4-carboxy-3-hydroxyphenylglycine has been researched along with Parkinson Disease in 1 studies
4-carboxy-3-hydroxyphenylglycine: weak agonist at metabotropic glutamate receptors; occludes the action of 1-aminocyclopentyl-1,3-dicarboxylate in hippocampus
Parkinson Disease: A progressive, degenerative neurologic disease characterized by a TREMOR that is maximal at rest, retropulsion (i.e. a tendency to fall backwards), rigidity, stooped posture, slowness of voluntary movements, and a masklike facial expression. Pathologic features include loss of melanin containing neurons in the substantia nigra and other pigmented nuclei of the brainstem. LEWY BODIES are present in the substantia nigra and locus coeruleus but may also be found in a related condition (LEWY BODY DISEASE, DIFFUSE) characterized by dementia in combination with varying degrees of parkinsonism. (Adams et al., Principles of Neurology, 6th ed, p1059, pp1067-75)
| Excerpt | Relevance | Reference |
|---|---|---|
| "In the search for a therapy of Parkinson's disease, ionotropic, mainly NMDA, receptor antagonists were found to have moderately beneficial, yet also some undesirable side-effects." | 1.31 | The role of metabotropic glutamate receptor (mGluR) ligands in parkinsonian muscle rigidity. ( Konieczny, J; Lorenc-Koci, E; Ossowska, K; Pilc, A; Wolfarth, S, 2000) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (100.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Wolfarth, S | 1 |
| Konieczny, J | 1 |
| Lorenc-Koci, E | 1 |
| Ossowska, K | 1 |
| Pilc, A | 1 |
1 other study available for 4-carboxy-3-hydroxyphenylglycine and Parkinson Disease
| Article | Year |
|---|---|
The role of metabotropic glutamate receptor (mGluR) ligands in parkinsonian muscle rigidity.
Topics: Animals; Bridged Bicyclo Compounds; Electromyography; Glycine; Ligands; Male; Muscle Rigidity; Parki | 2000 |