Page last updated: 2024-08-18

4-butyrolactone and Pseudomonas Infections

4-butyrolactone has been researched along with Pseudomonas Infections in 71 studies

Research

Studies (71)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	2 (2.82)	18.2507
2000's	29 (40.85)	29.6817
2010's	36 (50.70)	24.3611
2020's	4 (5.63)	2.80

Authors

Authors	Studies
Agarwal, V; Kushwaha, A; Verma, RS	1
Bedi, B; Goldberg, JB; Hart, CM; Koval, M; Maurice, NM; Sadikot, RT; Yuan, Z	1
Coenye, T; Crabbé, A; Dandekar, AA; Lemarcq, A; Sass, A; Vandeplassche, E	1
Geng, YF; Mei, J; Sun, YJ; Tao, SN; Yang, C; Zhang, XC; Zhang, Y; Zhao, BT	1
Combs, C; Gao, P; Guo, K; Khan, N; Lin, P; Pu, Q; Qin, S; Wang, Z; Wu, M; Xia, Z	1
Chen, C; Li, MO; Li, S; Li, Y; Liu, J; Liu, Y; Lu, Y; Luo, Y; Wang, L; Zhang, W; Zhang, X; Zhang, Y	1
Bassler, BL; Goldberg, JB; Moustafa, D; Mukherjee, S; Smith, CD	1
Biswas, R; Chatterjee, M; D'Morris, S; Mohan, CG; Nair, SS; Paul, V; Paul-Prasanth, B; Vanuopadath, M; Vasudevan, AK; Warrier, S	1
Alhede, M; Bjarnsholt, T; Givskov, M; Hultqvist, LD; Jakobsen, TH	1
Chang, YQ; Chen, WM; Lin, J; Liu, J; Sun, PH; Wang, F; Xu, XJ; Zeng, T	1
D'Angelo, F; Kuruma, Y; Leoni, L; Messina, M; Rampioni, G; Stano, P; Tofani, D; Zennaro, A	1
Alayande, AB; Aung, MM; Kim, IS	1
Bae, H; Chi, YT; Choi, GW; Choi, HJ; Jang, MC; Jo, AR; Ku, YG; Lee, DJ; Nam, J; Sung, HY	1
Blackwell, HE; Boursier, ME; Brown, EC; Combs, JB; Heitman, KM; Koenig, LC; Moore, JD; Nagarajan, R; Shepardson-Fungairino, SP; Shin, D	1
Turkina, MV; Vikström, E	1
Amrein, MW; Chen, P; Cheng, J; Fan, Z; Fang, X; Kang, N; Li, N; Li, T; Lin, X; Lü, J; Meng, J; Mu, L; Ren, W; Ruan, H; Shi, Y; Shu, F; Song, D; Tu, Z; Wang, X; Wu, W; Xia, T; Xu, Y; Yan, LT; Zhu, J	1
Agarwal, V; Sharma, D; Singh, PK; Singh, SK; Yadav, VK	1
Gotoh, N; Hatanaka, A; Hayashi, D; Imai, Y; Ishii, K; Kanno, E; Kawakami, K; Maruyama, R; Miyairi, S; Otomaru, H; Sato, S; Shibuya, N; Tachi, M; Tanno, H	1
Bourquard, N; Devarajan, A; Ganapathy, E; Gao, F; Grijalva, VR; Reddy, ST; Verma, J	1
Boon, C; Chen, S; Deng, Y; Lim, A; Zhang, LH	1
Broadbent, I; Charlton, K; Downham, C; Palliyil, S; Porter, AJ	1
Fu, Z; Li, C; Machen, TE; Morita, T; Neely, AM; Schwarzer, C; Whitt, AG	1
Golpasha, ID; Irani, S; Mousavi, SF; Owlia, P; Siadat, SD	1
Byun, Y; Kim, HS; Kim, Y; Ok, K; Park, HD; Park, S	1
Bortolotti, D; Carosella, ED; Di Luca, D; LeMaoult, J; Rizzo, R; Trapella, C	1
Alexandar, V; Chhibber, S; Harjai, K; Vadekeetil, A	1
Holm, A; Magnusson, KE; Vikström, E	1
Bai, D; Chen, L; Duan, K; Guo, Q; Jin, S; Liu, Y; Wu, Q; Wu, Y	1
Rousseau, S; Roussel, L	1
Corção, G; da Silva Campos, M; Meneghetti, KL; Otton, LM	1
Grauer, DC; Janda, KD; Katz, AZ; Kaufmann, GF; Kravchenko, VV; Lehmann, M; Mathison, JC; Meijler, MM; Scott, DA; Ulevitch, RJ	1
Conibear, TCR; Givskov, M; Hume, EBH; Kjelleberg, S; Rice, SA; Willcox, MDP; Zhu, H	1
Chen, J; Li, H; Lu, Z; Mao, Y; Song, J; Wang, L; Xia, C; Xie, X; Ye, L	1
Karatuna, O; Yagci, A	1
Barrett, DA; Cámara, M; Cifelli, PM; Erskine, P; Givskov, M; Holland, ED; Knox, A; Lewis, S; Ortori, CA; Righetti, K; Smyth, AR; Williams, P	1
Baziard, G; Berge, M; El Hage, S; Furiga, A; Khalilzadeh, P; Lajoie, B; Roques, C	1
Høiby, N; Kong, KF; Maricic, N; Mathee, K; Priestap, H; Quirke, JM; Ramalingam, B; Schneper, L; Song, Z; Wu, H	1
Arant, RJ; Foskett, JK; Hofer, AM; Ianowski, JP; Illek, B; Isacoff, E; Machen, TE; Maiellaro, I; Matthes, E; Schwarzer, C; Shi, J; Vais, H; Wong, S	1
Chang, MW; Leong, SS; Ling, H; Lo, TM; Nguyen, HX; Poh, CL; Saeidi, N; Wong, CK	1
Jarosz, LM; Krom, BP; Meijler, MM; Ovchinnikova, ES	1
Brenner-Weiss, G; Hänsch, GM; Kahle, NA; Obst, U; Overhage, J	1
Canning, BJ; Krasteva, G; Kummer, W; Papadakis, T	1
Bartolucci, N; Della Valle, M; Galloway, WR; Hodgkinson, JT; Ibbeson, BM; Morkunas, B; O'Connell, KM; Spring, DR; Welch, M; Wright, M	1
Lewenza, S; Sokol, PA; Visser, MB	1
Tateda, K	1
Horikawa, M; Ishiguro, M; Ishii, Y; Matsumoto, T; Miyairi, S; Pechere, JC; Standiford, TJ; Tateda, K; Yamaguchi, K	1
Carty, NL; Cheluvappa, R; Graham, ED; Griswold, JA; Hamood, AN; McDonald, NA; Schaber, JA	1
Eberl, L; Tümmler, B	1
Anguige, K; King, JR; Ward, JP; Williams, P	1
Ishii, Y; Tateda, K; Yamaguchi, K	1
Aendekerk, S; Cámara, M; Cornelis, P; Diggle, SP; Høiby, N; Song, Z; Williams, P	1
Aridoğan, B; Boşgelmez-Tinaz, G; Eroğlu, F; Kaya, S; Ulusoy, S	1
Chun, C; Furlong, C; Greenberg, EP; Lusis, AJ; Ozer, EA; Pezzulo, A; Shih, DM; Zabner, J	1
Chole, RA; Jung, JY; Nason, R; Pashia, ME; Scholnick, S; Wang, EW	1
Dénervaud, V; Haas, D; Heurlier, K	1
Fuse, ET; Horikawa, M; Ishiguro, M; Ishii, Y; Miyairi, S; Saito, H; Standiford, TJ; Takabatake, T; Tateda, K; Ueda, C; Yamaguchi, K	1
Yamaguchi, K	1
Bjarnsholt, T; Givskov, M	1
Bazzo, R; Bottomley, MJ; Carfì, A; Muraglia, E	1
Ciznár, I; Hostacká, A; Kotulová, D; Slobodníkova, L	1
Boşgelmez-Tinaz, G; Ulusoy, S	1
Ader, F; Courcol, R; Faure, K; Guery, BP; Kipnis, E; Le Berre, R; Nguyen, S; Nowak, E; Pierre, M	1
Boontham, P; Cámara, M; Chandran, P; Chuthapisith, S; Eremin, O; McKechnie, A; Pritchard, D; Robins, A; Rowlands, BJ; Williams, P	1
Doroques, DB; Frank, DW; Gropper, MA; Kurahashi, K; Long, T; Ohara, M; Sawa, T; Twining, SS; Wiener-Kronish, JP	1
Bycroft, BW; Finch, RG; Pritchard, DI; Stewart, GS; Williams, P	1
Eberl, L; Geisenberger, O; Givskov, M; Høiby, N; Riedel, K; Tümmler, B	1
Andersen, JB; Eberl, L; Givskov, M; Hentzer, M; Heydorn, A; Høiby, N; Mathee, K; Molin, S; Moser, C; Song, Z; Wu, H	1
Greenberg, EP; Moninger, TO; Parsek, MR; Schaefer, AL; Singh, PK; Welsh, MJ	1
Blanc, D; Favre-Bonté, S; Pache, JC; Pechère, JC; Robert, J; van Delden, C	1
Cámara, M; Hardman, A; Knox, AJ; Middleton, B; Rodgers, HC; Williams, P	1
Croft, JM; King, JR; Koerber, AJ; Sockett, RE; Ward, JP; Williams, P	1

Reviews

9 review(s) available for 4-butyrolactone and Pseudomonas Infections

Article	Year
Bacteria-Host Crosstalk: Sensing of the Quorum in the Context of Pseudomonas aeruginosa Infections. Journal of innate immunity, 2019, Volume: 11, Issue:3 Topics: 4-Butyrolactone; Bacterial Adhesion; Biofilms; Calcium Signaling; Cell Movement; Homoserine; Host Microbial Interactions; Humans; Iron; Lipopolysaccharides; Pseudomonas aeruginosa; Pseudomonas Infections; Quorum Sensing	2019
Role of quorum sensing by Pseudomonas aeruginosa in microbial keratitis and cystic fibrosis. Microbiology (Reading, England), 2008, Volume: 154, Issue:Pt 8 Topics: 4-Butyrolactone; Cystic Fibrosis; Gene Expression Regulation, Bacterial; Humans; Keratitis; Pseudomonas aeruginosa; Pseudomonas Infections; Quorum Sensing; Virulence; Virulence Factors	2008
[Quorum-sensing systems in bacteria]. Nihon rinsho. Japanese journal of clinical medicine, 2003, Volume: 61 Suppl 3 Topics: 4-Butyrolactone; Animals; Anti-Bacterial Agents; Bacterial Physiological Phenomena; Biofilms; Drug Design; Gene Expression Regulation, Bacterial; Genes, Bacterial; Humans; Macrolides; Pseudomonas aeruginosa; Pseudomonas Infections; Signal Transduction; Vibrio; Virulence	2003
Pseudomonas aeruginosa and Burkholderia cepacia in cystic fibrosis: genome evolution, interactions and adaptation. International journal of medical microbiology : IJMM, 2004, Volume: 294, Issue:2-3 Topics: 4-Butyrolactone; Adaptation, Physiological; Biofilms; Burkholderia cepacia; Burkholderia Infections; Cystic Fibrosis; Evolution, Molecular; Gene Expression Regulation, Bacterial; Gene Transfer, Horizontal; Genome, Bacterial; Genomic Islands; Humans; Lung; Pseudomonas aeruginosa; Pseudomonas Infections; Recombination, Genetic; Signal Transduction; Virulence Factors	2004
[Quorum-sensing system of Pseudomonas aeruginosa--a novel target for antibacterial agents]. Nihon saikingaku zasshi. Japanese journal of bacteriology, 2004, Volume: 59, Issue:4 Topics: 4-Butyrolactone; Anti-Bacterial Agents; Biofilms; Cytokines; Drug Design; Humans; Macrolides; Pseudomonas aeruginosa; Pseudomonas Infections; Signal Transduction; Virulence	2004
Impact of quorum sensing on fitness of Pseudomonas aeruginosa. International journal of medical microbiology : IJMM, 2006, Volume: 296, Issue:2-3 Topics: 4-Butyrolactone; Bacterial Proteins; Cell Communication; Deoxyadenosines; DNA-Binding Proteins; Humans; Pseudomonas aeruginosa; Pseudomonas Infections; Thionucleosides; Trans-Activators; Virulence	2006
[New developments in therapeutics for infectious diseases]. Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine, 2006, Sep-10, Volume: 95, Issue:9 Topics: 4-Butyrolactone; Adjuvants, Immunologic; Animals; Anti-Bacterial Agents; Apoptosis; Cytokines; Disease Models, Animal; Galactosylceramides; Humans; Immunity, Cellular; Killer Cells, Natural; Legionnaires' Disease; Macrolides; Pneumonia, Pneumococcal; Pseudomonas aeruginosa; Pseudomonas Infections; Quorum Sensing; Th1 Cells; Vaccines	2006
Quorum-sensing blockade as a strategy for enhancing host defences against bacterial pathogens. Philosophical transactions of the Royal Society of London. Series B, Biological sciences, 2007, Jul-29, Volume: 362, Issue:1483 Topics: 4-Butyrolactone; Anti-Bacterial Agents; Biofilms; Cystic Fibrosis; Humans; Pseudomonas aeruginosa; Pseudomonas Infections; Quorum Sensing; Virulence	2007
Quorum sensing: a novel target for anti-infective therapy. The Journal of antimicrobial chemotherapy, 1998, Volume: 42, Issue:5 Topics: 4-Butyrolactone; Anti-Bacterial Agents; Gene Expression Regulation, Bacterial; Humans; Pseudomonas aeruginosa; Pseudomonas Infections; Signal Transduction; Virulence	1998

Trials

1 trial(s) available for 4-butyrolactone and Pseudomonas Infections

Article	Year
Garlic as an inhibitor of Pseudomonas aeruginosa quorum sensing in cystic fibrosis--a pilot randomized controlled trial. Pediatric pulmonology, 2010, Volume: 45, Issue:4 Topics: 4-Butyrolactone; Adolescent; Adult; Child; Cystic Fibrosis; Female; Garlic; Homoserine; Humans; Male; Middle Aged; Phytotherapy; Pilot Projects; Plant Oils; Plasma; Pseudomonas aeruginosa; Pseudomonas Infections; Quorum Sensing; Respiratory Function Tests; Sputum; Treatment Outcome; Young Adult	2010

Article

Year

Garlic as an inhibitor of Pseudomonas aeruginosa quorum sensing in cystic fibrosis--a pilot randomized controlled trial.

Pediatric pulmonology, 2010, Volume: 45, Issue:4

Topics: 4-Butyrolactone; Adolescent; Adult; Child; Cystic Fibrosis; Female; Garlic; Homoserine; Humans; Male; Middle Aged; Phytotherapy; Pilot Projects; Plant Oils; Plasma; Pseudomonas aeruginosa; Pseudomonas Infections; Quorum Sensing; Respiratory Function Tests; Sputum; Treatment Outcome; Young Adult

2010

Other Studies

61 other study(ies) available for 4-butyrolactone and Pseudomonas Infections

Article	Year
Pseudomonas aeruginosa quorum-sensing molecule N-(3-oxododecanoyl) homoserine lactone induces calcium signaling-dependent crosstalk between autophagy and apoptosis in human macrophages. Cellular signalling, 2022, Volume: 99 Topics: 4-Butyrolactone; Apoptosis; Autophagy; Beclin-1; Calcium; Calcium Signaling; Chelating Agents; Chloroquine; Egtazic Acid; Homoserine; Humans; Macrophages; Phosphatidylserines; Protein Kinases; Pseudomonas aeruginosa; Pseudomonas Infections; Quorum Sensing; Reactive Oxygen Species; Sirolimus; Virulence Factors	2022
Pseudomonas aeruginosa Induced Host Epithelial Cell Mitochondrial Dysfunction. Scientific reports, 2019, 08-15, Volume: 9, Issue:1 Topics: 4-Butyrolactone; Apoptosis; Bronchi; Cell Line; Cell Respiration; DNA Damage; DNA, Mitochondrial; Epithelial Cells; Homoserine; Host-Pathogen Interactions; Humans; Metformin; Mitochondria; Models, Biological; Organelle Biogenesis; Oxidation-Reduction; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; Pseudomonas aeruginosa; Pseudomonas Infections; Quorum Sensing; Reactive Oxygen Species; Resveratrol	2019
In vitro evolution of Pseudomonas aeruginosa AA2 biofilms in the presence of cystic fibrosis lung microbiome members. Scientific reports, 2019, 09-06, Volume: 9, Issue:1 Topics: 4-Butyrolactone; Adaptation, Physiological; Bacterial Proteins; Biofilms; Cystic Fibrosis; Drug Resistance, Bacterial; Humans; Lung; Microbiota; Mutation; Peptide Hydrolases; Phenotype; Pseudomonas aeruginosa; Pseudomonas Infections; Pyocyanine; Quorum Sensing; Virulence Factors	2019
An innovative role for luteolin as a natural quorum sensing inhibitor in Pseudomonas aeruginosa. Life sciences, 2021, Jun-01, Volume: 274 Topics: 4-Butyrolactone; Bacterial Proteins; Biofilms; Gene Expression Regulation, Bacterial; Homoserine; Humans; Luteolin; Molecular Docking Simulation; Pseudomonas aeruginosa; Pseudomonas Infections; Quorum Sensing; Trans-Activators; Virulence Factors	2021
Bitter receptor TAS2R138 facilitates lipid droplet degradation in neutrophils during Pseudomonas aeruginosa infection. Signal transduction and targeted therapy, 2021, 06-04, Volume: 6, Issue:1 Topics: 4-Butyrolactone; Animals; Cell Nucleus; Cytoplasm; Homoserine; Host-Pathogen Interactions; Humans; Lipid Droplets; Mice; Neutrophils; Perilipin-2; PPAR gamma; Pseudomonas aeruginosa; Pseudomonas Infections; Receptors, G-Protein-Coupled; Tongue	2021
N-3-(oxododecanoyl)-L-homoserine lactone suppresses dendritic cell maturation by upregulating the long noncoding RNA NRIR. Journal of biosciences, 2021, Volume: 46 Topics: 4-Butyrolactone; Case-Control Studies; Cell Differentiation; Dendritic Cells; Homoserine; Humans; Interleukin-6; Monocytes; Pseudomonas aeruginosa; Pseudomonas Infections; RNA, Long Noncoding	2021
The RhlR quorum-sensing receptor controls Pseudomonas aeruginosa pathogenesis and biofilm development independently of its canonical homoserine lactone autoinducer. PLoS pathogens, 2017, Volume: 13, Issue:7 Topics: 4-Butyrolactone; Animals; Bacterial Proteins; Biofilms; Female; Gene Expression Regulation, Bacterial; Humans; Mice; Mice, Inbred BALB C; Pseudomonas aeruginosa; Pseudomonas Infections; Quorum Sensing; Regulon; Virulence	2017
Mechanistic understanding of Phenyllactic acid mediated inhibition of quorum sensing and biofilm development in Pseudomonas aeruginosa. Applied microbiology and biotechnology, 2017, Volume: 101, Issue:22 Topics: 4-Butyrolactone; Animals; Anti-Bacterial Agents; Biofilms; Catheters; Computer Simulation; Disease Models, Animal; Gene Expression; Genetic Complementation Test; Lactates; Lactobacillus; Oryzias; Pseudomonas aeruginosa; Pseudomonas Infections; Pyocyanine; Quorum Sensing; Virulence Factors	2017
Imaging N-Acyl Homoserine Lactone Quorum Sensing In Vivo. Methods in molecular biology (Clifton, N.J.), 2018, Volume: 1673 Topics: 4-Butyrolactone; Alginates; Animals; Female; Glucuronic Acid; Hexuronic Acids; Imaging, Three-Dimensional; Mice, Inbred BALB C; Microspheres; Microtomy; Pseudomonas aeruginosa; Pseudomonas Infections; Quorum Sensing	2018
4-arylamidobenzyl substituted 5-bromomethylene-2(5H)-furanones for chronic bacterial infection. European journal of medicinal chemistry, 2018, Jan-20, Volume: 144 Topics: 4-Butyrolactone; Animals; Anti-Bacterial Agents; Anti-Inflammatory Agents; Chronic Disease; Humans; Lipopolysaccharides; Male; Mice; Molecular Docking Simulation; NF-kappa B; Nitric Oxide; PPAR gamma; Pseudomonas aeruginosa; Pseudomonas Infections; Quorum Sensing; RAW 264.7 Cells	2018
Synthetic cells produce a quorum sensing chemical signal perceived by Pseudomonas aeruginosa. Chemical communications (Cambridge, England), 2018, Feb-22, Volume: 54, Issue:17 Topics: 4-Butyrolactone; Artificial Cells; Humans; Pseudomonas aeruginosa; Pseudomonas Infections; Quorum Sensing; Synthetic Biology	2018
Correlation Between Quorum Sensing Signal Molecules and Pseudomonas aeruginosa's Biofilm Development and Virulency. Current microbiology, 2018, Volume: 75, Issue:7 Topics: 4-Butyrolactone; Biofilms; Humans; Pseudomonas aeruginosa; Pseudomonas Infections; Pyocyanine; Quorum Sensing; Virulence; Virulence Factors	2018
Analysis of two quorum sensing-deficient isolates of Pseudomonas aeruginosa. Microbial pathogenesis, 2018, Volume: 119 Topics: 4-Butyrolactone; Bacterial Proteins; Biofilms; DNA, Bacterial; Drug Resistance, Multiple, Bacterial; Gene Expression Regulation, Bacterial; Genes, Bacterial; Glycolipids; Kanamycin; Oligopeptides; Pseudomonas aeruginosa; Pseudomonas Infections; Pyocyanine; Quorum Sensing; Sequence Analysis; Sequence Analysis, DNA; Sigma Factor; Tobramycin; Virulence Factors	2018
Structure-Function Analyses of the N-Butanoyl l-Homoserine Lactone Quorum-Sensing Signal Define Features Critical to Activity in RhlR. ACS chemical biology, 2018, 09-21, Volume: 13, Issue:9 Topics: 4-Butyrolactone; Bacterial Proteins; Humans; Pseudomonas aeruginosa; Pseudomonas Infections; Quorum Sensing; Small Molecule Libraries	2018
Pseudomonas aeruginosa quorum-sensing metabolite induces host immune cell death through cell surface lipid domain dissolution. Nature microbiology, 2019, Volume: 4, Issue:1 Topics: 4-Butyrolactone; Animals; Apoptosis; Caspase 3; Caspase 8; Cell Line; Chlorocebus aethiops; COS Cells; HeLa Cells; Homoserine; Humans; Immune Evasion; Membrane Lipids; Mice; Mice, Inbred C57BL; Mice, Knockout; Pseudomonas aeruginosa; Pseudomonas Infections; Quorum Sensing; RAW 264.7 Cells; Receptors, Tumor Necrosis Factor, Type I	2019
Mechanism underlying N-(3-oxo-dodecanoyl)-L-homoserine lactone mediated intracellular calcium mobilization in human platelets. Blood cells, molecules & diseases, 2019, Volume: 79 Topics: 4-Butyrolactone; Blood Platelets; Calcium; Calcium Signaling; Homoserine; Humans; Pseudomonas aeruginosa; Pseudomonas Infections; Quorum Sensing; Virulence	2019
Neutrophil-derived tumor necrosis factor-α contributes to acute wound healing promoted by N-(3-oxododecanoyl)-L-homoserine lactone from Pseudomonas aeruginosa. Journal of dermatological science, 2013, Volume: 70, Issue:2 Topics: 4-Butyrolactone; Animals; Antibodies, Anti-Idiotypic; Cell Proliferation; Disease Models, Animal; Epidermis; Homoserine; Male; Neovascularization, Physiologic; Neutrophils; Pseudomonas aeruginosa; Pseudomonas Infections; Rats; Rats, Sprague-Dawley; Tumor Necrosis Factor-alpha; Wound Healing	2013
Role of PON2 in innate immune response in an acute infection model. Molecular genetics and metabolism, 2013, Volume: 110, Issue:3 Topics: 4-Butyrolactone; Animals; Antioxidants; Aryldialkylphosphatase; Homoserine; Immunity, Innate; Inflammation Mediators; Macrophages; Male; Mice; Mice, Knockout; Oxidative Stress; Phagocytosis; Pseudomonas aeruginosa; Pseudomonas Infections; Quorum Sensing; Reactive Oxygen Species	2013
Cis-2-dodecenoic acid signal modulates virulence of Pseudomonas aeruginosa through interference with quorum sensing systems and T3SS. BMC microbiology, 2013, Oct-18, Volume: 13 Topics: 4-Butyrolactone; Animals; Antibiosis; Bacterial Secretion Systems; Biofilms; Burkholderia cenocepacia; Disease Models, Animal; Epithelial Cells; Fatty Acids, Monounsaturated; Gene Expression Profiling; HeLa Cells; Homoserine; Humans; Pseudomonas aeruginosa; Pseudomonas Infections; Quinolones; Quorum Sensing; Signal Transduction; Virulence; Virulence Factors; Zebrafish	2013
High-sensitivity monoclonal antibodies specific for homoserine lactones protect mice from lethal Pseudomonas aeruginosa infections. Applied and environmental microbiology, 2014, Volume: 80, Issue:2 Topics: 4-Butyrolactone; Animals; Antibodies, Monoclonal; Caenorhabditis elegans; Cross Reactions; Immune Sera; Mice; Mice, Inbred Strains; Pancreatic Elastase; Peptide Library; Pseudomonas aeruginosa; Pseudomonas Infections; Quorum Sensing; Sheep	2014
Paraoxonase 2 serves a proapopotic function in mouse and human cells in response to the Pseudomonas aeruginosa quorum-sensing molecule N-(3-Oxododecanoyl)-homoserine lactone. The Journal of biological chemistry, 2015, Mar-13, Volume: 290, Issue:11 Topics: 4-Butyrolactone; Animals; Apoptosis; Aryldialkylphosphatase; Cells, Cultured; HEK293 Cells; Homoserine; Host-Pathogen Interactions; Humans; Mice; Pseudomonas aeruginosa; Pseudomonas Infections; Quorum Sensing	2015
Immunization with 3-oxododecanoyl-L-homoserine lactone-r-PcrV conjugate enhances survival of mice against lethal burn infections caused by Pseudomonas aeruginosa. Bosnian journal of basic medical sciences, 2015, May-25, Volume: 15, Issue:2 Topics: 4-Butyrolactone; Animals; Antibodies, Bacterial; Antigens, Bacterial; Bacterial Toxins; Burns; Disease Models, Animal; Female; Homoserine; Immunity, Humoral; Immunization; Liver; Mice; Mice, Inbred BALB C; Pore Forming Cytotoxic Proteins; Pseudomonas aeruginosa; Pseudomonas Infections; Skin; Spleen; Survival Rate; Vaccines, Conjugate	2015
Design, synthesis and biological evaluation of 4-(alkyloxy)-6-methyl-2H-pyran-2-one derivatives as quorum sensing inhibitors. Bioorganic & medicinal chemistry letters, 2015, Aug-01, Volume: 25, Issue:15 Topics: 4-Butyrolactone; Anti-Bacterial Agents; Bacterial Proteins; Biofilms; Homoserine; Humans; Molecular Docking Simulation; Pseudomonas aeruginosa; Pseudomonas Infections; Pyrones; Quorum Sensing; Structure-Activity Relationship; Trans-Activators	2015
Pseudomonas aeruginosa Quorum Sensing Molecule N-(3-Oxododecanoyl)-L-Homoserine-Lactone Induces HLA-G Expression in Human Immune Cells. Infection and immunity, 2015, Volume: 83, Issue:10 Topics: 4-Butyrolactone; HLA-G Antigens; Homoserine; Humans; Interleukin-10; Monocytes; Pseudomonas aeruginosa; Pseudomonas Infections; Quorum Sensing; T-Lymphocytes; U937 Cells; Up-Regulation	2015
Adjuvant effect of cranberry proanthocyanidin active fraction on antivirulent property of ciprofloxacin against Pseudomonas aeruginosa. Microbial pathogenesis, 2016, Volume: 90 Topics: 4-Butyrolactone; Acyl-Butyrolactones; Adjuvants, Pharmaceutic; Anti-Bacterial Agents; Biofilms; Ciprofloxacin; Drug Synergism; Microbial Sensitivity Tests; Molecular Docking Simulation; Plant Extracts; Proanthocyanidins; Pseudomonas aeruginosa; Pseudomonas Infections; Quinolones; Quorum Sensing; Vaccinium macrocarpon; Virulence	2016
Pseudomonas aeruginosa N-3-oxo-dodecanoyl-homoserine Lactone Elicits Changes in Cell Volume, Morphology, and AQP9 Characteristics in Macrophages. Frontiers in cellular and infection microbiology, 2016, Volume: 6 Topics: 4-Butyrolactone; Aquaporins; Biofilms; Cell Shape; Cell Size; Cells, Cultured; Homoserine; Host-Pathogen Interactions; Humans; Immunity, Innate; Macrophages; Pseudomonas aeruginosa; Pseudomonas Infections; Quorum Sensing; RNA, Messenger; Signal Transduction; Virulence Factors; Water	2016
Potential Use of Dimethyl Sulfoxide in Treatment of Infections Caused by Pseudomonas aeruginosa. Antimicrobial agents and chemotherapy, 2016, Volume: 60, Issue:12 Topics: 4-Butyrolactone; Animals; Anti-Bacterial Agents; Biofilms; Dimethyl Sulfoxide; Disease Models, Animal; Female; Gene Expression Regulation, Bacterial; Glycolipids; Metalloproteases; Mice, Inbred C57BL; Pseudomonas aeruginosa; Pseudomonas Infections; Pyocyanine; Virulence Factors; Wound Infection	2016
Exposure of airway epithelial cells to Pseudomonas aeruginosa biofilm-derived quorum sensing molecules decrease the activity of the anti-oxidant response element bound by NRF2. Biochemical and biophysical research communications, 2017, 02-05, Volume: 483, Issue:2 Topics: 4-Butyrolactone; Antioxidant Response Elements; Biofilms; Cell Line; Cystic Fibrosis; Epithelial Cells; Gene Expression Regulation; Heme Oxygenase-1; Homoserine; Humans; Interleukin-8; Lung; NAD(P)H Dehydrogenase (Quinone); NF-E2-Related Factor 2; Pseudomonas aeruginosa; Pseudomonas Infections; Quorum Sensing	2017
Influence of twitching and swarming motilities on biofilm formation in Pseudomonas strains. Archives of microbiology, 2017, Volume: 199, Issue:5 Topics: 4-Butyrolactone; Bacterial Adhesion; Biofilms; Fimbriae, Bacterial; Pseudomonas aeruginosa; Pseudomonas Infections; Virulence Factors	2017
Modulation of gene expression via disruption of NF-kappaB signaling by a bacterial small molecule. Science (New York, N.Y.), 2008, Jul-11, Volume: 321, Issue:5886 Topics: 4-Butyrolactone; Adult; Animals; Cyclic AMP Response Element-Binding Protein; Cystic Fibrosis; Female; Gene Expression Regulation; Homoserine; Humans; I-kappa B Kinase; I-kappa B Proteins; Immunity, Innate; Interferon-gamma; Lipopolysaccharides; Macrophage Activation; Macrophages; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Middle Aged; NF-kappa B; NF-KappaB Inhibitor alpha; Phosphorylation; Pseudomonas aeruginosa; Pseudomonas Infections; Signal Transduction; Toll-Like Receptors; Transcription Factor RelA	2008
Influence of Pseudomonas aeruginosa quorum sensing signal molecule N-(3-oxododecanoyl) homoserine lactone on mast cells. Medical microbiology and immunology, 2009, Volume: 198, Issue:2 Topics: 4-Butyrolactone; Animals; Apoptosis; Calcium; Cell Degranulation; Cell Line; Cell Proliferation; Cell Survival; Histamine; Homoserine; Interleukin-6; Mast Cells; Mice; Pseudomonas aeruginosa; Pseudomonas Infections; Quorum Sensing; Virulence	2009
Analysis of quorum sensing-dependent virulence factor production and its relationship with antimicrobial susceptibility in Pseudomonas aeruginosa respiratory isolates. Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases, 2010, Volume: 16, Issue:12 Topics: 4-Butyrolactone; Acyl-Butyrolactones; Bacterial Proteins; Biofilms; Drug Resistance, Multiple, Bacterial; Endopeptidases; Gene Expression Regulation, Bacterial; Homoserine; Humans; Ligases; Metalloendopeptidases; Polymerase Chain Reaction; Pseudomonas aeruginosa; Pseudomonas Infections; Pyocyanine; Quorum Sensing; Respiratory Tract Infections; Signal Transduction; Trans-Activators; Transcription Factors; Virulence Factors	2010
Growth inhibition of adherent Pseudomonas aeruginosa by an N-butanoyl-L-homoserine lactone analog. Canadian journal of microbiology, 2010, Volume: 56, Issue:4 Topics: 4-Butyrolactone; Anti-Bacterial Agents; Biofilms; Drug Design; Drug Evaluation, Preclinical; Humans; Pseudomonas aeruginosa; Pseudomonas Infections; Quorum Sensing; Structure-Activity Relationship; Virulence Factors	2010
Panax ginseng has anti-infective activity against opportunistic pathogen Pseudomonas aeruginosa by inhibiting quorum sensing, a bacterial communication process critical for establishing infection. Phytomedicine : international journal of phytotherapy and phytopharmacology, 2010, Volume: 17, Issue:13 Topics: 4-Butyrolactone; Alginates; Anti-Infective Agents; Bacterial Proteins; Chromatography, High Pressure Liquid; Down-Regulation; Glucuronic Acid; Hexuronic Acids; Metalloendopeptidases; Panax; Phytotherapy; Plant Extracts; Pseudomonas aeruginosa; Pseudomonas Infections; Signal Transduction; Virulence; Virulence Factors	2010
Pseudomonas aeruginosa Homoserine lactone activates store-operated cAMP and cystic fibrosis transmembrane regulator-dependent Cl- secretion by human airway epithelia. The Journal of biological chemistry, 2010, Nov-05, Volume: 285, Issue:45 Topics: 4-Butyrolactone; Anions; Calcium; Calcium Signaling; Cell Line, Transformed; Chlorides; Cyclic AMP; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; Endoplasmic Reticulum; Enzyme Inhibitors; Gene Expression Regulation; Humans; Inositol 1,4,5-Trisphosphate Receptors; Membrane Proteins; Neoplasm Proteins; Pseudomonas aeruginosa; Pseudomonas Infections; Quorum Sensing; Respiratory Mucosa; Stromal Interaction Molecule 1	2010
Engineering microbes to sense and eradicate Pseudomonas aeruginosa, a human pathogen. Molecular systems biology, 2011, Aug-16, Volume: 7 Topics: 4-Butyrolactone; Anti-Bacterial Agents; Antibiosis; Bacterial Proteins; Biofilms; Biosensing Techniques; Escherichia coli; Gene Expression Regulation, Bacterial; Genes, Reporter; Green Fluorescent Proteins; Homoserine; Humans; Organisms, Genetically Modified; Plasmids; Pseudomonas aeruginosa; Pseudomonas Infections; Pyocins; Quorum Sensing; Recombinant Fusion Proteins; Synthetic Biology	2011
Microbial spy games and host response: roles of a Pseudomonas aeruginosa small molecule in communication with other species. PLoS pathogens, 2011, Volume: 7, Issue:11 Topics: 4-Butyrolactone; Candida albicans; Homoserine; Host-Pathogen Interactions; Humans; Pseudomonas aeruginosa; Pseudomonas Infections; Quorum Sensing; Staphylococcus aureus	2011
Bacterial quorum sensing molecule induces chemotaxis of human neutrophils via induction of p38 and leukocyte specific protein 1 (LSP1). Immunobiology, 2013, Volume: 218, Issue:2 Topics: 4-Butyrolactone; Actins; Biofilms; Cells, Cultured; Chemotaxis; Homoserine; Humans; Imidazoles; Intracellular Signaling Peptides and Proteins; MAP Kinase Signaling System; Microfilament Proteins; Neutrophils; p38 Mitogen-Activated Protein Kinases; Protein Serine-Threonine Kinases; Pseudomonas aeruginosa; Pseudomonas Infections; Pyridines; Quorum Sensing	2013
Cholinergic brush cells in the trachea mediate respiratory responses to quorum sensing molecules. Life sciences, 2012, Nov-27, Volume: 91, Issue:21-22 Topics: 4-Butyrolactone; Animals; Homoserine; Host-Pathogen Interactions; Male; Mecamylamine; Mice; Mice, Inbred C57BL; Nicotinic Antagonists; Pseudomonas aeruginosa; Pseudomonas Infections; Quorum Sensing; Receptors, Nicotinic; Respiration; Respiratory Mucosa; Trachea	2012
Inhibition of the production of the Pseudomonas aeruginosa virulence factor pyocyanin in wild-type cells by quorum sensing autoinducer-mimics. Organic & biomolecular chemistry, 2012, Nov-14, Volume: 10, Issue:42 Topics: 4-Butyrolactone; Homoserine; Humans; Pseudomonas aeruginosa; Pseudomonas Infections; Pyocyanine; Quorum Sensing; Small Molecule Libraries; Virulence Factors	2012
Interspecies communication between Burkholderia cepacia and Pseudomonas aeruginosa. Canadian journal of microbiology, 2002, Volume: 48, Issue:8 Topics: 4-Butyrolactone; Bacterial Proteins; Burkholderia cepacia; Burkholderia Infections; Humans; Lac Operon; Ligases; Mutation; Pseudomonas aeruginosa; Pseudomonas Infections; Transcription Factors; Virulence Factors	2002
The Pseudomonas aeruginosa autoinducer N-3-oxododecanoyl homoserine lactone accelerates apoptosis in macrophages and neutrophils. Infection and immunity, 2003, Volume: 71, Issue:10 Topics: 4-Butyrolactone; Animals; Apoptosis; Cell Line; Chemokine CCL2; Chemokine CXCL2; Chemokines; Homoserine; Humans; In Vitro Techniques; Macrophages; Mice; Mice, Inbred C57BL; Neutrophils; Pseudomonas aeruginosa; Pseudomonas Infections; U937 Cells; Virulence	2003
Analysis of quorum sensing-deficient clinical isolates of Pseudomonas aeruginosa. Journal of medical microbiology, 2004, Volume: 53, Issue:Pt 9 Topics: 4-Butyrolactone; Bacterial Proteins; Biofilms; Gene Expression Regulation, Bacterial; Humans; Metalloendopeptidases; Mutation; Pseudomonas aeruginosa; Pseudomonas Infections; Transcription, Genetic; Virulence	2004
Mathematical modelling of therapies targeted at bacterial quorum sensing. Mathematical biosciences, 2004, Volume: 192, Issue:1 Topics: 4-Butyrolactone; Algorithms; Anti-Bacterial Agents; Bacterial Proteins; Cell Division; DNA-Binding Proteins; Humans; Kinetics; Models, Biological; Pseudomonas aeruginosa; Pseudomonas Infections; RNA, Messenger; Trans-Activators	2004
The MexGHI-OpmD multidrug efflux pump controls growth, antibiotic susceptibility and virulence in Pseudomonas aeruginosa via 4-quinolone-dependent cell-to-cell communication. Microbiology (Reading, England), 2005, Volume: 151, Issue:Pt 4 Topics: 4-Butyrolactone; 4-Quinolones; Animals; Bacterial Outer Membrane Proteins; Base Sequence; DNA, Bacterial; Drug Resistance, Multiple, Bacterial; Female; Gene Expression; Genes, Bacterial; Lactuca; Membrane Transport Proteins; Mutation; Phenotype; Plant Diseases; Pseudomonas aeruginosa; Pseudomonas Infections; Quinolones; Rats; Rats, Inbred Lew; Signal Transduction; Virulence	2005
N-butanoyl-L-homoserine lactone (BHL) deficient Pseudomonas aeruginosa isolates from an intensive care unit. Microbiological research, 2005, Volume: 160, Issue:4 Topics: 4-Butyrolactone; Acinetobacter baumannii; Agrobacterium tumefaciens; Chromobacterium; Escherichia coli; Humans; Inpatients; Intensive Care Units; Klebsiella pneumoniae; Pseudomonas aeruginosa; Pseudomonas Infections	2005
Human and murine paraoxonase 1 are host modulators of Pseudomonas aeruginosa quorum-sensing. FEMS microbiology letters, 2005, Dec-01, Volume: 253, Issue:1 Topics: 4-Butyrolactone; Animals; Aryldialkylphosphatase; Biofilms; Genes, Bacterial; Humans; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Peritonitis; Pseudomonas aeruginosa; Pseudomonas Infections; Sepsis; Signal Transduction	2005
Otopathogenic Pseudomonas aeruginosa strains as competent biofilm formers. Archives of otolaryngology--head & neck surgery, 2005, Volume: 131, Issue:11 Topics: 4-Butyrolactone; Bacterial Adhesion; Biofilms; Cell Adhesion; Cholesteatoma; Cystic Fibrosis; Gene Expression Regulation, Bacterial; Humans; Keratinocytes; Microbial Sensitivity Tests; Pneumonia; Pseudomonas aeruginosa; Pseudomonas Infections; Reverse Transcriptase Polymerase Chain Reaction	2005
Immunization with 3-oxododecanoyl-L-homoserine lactone-protein conjugate protects mice from lethal Pseudomonas aeruginosa lung infection. Journal of medical microbiology, 2006, Volume: 55, Issue:Pt 10 Topics: 4-Butyrolactone; Animals; Antibodies, Bacterial; Apoptosis; Cell Line; Colony Count, Microbial; Homoserine; Immune Sera; Injections, Subcutaneous; Lung; Macrophages; Mice; Mice, Inbred BALB C; Pneumonia, Bacterial; Pseudomonas aeruginosa; Pseudomonas Infections; Serum Albumin, Bovine; Tumor Necrosis Factor-alpha; Vaccination; Vaccines, Conjugate; Vaccines, Synthetic	2006
Molecular insights into quorum sensing in the human pathogen Pseudomonas aeruginosa from the structure of the virulence regulator LasR bound to its autoinducer. The Journal of biological chemistry, 2007, May-04, Volume: 282, Issue:18 Topics: 4-Butyrolactone; Bacterial Proteins; Crystallography, X-Ray; Cystic Fibrosis; DNA-Binding Proteins; Escherichia coli Proteins; Humans; Lactones; Opportunistic Infections; Protein Structure, Tertiary; Pseudomonas aeruginosa; Pseudomonas Infections; Quorum Sensing; Structural Homology, Protein; Trans-Activators; Virulence Factors	2007
Clinical pseudomonas aeruginosa: potential factors of pathogenicity and resistance to antimicrobials. Folia microbiologica, 2006, Volume: 51, Issue:6 Topics: 4-Butyrolactone; Adaptation, Physiological; Anti-Bacterial Agents; Biofilms; Drug Resistance, Bacterial; Gentian Violet; Humans; Hydrogen Peroxide; Hydrophobic and Hydrophilic Interactions; Movement; Oxidants; Oxidative Stress; Phenotype; Pseudomonas aeruginosa; Pseudomonas Infections; Virulence	2006
Characterization of N-butanoyl-L-homoserine lactone (C4-HSL) deficient clinical isolates of Pseudomonas aeruginosa. Microbial pathogenesis, 2008, Volume: 44, Issue:1 Topics: 4-Butyrolactone; Bacterial Proteins; Humans; Ligases; Movement; Mutation; Pseudomonas aeruginosa; Pseudomonas Infections; Quorum Sensing; Transcription Factors; Virulence Factors	2008
Quorum-sensing activity and related virulence factor expression in clinically pathogenic isolates of Pseudomonas aeruginosa. Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases, 2008, Volume: 14, Issue:4 Topics: 4-Butyrolactone; Bacterial Proteins; Gene Expression Regulation, Bacterial; Humans; Pancreatic Elastase; Pneumonia, Ventilator-Associated; Pseudomonas aeruginosa; Pseudomonas Infections; Pyocyanine; Quorum Sensing; Virulence Factors	2008
Significant immunomodulatory effects of Pseudomonas aeruginosa quorum-sensing signal molecules: possible link in human sepsis. Clinical science (London, England : 1979), 2008, Volume: 115, Issue:11 Topics: 4-Butyrolactone; Apoptosis; B7-2 Antigen; Bacterial Proteins; Cells, Cultured; Coculture Techniques; Cytokines; Dendritic Cells; Homoserine; Humans; Immune Tolerance; Lymphocyte Activation; Pseudomonas aeruginosa; Pseudomonas Infections; Quorum Sensing; Sepsis; T-Lymphocyte Subsets; Th2 Cells	2008
In vitro cellular toxicity predicts Pseudomonas aeruginosa virulence in lung infections. Infection and immunity, 1998, Volume: 66, Issue:7 Topics: 4-Butyrolactone; Animals; Cell Line; Endopeptidases; Homoserine; Humans; Lung; Lung Diseases; Mice; Pseudomonas aeruginosa; Pseudomonas Infections; Virulence	1998
Production of N-acyl-L-homoserine lactones by P. aeruginosa isolates from chronic lung infections associated with cystic fibrosis. FEMS microbiology letters, 2000, Mar-15, Volume: 184, Issue:2 Topics: 4-Butyrolactone; Burkholderia cepacia; Burkholderia Infections; Chromatography, Thin Layer; Chronic Disease; Cystic Fibrosis; Gene Expression Regulation, Bacterial; Humans; Lung Diseases; Pseudomonas aeruginosa; Pseudomonas Infections; Signal Transduction	2000
Detection of N-acylhomoserine lactones in lung tissues of mice infected with Pseudomonas aeruginosa. Microbiology (Reading, England), 2000, Volume: 146 ( Pt 10) Topics: 4-Butyrolactone; Animals; Cystic Fibrosis; Disease Models, Animal; Gene Expression Regulation, Bacterial; Green Fluorescent Proteins; Humans; Luminescent Proteins; Lung; Mice; Mice, Inbred CBA; Pseudomonas aeruginosa; Pseudomonas Infections; Signal Transduction	2000
Quorum-sensing signals indicate that cystic fibrosis lungs are infected with bacterial biofilms. Nature, 2000, Oct-12, Volume: 407, Issue:6805 Topics: 4-Butyrolactone; Biofilms; Cystic Fibrosis; Gene Expression Regulation, Bacterial; Lung; Mucus; Pseudomonas aeruginosa; Pseudomonas Infections; Signal Transduction; Sputum	2000
Detection of Pseudomonas aeruginosa cell-to-cell signals in lung tissue of cystic fibrosis patients. Microbial pathogenesis, 2002, Volume: 32, Issue:3 Topics: 4-Butyrolactone; Adult; Bronchi; Cystic Fibrosis; Female; Homoserine; Humans; Lung; Male; Pseudomonas aeruginosa; Pseudomonas Infections; Signal Transduction	2002
Direct detection of N-acylhomoserine lactones in cystic fibrosis sputum. FEMS microbiology letters, 2002, Jan-22, Volume: 207, Issue:1 Topics: 4-Butyrolactone; Burkholderia cepacia; Burkholderia Infections; Cystic Fibrosis; Humans; Pseudomonas aeruginosa; Pseudomonas Infections; Signal Transduction; Sputum	2002
A mathematical model of partial-thickness burn-wound infection by Pseudomonas aeruginosa: quorum sensing and the build-up to invasion. Bulletin of mathematical biology, 2002, Volume: 64, Issue:2 Topics: 4-Butyrolactone; Burns; Homoserine; Humans; Models, Biological; Numerical Analysis, Computer-Assisted; Pseudomonas aeruginosa; Pseudomonas Infections	2002