4-butyrolactone has been researched along with Seizures in 26 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 7 (26.92) | 18.7374 |
| 1990's | 9 (34.62) | 18.2507 |
| 2000's | 6 (23.08) | 29.6817 |
| 2010's | 2 (7.69) | 24.3611 |
| 2020's | 2 (7.69) | 2.80 |
| Authors | Studies |
|---|---|
| Chen, H; Chen, S; Guo, M; Huang, Y; Jia, D; Lao, J; Li, Q; Liang, J; Tong, J | 1 |
| Breitinger, HG; Breitinger, U; Noureldin, N; Raafat, KM; Saleh, HA; Temraz, TA | 1 |
| Danko, G; Forcelli, PA; Hammack, R; Kobayashi, I; Santos, VR | 1 |
| Arcaro, J; Chu, L; Kuo, M; Ma, J; Mirsattari, SM; Stan Leung, L | 1 |
| Palmer, RB | 1 |
| Carai, MA; Colombo, G; Gessa, GL; Lobina, C; Maccioni, P; Maher, TJ; Orru, A; Quang, LS | 1 |
| Wax, PM; Wojtowicz, JM; Yarema, MC | 1 |
| Czarnecki, R; Sobański, H | 1 |
| Sokoloff, L | 2 |
| Snead, OC | 3 |
| Covey, DF; Ferrendelli, JA; Klunk, WE | 2 |
| Bowyer, JF; Winters, WD | 1 |
| Baba, H; Ono, K; Sugai, S | 1 |
| Covey, DF; Ferrendelli, JA; Holland, KD; McKeon, AC; Peterson, EM; Rothman, SM; Xu, K | 1 |
| Aizawa, M; Fukuda, H; Ishige, K; Ito, Y | 1 |
| Feigenbaum, JJ; Howard, SG | 1 |
| Covey, DF; de la Cruz, MA; Hill, MW; Rothman, SM | 1 |
| Quang, LS; Shannon, M | 1 |
| Jain, AL; Swadron, SP | 1 |
| Jeong, MJ; Keum, S; Kim, D; Kim, SS; Lee, T; McEnery, MW; Shin, HS; Song, I | 1 |
| Canney, DJ; Covey, DF; Ferrendelli, JA; Holland, KD; Levine, JA; McKeon, AC | 1 |
| Donald, AE; Foster, AC; Hutson, PH; Iversen, LL; Iversen, SD; Kemp, JA; Leeson, PD; Marshall, GR; Oles, RJ; Singh, L | 1 |
6 review(s) available for 4-butyrolactone and Seizures
| Article | Year |
|---|---|
Gamma-butyrolactone and 1,4-butanediol: abused analogues of gamma-hydroxybutyrate.
Topics: 4-Butyrolactone; Body Temperature Regulation; Butylene Glycols; GABA Modulators; Humans; Illicit Drugs; Seizures; Sodium Oxybate; Substance Withdrawal Syndrome; Substance-Related Disorders | 2004 |
Withdrawal from gamma-hydroxybutyrate, 1,4-butanediol and gamma-butyrolactone: a case report and systematic review.
Topics: 4-Butyrolactone; Adult; Butylene Glycols; Humans; Illicit Drugs; Male; Rhabdomyolysis; Seizures; Sodium Oxybate; Substance Withdrawal Syndrome | 2008 |
Measurement of local glucose utilization and its use in localization of functional activity in the central nervous system of animals and man.
Topics: 4-Butyrolactone; Animals; Auditory Pathways; Autoradiography; Blood-Brain Barrier; Brain; Circadian Rhythm; Deoxyglucose; Electric Stimulation; Energy Metabolism; Female; Glucose; Humans; Hypothalamo-Hypophyseal System; Macaca mulatta; Olfactory Pathways; Rats; Rats, Brattleboro; Rats, Inbred BN; Rats, Inbred Strains; Sciatic Nerve; Seizures; Visual Cortex | 1983 |
Localization of functional activity in the central nervous system by measurement of glucose utilization with radioactive deoxyglucose.
Topics: 4-Butyrolactone; Aging; Animals; Auditory Diseases, Central; Autoradiography; Blood Glucose; Blood-Brain Barrier; Brain; Carbon Radioisotopes; Cats; Central Nervous System; Cerebrovascular Circulation; Deoxy Sugars; Deoxyglucose; Dogs; Electrophysiology; Energy Metabolism; Humans; Macaca mulatta; Morphine; Rats; Rats, Inbred Strains; Receptors, Dopamine; Sciatic Nerve; Seizures; Thiopental; Visual Cortex | 1981 |
Gamma hydroxybutyrate is not a GABA agonist.
Topics: 4-Butyrolactone; Animals; Central Nervous System; Convulsants; Electroencephalography; GABA Agonists; gamma-Aminobutyric Acid; Humans; Mammals; Muscle Contraction; Picrotoxin; Rabbits; Rats; Receptors, GABA; Respiration; Seizures; Sodium Oxybate | 1996 |
Gamma-hydroxybutyrate, gamma-butyrolactone, and 1,4-butanediol: a case report and review of the literature.
Topics: 4-Butyrolactone; Adjuvants, Anesthesia; Adolescent; Butylene Glycols; Emergency Medical Services; Female; Humans; Lorazepam; Seizures; Sodium Oxybate; Structure-Activity Relationship; Substance-Related Disorders; Treatment Outcome | 2000 |
20 other study(ies) available for 4-butyrolactone and Seizures
| Article | Year |
|---|---|
3BDO Alleviates Seizures and Improves Cognitive Function by Regulating Autophagy in Pentylenetetrazol (PTZ)-Kindled Epileptic Mice Model.
Topics: 4-Butyrolactone; Animals; Autophagy; Cognition; Disease Models, Animal; Epilepsy; Hippocampus; Kindling, Neurologic; Mice; Pentylenetetrazole; Ribosomal Protein S6 Kinases, 70-kDa; Seizures; TOR Serine-Threonine Kinases | 2022 |
Sarcophine and (7S, 8R)-dihydroxydeepoxysarcophine from the Red Sea soft coral Sarcophyton glaucum as in vitro and in vivo modulators of glycine receptors.
Topics: 4-Butyrolactone; Animals; Anthozoa; Binding Sites; Binding, Competitive; Brain; Disease Models, Animal; Excitatory Amino Acid Antagonists; HEK293 Cells; Humans; Male; Mice; Protein Binding; Receptors, Glycine; Seizures; Strychnine | 2020 |
Impact of strain, sex, and estrous cycle on gamma butyrolactone-evoked absence seizures in rats.
Topics: 4-Butyrolactone; Analysis of Variance; Animals; Convulsants; Disease Models, Animal; Dose-Response Relationship, Drug; Electrodes, Implanted; Electroencephalography; Estrous Cycle; Female; Immobility Response, Tonic; Male; Rats; Rats, Long-Evans; Rats, Sprague-Dawley; Rats, Wistar; Seizures; Sex Characteristics; Species Specificity | 2018 |
The hippocampus participates in a pharmacological rat model of absence seizures.
Topics: 4-Butyrolactone; Animals; Cerebral Cortex; Cortical Synchronization; Disease Models, Animal; Electrodes, Implanted; Epilepsy, Absence; GABA-A Receptor Agonists; Hippocampus; Male; Muscimol; Neural Pathways; Neurons; Rats, Long-Evans; Receptors, GABA-A; Seizures; Thalamus; Theta Rhythm | 2016 |
Evaluation for the withdrawal syndrome from gamma-hydroxybutyric acid (GHB), gamma-butyrolactone (GBL), and 1,4-butanediol (1,4-BD) in different rat lines.
Topics: 4-Butyrolactone; Animals; Behavior, Animal; Butylene Glycols; Female; Hydroxybutyrates; Rats; Rats, Inbred Strains; Rats, Sprague-Dawley; Rats, Wistar; Seizures; Substance Withdrawal Syndrome | 2006 |
Anticonvulsive properties of 5-allyl-(beta-hydroxy)propyl-N-phenylbarbituric acid and the corresponding lactone.
Topics: 4-Butyrolactone; Animals; Anticonvulsants; Barbiturates; Convulsants; Electroshock; Furans; Lethal Dose 50; Male; Mice; Phenobarbital; Seizures | 1980 |
An investigation of the relationship between the dopaminergic and electroencephalographic effects of gamma-butyrolactone.
Topics: 3,4-Dihydroxyphenylacetic Acid; 4-Butyrolactone; Animals; Anticonvulsants; Cerebral Cortex; Corpus Striatum; Dopamine; Dose-Response Relationship, Drug; Electroencephalography; Evoked Potentials; Furans; Male; Rats; Rats, Inbred Strains; Receptors, Dopamine; Seizures | 1982 |
Comparison of epileptogenic properties of unsubstituted and beta-alkyl-substituted gamma-butyrolactones.
Topics: 4-Butyrolactone; Animals; Behavior, Animal; Blood Pressure; Convulsants; Electroencephalography; Evoked Potentials; Female; Furans; Guinea Pigs; Hippocampus; In Vitro Techniques; Mice; Seizures; Structure-Activity Relationship | 1982 |
Anticonvulsant properties of alpha, gamma, and alpha, gamma-substituted gamma-butyrolactones.
Topics: 4-Butyrolactone; Animals; Anticonvulsants; Behavior, Animal; Dose-Response Relationship, Drug; Electroencephalography; Evoked Potentials; Female; Furans; Guinea Pigs; Hippocampus; In Vitro Techniques; Mice; Seizures; Structure-Activity Relationship | 1982 |
The effects of various anesthetics on amygdaloid kindled seizures.
Topics: 4-Butyrolactone; Amygdala; Anesthetics; Animals; Central Nervous System; Electroencephalography; Hydroxybutyrates; Ketamine; Male; Pentylenetetrazole; Phencyclidine; Rats; Seizures; Sodium Oxybate | 1981 |
A new chronic model of spontaneous nonconvulsive generalized seizures.
Topics: 4-Butyrolactone; Animals; Cerebral Cortex; Corpus Callosum; Electroencephalography; Epilepsy, Absence; Epilepsy, Generalized; Ethosuximide; Evoked Potentials; Injections, Intraperitoneal; Male; Phenytoin; Rats; Rats, Wistar; Seizures; Sodium Oxybate; Valproic Acid | 1993 |
Alpha-spirocyclopentyl- and alpha-spirocyclopropyl-gamma-butyrolactones: conformationally constrained derivatives of anticonvulsant and convulsant alpha,alpha-disubstituted gamma-butyrolactones.
Topics: 4-Butyrolactone; Animals; Anticonvulsants; Cells, Cultured; Chloride Channels; Convulsants; Female; Hippocampus; Mice; Models, Molecular; Neurons; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Seizures; Spiro Compounds; Structure-Activity Relationship | 1994 |
gamma-Butyrolactone-induced absence-like seizures increase nuclear CRE- and AP-1 DNA-binding activities in mouse brain.
Topics: 4-Butyrolactone; Animals; Binding, Competitive; Brain; DNA; Dose-Response Relationship, Drug; Male; Mice; Mice, Inbred Strains; Seizures; Transcription Factors | 1996 |
Effects of anticonvulsant lactams on in vitro seizures in the hippocampal slice preparation.
Topics: 4-Butyrolactone; Animals; Anticonvulsants; Calcium Channel Blockers; Electrophysiology; gamma-Aminobutyric Acid; Hippocampus; In Vitro Techniques; Lactams; Mice; Phenytoin; Piperidines; Potassium Channel Blockers; Receptors, GABA-A; Seizures; Sodium Channel Blockers; Synaptic Transmission | 1999 |
Gamma-hydroxybutyrate, gamma-butyrolactone, and 1,4-butanediol.
Topics: 4-Butyrolactone; Acid-Base Equilibrium; Bromides; Butylene Glycols; Coma; Humans; Prodrugs; Seizures | 2001 |
Lack of the burst firing of thalamocortical relay neurons and resistance to absence seizures in mice lacking alpha(1G) T-type Ca(2+) channels.
Topics: 4-Butyrolactone; Animals; Baclofen; Calcium Channels, T-Type; Cerebral Cortex; Electroencephalography; Epilepsy, Absence; Immunity, Innate; Membrane Potentials; Mice; Mice, Inbred C57BL; Mice, Knockout; Neurons; Protein Subunits; Receptors, GABA-B; Seizures; Thalamic Nuclei; Thalamus | 2001 |
Synthesis and structure-activity studies of alkyl-substituted gamma-butyrolactones and gamma-thiobutyrolactones: ligands for the picrotoxin receptor.
Topics: 4-Butyrolactone; Alkylation; Animals; Anticonvulsants; Brain; Convulsants; Female; Ligands; Mice; Mice, Inbred Strains; Molecular Structure; Neurotoxins; Picrotoxin; Receptors, GABA-A; Seizures; Structure-Activity Relationship | 1991 |
The gamma-hydroxybutyrate model of absence seizures: correlation of regional brain levels of gamma-hydroxybutyric acid and gamma-butyrolactone with spike wave discharges.
Topics: 4-Butyrolactone; Animals; Brain; Brain Chemistry; Dose-Response Relationship, Drug; Electrodes; Electroencephalography; Epilepsy; Gas Chromatography-Mass Spectrometry; Injections, Intraperitoneal; Male; Rats; Rats, Inbred Strains; Seizures; Sodium Oxybate | 1991 |
Effect of gamma-crotonolactone in experimental models of generalized absence seizures.
Topics: 4-Butyrolactone; Animals; Anticonvulsants; Disease Models, Animal; Electroencephalography; Furans; Male; Pentylenetetrazole; Rats; Rats, Inbred Strains; Seizures; Sodium Oxybate; Time Factors | 1991 |
Enantiomers of HA-966 (3-amino-1-hydroxypyrrolid-2-one) exhibit distinct central nervous system effects: (+)-HA-966 is a selective glycine/N-methyl-D-aspartate receptor antagonist, but (-)-HA-966 is a potent gamma-butyrolactone-like sedative.
Topics: 4-Butyrolactone; Acoustic Stimulation; Animals; Aspartic Acid; Cerebral Cortex; Corpus Striatum; Dopamine; Furans; Glycine; In Vitro Techniques; Isomerism; Kinetics; Male; Membrane Potentials; Mice; Mice, Inbred DBA; Motor Activity; N-Methylaspartate; Pyrrolidinones; Rats; Rats, Inbred Strains; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Reference Values; Seizures; Serotonin | 1990 |