4-cresol has been researched along with Kidney Failure, Chronic in 29 studies
4-cresol: RN given refers to parent cpd
p-cresol : A cresol that consists of toluene substituted by a hydroxy group at position 4. It is a metabolite of aromatic amino acid metabolism produced by intestinal microflora in humans and animals.
Kidney Failure, Chronic: The end-stage of CHRONIC RENAL INSUFFICIENCY. It is characterized by the severe irreversible kidney damage (as measured by the level of PROTEINURIA) and the reduction in GLOMERULAR FILTRATION RATE to less than 15 ml per min (Kidney Foundation: Kidney Disease Outcome Quality Initiative, 2002). These patients generally require HEMODIALYSIS or KIDNEY TRANSPLANTATION.
| Excerpt | Relevance | Reference |
|---|---|---|
| "No significant risk of IH or septicemia was noted with higher levels of free or total IS in either GI or no-GI disease group." | 2.84 | Free and total p-cresol sulfate levels and infectious hospitalizations in hemodialysis patients in CHOICE and HEMO. ( Banerjee, T; Hostetter, TH; Melamed, M; Meyer, TW; Powe, NR; Shafi, T; Zhu, Y, 2017) |
| "Stool and blood samples from 20 ESRD patients on maintenance hemodialysis were collected." | 1.72 | Correlation of inflammatory biomarkers with the diversity of Bacteroidaceae, Bifidobacteriaceae, Prevotellaceae and Lactobacillaceae families in the intestinal microbiota of patients with end stage renal disease. ( Asgharian, M; Ghojazadeh, M; Gholizadeh, P; Jouyban, A; Samadi Kafil, H; Samadi, A; Soleymani, J; Tayebi Khosroshahi, H, 2022) |
| "Patients with chronic renal failure (CRF) exhibit endothelial dysfunction, which may involve uremic retention solutes that accumulate in blood and tissues." | 1.32 | P-cresol, a uremic retention solute, alters the endothelial barrier function in vitro. ( Anfosso, F; Berland, Y; Brunet, P; Cerini, C; De Smet, R; Dignat-George, F; Dou, L; Glorieux, G; Moal, V; Sabatier, F; Sampol, J; Vanholder, R, 2004) |
| "Compared with the control subjects, ESRD patients had significantly lower breath-test derived indexes of protein assimilation [%max=3." | 1.32 | Impairment of small intestinal protein assimilation in patients with end-stage renal disease: extending the malnutrition-inflammation-atherosclerosis concept. ( Bammens, B; Evenepoel, P; Vanrenterghem, Y; Verbeke, K, 2004) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (6.90) | 18.2507 |
| 2000's | 12 (41.38) | 29.6817 |
| 2010's | 10 (34.48) | 24.3611 |
| 2020's | 5 (17.24) | 2.80 |
| Authors | Studies |
|---|---|
| Asgharian, M | 1 |
| Gholizadeh, P | 1 |
| Samadi Kafil, H | 1 |
| Ghojazadeh, M | 1 |
| Samadi, A | 1 |
| Soleymani, J | 1 |
| Jouyban, A | 1 |
| Tayebi Khosroshahi, H | 1 |
| Di Paola, R | 1 |
| De, A | 1 |
| Izhar, R | 1 |
| Abate, M | 1 |
| Zappavigna, S | 1 |
| Capasso, A | 1 |
| Perna, AF | 1 |
| La Russa, A | 1 |
| Capasso, G | 1 |
| Caraglia, M | 1 |
| Simeoni, M | 1 |
| Vega-Vega, O | 1 |
| Caballero-Islas, AE | 1 |
| Del Toro-Cisneros, N | 1 |
| Hernandez-Ordoñez, SÓ | 1 |
| Arvizu-Hernández, M | 1 |
| Martínez-Rueda, A | 1 |
| Camacho-Colin, D | 1 |
| Gómez-Correa, LL | 1 |
| Correa-Rotter, R | 1 |
| Sato, E | 1 |
| Hosomi, K | 1 |
| Sekimoto, A | 1 |
| Mishima, E | 1 |
| Oe, Y | 1 |
| Saigusa, D | 1 |
| Ito, S | 1 |
| Abe, T | 1 |
| Sato, H | 1 |
| Kunisawa, J | 1 |
| Niwa, T | 1 |
| Takahashi, N | 1 |
| Chaves, LD | 1 |
| Abyad, S | 1 |
| Honan, AM | 1 |
| Bryniarski, MA | 1 |
| McSkimming, DI | 1 |
| Stahura, CM | 1 |
| Wells, SC | 1 |
| Ruszaj, DM | 1 |
| Morris, ME | 1 |
| Quigg, RJ | 1 |
| Yacoub, R | 1 |
| Guida, B | 3 |
| Cataldi, M | 3 |
| Riccio, E | 2 |
| Grumetto, L | 3 |
| Pota, A | 1 |
| Borrelli, S | 1 |
| Memoli, A | 2 |
| Barbato, F | 2 |
| Argentino, G | 2 |
| Salerno, G | 1 |
| Memoli, B | 3 |
| Sirich, TL | 1 |
| Funk, BA | 1 |
| Plummer, NS | 1 |
| Hostetter, TH | 2 |
| Meyer, TW | 2 |
| Wong, J | 1 |
| Piceno, YM | 1 |
| DeSantis, TZ | 1 |
| Pahl, M | 1 |
| Andersen, GL | 1 |
| Vaziri, ND | 1 |
| Minco, M | 1 |
| Russo, R | 1 |
| Brancaccio, S | 1 |
| Postiglione, L | 1 |
| Germanò, R | 1 |
| Trio, R | 1 |
| Russo, D | 1 |
| Bosco, AM | 1 |
| Pereira, PP | 1 |
| Almeida, BF | 1 |
| Narciso, LG | 1 |
| Dos Santos, DB | 1 |
| Santos-Neto, ÁJ | 1 |
| Ferreira, WL | 1 |
| Ciarlini, PC | 1 |
| Banerjee, T | 1 |
| Shafi, T | 1 |
| Melamed, M | 1 |
| Zhu, Y | 1 |
| Powe, NR | 1 |
| Tsujimoto, M | 2 |
| Kinoshita, Y | 1 |
| Hirata, S | 2 |
| Otagiri, M | 2 |
| Ohtani, H | 1 |
| Sawada, Y | 1 |
| Kawakami, K | 2 |
| Makino, I | 1 |
| Kato, I | 2 |
| Uchida, K | 2 |
| Onoue, M | 1 |
| Higuchi, K | 1 |
| Shima, D | 1 |
| Yokota, H | 1 |
| Furukubo, T | 1 |
| Izumi, S | 1 |
| Yamakawa, T | 1 |
| Takara, K | 1 |
| Nishiguchi, K | 1 |
| Nakabayashi, I | 1 |
| Nakamura, M | 1 |
| Ohta, T | 1 |
| Yoshida, M | 1 |
| Huang, ST | 1 |
| Shu, KH | 1 |
| Cheng, CH | 1 |
| Wu, MJ | 1 |
| Yu, TM | 1 |
| Chuang, YW | 1 |
| Chen, CH | 1 |
| De Smet, R | 4 |
| Van Kaer, J | 2 |
| Van Vlem, B | 1 |
| De Cubber, A | 1 |
| Brunet, P | 4 |
| Lameire, N | 3 |
| Vanholder, R | 4 |
| Dhondt, AW | 1 |
| Vanholder, RC | 1 |
| De Smet, RV | 1 |
| Claus, SA | 1 |
| Waterloos, MA | 2 |
| Glorieux, GL | 1 |
| Delanghe, JR | 1 |
| Lameire, NH | 1 |
| Bammens, B | 4 |
| Verbeke, K | 4 |
| Vanrenterghem, Y | 4 |
| Evenepoel, P | 4 |
| Cerini, C | 3 |
| Dou, L | 2 |
| Anfosso, F | 1 |
| Sabatier, F | 2 |
| Moal, V | 1 |
| Glorieux, G | 1 |
| Dignat-George, F | 3 |
| Sampol, J | 2 |
| Berland, Y | 3 |
| Faure, V | 2 |
| Keuleers, H | 1 |
| Ketteler, M | 1 |
| Paul, P | 1 |
| Van Landschoot, N | 1 |
| Vogeleere, P | 1 |
| Lambert, MC | 1 |
| Vijt, D | 1 |
| Ringoir, S | 1 |
| David, F | 1 |
| Sandra, P | 1 |
| Lesaffer, G | 1 |
| Dhondt, A | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Effects of Synbiotics Supplementation on the Concentration of the Uremic Toxin Indoxyl Sulfate, Symptoms of Constipation, and Constipation-related Quality of Life in End-stage Renal Disease Patients Undergoing Hemodialysis[NCT04527640] | 60 participants (Anticipated) | Interventional | 2020-09-15 | Not yet recruiting | |||
| Prebiotic Therapy to Improve Outcomes of Renal Transplant[NCT04428190] | Early Phase 1 | 60 participants (Anticipated) | Interventional | 2022-02-23 | Recruiting | ||
| Role of HFR Cartridge in the Removal of Mediators of Inflammation and P-cresol in Hemodialysis Patients[NCT01865773] | 8 participants (Actual) | Interventional | 2011-01-31 | Completed | |||
| Fecal Microbiota Transplantation as a Therapeutic Strategy in the Progression of Chronic Kidney Disease[NCT04361097] | 28 participants (Actual) | Interventional | 2018-08-07 | Completed | |||
| EFFECT OF SHORT-TERM TREATMENT WITH THE SYNBIOTIC PROBINUL-NEUTRO® ON GASTROINTESTINAL SYMPTOMS AND CIRCULATING PLASMA p-CRESOL LEVEL IN PATIENTS WITH CHRONIC RENAL FAILURE: A RANDOMIZED DOUBLE BLIND PILOT STUDY.[NCT02008331] | Phase 4 | 30 participants (Actual) | Interventional | 2013-04-30 | Completed | ||
| Study on the Effect of Flucloxacillin on the Serum Level of P-cresol in Peritoneal Dialysis Patients[NCT00433342] | Phase 1 | 9 participants (Actual) | Interventional | 2006-03-31 | Terminated | ||
| A Multicentric Observational Trial on Protein Bound Uremic Toxins in Nocturnal Hemodialysis[NCT00417339] | 38 participants (Actual) | Observational | 2006-12-31 | Completed | |||
| A Multicentric Observational Study on the Removal of Protein-Bound Uremic Retention Solutes in Nocturnal Hemodialysis: A Cross-Sectional Analysis[NCT00417105] | 120 participants (Actual) | Observational | 2006-12-31 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for 4-cresol and Kidney Failure, Chronic
| Article | Year |
|---|---|
Possible Effects of Uremic Toxins p-Cresol, Indoxyl Sulfate, p-Cresyl Sulfate on the Development and Progression of Colon Cancer in Patients with Chronic Renal Failure.
Topics: Colonic Neoplasms; Humans; Indican; Inflammation; Kidney Failure, Chronic; Renal Insufficiency, Chro | 2023 |
7 trials available for 4-cresol and Kidney Failure, Chronic
| Article | Year |
|---|---|
Improved β2-Microglobulin and Phosphorous Removal with Expanded Hemodialysis and Online Hemodiafiltration versus High-Flux Hemodialysis: A Cross-Over Randomized Clinical Trial.
Topics: beta 2-Microglobulin; Cross-Over Studies; Hemodiafiltration; Humans; Indican; Interleukin-10; Interl | 2023 |
Plasma p-cresol lowering effect of sevelamer in peritoneal dialysis patients: evidence from a Cross-Sectional Observational Study.
Topics: Adult; Aged; Chelating Agents; Cresols; Cross-Sectional Studies; Female; Humans; Hyperphosphatemia; | 2013 |
Effect of short-term synbiotic treatment on plasma p-cresol levels in patients with chronic renal failure: a randomized clinical trial.
Topics: Aged; Cresols; Disease Progression; Double-Blind Method; Female; Glomerular Filtration Rate; Humans; | 2014 |
Effect of short-term synbiotic treatment on plasma p-cresol levels in patients with chronic renal failure: a randomized clinical trial.
Topics: Aged; Cresols; Disease Progression; Double-Blind Method; Female; Glomerular Filtration Rate; Humans; | 2014 |
Effect of short-term synbiotic treatment on plasma p-cresol levels in patients with chronic renal failure: a randomized clinical trial.
Topics: Aged; Cresols; Disease Progression; Double-Blind Method; Female; Glomerular Filtration Rate; Humans; | 2014 |
Effect of short-term synbiotic treatment on plasma p-cresol levels in patients with chronic renal failure: a randomized clinical trial.
Topics: Aged; Cresols; Disease Progression; Double-Blind Method; Female; Glomerular Filtration Rate; Humans; | 2014 |
Free and total p-cresol sulfate levels and infectious hospitalizations in hemodialysis patients in CHOICE and HEMO.
Topics: Adult; Aged; Aged, 80 and over; Cresols; Female; Gastrointestinal Diseases; Humans; Indican; Kidney | 2017 |
Studies on dialysate mixing in the Genius single-pass batch system for hemodialysis therapy.
Topics: Aged; Creatinine; Cresols; Female; Hemodialysis Solutions; Humans; Kidney Failure, Chronic; Male; Mi | 2003 |
Removal of the protein-bound solute p-cresol by convective transport: a randomized crossover study.
Topics: Aged; beta 2-Microglobulin; Blood Proteins; Convection; Creatinine; Cresols; Cross-Over Studies; Equ | 2004 |
Elevation of circulating endothelial microparticles in patients with chronic renal failure.
Topics: Adult; Aged; Aged, 80 and over; Annexin A5; Antigens, CD; Cadherins; CD146 Antigen; Cells, Cultured; | 2006 |
21 other studies available for 4-cresol and Kidney Failure, Chronic
| Article | Year |
|---|---|
Correlation of inflammatory biomarkers with the diversity of Bacteroidaceae, Bifidobacteriaceae, Prevotellaceae and Lactobacillaceae families in the intestinal microbiota of patients with end stage renal disease.
Topics: Antioxidants; Bacteroidaceae; Biomarkers; Gastrointestinal Microbiome; Humans; Indican; Interleukin- | 2022 |
Effects of the oral adsorbent AST-120 on fecal p-cresol and indole levels and on the gut microbiota composition.
Topics: Administration, Oral; Adsorption; Animals; Bacteria; Carbon; Cresols; Feces; Gastrointestinal Microb | 2020 |
Unconjugated p-cresol activates macrophage macropinocytosis leading to increased LDL uptake.
Topics: Animals; Aorta; Cholesterol; Cholesterol, LDL; Coronary Artery Disease; Coronary Vessels; Cresols; D | 2021 |
Prominent accumulation in hemodialysis patients of solutes normally cleared by tubular secretion.
Topics: Aged; Aged, 80 and over; Biomarkers; Case-Control Studies; Cresols; Female; Glutamine; Hippurates; H | 2014 |
Expansion of urease- and uricase-containing, indole- and p-cresol-forming and contraction of short-chain fatty acid-producing intestinal microbiota in ESRD.
Topics: Adult; Aged; Ammonia; Cresols; Diet; Fatty Acids, Volatile; Female; Humans; Indican; Indoles; Inflam | 2014 |
Expansion of urease- and uricase-containing, indole- and p-cresol-forming and contraction of short-chain fatty acid-producing intestinal microbiota in ESRD.
Topics: Adult; Aged; Ammonia; Cresols; Diet; Fatty Acids, Volatile; Female; Humans; Indican; Indoles; Inflam | 2014 |
Expansion of urease- and uricase-containing, indole- and p-cresol-forming and contraction of short-chain fatty acid-producing intestinal microbiota in ESRD.
Topics: Adult; Aged; Ammonia; Cresols; Diet; Fatty Acids, Volatile; Female; Humans; Indican; Indoles; Inflam | 2014 |
Expansion of urease- and uricase-containing, indole- and p-cresol-forming and contraction of short-chain fatty acid-producing intestinal microbiota in ESRD.
Topics: Adult; Aged; Ammonia; Cresols; Diet; Fatty Acids, Volatile; Female; Humans; Indican; Indoles; Inflam | 2014 |
Evidence that p-cresol and IL-6 are adsorbed by the HFR cartridge: towards a new strategy to decrease systemic inflammation in dialyzed patients?
Topics: Adsorption; Aged; Cresols; Female; Hemodiafiltration; Hemodialysis Solutions; Humans; Inflammation; | 2014 |
Free p-Cresol Alters Neutrophil Function in Dogs.
Topics: Animals; Apoptosis; Cresols; Dogs; Female; Kidney; Kidney Failure, Chronic; Male; Neutrophils; Oxida | 2016 |
Effects of uremic serum and uremic toxins on hepatic uptake of digoxin.
Topics: Animals; Biological Transport, Active; Cresols; Digoxin; Dose-Response Relationship, Drug; Furans; H | 2008 |
p-Cresol inhibits IL-12 production by murine macrophages stimulated with bacterial immunostimulant.
Topics: Animals; Cells, Cultured; Cresols; Immunization; Interleukin-12; Kidney Failure, Chronic; Lacticasei | 2009 |
Inhibitory effects of uraemic toxins 3-indoxyl sulfate and p-cresol on losartan metabolism in vitro.
Topics: Angiotensin II Type 1 Receptor Blockers; Aryl Hydrocarbon Hydroxylases; Cresols; Cytochrome P-450 CY | 2010 |
Effects of synbiotic treatment on serum level of p-cresol in haemodialysis patients: a preliminary study.
Topics: Administration, Oral; Adult; Aged; Aged, 80 and over; Cresols; Female; Graft Rejection; Humans; Kidn | 2011 |
Serum total p-cresol and indoxyl sulfate correlated with stage of chronic kidney disease in renal transplant recipients.
Topics: Adult; Cresols; Disease Progression; Female; Humans; Indican; Kidney Failure, Chronic; Kidney Transp | 2012 |
Toxicity of free p-cresol: a prospective and cross-sectional analysis.
Topics: Blood Proteins; Cresols; Cross-Sectional Studies; Female; Humans; Kidney Failure, Chronic; Leukocyte | 2003 |
Evidence for impaired assimilation of protein in chronic renal failure.
Topics: Absorption; Adult; Aged; Breath Tests; Carbon Isotopes; Cresols; Cross-Sectional Studies; Digestion; | 2003 |
P-cresol, a uremic retention solute, alters the endothelial barrier function in vitro.
Topics: Actins; Amides; Antigens, CD; Cadherins; Capillary Permeability; Cells, Cultured; Cresols; Cytoskele | 2004 |
Impairment of small intestinal protein assimilation in patients with end-stage renal disease: extending the malnutrition-inflammation-atherosclerosis concept.
Topics: Adult; Aged; Aged, 80 and over; Arteriosclerosis; Breath Tests; Carbon Isotopes; Case-Control Studie | 2004 |
Free serum concentrations of the protein-bound retention solute p-cresol predict mortality in hemodialysis patients.
Topics: Adult; Aged; Aged, 80 and over; Cohort Studies; Confidence Intervals; Creatinine; Cresols; Disease P | 2006 |
Free serum concentrations of the protein-bound retention solute p-cresol predict mortality in hemodialysis patients.
Topics: Adult; Aged; Aged, 80 and over; Cohort Studies; Confidence Intervals; Creatinine; Cresols; Disease P | 2006 |
Free serum concentrations of the protein-bound retention solute p-cresol predict mortality in hemodialysis patients.
Topics: Adult; Aged; Aged, 80 and over; Cohort Studies; Confidence Intervals; Creatinine; Cresols; Disease P | 2006 |
Free serum concentrations of the protein-bound retention solute p-cresol predict mortality in hemodialysis patients.
Topics: Adult; Aged; Aged, 80 and over; Cohort Studies; Confidence Intervals; Creatinine; Cresols; Disease P | 2006 |
Free serum concentrations of the protein-bound retention solute p-cresol predict mortality in hemodialysis patients.
Topics: Adult; Aged; Aged, 80 and over; Cohort Studies; Confidence Intervals; Creatinine; Cresols; Disease P | 2006 |
Free serum concentrations of the protein-bound retention solute p-cresol predict mortality in hemodialysis patients.
Topics: Adult; Aged; Aged, 80 and over; Cohort Studies; Confidence Intervals; Creatinine; Cresols; Disease P | 2006 |
Free serum concentrations of the protein-bound retention solute p-cresol predict mortality in hemodialysis patients.
Topics: Adult; Aged; Aged, 80 and over; Cohort Studies; Confidence Intervals; Creatinine; Cresols; Disease P | 2006 |
Free serum concentrations of the protein-bound retention solute p-cresol predict mortality in hemodialysis patients.
Topics: Adult; Aged; Aged, 80 and over; Cohort Studies; Confidence Intervals; Creatinine; Cresols; Disease P | 2006 |
Free serum concentrations of the protein-bound retention solute p-cresol predict mortality in hemodialysis patients.
Topics: Adult; Aged; Aged, 80 and over; Cohort Studies; Confidence Intervals; Creatinine; Cresols; Disease P | 2006 |
Kidney failure and the gut: p-cresol and the dangers from within.
Topics: Colon; Cresols; Disease Progression; Humans; Kidney Failure, Chronic; Predictive Value of Tests; Ren | 2006 |
The uremic solute p-cresol decreases leukocyte transendothelial migration in vitro.
Topics: Cells, Cultured; Chemotaxis, Leukocyte; Cresols; Cytokines; Endothelial Cells; Gene Expression Regul | 2006 |
Disturbed host defense in peritoneal cavity during CAPD: characterization of responsible factors in dwell fluid.
Topics: Ascitic Fluid; Bacterial Infections; Cresols; Dialysis Solutions; Glucose; Granulocytes; Humans; Hyd | 1996 |
A sensitive HPLC method for the quantification of free and total p-cresol in patients with chronic renal failure.
Topics: Artifacts; Chromatography, High Pressure Liquid; Cresols; Gas Chromatography-Mass Spectrometry; Huma | 1998 |