4-cresol-sulfate and Birth-Weight

Due to the global increase in obesity rates and success of bariatric surgery in weight reduction, an increasing number of women now present pregnant with a previous bariatric procedure. This study investigates the extent of bariatric-associated metabolic and gut microbial alterations during pregnancy and their impact on fetal development.. A parallel metabonomic (molecular phenotyping based on proton nuclear magnetic resonance spectroscopy) and gut bacterial (16S ribosomal RNA gene amplicon sequencing) profiling approach was used to determine maternal longitudinal phenotypes associated with malabsorptive/mixed (n=25) or restrictive (n=16) procedures, compared with women with similar early pregnancy body mass index but without bariatric surgery (n=70). Metabolic profiles of offspring at birth were also analysed.. Metabolism is altered in pregnant women with a previous malabsorptive bariatric surgery. These alterations may be beneficial for maternal outcomes, but the effect of elevated levels of phenolic and indolic compounds on fetal and infant health should be investigated further.

Topics: 3-Hydroxybutyric Acid; Adult; Amino Acids; Birth Weight; Body Mass Index; Clostridiales; Creatinine; Cresols; Enterococcus; Escherichia; Feces; Female; Fetal Development; Gastric Bypass; Gastrointestinal Microbiome; Gastroplasty; Glutamine; Hemiterpenes; Humans; Indican; Infant, Newborn; Insulin Resistance; Isobutyrates; Isoleucine; Keto Acids; Leucine; Metabolomics; Micrococcaceae; Phenotype; Phenylacetates; Pregnancy; Streptococcus; Sulfuric Acid Esters; Young Adult