4-dichlorobenzene and Acute Liver Injury, Drug-Induced studies

4-dichlorobenzene and Acute Liver Injury, Drug-Induced

dichlorobenzene : Any member of the class of chlorobenzenes carrying two chloro groups at unspecified positions.
1,4-dichlorobenzene : A dichlorobenzene carrying chloro groups at positions 1 and 4.

Research Excerpts

Excerpt	Relevance	Reference
" An understanding of structure-activity relationships (SARs) of chemicals can make a significant contribution to the identification of potential toxic effects early in the drug development process and aid in avoiding such problems."	1.36	Developing structure-activity relationships for the prediction of hepatotoxicity. ( Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ, 2010)
" Dose-response studies indicated that the rank order for acute hepatotoxicity of the isomers was m-DCB > o-DCB > or = p-DCB."	1.29	Isomer-specific acute toxicity and cell proliferation in livers of B6C3F1 mice exposed to dichlorobenzene. ( Kurokawa, Y; Saito, M; Takagi, A; Umemura, T, 1996)

Research

Studies (4)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	1 (25.00)	18.2507
2000's	1 (25.00)	29.6817
2010's	2 (50.00)	24.3611
2020's	0 (0.00)	2.80

Timeframe

Studies, this research(%)

All Research%

pre-1990

0 (0.00)

18.7374

1990's

1 (25.00)

18.2507

2000's

1 (25.00)

29.6817

2010's

2 (50.00)

24.3611

2020's

0 (0.00)

2.80

Authors

Authors	Studies
Greene, N	1
Fisk, L	1
Naven, RT	1
Note, RR	1
Patel, ML	1
Pelletier, DJ	1
Ekins, S	1
Williams, AJ	1
Xu, JJ	1
Kuczkowski, KM	1
Umemura, T	1
Saito, M	1
Takagi, A	1
Kurokawa, Y	1

Studies

Greene, N

Fisk, L

Naven, RT

Note, RR

Patel, ML

Pelletier, DJ

Ekins, S

Williams, AJ

Xu, JJ

Kuczkowski, KM

Umemura, T

Saito, M

Takagi, A

Kurokawa, Y

Other Studies

4 other studies available for 4-dichlorobenzene and Acute Liver Injury, Drug-Induced

Article	Year
Developing structure-activity relationships for the prediction of hepatotoxicity. Chemical research in toxicology, 2010, Jul-19, Volume: 23, Issue:7 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship;	2010
A predictive ligand-based Bayesian model for human drug-induced liver injury. Drug metabolism and disposition: the biological fate of chemicals, 2010, Volume: 38, Issue:12 Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands	2010
Mothballs and obstetric anesthesia. Annales francaises d'anesthesie et de reanimation, 2006, Volume: 25, Issue:4 Topics: Administration, Inhalation; Adult; Analgesia, Epidural; Analgesia, Obstetrical; Anemia; Chemical and	2006
Isomer-specific acute toxicity and cell proliferation in livers of B6C3F1 mice exposed to dichlorobenzene. Toxicology and applied pharmacology, 1996, Volume: 137, Issue:2 Topics: Acute Disease; Alanine Transaminase; Animals; Cell Division; Chemical and Drug Induced Liver Injury;	1996

Article

Year

Developing structure-activity relationships for the prediction of hepatotoxicity.

Chemical research in toxicology, 2010, Jul-19, Volume: 23, Issue:7

Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship;

2010

A predictive ligand-based Bayesian model for human drug-induced liver injury.

Drug metabolism and disposition: the biological fate of chemicals, 2010, Volume: 38, Issue:12

Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands

2010

Mothballs and obstetric anesthesia.

Annales francaises d'anesthesie et de reanimation, 2006, Volume: 25, Issue:4

Topics: Administration, Inhalation; Adult; Analgesia, Epidural; Analgesia, Obstetrical; Anemia; Chemical and

2006

Isomer-specific acute toxicity and cell proliferation in livers of B6C3F1 mice exposed to dichlorobenzene.

Toxicology and applied pharmacology, 1996, Volume: 137, Issue:2

Topics: Acute Disease; Alanine Transaminase; Animals; Cell Division; Chemical and Drug Induced Liver Injury;

1996