4-cresol has been researched along with Chronic Kidney Failure in 29 studies
4-cresol: RN given refers to parent cpd
p-cresol : A cresol that consists of toluene substituted by a hydroxy group at position 4. It is a metabolite of aromatic amino acid metabolism produced by intestinal microflora in humans and animals.
| Excerpt | Relevance | Reference |
|---|---|---|
| "No significant risk of IH or septicemia was noted with higher levels of free or total IS in either GI or no-GI disease group." | 2.84 | Free and total p-cresol sulfate levels and infectious hospitalizations in hemodialysis patients in CHOICE and HEMO. ( Banerjee, T; Hostetter, TH; Melamed, M; Meyer, TW; Powe, NR; Shafi, T; Zhu, Y, 2017) |
| "Stool and blood samples from 20 ESRD patients on maintenance hemodialysis were collected." | 1.72 | Correlation of inflammatory biomarkers with the diversity of Bacteroidaceae, Bifidobacteriaceae, Prevotellaceae and Lactobacillaceae families in the intestinal microbiota of patients with end stage renal disease. ( Asgharian, M; Ghojazadeh, M; Gholizadeh, P; Jouyban, A; Samadi Kafil, H; Samadi, A; Soleymani, J; Tayebi Khosroshahi, H, 2022) |
| "Patients with chronic renal failure (CRF) exhibit endothelial dysfunction, which may involve uremic retention solutes that accumulate in blood and tissues." | 1.32 | P-cresol, a uremic retention solute, alters the endothelial barrier function in vitro. ( Anfosso, F; Berland, Y; Brunet, P; Cerini, C; De Smet, R; Dignat-George, F; Dou, L; Glorieux, G; Moal, V; Sabatier, F; Sampol, J; Vanholder, R, 2004) |
| "Compared with the control subjects, ESRD patients had significantly lower breath-test derived indexes of protein assimilation [%max=3." | 1.32 | Impairment of small intestinal protein assimilation in patients with end-stage renal disease: extending the malnutrition-inflammation-atherosclerosis concept. ( Bammens, B; Evenepoel, P; Vanrenterghem, Y; Verbeke, K, 2004) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (6.90) | 18.2507 |
| 2000's | 12 (41.38) | 29.6817 |
| 2010's | 10 (34.48) | 24.3611 |
| 2020's | 5 (17.24) | 2.80 |
| Authors | Studies |
|---|---|
| Asgharian, M | 1 |
| Gholizadeh, P | 1 |
| Samadi Kafil, H | 1 |
| Ghojazadeh, M | 1 |
| Samadi, A | 1 |
| Soleymani, J | 1 |
| Jouyban, A | 1 |
| Tayebi Khosroshahi, H | 1 |
| Di Paola, R | 1 |
| De, A | 1 |
| Izhar, R | 1 |
| Abate, M | 1 |
| Zappavigna, S | 1 |
| Capasso, A | 1 |
| Perna, AF | 1 |
| La Russa, A | 1 |
| Capasso, G | 1 |
| Caraglia, M | 1 |
| Simeoni, M | 1 |
| Vega-Vega, O | 1 |
| Caballero-Islas, AE | 1 |
| Del Toro-Cisneros, N | 1 |
| Hernandez-Ordoñez, SÓ | 1 |
| Arvizu-Hernández, M | 1 |
| Martínez-Rueda, A | 1 |
| Camacho-Colin, D | 1 |
| Gómez-Correa, LL | 1 |
| Correa-Rotter, R | 1 |
| Sato, E | 1 |
| Hosomi, K | 1 |
| Sekimoto, A | 1 |
| Mishima, E | 1 |
| Oe, Y | 1 |
| Saigusa, D | 1 |
| Ito, S | 1 |
| Abe, T | 1 |
| Sato, H | 1 |
| Kunisawa, J | 1 |
| Niwa, T | 1 |
| Takahashi, N | 1 |
| Chaves, LD | 1 |
| Abyad, S | 1 |
| Honan, AM | 1 |
| Bryniarski, MA | 1 |
| McSkimming, DI | 1 |
| Stahura, CM | 1 |
| Wells, SC | 1 |
| Ruszaj, DM | 1 |
| Morris, ME | 1 |
| Quigg, RJ | 1 |
| Yacoub, R | 1 |
| Guida, B | 3 |
| Cataldi, M | 3 |
| Riccio, E | 2 |
| Grumetto, L | 3 |
| Pota, A | 1 |
| Borrelli, S | 1 |
| Memoli, A | 2 |
| Barbato, F | 2 |
| Argentino, G | 2 |
| Salerno, G | 1 |
| Memoli, B | 3 |
| Sirich, TL | 1 |
| Funk, BA | 1 |
| Plummer, NS | 1 |
| Hostetter, TH | 2 |
| Meyer, TW | 2 |
| Wong, J | 1 |
| Piceno, YM | 1 |
| DeSantis, TZ | 1 |
| Pahl, M | 1 |
| Andersen, GL | 1 |
| Vaziri, ND | 1 |
| Minco, M | 1 |
| Russo, R | 1 |
| Brancaccio, S | 1 |
| Postiglione, L | 1 |
| Germanò, R | 1 |
| Trio, R | 1 |
| Russo, D | 1 |
| Bosco, AM | 1 |
| Pereira, PP | 1 |
| Almeida, BF | 1 |
| Narciso, LG | 1 |
| Dos Santos, DB | 1 |
| Santos-Neto, ÁJ | 1 |
| Ferreira, WL | 1 |
| Ciarlini, PC | 1 |
| Banerjee, T | 1 |
| Shafi, T | 1 |
| Melamed, M | 1 |
| Zhu, Y | 1 |
| Powe, NR | 1 |
| Tsujimoto, M | 2 |
| Kinoshita, Y | 1 |
| Hirata, S | 2 |
| Otagiri, M | 2 |
| Ohtani, H | 1 |
| Sawada, Y | 1 |
| Kawakami, K | 2 |
| Makino, I | 1 |
| Kato, I | 2 |
| Uchida, K | 2 |
| Onoue, M | 1 |
| Higuchi, K | 1 |
| Shima, D | 1 |
| Yokota, H | 1 |
| Furukubo, T | 1 |
| Izumi, S | 1 |
| Yamakawa, T | 1 |
| Takara, K | 1 |
| Nishiguchi, K | 1 |
| Nakabayashi, I | 1 |
| Nakamura, M | 1 |
| Ohta, T | 1 |
| Yoshida, M | 1 |
| Huang, ST | 1 |
| Shu, KH | 1 |
| Cheng, CH | 1 |
| Wu, MJ | 1 |
| Yu, TM | 1 |
| Chuang, YW | 1 |
| Chen, CH | 1 |
| De Smet, R | 4 |
| Van Kaer, J | 2 |
| Van Vlem, B | 1 |
| De Cubber, A | 1 |
| Brunet, P | 4 |
| Lameire, N | 3 |
| Vanholder, R | 4 |
| Dhondt, AW | 1 |
| Vanholder, RC | 1 |
| De Smet, RV | 1 |
| Claus, SA | 1 |
| Waterloos, MA | 2 |
| Glorieux, GL | 1 |
| Delanghe, JR | 1 |
| Lameire, NH | 1 |
| Bammens, B | 4 |
| Verbeke, K | 4 |
| Vanrenterghem, Y | 4 |
| Evenepoel, P | 4 |
| Cerini, C | 3 |
| Dou, L | 2 |
| Anfosso, F | 1 |
| Sabatier, F | 2 |
| Moal, V | 1 |
| Glorieux, G | 1 |
| Dignat-George, F | 3 |
| Sampol, J | 2 |
| Berland, Y | 3 |
| Faure, V | 2 |
| Keuleers, H | 1 |
| Ketteler, M | 1 |
| Paul, P | 1 |
| Van Landschoot, N | 1 |
| Vogeleere, P | 1 |
| Lambert, MC | 1 |
| Vijt, D | 1 |
| Ringoir, S | 1 |
| David, F | 1 |
| Sandra, P | 1 |
| Lesaffer, G | 1 |
| Dhondt, A | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Effects of Synbiotics Supplementation on the Concentration of the Uremic Toxin Indoxyl Sulfate, Symptoms of Constipation, and Constipation-related Quality of Life in End-stage Renal Disease Patients Undergoing Hemodialysis[NCT04527640] | 60 participants (Anticipated) | Interventional | 2020-09-15 | Not yet recruiting | |||
| Prebiotic Therapy to Improve Outcomes of Renal Transplant[NCT04428190] | Early Phase 1 | 60 participants (Anticipated) | Interventional | 2022-02-23 | Recruiting | ||
| Role of HFR Cartridge in the Removal of Mediators of Inflammation and P-cresol in Hemodialysis Patients[NCT01865773] | 8 participants (Actual) | Interventional | 2011-01-31 | Completed | |||
| Fecal Microbiota Transplantation as a Therapeutic Strategy in the Progression of Chronic Kidney Disease[NCT04361097] | 28 participants (Actual) | Interventional | 2018-08-07 | Completed | |||
| EFFECT OF SHORT-TERM TREATMENT WITH THE SYNBIOTIC PROBINUL-NEUTRO® ON GASTROINTESTINAL SYMPTOMS AND CIRCULATING PLASMA p-CRESOL LEVEL IN PATIENTS WITH CHRONIC RENAL FAILURE: A RANDOMIZED DOUBLE BLIND PILOT STUDY.[NCT02008331] | Phase 4 | 30 participants (Actual) | Interventional | 2013-04-30 | Completed | ||
| Study on the Effect of Flucloxacillin on the Serum Level of P-cresol in Peritoneal Dialysis Patients[NCT00433342] | Phase 1 | 9 participants (Actual) | Interventional | 2006-03-31 | Terminated | ||
| A Multicentric Observational Trial on Protein Bound Uremic Toxins in Nocturnal Hemodialysis[NCT00417339] | 38 participants (Actual) | Observational | 2006-12-31 | Completed | |||
| A Multicentric Observational Study on the Removal of Protein-Bound Uremic Retention Solutes in Nocturnal Hemodialysis: A Cross-Sectional Analysis[NCT00417105] | 120 participants (Actual) | Observational | 2006-12-31 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for 4-cresol and Chronic Kidney Failure
| Article | Year |
|---|---|
Possible Effects of Uremic Toxins p-Cresol, Indoxyl Sulfate, p-Cresyl Sulfate on the Development and Progression of Colon Cancer in Patients with Chronic Renal Failure.
Topics: Colonic Neoplasms; Humans; Indican; Inflammation; Kidney Failure, Chronic; Renal Insufficiency, Chro | 2023 |
7 trials available for 4-cresol and Chronic Kidney Failure
| Article | Year |
|---|---|
Improved β2-Microglobulin and Phosphorous Removal with Expanded Hemodialysis and Online Hemodiafiltration versus High-Flux Hemodialysis: A Cross-Over Randomized Clinical Trial.
Topics: beta 2-Microglobulin; Cross-Over Studies; Hemodiafiltration; Humans; Indican; Interleukin-10; Interl | 2023 |
Plasma p-cresol lowering effect of sevelamer in peritoneal dialysis patients: evidence from a Cross-Sectional Observational Study.
Topics: Adult; Aged; Chelating Agents; Cresols; Cross-Sectional Studies; Female; Humans; Hyperphosphatemia; | 2013 |
Effect of short-term synbiotic treatment on plasma p-cresol levels in patients with chronic renal failure: a randomized clinical trial.
Topics: Aged; Cresols; Disease Progression; Double-Blind Method; Female; Glomerular Filtration Rate; Humans; | 2014 |
Effect of short-term synbiotic treatment on plasma p-cresol levels in patients with chronic renal failure: a randomized clinical trial.
Topics: Aged; Cresols; Disease Progression; Double-Blind Method; Female; Glomerular Filtration Rate; Humans; | 2014 |
Effect of short-term synbiotic treatment on plasma p-cresol levels in patients with chronic renal failure: a randomized clinical trial.
Topics: Aged; Cresols; Disease Progression; Double-Blind Method; Female; Glomerular Filtration Rate; Humans; | 2014 |
Effect of short-term synbiotic treatment on plasma p-cresol levels in patients with chronic renal failure: a randomized clinical trial.
Topics: Aged; Cresols; Disease Progression; Double-Blind Method; Female; Glomerular Filtration Rate; Humans; | 2014 |
Free and total p-cresol sulfate levels and infectious hospitalizations in hemodialysis patients in CHOICE and HEMO.
Topics: Adult; Aged; Aged, 80 and over; Cresols; Female; Gastrointestinal Diseases; Humans; Indican; Kidney | 2017 |
Studies on dialysate mixing in the Genius single-pass batch system for hemodialysis therapy.
Topics: Aged; Creatinine; Cresols; Female; Hemodialysis Solutions; Humans; Kidney Failure, Chronic; Male; Mi | 2003 |
Removal of the protein-bound solute p-cresol by convective transport: a randomized crossover study.
Topics: Aged; beta 2-Microglobulin; Blood Proteins; Convection; Creatinine; Cresols; Cross-Over Studies; Equ | 2004 |
Elevation of circulating endothelial microparticles in patients with chronic renal failure.
Topics: Adult; Aged; Aged, 80 and over; Annexin A5; Antigens, CD; Cadherins; CD146 Antigen; Cells, Cultured; | 2006 |
21 other studies available for 4-cresol and Chronic Kidney Failure
| Article | Year |
|---|---|
Correlation of inflammatory biomarkers with the diversity of Bacteroidaceae, Bifidobacteriaceae, Prevotellaceae and Lactobacillaceae families in the intestinal microbiota of patients with end stage renal disease.
Topics: Antioxidants; Bacteroidaceae; Biomarkers; Gastrointestinal Microbiome; Humans; Indican; Interleukin- | 2022 |
Effects of the oral adsorbent AST-120 on fecal p-cresol and indole levels and on the gut microbiota composition.
Topics: Administration, Oral; Adsorption; Animals; Bacteria; Carbon; Cresols; Feces; Gastrointestinal Microb | 2020 |
Unconjugated p-cresol activates macrophage macropinocytosis leading to increased LDL uptake.
Topics: Animals; Aorta; Cholesterol; Cholesterol, LDL; Coronary Artery Disease; Coronary Vessels; Cresols; D | 2021 |
Prominent accumulation in hemodialysis patients of solutes normally cleared by tubular secretion.
Topics: Aged; Aged, 80 and over; Biomarkers; Case-Control Studies; Cresols; Female; Glutamine; Hippurates; H | 2014 |
Expansion of urease- and uricase-containing, indole- and p-cresol-forming and contraction of short-chain fatty acid-producing intestinal microbiota in ESRD.
Topics: Adult; Aged; Ammonia; Cresols; Diet; Fatty Acids, Volatile; Female; Humans; Indican; Indoles; Inflam | 2014 |
Expansion of urease- and uricase-containing, indole- and p-cresol-forming and contraction of short-chain fatty acid-producing intestinal microbiota in ESRD.
Topics: Adult; Aged; Ammonia; Cresols; Diet; Fatty Acids, Volatile; Female; Humans; Indican; Indoles; Inflam | 2014 |
Expansion of urease- and uricase-containing, indole- and p-cresol-forming and contraction of short-chain fatty acid-producing intestinal microbiota in ESRD.
Topics: Adult; Aged; Ammonia; Cresols; Diet; Fatty Acids, Volatile; Female; Humans; Indican; Indoles; Inflam | 2014 |
Expansion of urease- and uricase-containing, indole- and p-cresol-forming and contraction of short-chain fatty acid-producing intestinal microbiota in ESRD.
Topics: Adult; Aged; Ammonia; Cresols; Diet; Fatty Acids, Volatile; Female; Humans; Indican; Indoles; Inflam | 2014 |
Evidence that p-cresol and IL-6 are adsorbed by the HFR cartridge: towards a new strategy to decrease systemic inflammation in dialyzed patients?
Topics: Adsorption; Aged; Cresols; Female; Hemodiafiltration; Hemodialysis Solutions; Humans; Inflammation; | 2014 |
Free p-Cresol Alters Neutrophil Function in Dogs.
Topics: Animals; Apoptosis; Cresols; Dogs; Female; Kidney; Kidney Failure, Chronic; Male; Neutrophils; Oxida | 2016 |
Effects of uremic serum and uremic toxins on hepatic uptake of digoxin.
Topics: Animals; Biological Transport, Active; Cresols; Digoxin; Dose-Response Relationship, Drug; Furans; H | 2008 |
p-Cresol inhibits IL-12 production by murine macrophages stimulated with bacterial immunostimulant.
Topics: Animals; Cells, Cultured; Cresols; Immunization; Interleukin-12; Kidney Failure, Chronic; Lacticasei | 2009 |
Inhibitory effects of uraemic toxins 3-indoxyl sulfate and p-cresol on losartan metabolism in vitro.
Topics: Angiotensin II Type 1 Receptor Blockers; Aryl Hydrocarbon Hydroxylases; Cresols; Cytochrome P-450 CY | 2010 |
Effects of synbiotic treatment on serum level of p-cresol in haemodialysis patients: a preliminary study.
Topics: Administration, Oral; Adult; Aged; Aged, 80 and over; Cresols; Female; Graft Rejection; Humans; Kidn | 2011 |
Serum total p-cresol and indoxyl sulfate correlated with stage of chronic kidney disease in renal transplant recipients.
Topics: Adult; Cresols; Disease Progression; Female; Humans; Indican; Kidney Failure, Chronic; Kidney Transp | 2012 |
Toxicity of free p-cresol: a prospective and cross-sectional analysis.
Topics: Blood Proteins; Cresols; Cross-Sectional Studies; Female; Humans; Kidney Failure, Chronic; Leukocyte | 2003 |
Evidence for impaired assimilation of protein in chronic renal failure.
Topics: Absorption; Adult; Aged; Breath Tests; Carbon Isotopes; Cresols; Cross-Sectional Studies; Digestion; | 2003 |
P-cresol, a uremic retention solute, alters the endothelial barrier function in vitro.
Topics: Actins; Amides; Antigens, CD; Cadherins; Capillary Permeability; Cells, Cultured; Cresols; Cytoskele | 2004 |
Impairment of small intestinal protein assimilation in patients with end-stage renal disease: extending the malnutrition-inflammation-atherosclerosis concept.
Topics: Adult; Aged; Aged, 80 and over; Arteriosclerosis; Breath Tests; Carbon Isotopes; Case-Control Studie | 2004 |
Free serum concentrations of the protein-bound retention solute p-cresol predict mortality in hemodialysis patients.
Topics: Adult; Aged; Aged, 80 and over; Cohort Studies; Confidence Intervals; Creatinine; Cresols; Disease P | 2006 |
Free serum concentrations of the protein-bound retention solute p-cresol predict mortality in hemodialysis patients.
Topics: Adult; Aged; Aged, 80 and over; Cohort Studies; Confidence Intervals; Creatinine; Cresols; Disease P | 2006 |
Free serum concentrations of the protein-bound retention solute p-cresol predict mortality in hemodialysis patients.
Topics: Adult; Aged; Aged, 80 and over; Cohort Studies; Confidence Intervals; Creatinine; Cresols; Disease P | 2006 |
Free serum concentrations of the protein-bound retention solute p-cresol predict mortality in hemodialysis patients.
Topics: Adult; Aged; Aged, 80 and over; Cohort Studies; Confidence Intervals; Creatinine; Cresols; Disease P | 2006 |
Free serum concentrations of the protein-bound retention solute p-cresol predict mortality in hemodialysis patients.
Topics: Adult; Aged; Aged, 80 and over; Cohort Studies; Confidence Intervals; Creatinine; Cresols; Disease P | 2006 |
Free serum concentrations of the protein-bound retention solute p-cresol predict mortality in hemodialysis patients.
Topics: Adult; Aged; Aged, 80 and over; Cohort Studies; Confidence Intervals; Creatinine; Cresols; Disease P | 2006 |
Free serum concentrations of the protein-bound retention solute p-cresol predict mortality in hemodialysis patients.
Topics: Adult; Aged; Aged, 80 and over; Cohort Studies; Confidence Intervals; Creatinine; Cresols; Disease P | 2006 |
Free serum concentrations of the protein-bound retention solute p-cresol predict mortality in hemodialysis patients.
Topics: Adult; Aged; Aged, 80 and over; Cohort Studies; Confidence Intervals; Creatinine; Cresols; Disease P | 2006 |
Free serum concentrations of the protein-bound retention solute p-cresol predict mortality in hemodialysis patients.
Topics: Adult; Aged; Aged, 80 and over; Cohort Studies; Confidence Intervals; Creatinine; Cresols; Disease P | 2006 |
Kidney failure and the gut: p-cresol and the dangers from within.
Topics: Colon; Cresols; Disease Progression; Humans; Kidney Failure, Chronic; Predictive Value of Tests; Ren | 2006 |
The uremic solute p-cresol decreases leukocyte transendothelial migration in vitro.
Topics: Cells, Cultured; Chemotaxis, Leukocyte; Cresols; Cytokines; Endothelial Cells; Gene Expression Regul | 2006 |
Disturbed host defense in peritoneal cavity during CAPD: characterization of responsible factors in dwell fluid.
Topics: Ascitic Fluid; Bacterial Infections; Cresols; Dialysis Solutions; Glucose; Granulocytes; Humans; Hyd | 1996 |
A sensitive HPLC method for the quantification of free and total p-cresol in patients with chronic renal failure.
Topics: Artifacts; Chromatography, High Pressure Liquid; Cresols; Gas Chromatography-Mass Spectrometry; Huma | 1998 |