4-cresol-sulfate and Ischemic-Stroke

Patients on hemodialysis over 6 months were enrolled in this prospective cohort study and were divided into 2 groups based on plasma p-cresyl sulfate level. The primary end point was the first episode of ischemic stroke during follow-up. The association between p-cresyl sulfate and ischemic stroke incidence was analyzed by Kaplan-Meier method and Cox proportional hazard model.. 220 patients were enrolled in this study. 44 patients experienced episodes of first ischemic stroke during follow-up for 87.8 (47.6-119.5) months. Kaplan-Meier analysis demonstrated that the incidence of ischemic stroke in the high p-cresyl sulfate group was significantly higher than that in the low p-cresyl sulfate group (Log-Rank. Plasma p-cresyl sulfate predicts the first incidence of ischemic stroke in hemodialysis patients.

Topics: Adult; Aged; Cohort Studies; Cresols; Female; Humans; Incidence; Ischemic Stroke; Male; Middle Aged; Predictive Value of Tests; Prospective Studies; Renal Dialysis; Sulfuric Acid Esters