4-carboxyphenylglycine has been researched along with Benign Neoplasms, Brain in 3 studies
4-carboxyphenylglycine: RN given for (+-)-isomer; RN for cpd without isomeric designation not available 3/93; glutamate receptor antagonist
| Excerpt | Relevance | Reference |
|---|---|---|
| "Sulfasalazine was able to reduce glutathione levels in tumor tissue and slow tumor growth in vivo in a commonly used intracranial xenograft animal model for human gliomas when administered by intraperitoneal injection." | 1.33 | Inhibition of cystine uptake disrupts the growth of primary brain tumors. ( Chung, WJ; Gillespie, GY; Gladson, CL; Hamza, H; Lyons, SA; Nelson, GM; Sontheimer, H, 2005) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (33.33) | 18.2507 |
| 2000's | 1 (33.33) | 29.6817 |
| 2010's | 1 (33.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Thomas, AG | 1 |
| Sattler, R | 1 |
| Tendyke, K | 1 |
| Loiacono, KA | 1 |
| Hansen, H | 1 |
| Sahni, V | 1 |
| Hashizume, Y | 1 |
| Rojas, C | 1 |
| Slusher, BS | 1 |
| Chung, WJ | 1 |
| Lyons, SA | 1 |
| Nelson, GM | 1 |
| Hamza, H | 1 |
| Gladson, CL | 1 |
| Gillespie, GY | 1 |
| Sontheimer, H | 2 |
| Ye, ZC | 1 |
| Rothstein, JD | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Role of Glutamate-mediate Excitotoxicity in Invasion and Progression Processes of Glioblastoma Multiforme[NCT05775458] | 50 participants (Anticipated) | Observational | 2020-06-01 | Recruiting | |||
| Phase I Trial Combining Sulfasalazine and Gamma Knife Radiosurgery for Recurrent Glioblastoma[NCT04205357] | Phase 1 | 24 participants (Actual) | Interventional | 2020-03-01 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
3 other studies available for 4-carboxyphenylglycine and Benign Neoplasms, Brain
| Article | Year |
|---|---|
High-Throughput Assay Development for Cystine-Glutamate Antiporter (xc-) Highlights Faster Cystine Uptake than Glutamate Release in Glioma Cells.
Topics: Amino Acid Transport System y+; Benzoates; Brain Neoplasms; Cell Line, Tumor; Cystine; Databases, Ch | 2015 |
Inhibition of cystine uptake disrupts the growth of primary brain tumors.
Topics: Amino Acid Transport Systems; Animals; Apoptosis; Benzoates; Brain Neoplasms; Caspases; Cell Divisio | 2005 |
Inhibition of cystine uptake disrupts the growth of primary brain tumors.
Topics: Amino Acid Transport Systems; Animals; Apoptosis; Benzoates; Brain Neoplasms; Caspases; Cell Divisio | 2005 |
Inhibition of cystine uptake disrupts the growth of primary brain tumors.
Topics: Amino Acid Transport Systems; Animals; Apoptosis; Benzoates; Brain Neoplasms; Caspases; Cell Divisio | 2005 |
Inhibition of cystine uptake disrupts the growth of primary brain tumors.
Topics: Amino Acid Transport Systems; Animals; Apoptosis; Benzoates; Brain Neoplasms; Caspases; Cell Divisio | 2005 |
Compromised glutamate transport in human glioma cells: reduction-mislocalization of sodium-dependent glutamate transporters and enhanced activity of cystine-glutamate exchange.
Topics: Amino Acid Substitution; Amino Acid Transport System X-AG; Animals; Astrocytes; ATP-Binding Cassette | 1999 |