4-cresol has been researched along with Renal Insufficiency, Chronic in 20 studies
4-cresol: RN given refers to parent cpd
p-cresol : A cresol that consists of toluene substituted by a hydroxy group at position 4. It is a metabolite of aromatic amino acid metabolism produced by intestinal microflora in humans and animals.
Renal Insufficiency, Chronic: Conditions in which the KIDNEYS perform below the normal level for more than three months. Chronic kidney insufficiency is classified by five stages according to the decline in GLOMERULAR FILTRATION RATE and the degree of kidney damage (as measured by the level of PROTEINURIA). The most severe form is the end-stage renal disease (CHRONIC KIDNEY FAILURE). (Kidney Foundation: Kidney Disease Outcome Quality Initiative, 2002)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Renal fibrosis is one of the main causes of chronic kidney disease." | 1.56 | Knockdown of CK2α reduces ( Go, G; Lee, SH; Lim, JH; Yoon, YM; Yun, CW, 2020) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (5.00) | 29.6817 |
| 2010's | 12 (60.00) | 24.3611 |
| 2020's | 7 (35.00) | 2.80 |
| Authors | Studies |
|---|---|
| Guerrero, F | 1 |
| Carmona, A | 1 |
| Jimenez, MJ | 1 |
| Obrero, T | 1 |
| Pulido, V | 1 |
| Moreno, JA | 1 |
| Soriano, S | 1 |
| Martín-Malo, A | 1 |
| Aljama, P | 1 |
| Stuivenberg, GA | 1 |
| Chmiel, JA | 1 |
| Akouris, PP | 1 |
| Burton, JP | 1 |
| Reid, G | 1 |
| Silva, LAP | 3 |
| Campagnolo, S | 3 |
| Fernandes, SR | 3 |
| Marques, SS | 3 |
| Barreiros, L | 3 |
| Sampaio-Maia, B | 3 |
| Segundo, MA | 3 |
| Di Paola, R | 1 |
| De, A | 1 |
| Izhar, R | 1 |
| Abate, M | 1 |
| Zappavigna, S | 1 |
| Capasso, A | 1 |
| Perna, AF | 1 |
| La Russa, A | 1 |
| Capasso, G | 1 |
| Caraglia, M | 1 |
| Simeoni, M | 1 |
| Yoon, YM | 2 |
| Go, G | 1 |
| Yun, CW | 2 |
| Lim, JH | 1 |
| Lee, SH | 3 |
| Kamprom, W | 1 |
| Tawonsawatruk, T | 1 |
| Mas-Oodi, S | 1 |
| Anansilp, K | 1 |
| Rattanasompattikul, M | 1 |
| Supokawej, A | 1 |
| Chaves, LD | 1 |
| Abyad, S | 1 |
| Honan, AM | 1 |
| Bryniarski, MA | 1 |
| McSkimming, DI | 1 |
| Stahura, CM | 1 |
| Wells, SC | 1 |
| Ruszaj, DM | 1 |
| Morris, ME | 1 |
| Quigg, RJ | 1 |
| Yacoub, R | 1 |
| Riccio, E | 1 |
| Sabbatini, M | 1 |
| Bruzzese, D | 1 |
| Grumetto, L | 1 |
| Marchetiello, C | 1 |
| Amicone, M | 1 |
| Andreucci, M | 1 |
| Guida, B | 1 |
| Passaretti, D | 1 |
| Russo, G | 1 |
| Pisani, A | 1 |
| Liu, Y | 1 |
| Li, J | 1 |
| Yu, J | 1 |
| Wang, Y | 1 |
| Lu, J | 1 |
| Shang, EX | 1 |
| Zhu, Z | 1 |
| Guo, J | 1 |
| Duan, J | 1 |
| Lee, JH | 2 |
| Hur, J | 1 |
| Bartlett, DE | 1 |
| Miller, RB | 1 |
| Thiesfeldt, S | 1 |
| Lakhani, HV | 1 |
| Khanal, T | 1 |
| D Pratt, R | 1 |
| Cottrill, CL | 1 |
| Klug, RL | 1 |
| Adkins, NS | 1 |
| Bown, PC | 1 |
| Nease, DB | 1 |
| Shapiro, JI | 1 |
| Sodhi, K | 1 |
| Korytowska, N | 1 |
| Wyczałkowska-Tomasik, A | 1 |
| Wiśniewska, A | 1 |
| Pączek, L | 1 |
| Giebułtowicz, J | 1 |
| Poesen, R | 1 |
| Viaene, L | 1 |
| Verbeke, K | 2 |
| Augustijns, P | 1 |
| Bammens, B | 2 |
| Claes, K | 1 |
| Kuypers, D | 1 |
| Evenepoel, P | 2 |
| Meijers, B | 1 |
| Salmean, YA | 1 |
| Segal, MS | 1 |
| Palii, SP | 1 |
| Dahl, WJ | 1 |
| Lin, HH | 1 |
| Huang, CC | 1 |
| Lin, TY | 1 |
| Lin, CY | 1 |
| Assis, RP | 1 |
| Castro, JF | 1 |
| Gutierres, VO | 1 |
| Arcaro, CA | 1 |
| Brotto, RS | 1 |
| Oliveira, OM | 1 |
| Baviera, AM | 1 |
| Brunetti, IL | 1 |
| Kieffer, DA | 1 |
| Piccolo, BD | 1 |
| Vaziri, ND | 1 |
| Liu, S | 1 |
| Lau, WL | 1 |
| Khazaeli, M | 1 |
| Nazertehrani, S | 1 |
| Moore, ME | 1 |
| Marco, ML | 1 |
| Martin, RJ | 1 |
| Adams, SH | 1 |
| Koppe, L | 1 |
| Pillon, NJ | 1 |
| Vella, RE | 1 |
| Croze, ML | 1 |
| Pelletier, CC | 1 |
| Chambert, S | 1 |
| Massy, Z | 1 |
| Glorieux, G | 1 |
| Vanholder, R | 1 |
| Dugenet, Y | 1 |
| Soula, HA | 1 |
| Fouque, D | 1 |
| Soulage, CO | 1 |
| Meijers, BK | 1 |
| Weber, V | 1 |
| Dehaen, W | 1 |
| Falkenhagen, D | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Effect of a Nutritional Supplement of Probiotics and/or Prebiotics vs Placebo on Serum Concentrations of Uremic Toxins and Inflammatory Cytokines in Automated Peritoneal Dialysis Patients.[NCT03770611] | 112 participants (Anticipated) | Interventional | 2019-01-07 | Not yet recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for 4-cresol and Renal Insufficiency, Chronic
| Article | Year |
|---|---|
Possible Effects of Uremic Toxins p-Cresol, Indoxyl Sulfate, p-Cresyl Sulfate on the Development and Progression of Colon Cancer in Patients with Chronic Renal Failure.
Topics: Colonic Neoplasms; Humans; Indican; Inflammation; Kidney Failure, Chronic; Renal Insufficiency, Chro | 2023 |
3 trials available for 4-cresol and Renal Insufficiency, Chronic
| Article | Year |
|---|---|
Plasma p-cresol lowering effect of sevelamer in non-dialysis CKD patients: evidence from a randomized controlled trial.
Topics: Adult; Aged; Chelating Agents; Cresols; Female; Humans; Male; Middle Aged; Renal Insufficiency, Chro | 2018 |
Cardiovascular disease relates to intestinal uptake of p-cresol in patients with chronic kidney disease.
Topics: Aged; Aged, 80 and over; Belgium; Biomarkers; Cardiovascular Diseases; Comorbidity; Cresols; Female; | 2014 |
Removal of the uremic retention solute p-cresol using fractionated plasma separation and adsorption.
Topics: Adsorption; Anion Exchange Resins; Arteriovenous Shunt, Surgical; Cresols; Cross-Over Studies; Human | 2008 |
16 other studies available for 4-cresol and Renal Insufficiency, Chronic
| Article | Year |
|---|---|
Passage Number-Induced Replicative Senescence Modulates the Endothelial Cell Response to Protein-Bound Uremic Toxins.
Topics: Aging; Cell Movement; Cellular Senescence; Cresols; Endothelium, Vascular; Human Umbilical Vein Endo | 2021 |
Probiotic Bifidobacteria Mitigate the Deleterious Effects of
Topics: Animals; Drosophila melanogaster; Drosophila Proteins; Probiotics; Renal Insufficiency, Chronic; Sod | 2022 |
Rapid and sustainable HPLC method for the determination of uremic toxins in human plasma samples.
Topics: Chromatography, High Pressure Liquid; Cresols; Humans; Indican; Phenol; Renal Insufficiency, Chronic | 2023 |
Rapid and sustainable HPLC method for the determination of uremic toxins in human plasma samples.
Topics: Chromatography, High Pressure Liquid; Cresols; Humans; Indican; Phenol; Renal Insufficiency, Chronic | 2023 |
Rapid and sustainable HPLC method for the determination of uremic toxins in human plasma samples.
Topics: Chromatography, High Pressure Liquid; Cresols; Humans; Indican; Phenol; Renal Insufficiency, Chronic | 2023 |
Rapid and sustainable HPLC method for the determination of uremic toxins in human plasma samples.
Topics: Chromatography, High Pressure Liquid; Cresols; Humans; Indican; Phenol; Renal Insufficiency, Chronic | 2023 |
Knockdown of CK2α reduces
Topics: Adenine; Animals; Casein Kinase II; Cell Line; Cellular Senescence; Cresols; Disease Models, Animal; | 2020 |
P
Topics: Cells, Cultured; Cellular Senescence; Chronic Kidney Disease-Mineral and Bone Disorder; Cresols; Hea | 2021 |
Unconjugated p-cresol activates macrophage macropinocytosis leading to increased LDL uptake.
Topics: Animals; Aorta; Cholesterol; Cholesterol, LDL; Coronary Artery Disease; Coronary Vessels; Cresols; D | 2021 |
Disorder of gut amino acids metabolism during CKD progression is related with gut microbiota dysbiosis and metagenome change.
Topics: Amino Acids; Animals; Bacteria; Bacterial Physiological Phenomena; Cresols; Disease Models, Animal; | 2018 |
Fucoidan Rescues p-Cresol-Induced Cellular Senescence in Mesenchymal Stem Cells via FAK-Akt-TWIST Axis.
Topics: Cell Cycle; Cell Proliferation; Cells, Cultured; Cellular Senescence; Cresols; Focal Adhesion Kinase | 2018 |
Uremic Toxins Activates Na/K-ATPase Oxidant Amplification Loop Causing Phenotypic Changes in Adipocytes in In Vitro Models.
Topics: 3T3-L1 Cells; Adipocytes; Animals; Biomarkers; Cell Proliferation; Cell Survival; Cells, Cultured; C | 2018 |
TUDCA-Treated Mesenchymal Stem Cells Protect against ER Stress in the Hippocampus of a Murine Chronic Kidney Disease Model.
Topics: Adenine; Animals; Cell Line; Cell Survival; Coculture Techniques; Cresols; Disease Models, Animal; E | 2019 |
Development of the LC-MS/MS method for determining the p-cresol level in plasma.
Topics: Chromatography, Liquid; Cresols; Humans; Limit of Detection; Multiple Organ Failure; Renal Dialysis; | 2019 |
Fiber supplementation lowers plasma p-cresol in chronic kidney disease patients.
Topics: Aged; Cresols; Defecation; Dietary Fiber; Female; Humans; Male; Middle Aged; Quality of Life; Renal | 2015 |
p-Cresol mediates autophagic cell death in renal proximal tubular cells.
Topics: Animals; Apoptosis; Apoptosis Regulatory Proteins; Autophagy; Beclin-1; Caspase 8; Cell Line; Cell S | 2015 |
Effects of uremic solutes on reactive oxygen species in vitro model systems as a possibility of support the renal function management.
Topics: Arginine; Biomarkers; Creatinine; Cresols; Hippurates; Humans; In Vitro Techniques; Kidney Function | 2015 |
Resistant starch alters gut microbiome and metabolomic profiles concurrent with amelioration of chronic kidney disease in rats.
Topics: Animals; Cecum; Cresols; Diet; Dietary Fiber; Gastrointestinal Microbiome; Hydrogen-Ion Concentratio | 2016 |
p-Cresyl sulfate promotes insulin resistance associated with CKD.
Topics: Adipocytes; Adipose Tissue, White; Animals; Cresols; Disease Models, Animal; Extracellular Signal-Re | 2013 |