4-cresol has been researched along with Chronic Kidney Diseases in 20 studies
4-cresol: RN given refers to parent cpd
p-cresol : A cresol that consists of toluene substituted by a hydroxy group at position 4. It is a metabolite of aromatic amino acid metabolism produced by intestinal microflora in humans and animals.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Renal fibrosis is one of the main causes of chronic kidney disease." | 1.56 | Knockdown of CK2α reduces ( Go, G; Lee, SH; Lim, JH; Yoon, YM; Yun, CW, 2020) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (5.00) | 29.6817 |
| 2010's | 12 (60.00) | 24.3611 |
| 2020's | 7 (35.00) | 2.80 |
| Authors | Studies |
|---|---|
| Guerrero, F | 1 |
| Carmona, A | 1 |
| Jimenez, MJ | 1 |
| Obrero, T | 1 |
| Pulido, V | 1 |
| Moreno, JA | 1 |
| Soriano, S | 1 |
| Martín-Malo, A | 1 |
| Aljama, P | 1 |
| Stuivenberg, GA | 1 |
| Chmiel, JA | 1 |
| Akouris, PP | 1 |
| Burton, JP | 1 |
| Reid, G | 1 |
| Silva, LAP | 3 |
| Campagnolo, S | 3 |
| Fernandes, SR | 3 |
| Marques, SS | 3 |
| Barreiros, L | 3 |
| Sampaio-Maia, B | 3 |
| Segundo, MA | 3 |
| Di Paola, R | 1 |
| De, A | 1 |
| Izhar, R | 1 |
| Abate, M | 1 |
| Zappavigna, S | 1 |
| Capasso, A | 1 |
| Perna, AF | 1 |
| La Russa, A | 1 |
| Capasso, G | 1 |
| Caraglia, M | 1 |
| Simeoni, M | 1 |
| Yoon, YM | 2 |
| Go, G | 1 |
| Yun, CW | 2 |
| Lim, JH | 1 |
| Lee, SH | 3 |
| Kamprom, W | 1 |
| Tawonsawatruk, T | 1 |
| Mas-Oodi, S | 1 |
| Anansilp, K | 1 |
| Rattanasompattikul, M | 1 |
| Supokawej, A | 1 |
| Chaves, LD | 1 |
| Abyad, S | 1 |
| Honan, AM | 1 |
| Bryniarski, MA | 1 |
| McSkimming, DI | 1 |
| Stahura, CM | 1 |
| Wells, SC | 1 |
| Ruszaj, DM | 1 |
| Morris, ME | 1 |
| Quigg, RJ | 1 |
| Yacoub, R | 1 |
| Riccio, E | 1 |
| Sabbatini, M | 1 |
| Bruzzese, D | 1 |
| Grumetto, L | 1 |
| Marchetiello, C | 1 |
| Amicone, M | 1 |
| Andreucci, M | 1 |
| Guida, B | 1 |
| Passaretti, D | 1 |
| Russo, G | 1 |
| Pisani, A | 1 |
| Liu, Y | 1 |
| Li, J | 1 |
| Yu, J | 1 |
| Wang, Y | 1 |
| Lu, J | 1 |
| Shang, EX | 1 |
| Zhu, Z | 1 |
| Guo, J | 1 |
| Duan, J | 1 |
| Lee, JH | 2 |
| Hur, J | 1 |
| Bartlett, DE | 1 |
| Miller, RB | 1 |
| Thiesfeldt, S | 1 |
| Lakhani, HV | 1 |
| Khanal, T | 1 |
| D Pratt, R | 1 |
| Cottrill, CL | 1 |
| Klug, RL | 1 |
| Adkins, NS | 1 |
| Bown, PC | 1 |
| Nease, DB | 1 |
| Shapiro, JI | 1 |
| Sodhi, K | 1 |
| Korytowska, N | 1 |
| Wyczałkowska-Tomasik, A | 1 |
| Wiśniewska, A | 1 |
| Pączek, L | 1 |
| Giebułtowicz, J | 1 |
| Poesen, R | 1 |
| Viaene, L | 1 |
| Verbeke, K | 2 |
| Augustijns, P | 1 |
| Bammens, B | 2 |
| Claes, K | 1 |
| Kuypers, D | 1 |
| Evenepoel, P | 2 |
| Meijers, B | 1 |
| Salmean, YA | 1 |
| Segal, MS | 1 |
| Palii, SP | 1 |
| Dahl, WJ | 1 |
| Lin, HH | 1 |
| Huang, CC | 1 |
| Lin, TY | 1 |
| Lin, CY | 1 |
| Assis, RP | 1 |
| Castro, JF | 1 |
| Gutierres, VO | 1 |
| Arcaro, CA | 1 |
| Brotto, RS | 1 |
| Oliveira, OM | 1 |
| Baviera, AM | 1 |
| Brunetti, IL | 1 |
| Kieffer, DA | 1 |
| Piccolo, BD | 1 |
| Vaziri, ND | 1 |
| Liu, S | 1 |
| Lau, WL | 1 |
| Khazaeli, M | 1 |
| Nazertehrani, S | 1 |
| Moore, ME | 1 |
| Marco, ML | 1 |
| Martin, RJ | 1 |
| Adams, SH | 1 |
| Koppe, L | 1 |
| Pillon, NJ | 1 |
| Vella, RE | 1 |
| Croze, ML | 1 |
| Pelletier, CC | 1 |
| Chambert, S | 1 |
| Massy, Z | 1 |
| Glorieux, G | 1 |
| Vanholder, R | 1 |
| Dugenet, Y | 1 |
| Soula, HA | 1 |
| Fouque, D | 1 |
| Soulage, CO | 1 |
| Meijers, BK | 1 |
| Weber, V | 1 |
| Dehaen, W | 1 |
| Falkenhagen, D | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Effect of a Nutritional Supplement of Probiotics and/or Prebiotics vs Placebo on Serum Concentrations of Uremic Toxins and Inflammatory Cytokines in Automated Peritoneal Dialysis Patients.[NCT03770611] | 112 participants (Anticipated) | Interventional | 2019-01-07 | Not yet recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for 4-cresol and Chronic Kidney Diseases
| Article | Year |
|---|---|
Possible Effects of Uremic Toxins p-Cresol, Indoxyl Sulfate, p-Cresyl Sulfate on the Development and Progression of Colon Cancer in Patients with Chronic Renal Failure.
Topics: Colonic Neoplasms; Humans; Indican; Inflammation; Kidney Failure, Chronic; Renal Insufficiency, Chro | 2023 |
3 trials available for 4-cresol and Chronic Kidney Diseases
| Article | Year |
|---|---|
Plasma p-cresol lowering effect of sevelamer in non-dialysis CKD patients: evidence from a randomized controlled trial.
Topics: Adult; Aged; Chelating Agents; Cresols; Female; Humans; Male; Middle Aged; Renal Insufficiency, Chro | 2018 |
Cardiovascular disease relates to intestinal uptake of p-cresol in patients with chronic kidney disease.
Topics: Aged; Aged, 80 and over; Belgium; Biomarkers; Cardiovascular Diseases; Comorbidity; Cresols; Female; | 2014 |
Removal of the uremic retention solute p-cresol using fractionated plasma separation and adsorption.
Topics: Adsorption; Anion Exchange Resins; Arteriovenous Shunt, Surgical; Cresols; Cross-Over Studies; Human | 2008 |
16 other studies available for 4-cresol and Chronic Kidney Diseases
| Article | Year |
|---|---|
Passage Number-Induced Replicative Senescence Modulates the Endothelial Cell Response to Protein-Bound Uremic Toxins.
Topics: Aging; Cell Movement; Cellular Senescence; Cresols; Endothelium, Vascular; Human Umbilical Vein Endo | 2021 |
Probiotic Bifidobacteria Mitigate the Deleterious Effects of
Topics: Animals; Drosophila melanogaster; Drosophila Proteins; Probiotics; Renal Insufficiency, Chronic; Sod | 2022 |
Rapid and sustainable HPLC method for the determination of uremic toxins in human plasma samples.
Topics: Chromatography, High Pressure Liquid; Cresols; Humans; Indican; Phenol; Renal Insufficiency, Chronic | 2023 |
Rapid and sustainable HPLC method for the determination of uremic toxins in human plasma samples.
Topics: Chromatography, High Pressure Liquid; Cresols; Humans; Indican; Phenol; Renal Insufficiency, Chronic | 2023 |
Rapid and sustainable HPLC method for the determination of uremic toxins in human plasma samples.
Topics: Chromatography, High Pressure Liquid; Cresols; Humans; Indican; Phenol; Renal Insufficiency, Chronic | 2023 |
Rapid and sustainable HPLC method for the determination of uremic toxins in human plasma samples.
Topics: Chromatography, High Pressure Liquid; Cresols; Humans; Indican; Phenol; Renal Insufficiency, Chronic | 2023 |
Knockdown of CK2α reduces
Topics: Adenine; Animals; Casein Kinase II; Cell Line; Cellular Senescence; Cresols; Disease Models, Animal; | 2020 |
P
Topics: Cells, Cultured; Cellular Senescence; Chronic Kidney Disease-Mineral and Bone Disorder; Cresols; Hea | 2021 |
Unconjugated p-cresol activates macrophage macropinocytosis leading to increased LDL uptake.
Topics: Animals; Aorta; Cholesterol; Cholesterol, LDL; Coronary Artery Disease; Coronary Vessels; Cresols; D | 2021 |
Disorder of gut amino acids metabolism during CKD progression is related with gut microbiota dysbiosis and metagenome change.
Topics: Amino Acids; Animals; Bacteria; Bacterial Physiological Phenomena; Cresols; Disease Models, Animal; | 2018 |
Fucoidan Rescues p-Cresol-Induced Cellular Senescence in Mesenchymal Stem Cells via FAK-Akt-TWIST Axis.
Topics: Cell Cycle; Cell Proliferation; Cells, Cultured; Cellular Senescence; Cresols; Focal Adhesion Kinase | 2018 |
Uremic Toxins Activates Na/K-ATPase Oxidant Amplification Loop Causing Phenotypic Changes in Adipocytes in In Vitro Models.
Topics: 3T3-L1 Cells; Adipocytes; Animals; Biomarkers; Cell Proliferation; Cell Survival; Cells, Cultured; C | 2018 |
TUDCA-Treated Mesenchymal Stem Cells Protect against ER Stress in the Hippocampus of a Murine Chronic Kidney Disease Model.
Topics: Adenine; Animals; Cell Line; Cell Survival; Coculture Techniques; Cresols; Disease Models, Animal; E | 2019 |
Development of the LC-MS/MS method for determining the p-cresol level in plasma.
Topics: Chromatography, Liquid; Cresols; Humans; Limit of Detection; Multiple Organ Failure; Renal Dialysis; | 2019 |
Fiber supplementation lowers plasma p-cresol in chronic kidney disease patients.
Topics: Aged; Cresols; Defecation; Dietary Fiber; Female; Humans; Male; Middle Aged; Quality of Life; Renal | 2015 |
p-Cresol mediates autophagic cell death in renal proximal tubular cells.
Topics: Animals; Apoptosis; Apoptosis Regulatory Proteins; Autophagy; Beclin-1; Caspase 8; Cell Line; Cell S | 2015 |
Effects of uremic solutes on reactive oxygen species in vitro model systems as a possibility of support the renal function management.
Topics: Arginine; Biomarkers; Creatinine; Cresols; Hippurates; Humans; In Vitro Techniques; Kidney Function | 2015 |
Resistant starch alters gut microbiome and metabolomic profiles concurrent with amelioration of chronic kidney disease in rats.
Topics: Animals; Cecum; Cresols; Diet; Dietary Fiber; Gastrointestinal Microbiome; Hydrogen-Ion Concentratio | 2016 |
p-Cresyl sulfate promotes insulin resistance associated with CKD.
Topics: Adipocytes; Adipose Tissue, White; Animals; Cresols; Disease Models, Animal; Extracellular Signal-Re | 2013 |