4-cresol and Uremia
4-cresol has been researched along with Uremia in 50 studies
4-cresol: RN given refers to parent cpd
p-cresol : A cresol that consists of toluene substituted by a hydroxy group at position 4. It is a metabolite of aromatic amino acid metabolism produced by intestinal microflora in humans and animals.
Uremia: A clinical syndrome associated with the retention of renal waste products or uremic toxins in the blood. It is usually the result of RENAL INSUFFICIENCY. Most uremic toxins are end products of protein or nitrogen CATABOLISM, such as UREA or CREATININE. Severe uremia can lead to multiple organ dysfunctions with a constellation of symptoms.
Research Excerpts
| Excerpt | Relevance | Reference |
|---|---|---|
| "To understand the impact of PC on bladder cancer progression, human bladder cancer TSGH8301 cells were treated PC with various concentration (25-100 μM)." | 1.51 | The uremic toxin p-cresol promotes the invasion and migration on carcinoma cells via Ras and mTOR signaling. ( Chang, HR; Hsu, YH; Huang, HP, 2019) |
| "Patients with chronic renal failure (CRF) exhibit endothelial dysfunction, which may involve uremic retention solutes that accumulate in blood and tissues." | 1.32 | P-cresol, a uremic retention solute, alters the endothelial barrier function in vitro. ( Anfosso, F; Berland, Y; Brunet, P; Cerini, C; De Smet, R; Dignat-George, F; Dou, L; Glorieux, G; Moal, V; Sabatier, F; Sampol, J; Vanholder, R, 2004) |
| "Hippuric acid removal was more pronounced than that of the remaining protein-bound compounds (P<0." | 1.31 | Intradialytic removal of protein-bound uraemic toxins: role of solute characteristics and of dialyser membrane. ( De Smet, R; Dhondt, A; Duym, P; Lameire, N; Lesaffer, G; Vanholder, R, 2000) |
| " Dose-response curves confirmed that Al uptake and cell toxicity were proportional to p-cresol from 1." | 1.30 | P-Cresol, a uremic compound, enhances the uptake of aluminum in hepatocytes. ( Abreo, K; De Smet, R; Gautreaux, S; Ringoir, S; Sella, M; Vanholder, R; Vogeleere, P, 1997) |
Research
Studies (50)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (2.00) | 18.7374 |
| 1990's | 8 (16.00) | 18.2507 |
| 2000's | 21 (42.00) | 29.6817 |
| 2010's | 17 (34.00) | 24.3611 |
| 2020's | 3 (6.00) | 2.80 |
Authors
| Authors | Studies |
|---|---|
| Heaney, LM | 1 |
| Yen, SC | 1 |
| Liu, ZW | 1 |
| Juang, RS | 1 |
| Sahoo, S | 1 |
| Huang, CH | 1 |
| Chen, P | 1 |
| Hsiao, YS | 1 |
| Fang, JT | 1 |
| Guerrero, F | 1 |
| Carmona, A | 1 |
| Obrero, T | 1 |
| Jiménez, MJ | 1 |
| Soriano, S | 1 |
| Moreno, JA | 1 |
| Martín-Malo, A | 1 |
| Aljama, P | 1 |
| Kamprom, W | 1 |
| Tawonsawatruk, T | 1 |
| Mas-Oodi, S | 1 |
| Anansilp, K | 1 |
| Rattanasompattikul, M | 1 |
| Supokawej, A | 1 |
| Vila Cuenca, M | 1 |
| van Bezu, J | 1 |
| Beelen, RHJ | 1 |
| Vervloet, MG | 1 |
| Hordijk, PL | 1 |
| Hsu, YH | 1 |
| Huang, HP | 1 |
| Chang, HR | 1 |
| Idziak, M | 1 |
| Pędzisz, P | 1 |
| Burdzińska, A | 1 |
| Gala, K | 1 |
| Pączek, L | 1 |
| Noh, H | 1 |
| Yu, MR | 1 |
| Kim, HJ | 1 |
| Jang, EJ | 1 |
| Hwang, ES | 1 |
| Jeon, JS | 1 |
| Kwon, SH | 1 |
| Han, DC | 1 |
| Barnes, KJ | 1 |
| Rowland, A | 1 |
| Polasek, TM | 1 |
| Miners, JO | 1 |
| Salmean, YA | 1 |
| Segal, MS | 1 |
| Palii, SP | 1 |
| Dahl, WJ | 1 |
| Bosco, AM | 1 |
| Pereira, PP | 1 |
| Almeida, BF | 1 |
| Narciso, LG | 1 |
| Dos Santos, DB | 1 |
| Santos-Neto, ÁJ | 1 |
| Ferreira, WL | 1 |
| Ciarlini, PC | 1 |
| Kieffer, DA | 1 |
| Piccolo, BD | 1 |
| Vaziri, ND | 1 |
| Liu, S | 1 |
| Lau, WL | 1 |
| Khazaeli, M | 1 |
| Nazertehrani, S | 1 |
| Moore, ME | 1 |
| Marco, ML | 1 |
| Martin, RJ | 1 |
| Adams, SH | 1 |
| Lee, CH | 1 |
| Hung, YJ | 1 |
| Shieh, YS | 1 |
| Chien, CY | 1 |
| Hsu, YJ | 1 |
| Lin, CY | 1 |
| Chiang, CF | 1 |
| Huang, CL | 1 |
| Hsieh, CH | 1 |
| Pan, L | 1 |
| Ye, X | 1 |
| Ding, J | 1 |
| Zhou, Y | 1 |
| Tsujimoto, M | 2 |
| Kinoshita, Y | 1 |
| Hirata, S | 2 |
| Otagiri, M | 2 |
| Ohtani, H | 1 |
| Sawada, Y | 1 |
| Meijers, BK | 2 |
| Van Kerckhoven, S | 1 |
| Verbeke, K | 6 |
| Dehaen, W | 2 |
| Vanrenterghem, Y | 4 |
| Hoylaerts, MF | 1 |
| Evenepoel, P | 7 |
| Higuchi, K | 1 |
| Shima, D | 1 |
| Yokota, H | 1 |
| Furukubo, T | 1 |
| Izumi, S | 1 |
| Yamakawa, T | 1 |
| Takara, K | 1 |
| Nishiguchi, K | 1 |
| Vanholder, R | 18 |
| Bammens, B | 6 |
| de Loor, H | 2 |
| Glorieux, G | 7 |
| Meijers, B | 1 |
| Schepers, E | 4 |
| Massy, Z | 2 |
| Chang, MC | 1 |
| Wang, TM | 1 |
| Yeung, SY | 1 |
| Jeng, PY | 1 |
| Liao, CH | 1 |
| Lin, TY | 1 |
| Lin, CC | 1 |
| Lin, BR | 1 |
| Jeng, JH | 1 |
| Neirynck, N | 1 |
| Eloot, S | 1 |
| Pletinck, A | 1 |
| Mutsaers, HA | 1 |
| Wilmer, MJ | 1 |
| Reijnders, D | 1 |
| Jansen, J | 1 |
| van den Broek, PH | 1 |
| Forkink, M | 1 |
| van den Heuvel, LP | 1 |
| Hoenderop, JG | 1 |
| Masereeuw, R | 1 |
| Koppe, L | 1 |
| Pillon, NJ | 1 |
| Vella, RE | 1 |
| Croze, ML | 1 |
| Pelletier, CC | 1 |
| Chambert, S | 1 |
| Dugenet, Y | 1 |
| Soula, HA | 1 |
| Fouque, D | 1 |
| Soulage, CO | 1 |
| Dou, L | 6 |
| Cerini, C | 6 |
| Brunet, P | 7 |
| Guilianelli, C | 1 |
| Moal, V | 2 |
| Grau, G | 1 |
| De Smet, R | 11 |
| Sampol, J | 4 |
| Berland, Y | 7 |
| Dhondt, AW | 1 |
| Vanholder, RC | 1 |
| De Smet, RV | 1 |
| Claus, SA | 1 |
| Waterloos, MA | 2 |
| Glorieux, GL | 1 |
| Delanghe, JR | 1 |
| Lameire, NH | 1 |
| Lesaffer, G | 4 |
| Belpaire, FM | 2 |
| Van Vlem, B | 1 |
| Van Hulle, M | 1 |
| Cornelis, R | 2 |
| Lameire, N | 5 |
| D'Heuvaert, T | 1 |
| Bertrand, E | 1 |
| Faure, V | 4 |
| Anfosso, F | 1 |
| Sabatier, F | 2 |
| Dignat-George, F | 3 |
| De Preter, V | 1 |
| Wernert, V | 1 |
| Schäf, O | 1 |
| Boulet, P | 1 |
| Kuchta, B | 1 |
| Denoyel, R | 1 |
| Paul, P | 1 |
| Meert, N | 1 |
| Goeman, J | 1 |
| Van der Eycken, J | 1 |
| Weber, V | 1 |
| Falkenhagen, D | 1 |
| Van Landschoot, N | 1 |
| Vogeleere, P | 2 |
| Hoste, E | 1 |
| Ringoir, S | 2 |
| Niwa, T | 2 |
| Ise, M | 1 |
| Miyazaki, T | 1 |
| Meada, K | 1 |
| Hida, M | 1 |
| Aiba, Y | 1 |
| Sawamura, S | 1 |
| Suzuki, N | 1 |
| Satoh, T | 1 |
| Koga, Y | 1 |
| Abreo, K | 1 |
| Sella, M | 1 |
| Gautreaux, S | 1 |
| Hsu, C | 1 |
| De Kimpe, J | 1 |
| Dhondt, A | 1 |
| Duym, P | 1 |
| Hohenegger, M | 1 |
| Vermes, M | 1 |
| Esposito, R | 1 |
| Giordano, C | 1 |
Clinical Trials (3)
Trial Overview
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Effect of a Nutritional Supplement of Probiotics and/or Prebiotics vs Placebo on Serum Concentrations of Uremic Toxins and Inflammatory Cytokines in Automated Peritoneal Dialysis Patients.[NCT03770611] | 112 participants (Anticipated) | Interventional | 2019-01-07 | Not yet recruiting | |||
| Effect of Probiotics on Modulating the Bacterial Translocation and Improving Micro-inflammation in Hemodialysis Patients[NCT02929225] | Early Phase 1 | 50 participants (Actual) | Interventional | 2016-12-31 | Completed | ||
| Effects of Synbiotics Supplementation on the Concentration of the Uremic Toxin Indoxyl Sulfate, Symptoms of Constipation, and Constipation-related Quality of Life in End-stage Renal Disease Patients Undergoing Hemodialysis[NCT04527640] | 60 participants (Anticipated) | Interventional | 2020-09-15 | Not yet recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Reviews
6 reviews available for 4-cresol and Uremia
| Article | Year |
|---|---|
Applying mass spectrometry-based assays to explore gut microbial metabolism and associations with disease.
Topics: Animals; Bacteria; Biomarkers; Chromatography, High Pressure Liquid; Cresols; Fatty Acids, Volatile; | 2020 |
An update on uremic toxins.
Topics: beta 2-Microglobulin; Biomarkers; Cardiovascular Diseases; Cresols; Dialysis Solutions; Fibroblast G | 2013 |
Protein-bound uremic retention solutes.
Topics: Animals; Blood Proteins; Cresols; Furans; Hippurates; Homocysteine; Humans; Indican; Propionates; Re | 2003 |
p-cresol and uric acid: two old uremic toxins revisited.
Topics: Cresols; Humans; In Vitro Techniques; Kidney; Renal Insufficiency; Toxins, Biological; Uremia; Uric | 1997 |
Protein-bound uremic solutes: the forgotten toxins.
Topics: Animals; Cresols; Furans; Hippurates; Homocysteine; Humans; Indican; Intestinal Mucosa; Kinetics; Pr | 2001 |
Uremic toxins and peritoneal dialysis.
Topics: Animals; beta 2-Microglobulin; Cardiovascular Diseases; Cresols; Cytokines; Glycation End Products, | 2001 |
Trials
4 trials available for 4-cresol and Uremia
| Article | Year |
|---|---|
Studies on dialysate mixing in the Genius single-pass batch system for hemodialysis therapy.
Topics: Aged; Creatinine; Cresols; Female; Hemodialysis Solutions; Humans; Kidney Failure, Chronic; Male; Mi | 2003 |
Removal of the protein-bound solute p-cresol by convective transport: a randomized crossover study.
Topics: Aged; beta 2-Microglobulin; Blood Proteins; Convection; Creatinine; Cresols; Cross-Over Studies; Equ | 2004 |
Elevation of circulating endothelial microparticles in patients with chronic renal failure.
Topics: Adult; Aged; Aged, 80 and over; Annexin A5; Antigens, CD; Cadherins; CD146 Antigen; Cells, Cultured; | 2006 |
Removal of the uremic retention solute p-cresol using fractionated plasma separation and adsorption.
Topics: Adsorption; Anion Exchange Resins; Arteriovenous Shunt, Surgical; Cresols; Cross-Over Studies; Human | 2008 |
Other Studies
40 other studies available for 4-cresol and Uremia
| Article | Year |
|---|---|
Carbon Nanotube/Conducting Polymer Hybrid Nanofibers as Novel Organic Bioelectronic Interfaces for Efficient Removal of Protein-Bound Uremic Toxins.
Topics: Adsorption; Cresols; Electronics; Hippurates; Humans; Indican; Nanotubes, Carbon; Polymers; Proteins | 2019 |
Role of endothelial microvesicles released by p-cresol on endothelial dysfunction.
Topics: Cell Movement; Cell-Derived Microparticles; Cells, Cultured; Cellular Senescence; Cresols; Endotheli | 2020 |
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Topics: Cells, Cultured; Cellular Senescence; Chronic Kidney Disease-Mineral and Bone Disorder; Cresols; Hea | 2021 |
Stabilization of cell-cell junctions by active vitamin D ameliorates uraemia-induced loss of human endothelial barrier function.
Topics: Actins; Adult; Aged; Antigens, CD; Cadherins; Cell Adhesion; Cell Movement; Cells, Cultured; Cresols | 2019 |
The uremic toxin p-cresol promotes the invasion and migration on carcinoma cells via Ras and mTOR signaling.
Topics: Amides; Cell Line, Tumor; Cell Movement; Cell Proliferation; Cresols; Everolimus; Humans; NF-kappa B | 2019 |
Uremic toxins impair human bone marrow-derived mesenchymal stem cells functionality in vitro.
Topics: Apoptosis; Cell Adhesion; Cell Membrane; Cell Proliferation; Cell Survival; Cells, Cultured; Cresols | 2014 |
Uremic toxin p-cresol induces Akt-pathway-selective insulin resistance in bone marrow-derived mesenchymal stem cells.
Topics: Animals; Bone Marrow; Cell Differentiation; Cells, Cultured; Cresols; HEK293 Cells; Humans; Insulin | 2014 |
Inhibition of human drug-metabolising cytochrome P450 and UDP-glucuronosyltransferase enzyme activities in vitro by uremic toxins.
Topics: Benzyl Alcohol; Cresols; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Glucuro | 2014 |
Fiber supplementation lowers plasma p-cresol in chronic kidney disease patients.
Topics: Aged; Cresols; Defecation; Dietary Fiber; Female; Humans; Male; Middle Aged; Quality of Life; Renal | 2015 |
Free p-Cresol Alters Neutrophil Function in Dogs.
Topics: Animals; Apoptosis; Cresols; Dogs; Female; Kidney; Kidney Failure, Chronic; Male; Neutrophils; Oxida | 2016 |
Resistant starch alters gut microbiome and metabolomic profiles concurrent with amelioration of chronic kidney disease in rats.
Topics: Animals; Cecum; Cresols; Diet; Dietary Fiber; Gastrointestinal Microbiome; Hydrogen-Ion Concentratio | 2016 |
Cilostazol inhibits uremic toxin-induced vascular smooth muscle cell dysfunction: role of Axl signaling.
Topics: Animals; Axl Receptor Tyrosine Kinase; Cell Line; Cell Movement; Cell Survival; Cilostazol; Cresols; | 2017 |
Antiproliferation effect of the uremic toxin para‑cresol on endothelial progenitor cells is related to its antioxidant activity.
Topics: Catalase; Cell Line; Cell Proliferation; Cresols; Endothelial Progenitor Cells; Gene Expression Regu | 2017 |
Effects of uremic serum and uremic toxins on hepatic uptake of digoxin.
Topics: Animals; Biological Transport, Active; Cresols; Digoxin; Dose-Response Relationship, Drug; Furans; H | 2008 |
The uremic retention solute p-cresyl sulfate and markers of endothelial damage.
Topics: Aged; Biomarkers; Cells, Cultured; Chronic Disease; Cresols; Endothelium, Vascular; Female; Humans; | 2009 |
Inhibitory effects of uraemic toxins 3-indoxyl sulfate and p-cresol on losartan metabolism in vitro.
Topics: Angiotensin II Type 1 Receptor Blockers; Aryl Hydrocarbon Hydroxylases; Cresols; Cytochrome P-450 CY | 2010 |
Warning: the unfortunate end of p-cresol as a uraemic toxin.
Topics: Cresols; Humans; Prognosis; Toxins, Biological; Uremia | 2011 |
Antiplatelet effect by p-cresol, a uremic and environmental toxicant, is related to inhibition of reactive oxygen species, ERK/p38 signaling and thromboxane A2 production.
Topics: Animals; Blood Cell Count; Blood Platelets; Cresols; Dose-Response Relationship, Drug; Environmental | 2011 |
Uremic toxins inhibit renal metabolic capacity through interference with glucuronidation and mitochondrial respiration.
Topics: Cell Line; Cresols; Drug-Related Side Effects and Adverse Reactions; Electron Transport; Glucuronosy | 2013 |
p-Cresyl sulfate promotes insulin resistance associated with CKD.
Topics: Adipocytes; Adipose Tissue, White; Animals; Cresols; Disease Models, Animal; Extracellular Signal-Re | 2013 |
P-cresol, a uremic toxin, decreases endothelial cell response to inflammatory cytokines.
Topics: Antineoplastic Agents; Cell Adhesion; Cells, Cultured; Cresols; Down-Regulation; Endothelium, Vascul | 2002 |
Urinary excretion of the uraemic toxin p-cresol in the rat: contribution of glucuronidation to its metabolization.
Topics: Animals; Biotransformation; Chromatography, High Pressure Liquid; Cresols; Disease Models, Animal; G | 2003 |
Comparative kinetics of the uremic toxin p-cresol versus creatinine in rats with and without renal failure.
Topics: Animals; Creatinine; Cresols; Glucuronides; Hydrolysis; Male; Osmolar Concentration; Rats; Rats, Inb | 2003 |
Removal of middle molecules and protein-bound solutes by peritoneal dialysis and relation with uremic symptoms.
Topics: beta 2-Microglobulin; Cresols; Cross-Sectional Studies; Female; Humans; Male; Middle Aged; Peritonea | 2003 |
The uremic solutes p-cresol and indoxyl sulfate inhibit endothelial proliferation and wound repair.
Topics: Apoptosis; Cell Division; Cell Survival; Cells, Cultured; Cresols; Endothelium, Vascular; Humans; In | 2004 |
P-cresol, a uremic retention solute, alters the endothelial barrier function in vitro.
Topics: Actins; Amides; Antigens, CD; Cadherins; Capillary Permeability; Cells, Cultured; Cresols; Cytoskele | 2004 |
Gas chromatographic-mass spectrometric analysis for measurement of p-cresol and its conjugated metabolites in uremic and normal serum.
Topics: Adult; Aged; Cresols; Gas Chromatography-Mass Spectrometry; Glucuronates; Glucuronides; Heating; Hum | 2005 |
Time profiles of peritoneal and renal clearances of different uremic solutes in incident peritoneal dialysis patients.
Topics: Adult; Aged; Ascitic Fluid; beta 2-Microglobulin; Comorbidity; Creatinine; Cresols; Female; Follow-U | 2005 |
Adsorption of the uremic toxin p-cresol onto hemodialysis membranes and microporous adsorbent zeolite silicalite.
Topics: Adsorption; Cresols; Humans; Membranes, Artificial; Porosity; Renal Dialysis; Silicon Dioxide; Uremi | 2006 |
The uremic solute p-cresol decreases leukocyte transendothelial migration in vitro.
Topics: Cells, Cultured; Chemotaxis, Leukocyte; Cresols; Cytokines; Endothelial Cells; Gene Expression Regul | 2006 |
P-cresylsulphate, the main in vivo metabolite of p-cresol, activates leucocyte free radical production.
Topics: Biomarkers; Cresols; Endotoxins; Escherichia coli; Free Radicals; Humans; Leukocytes; Respiratory Bu | 2007 |
Mechanisms of uremic inhibition of phagocyte reactive species production: characterization of the role of p-cresol.
Topics: Chromatography, High Pressure Liquid; Cresols; Dose-Response Relationship, Drug; Humans; Phagocytes; | 1995 |
Suppressive effect of an oral sorbent on the accumulation of p-cresol in the serum of experimental uremic rats.
Topics: Administration, Oral; Adsorption; Animals; Blood Urea Nitrogen; Carbon; Creatinine; Cresols; Female; | 1993 |
Phenol and p-cresol accumulated in uremic serum measured by HPLC with fluorescence detection.
Topics: Adult; Aged; Chromatography, High Pressure Liquid; Creatinine; Cresols; Female; Humans; Male; Middle | 1993 |
Inhibition of the accumulation of uremic toxins in the blood and their precursors in the feces after oral administration of Lebenin, a lactic acid bacteria preparation, to uremic patients undergoing hemodialysis.
Topics: Administration, Oral; Adult; Bacteria, Aerobic; Bacteria, Anaerobic; Bifidobacterium; Capsules; Cres | 1996 |
Inhibition of the accumulation of uremic toxins in the blood and their precursors in the feces after oral administration of Lebenin, a lactic acid bacteria preparation, to uremic patients undergoing hemodialysis.
Topics: Administration, Oral; Adult; Bacteria, Aerobic; Bacteria, Anaerobic; Bifidobacterium; Capsules; Cres | 1996 |
Inhibition of the accumulation of uremic toxins in the blood and their precursors in the feces after oral administration of Lebenin, a lactic acid bacteria preparation, to uremic patients undergoing hemodialysis.
Topics: Administration, Oral; Adult; Bacteria, Aerobic; Bacteria, Anaerobic; Bifidobacterium; Capsules; Cres | 1996 |
Inhibition of the accumulation of uremic toxins in the blood and their precursors in the feces after oral administration of Lebenin, a lactic acid bacteria preparation, to uremic patients undergoing hemodialysis.
Topics: Administration, Oral; Adult; Bacteria, Aerobic; Bacteria, Anaerobic; Bifidobacterium; Capsules; Cres | 1996 |
P-Cresol, a uremic compound, enhances the uptake of aluminum in hepatocytes.
Topics: Aluminum; Animals; Cells, Cultured; Chromatography, High Pressure Liquid; Cresols; Drug Synergism; L | 1997 |
In vitro methylation of arsenite by rabbit liver cytosol: effect of metal ions, metal chelating agents, methyltransferase inhibitors and uremic toxins.
Topics: Animals; Arsenites; Cresols; Cytosol; Edetic Acid; Enzyme Inhibitors; Homocysteine; Hypoxanthine; In | 1999 |
p-cresol: a toxin revealing many neglected but relevant aspects of uraemic toxicity.
Topics: Animals; Cresols; Humans; Peritoneal Dialysis, Continuous Ambulatory; Renal Dialysis; Uremia | 1999 |
Intradialytic removal of protein-bound uraemic toxins: role of solute characteristics and of dialyser membrane.
Topics: Aged; Aged, 80 and over; Creatinine; Cresols; Female; Furans; Hippurates; Humans; Indican; Kidneys, | 2000 |
Effect of some uremic toxins on oxygen consumption of rats in vivo and in vitro.
Topics: Acetoin; Animals; Cresols; Drug Combinations; Indoles; Male; Methylguanidine; Oxygen Consumption; Pu | 1988 |