4-carboxyphenylglycine has been researched along with Brain Neoplasms in 3 studies
4-carboxyphenylglycine: RN given for (+-)-isomer; RN for cpd without isomeric designation not available 3/93; glutamate receptor antagonist
Brain Neoplasms: Neoplasms of the intracranial components of the central nervous system, including the cerebral hemispheres, basal ganglia, hypothalamus, thalamus, brain stem, and cerebellum. Brain neoplasms are subdivided into primary (originating from brain tissue) and secondary (i.e., metastatic) forms. Primary neoplasms are subdivided into benign and malignant forms. In general, brain tumors may also be classified by age of onset, histologic type, or presenting location in the brain.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Sulfasalazine was able to reduce glutathione levels in tumor tissue and slow tumor growth in vivo in a commonly used intracranial xenograft animal model for human gliomas when administered by intraperitoneal injection." | 1.33 | Inhibition of cystine uptake disrupts the growth of primary brain tumors. ( Chung, WJ; Gillespie, GY; Gladson, CL; Hamza, H; Lyons, SA; Nelson, GM; Sontheimer, H, 2005) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (33.33) | 18.2507 |
| 2000's | 1 (33.33) | 29.6817 |
| 2010's | 1 (33.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Thomas, AG | 1 |
| Sattler, R | 1 |
| Tendyke, K | 1 |
| Loiacono, KA | 1 |
| Hansen, H | 1 |
| Sahni, V | 1 |
| Hashizume, Y | 1 |
| Rojas, C | 1 |
| Slusher, BS | 1 |
| Chung, WJ | 1 |
| Lyons, SA | 1 |
| Nelson, GM | 1 |
| Hamza, H | 1 |
| Gladson, CL | 1 |
| Gillespie, GY | 1 |
| Sontheimer, H | 2 |
| Ye, ZC | 1 |
| Rothstein, JD | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Role of Glutamate-mediate Excitotoxicity in Invasion and Progression Processes of Glioblastoma Multiforme[NCT05775458] | 50 participants (Anticipated) | Observational | 2020-06-01 | Recruiting | |||
| Phase I Trial Combining Sulfasalazine and Gamma Knife Radiosurgery for Recurrent Glioblastoma[NCT04205357] | Phase 1 | 24 participants (Actual) | Interventional | 2020-03-01 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
3 other studies available for 4-carboxyphenylglycine and Brain Neoplasms
| Article | Year |
|---|---|
High-Throughput Assay Development for Cystine-Glutamate Antiporter (xc-) Highlights Faster Cystine Uptake than Glutamate Release in Glioma Cells.
Topics: Amino Acid Transport System y+; Benzoates; Brain Neoplasms; Cell Line, Tumor; Cystine; Databases, Ch | 2015 |
Inhibition of cystine uptake disrupts the growth of primary brain tumors.
Topics: Amino Acid Transport Systems; Animals; Apoptosis; Benzoates; Brain Neoplasms; Caspases; Cell Divisio | 2005 |
Inhibition of cystine uptake disrupts the growth of primary brain tumors.
Topics: Amino Acid Transport Systems; Animals; Apoptosis; Benzoates; Brain Neoplasms; Caspases; Cell Divisio | 2005 |
Inhibition of cystine uptake disrupts the growth of primary brain tumors.
Topics: Amino Acid Transport Systems; Animals; Apoptosis; Benzoates; Brain Neoplasms; Caspases; Cell Divisio | 2005 |
Inhibition of cystine uptake disrupts the growth of primary brain tumors.
Topics: Amino Acid Transport Systems; Animals; Apoptosis; Benzoates; Brain Neoplasms; Caspases; Cell Divisio | 2005 |
Compromised glutamate transport in human glioma cells: reduction-mislocalization of sodium-dependent glutamate transporters and enhanced activity of cystine-glutamate exchange.
Topics: Amino Acid Substitution; Amino Acid Transport System X-AG; Animals; Astrocytes; ATP-Binding Cassette | 1999 |