4-cresol has been researched along with Autism Spectrum Disorder in 6 studies
4-cresol: RN given refers to parent cpd
p-cresol : A cresol that consists of toluene substituted by a hydroxy group at position 4. It is a metabolite of aromatic amino acid metabolism produced by intestinal microflora in humans and animals.
Autism Spectrum Disorder: Wide continuum of associated cognitive and neurobehavioral disorders, including, but not limited to, three core-defining features: impairments in socialization, impairments in verbal and nonverbal communication, and restricted and repetitive patterns of behaviors. (from DSM-V)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Chronic constipation is common among children with ASD and is associated with more severe hyperactivity, anxiety, irritability, and repetitive behaviors." | 1.72 | Gut mobilization improves behavioral symptoms and modulates urinary p-cresol in chronically constipated autistic children: A prospective study. ( Bellomo, F; Boncoddo, M; Cucinotta, F; Mirabelli, S; Persico, AM; Ricciardello, A; Rossi, M; Scattoni, ML; Turriziani, L; Turturo, G, 2022) |
| "© 2015 International Society for Autism Research, Wiley Periodicals, Inc." | 1.43 | Slow intestinal transit contributes to elevate urinary p-cresol level in Italian autistic children. ( Altieri, L; Bombace, F; Bravaccio, C; De Magistris, L; Gabriele, S; Iovene, MR; Neri, C; Persico, AM; Riccio, MP; Sacco, R; Urbani, A, 2016) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (16.67) | 24.3611 |
| 2020's | 5 (83.33) | 2.80 |
| Authors | Studies |
|---|---|
| Turriziani, L | 1 |
| Ricciardello, A | 1 |
| Cucinotta, F | 1 |
| Bellomo, F | 1 |
| Turturo, G | 1 |
| Boncoddo, M | 1 |
| Mirabelli, S | 1 |
| Scattoni, ML | 1 |
| Rossi, M | 1 |
| Persico, AM | 2 |
| Daneberga, Z | 1 |
| Nakazawa-Miklasevica, M | 1 |
| Berga-Svitina, E | 1 |
| Murmane, D | 1 |
| Isarova, D | 1 |
| Cupane, L | 1 |
| Masinska, M | 1 |
| Nartisa, I | 1 |
| Lazdane, A | 1 |
| Miklasevics, E | 1 |
| Guzmán-Salas, S | 1 |
| Weber, A | 1 |
| Malci, A | 1 |
| Lin, X | 1 |
| Herrera-Molina, R | 1 |
| Cerpa, W | 1 |
| Dorador, C | 1 |
| Signorelli, J | 1 |
| Zamorano, P | 1 |
| Gevi, F | 1 |
| Belardo, A | 1 |
| Zolla, L | 1 |
| Bermudez-Martin, P | 1 |
| Becker, JAJ | 1 |
| Caramello, N | 1 |
| Fernandez, SP | 1 |
| Costa-Campos, R | 1 |
| Canaguier, J | 1 |
| Barbosa, S | 1 |
| Martinez-Gili, L | 1 |
| Myridakis, A | 1 |
| Dumas, ME | 1 |
| Bruneau, A | 1 |
| Cherbuy, C | 1 |
| Langella, P | 1 |
| Callebert, J | 1 |
| Launay, JM | 1 |
| Chabry, J | 1 |
| Barik, J | 1 |
| Le Merrer, J | 1 |
| Glaichenhaus, N | 1 |
| Davidovic, L | 1 |
| Gabriele, S | 1 |
| Sacco, R | 1 |
| Altieri, L | 1 |
| Neri, C | 1 |
| Urbani, A | 1 |
| Bravaccio, C | 1 |
| Riccio, MP | 1 |
| Iovene, MR | 1 |
| Bombace, F | 1 |
| De Magistris, L | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Gut Mobilization With Oral Administration of Polyethylene Glycol (PEG) at the Dose of 6.9 g/d Once a Day for 6 Months in Chronically Constipated Autistic Children.[NCT05025553] | 21 participants (Actual) | Interventional | 2018-01-01 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
6 other studies available for 4-cresol and Autism Spectrum Disorder
| Article | Year |
|---|---|
Gut mobilization improves behavioral symptoms and modulates urinary p-cresol in chronically constipated autistic children: A prospective study.
Topics: Autism Spectrum Disorder; Autistic Disorder; Behavioral Symptoms; Child; Child, Preschool; Constipat | 2022 |
Urinary organic acids spectra in children with altered gut microbiota composition and autistic spectrum disorder.
Topics: Autism Spectrum Disorder; Biomarkers; Child; Cresols; Gastrointestinal Microbiome; Humans | 2022 |
The metabolite p-cresol impairs dendritic development, synaptogenesis, and synapse function in hippocampal neurons: Implications for autism spectrum disorder.
Topics: Animals; Autism Spectrum Disorder; Calcium; Cells, Cultured; Cresols; Dysbiosis; Hippocampus; Humans | 2022 |
A metabolomics approach to investigate urine levels of neurotransmitters and related metabolites in autistic children.
Topics: Autism Spectrum Disorder; Brain; Case-Control Studies; Child; Child, Preschool; Cresols; Female; Gas | 2020 |
The microbial metabolite p-Cresol induces autistic-like behaviors in mice by remodeling the gut microbiota.
Topics: Animals; Autism Spectrum Disorder; Autistic Disorder; Cresols; Fecal Microbiota Transplantation; Gas | 2021 |
Slow intestinal transit contributes to elevate urinary p-cresol level in Italian autistic children.
Topics: Autism Spectrum Disorder; Autistic Disorder; Child; Cresols; Feces; Gastrointestinal Transit; Humans | 2016 |