Yu, XJ

Zhao, ZH

Zang, WJ

Bi, X

Yu, X

Lu, X

Zang, W

Other Studies

2 other studies available for 4-diphenylacetoxy-1,1-dimethylpiperidinium and Reperfusion Injury

Article	Year
Activation of M3 cholinoceptors attenuates vascular injury after ischaemia/reperfusion by inhibiting the Ca2+/calmodulin-dependent protein kinase II pathway. British journal of pharmacology, 2015, Volume: 172, Issue:23 Topics: Administration, Intravenous; Animals; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Choline; C	2015
Acetylcholine ameliorates endoplasmic reticulum stress in endothelial cells after hypoxia/reoxygenation via M3 AChR-AMPK signaling. Cell cycle (Georgetown, Tex.), 2015, Aug-03, Volume: 14, Issue:15 Topics: Acetylcholine; AMP-Activated Protein Kinases; Apoptosis; Caspase 12; Cell Hypoxia; Cell Line; DNA Nu	2015

Article

Year

Activation of M3 cholinoceptors attenuates vascular injury after ischaemia/reperfusion by inhibiting the Ca2+/calmodulin-dependent protein kinase II pathway.

British journal of pharmacology, 2015, Volume: 172, Issue:23

Topics: Administration, Intravenous; Animals; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Choline; C

2015

Acetylcholine ameliorates endoplasmic reticulum stress in endothelial cells after hypoxia/reoxygenation via M3 AChR-AMPK signaling.

Cell cycle (Georgetown, Tex.), 2015, Aug-03, Volume: 14, Issue:15

Topics: Acetylcholine; AMP-Activated Protein Kinases; Apoptosis; Caspase 12; Cell Hypoxia; Cell Line; DNA Nu

2015