Compounds > 4-butyrolactone
Page last updated: 2024-08-18

4-butyrolactone and Inflammation

4-butyrolactone has been researched along with Inflammation in 40 studies

Research

Studies (40)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (2.50)18.2507
2000's5 (12.50)29.6817
2010's23 (57.50)24.3611
2020's11 (27.50)2.80

Authors

AuthorsStudies
Cao, Y; Dong, Z; Ma, X; Wang, X; Yang, D1
Sun, KY; Xiong, W; Zhang, X; Zhou, YH; Zhu, Y; Zou, X1
Gou, J; Huang, R; Lee, CH; Li, L; Li, Q; Li, S; Liu, T; Ma, K; Tian, C; Xiang, M; Xu, C; Zhang, Y1
Chen, TQ; Deng, YF; Mao, LN; Ming, JX; Ren, H; Sun, WG; Wang, YF; Xu, QQ; Zhang, YH; Zhou, JJ; Zhou, Q1
Tian-Qi, C; Yan-Fang, D; Yan-Yan, W; Yong-Hui, Z1
Cai, WW; Dai, Z; Li, BY; Liu, HF; Liu, XQ; Luo, Y; Pan, HF; Wang, H; Wang, Q; Wei, SF; Xu, TT; Zhang, SJ; Zheng, JY; Zhu, WL1
Gerwick, L; Gerwick, WH; Glukhov, E; Lei, XL; Liu, YY; Ma, XX; Nie, YY; Yang, JM; Yang, WC; Zhang, Y1
Fang, J; Fang, S; Huang, Y; Li, M; Luo, Y; Mei, Y; Pan, H; Wan, T; Wang, Q; Wang, Z; Xue, J; Zhang, Y1
Li, T; Lou, H; Peng, P; Song, W; Sun, Y; Xu, L1
Benson, SM; Berghaus, LJ; Berghaus, RD; Burden, CA; Giguère, S; Hart, KA; Hayna, JT; Horohov, DW; Kelleman, AA; Lyle, SK; Macpherson, ML; Mallicote, MF; Pozor, MA; Randell, SA; Varner, JC1
Cheng, W; Tan, X; Tao, S; Wang, Z; Wei, H; Wu, Z; Xiong, Y; Yang, Y; Zhang, H; Zhu, X1
Barbosa, ALDR; da Silva Martins, C; de Aguiar Magalhãres, D; de Brito, TV; de Sousa de Almeida Leite, JR; Fernando Pereira Vasconcelos, D; Guimarães Sousa, S; José Dias Júnior, G; Maria Costa Véras, L; Oliveira Silva, R; Rodolfo Pereira da Silva, F; Rodrigues de Carvalho, L; Santos Martins, D; Simião da C Júnior, J; Soares de Oliveira, J1
Lei, XL; Qian, ZJ; Yao, YB; Zhang, Y; Zhang, YY1
Behrens, S; Chang-Claude, J; Flesch-Janys, D; Jaskulski, S; Johnson, T; Jung, AY; Kaaks, R; Sookthai, D; Thöne, K1
Chamoun-Emanuelli, AM; Cohen, ND; Dockery, HJ; Richardson, LM; Whitfield-Cargile, CM1
Abrahamsson, A; Dabrosin, C; Lindahl, G1
Berk, K; Chabowski, A; Charytoniuk, T; Drygalski, K; Harasim-Symbor, E; Iłowska, N; Konstantynowicz-Nowicka, K; Łukaszuk, B1
Alvarenga, MA; Correal, SB; Cyrino, M; Dell'Aqua, JA; Freitas-Dell'Aqua, CP; Friso, AM; Miró, J; Papa, FO; Segabinazzi, LGTM; Teoro do Carmo, M1
Huang, J; Li, GY; Lin, RC; Lu, J; Lu, XQ; Wang, JH; Zhang, C1
Eichholzer, M; Linseisen, J; Nicastro, HL; Platz, EA; Richard, A; Rohrmann, S1
Chen, C; Du, JR; He, Q; Kuang, X; Li, YJ; Wang, LF; Wang, YN; Yu, L1
Gao, YJ; Wang, XT; Zhang, ZJ; Zhao, LX; Zhu, MD1
Aja, S; Bandaru, VV; Haughey, NJ; Kim, EK; Kuhajda, FP; Li, Q; McFadden, JW; Ronnett, GV1
Dong, YL; Gao, YJ; Li, F; Qian, B; Zhang, ZJ; Zhao, LX1
Coppa, GF; Corbo, L; Idrovo, JP; Jacob, A; Nicastro, J; Wang, P; Yang, WL1
Huang, Z; Huo, HX; Li, J; Sun, J; Tu, PF; Zhang, J1
Du, JR; Gu, MX; Liu, DL; Long, FY; Zhao, LX; Zhou, HJ1
Aquino, M; Bruno, I; Guerrero, MD; Payá, M; Riccio, R; Terencio, MC1
Chao, WW; Chen, ML; Hong, YH; Lin, BF1
Du, JR; Kuang, X; Wang, CY; Wang, J; Wang, Y1
Blohmke, CJ; Hancock, RE; Mayer, ML; Sheridan, JA; Turvey, SE1
Akase, T; Asada, M; Huang, L; Ikeda, T; Minematsu, T; Morohoshi, T; Nagase, T; Nakagami, G; Ohta, Y; Sanada, H1
Bai, L; Ma, Z2
Librowski, T; Malawska, B; Moniczewski, A; Salat, K; Stanisz-Wallis, K; Wieckowski, K1
Iglewski, BH; Kelly, R; Phipps, RP; Smith, RS1
Brown, A; Bycroft, BW; Chhabra, SR; Pritchard, DI; Todd, I; Williams, P; Wood, P1
Bryan, A; Gyorke, S; Li, G; Martinez-Zaguilan, R; Rumbaugh, KP; Sennoune, S; Shiner, EK; Terentyev, D; Williams, SC1
Bruun, JM; Bügel, S; Hallund, J; Tetens, I; Tholstrup, T1
Alcaraz, MJ; De Giulio, A; De Rosa, S; García Pastor, P; Payá, M1

Trials

2 trial(s) available for 4-butyrolactone and Inflammation

ArticleYear
Periovulatory administration of firocoxib did not alter ovulation rates and mitigated post-breeding inflammatory response in mares.
    Theriogenology, 2019, Oct-15, Volume: 138

    Topics: 4-Butyrolactone; Animals; Anti-Inflammatory Agents, Non-Steroidal; Breeding; Cross-Over Studies; Drug Administration Schedule; Endometritis; Estrous Cycle; Female; Horse Diseases; Horses; Inflammation; Insemination, Artificial; Male; Ovulation; Pregnancy; Pregnancy Rate; Sulfones; Treatment Outcome

2019
The effect of a lignan complex isolated from flaxseed on inflammation markers in healthy postmenopausal women.
    Nutrition, metabolism, and cardiovascular diseases : NMCD, 2008, Volume: 18, Issue:7

    Topics: 4-Butyrolactone; Biomarkers; C-Reactive Protein; Cross-Over Studies; Double-Blind Method; Female; Flax; Humans; Inflammation; Lignans; Middle Aged; Phytoestrogens; Postmenopause; Time Factors

2008

Other Studies

38 other study(ies) available for 4-butyrolactone and Inflammation

ArticleYear
Alleviation of glucolipotoxicity-incurred cardiomyocyte dysfunction by Z-ligustilide involves in the suppression of oxidative insult, inflammation and fibrosis.
    Chemistry and physics of lipids, 2021, Volume: 241

    Topics: 4-Butyrolactone; Animals; Apoptosis; Cell Survival; Cells, Cultured; Fibrosis; Inflammation; Molecular Structure; Myocytes, Cardiac; Oxidation-Reduction; Rats

2021
Metformin alleviates inflammation through suppressing FASN-dependent palmitoylation of Akt.
    Cell death & disease, 2021, 10-12, Volume: 12, Issue:10

    Topics: 4-Butyrolactone; Animals; Cell Membrane; Colitis; Dextran Sulfate; Down-Regulation; Enzyme Activation; Fatty Acid Synthases; Inflammation; Intestinal Mucosa; Lipopolysaccharides; Lipoylation; Macrophages; Male; Metformin; Mice; Mice, Inbred C57BL; Palmitates; Phosphorylation; Proto-Oncogene Proteins c-akt; RAW 264.7 Cells; Signal Transduction; TOR Serine-Threonine Kinases; Transcription Factor RelA

2021
Kinsenoside attenuates liver fibro-inflammation by suppressing dendritic cells via the PI3K-AKT-FoxO1 pathway.
    Pharmacological research, 2022, Volume: 177

    Topics: 4-Butyrolactone; Animals; B7-H1 Antigen; Dendritic Cells; Forkhead Box Protein O1; Hepatitis; Inflammation; Interleukin-12; Mice; Monosaccharides; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt

2022
Kinsenoside alleviates inflammation and fibrosis in experimental NASH mice by suppressing the NF-κB/NLRP3 signaling pathway.
    Phytomedicine : international journal of phytotherapy and phytopharmacology, 2022, Volume: 104

    Topics: 4-Butyrolactone; Animals; Fibrosis; Inflammation; Lipopolysaccharides; Liver; Methionine; Mice; Mice, Inbred C57BL; Monosaccharides; NF-kappa B; NLR Family, Pyrin Domain-Containing 3 Protein; Non-alcoholic Fatty Liver Disease; Signal Transduction; Transforming Growth Factor beta1

2022
Butyrolactone I attenuates inflammation in murine NASH by inhibiting the NF-κB signaling pathway.
    Biochemical and biophysical research communications, 2022, 10-20, Volume: 626

    Topics: 4-Butyrolactone; Animals; Disease Models, Animal; Inflammation; Lipopolysaccharides; Liver; Mice; Mice, Inbred C57BL; NF-kappa B; Non-alcoholic Fatty Liver Disease; Signal Transduction

2022
Ligustilide improves aging-induced memory deficit by regulating mitochondrial related inflammation in SAMP8 mice.
    Aging, 2020, 02-16, Volume: 12, Issue:4

    Topics: 4-Butyrolactone; Aging; Animals; Apoptosis; Brain; Inflammation; Male; Maze Learning; Memory Disorders; Mice; Mitochondria; Neuroprotective Agents; Oxidative Stress; Spatial Memory

2020
An anti-inflammatory isoflavone from soybean inoculated with a marine fungus
    Bioscience, biotechnology, and biochemistry, 2020, Volume: 84, Issue:8

    Topics: 4-Butyrolactone; Acetylcholinesterase; Animals; Anti-Infective Agents; Anti-Inflammatory Agents; Aspergillus; Cholinesterase Inhibitors; Cyclohexanones; Free Radical Scavengers; Furocoumarins; Genistein; Glycine max; Inflammation; Isoflavones; Lipopolysaccharides; Mice; RAW 264.7 Cells

2020
Systems pharmacology approach uncovers Ligustilide attenuates experimental colitis in mice by inhibiting PPARγ-mediated inflammation pathways.
    Cell biology and toxicology, 2021, Volume: 37, Issue:1

    Topics: 4-Butyrolactone; Animals; Biological Products; Colitis; Colon; Cytokines; Dextran Sulfate; Female; Inflammation; Inflammation Mediators; Inflammatory Bowel Diseases; Mice, Inbred C57BL; Models, Biological; Network Pharmacology; NF-kappa B; PPAR gamma; Signal Transduction; Transcription Factor AP-1

2021
Synthesis of nature product kinsenoside analogues with anti-inflammatory activity.
    Bioorganic & medicinal chemistry, 2021, 01-01, Volume: 29

    Topics: 4-Butyrolactone; Animals; Anti-Inflammatory Agents, Non-Steroidal; Biological Products; Cell Survival; Dose-Response Relationship, Drug; Inflammation; Lipopolysaccharides; Mice; Molecular Structure; Monosaccharides; NF-kappa B; Nitric Oxide; RAW 264.7 Cells; Signal Transduction; Structure-Activity Relationship

2021
Evidence for anti-inflammatory effects of firocoxib administered to mares with experimentally induced placentitis.
    American journal of reproductive immunology (New York, N.Y. : 1989), 2021, Volume: 86, Issue:1

    Topics: 4-Butyrolactone; Animals; Anti-Inflammatory Agents; Cyclooxygenase 2 Inhibitors; Female; Horse Diseases; Horses; Inflammation; Interleukin-6; Matrix Metalloproteinase 1; Placenta; Placenta Diseases; Pregnancy; Prostaglandins; Sulfones; Tumor Necrosis Factor-alpha

2021
N-(3-oxododecanoyl)-homoserine lactone disrupts intestinal barrier and induces systemic inflammation through perturbing gut microbiome in mice.
    The Science of the total environment, 2021, Jul-15, Volume: 778

    Topics: 4-Butyrolactone; Animals; Gastrointestinal Microbiome; Homoserine; Inflammation; Mice; Quorum Sensing

2021
Epiisopiloturine, an imidazole alkaloid, reverses inflammation and lipid peroxidation parameters in the Crohn disease model induced by trinitrobenzenosulfonic acid in Wistar rats.
    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2018, Volume: 102

    Topics: 4-Butyrolactone; Alkaloids; Animals; Anti-Inflammatory Agents; Crohn Disease; Disease Models, Animal; Female; Imidazoles; Inflammation; Intestinal Mucosa; Lipid Peroxidation; Rats, Wistar; Trinitrobenzenesulfonic Acid

2018
Butyrolactone-I from Coral-Derived Fungus
    Marine drugs, 2018, Jun-07, Volume: 16, Issue:6

    Topics: 4-Butyrolactone; Animals; Anthozoa; Anti-Inflammatory Agents; Aspergillus; Cell Line; Cyclooxygenase 2; I-kappa B Proteins; Inflammation; Interleukin-1beta; Lipopolysaccharides; Mice; Microglia; NF-kappa B; Nitric Oxide; Nitric Oxide Synthase Type II; Phosphorylation; Signal Transduction

2018
Circulating enterolactone concentrations and prognosis of postmenopausal breast cancer: assessment of mediation by inflammatory markers.
    International journal of cancer, 2018, 12-01, Volume: 143, Issue:11

    Topics: 4-Butyrolactone; Aged; Biomarkers; Breast Neoplasms; Case-Control Studies; Disease-Free Survival; Female; Humans; Inflammation; Lignans; Middle Aged; Postmenopause; Prognosis; Proportional Hazards Models; Prospective Studies

2018
Effect of selective versus nonselective cyclooxygenase inhibitors on gastric ulceration scores and intestinal inflammation in horses.
    Veterinary surgery : VS, 2018, Volume: 47, Issue:6

    Topics: 4-Butyrolactone; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase 2 Inhibitors; Feces; Gastrointestinal Diseases; Horse Diseases; Horses; Inflammation; Peroxidase; Phenylbutazone; Random Allocation; Stomach Ulcer; Sulfones

2018
Dietary flaxseed and tamoxifen affect the inflammatory microenvironment in vivo in normal human breast tissue of postmenopausal women.
    European journal of clinical nutrition, 2019, Volume: 73, Issue:9

    Topics: 4-Butyrolactone; Breast; Breast Neoplasms; Diet; Estrogen Antagonists; Female; Flax; Humans; Inflammation; Interleukin 1 Receptor Antagonist Protein; Interleukin-18; Interleukin-1beta; Interleukin-8; Lignans; Matrix Metalloproteinase 9; Microdialysis; Middle Aged; Postmenopause; Seeds; Tamoxifen; Tumor Microenvironment

2019
The effect of enterolactone on liver lipid precursors of inflammation.
    Life sciences, 2019, Mar-15, Volume: 221

    Topics: 4-Butyrolactone; Eicosanoids; Fatty Acids; Fatty Acids, Nonesterified; Fatty Acids, Omega-3; Fatty Acids, Unsaturated; Hep G2 Cells; Hepatocytes; Humans; Inflammation; Lignans; Lipid Metabolism; Lipids; Liver; Palmitic Acid; Prostaglandins; Triglycerides

2019
Anti-inflammatory ligustilides from Ligusticum chuanxiong Hort.
    Fitoterapia, 2013, Volume: 91

    Topics: 4-Butyrolactone; Animals; Anti-Inflammatory Agents; Benzofurans; Drugs, Chinese Herbal; Inflammation; Ligusticum; Lipopolysaccharides; Macrophages; Mice; Molecular Structure; Nitric Oxide; Phytotherapy; Plant Roots

2013
Urinary lignans and inflammatory markers in the US National Health and Nutrition Examination Survey (NHANES) 1999-2004 and 2005-2008.
    Cancer causes & control : CCC, 2014, Volume: 25, Issue:3

    Topics: 4-Butyrolactone; Adult; Aged; Biomarkers; C-Reactive Protein; Chronic Disease; Cross-Sectional Studies; Female; Humans; Inflammation; Leukocyte Count; Lignans; Male; Middle Aged; Nutrition Surveys; United States

2014
Ligustilide ameliorates neuroinflammation and brain injury in focal cerebral ischemia/reperfusion rats: involvement of inhibition of TLR4/peroxiredoxin 6 signaling.
    Free radical biology & medicine, 2014, Volume: 71

    Topics: 4-Butyrolactone; Animals; Anti-Inflammatory Agents, Non-Steroidal; Astrocytes; Brain Ischemia; Cell Movement; Gene Expression Regulation; Inflammation; Injections, Intraperitoneal; Macrophage Activation; Male; Microglia; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Neurons; NF-kappa B; Oxidative Stress; Peroxiredoxin VI; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Signal Transduction; STAT3 Transcription Factor; T-Lymphocytes; Toll-Like Receptor 4

2014
Ligustilide inhibits microglia-mediated proinflammatory cytokines production and inflammatory pain.
    Brain research bulletin, 2014, Volume: 109

    Topics: 4-Butyrolactone; Animals; Anti-Inflammatory Agents; Calcium-Binding Proteins; Cell Line, Transformed; Cytokines; Disease Models, Animal; Dose-Response Relationship, Drug; Freund's Adjuvant; Inflammation; Lipopolysaccharides; Male; Mice; Microfilament Proteins; Microglia; Pain; Pain Measurement; Pain Threshold; RNA, Messenger; Spinal Cord; Time Factors

2014
Increasing fatty acid oxidation remodels the hypothalamic neurometabolome to mitigate stress and inflammation.
    PloS one, 2014, Volume: 9, Issue:12

    Topics: 4-Butyrolactone; Adenosine Triphosphate; AMP-Activated Protein Kinases; Animals; Appetite Depressants; Cell Line; Cells, Cultured; Ceramides; Cholesterol Esters; Cricetinae; Glycerides; Glycerol-3-Phosphate O-Acyltransferase; Humans; Hypothalamus; Inflammation; Metabolome; Mice; Neurons; ortho-Aminobenzoates; Oxidation-Reduction; Palmitates; Reactive Oxygen Species; Stress, Physiological; Sulfonamides

2014
Ligustilide Ameliorates Inflammatory Pain and Inhibits TLR4 Upregulation in Spinal Astrocytes Following Complete Freund's Adjuvant Peripheral Injection.
    Cellular and molecular neurobiology, 2016, Volume: 36, Issue:1

    Topics: 4-Butyrolactone; Animals; Astrocytes; Cells, Cultured; Freund's Adjuvant; Hot Temperature; Hyperalgesia; Inflammation; Male; Mice, Inbred ICR; Pain; RNA, Messenger; Spinal Cord; Toll-Like Receptor 4; Up-Regulation

2016
Inhibition of lipogenesis reduces inflammation and organ injury in sepsis.
    The Journal of surgical research, 2016, Volume: 200, Issue:1

    Topics: 4-Butyrolactone; Animals; Biomarkers; Enzyme Inhibitors; Hepatic Insufficiency; Inflammation; Lipogenesis; Liver; Male; Mice; Mice, Inbred C57BL; Sepsis; Treatment Outcome

2016
A new γ-alkylated-γ-butyrolactone from the roots of Solanum melongena.
    Chinese journal of natural medicines, 2015, Volume: 13, Issue:9

    Topics: 4-Butyrolactone; Animals; Furans; Inflammation; Inhibitory Concentration 50; Kaempferols; Lignans; Macrophages; Mice; Nitric Oxide; Plant Extracts; Plant Roots; RAW 264.7 Cells; Solanum melongena; Triterpenes

2015
Differences in Proinflammatory Property of Six Subtypes of Peroxiredoxins and Anti-Inflammatory Effect of Ligustilide in Macrophages.
    PloS one, 2016, Volume: 11, Issue:10

    Topics: 4-Butyrolactone; Animals; Anti-Inflammatory Agents; Cell Line; Inflammation; Interleukin-6; Macrophages; Mice; NF-kappa B; Nitric Oxide; Nitric Oxide Synthase Type II; Peroxiredoxins; Signal Transduction; Toll-Like Receptor 4; Tumor Necrosis Factor-alpha

2016
Anti-inflammatory and analgesic activity of a novel inhibitor of microsomal prostaglandin E synthase-1 expression.
    European journal of pharmacology, 2009, Oct-12, Volume: 620, Issue:1-3

    Topics: 4-Butyrolactone; Acetates; Analgesics; Animals; Anti-Inflammatory Agents; Arthritis, Experimental; Behavior, Animal; Blood Platelets; Cattle; Chronic Disease; Gene Expression Regulation, Enzymologic; Humans; Hyperalgesia; Inflammation; Intramolecular Oxidoreductases; Leukotriene B4; Male; Mice; Neutrophils; Prostaglandin-E Synthases; Thiophenes; Thromboxane B2

2009
Inhibitory effects of Angelica sinensis ethyl acetate extract and major compounds on NF-kappaB trans-activation activity and LPS-induced inflammation.
    Journal of ethnopharmacology, 2010, May-27, Volume: 129, Issue:2

    Topics: 4-Butyrolactone; Angelica sinensis; Animals; Anti-Inflammatory Agents; Cell Line; Coumaric Acids; Female; Inflammation; Inflammation Mediators; Lipopolysaccharides; Luciferases; Macrophages; Mice; Mice, Inbred BALB C; NF-kappa B; Phytotherapy; Plant Extracts

2010
Z-ligustilide attenuates lipopolysaccharide-induced proinflammatory response via inhibiting NF-kappaB pathway in primary rat microglia.
    Acta pharmacologica Sinica, 2010, Volume: 31, Issue:7

    Topics: 4-Butyrolactone; Animals; Anti-Inflammatory Agents; Cyclooxygenase 2; Dose-Response Relationship, Drug; Inflammation; Lipopolysaccharides; Microglia; Neuroprotective Agents; NF-kappa B; Nitric Oxide Synthase Type II; Rats; Rats, Sprague-Dawley; Stereoisomerism

2010
The Pseudomonas aeruginosa autoinducer 3O-C12 homoserine lactone provokes hyperinflammatory responses from cystic fibrosis airway epithelial cells.
    PloS one, 2011, Jan-31, Volume: 6, Issue:1

    Topics: 4-Butyrolactone; Calcium; Cystic Fibrosis; Cytokines; Epithelial Cells; Homoserine; Humans; Inflammation; Lactones; Pseudomonas aeruginosa; Respiratory System

2011
The Pseudomonas aeruginosa quorum-sensing signal N-(3-oxododecanoyl) homoserine lactone can accelerate cutaneous wound healing through myofibroblast differentiation in rats.
    FEMS immunology and medical microbiology, 2011, Volume: 62, Issue:2

    Topics: 4-Butyrolactone; Animals; Cell Differentiation; Cells, Cultured; Cyclooxygenase 2; Disease Models, Animal; Gene Expression; Histocytochemistry; Homoserine; Inflammation; Male; Myofibroblasts; Neutrophils; Pseudomonas aeruginosa; Rats; Rats, Sprague-Dawley; Up-Regulation; Wound Healing; Wounds and Injuries

2011
The anti-inflammatory effect of Z-Ligustilide in experimental ovariectomized osteopenic rats.
    Inflammation, 2012, Volume: 35, Issue:6

    Topics: 4-Butyrolactone; Aldehydes; Animals; Anti-Inflammatory Agents; Cyclooxygenase 2; Female; Inflammation; Intercellular Adhesion Molecule-1; Interleukin-1beta; Neutrophils; NF-kappa B; Nitric Oxide Synthase Type II; Osteoporosis; Ovariectomy; Rats; Rats, Wistar; Tumor Necrosis Factor-alpha; Up-Regulation

2012
Analgesic, antioedematous and antioxidant activity of γ-butyrolactone derivatives in rodents.
    Behavioural pharmacology, 2012, Volume: 23, Issue:4

    Topics: 4-Butyrolactone; Administration, Oral; Analgesics; Animals; Antioxidants; Disease Models, Animal; Dose-Response Relationship, Drug; Edema; Free Radical Scavengers; Inflammation; Injections, Intraperitoneal; Male; Mice; Motor Activity; Pain; Rats; Rats, Wistar

2012
Anti-inflammatory effects of Z-ligustilide nanoemulsion.
    Inflammation, 2013, Volume: 36, Issue:2

    Topics: 4-Butyrolactone; Angelica sinensis; Animals; Anti-Inflammatory Agents; Biological Availability; Emulsions; Inflammation; Inflammation Mediators; Interleukin-17; Interleukin-1beta; Lipopolysaccharides; Male; Nanoparticles; Plant Oils; Rats; Rats, Wistar; Tumor Necrosis Factor-alpha; Uveitis; Vascular Endothelial Growth Factor A

2013
The Pseudomonas autoinducer N-(3-oxododecanoyl) homoserine lactone induces cyclooxygenase-2 and prostaglandin E2 production in human lung fibroblasts: implications for inflammation.
    Journal of immunology (Baltimore, Md. : 1950), 2002, Sep-01, Volume: 169, Issue:5

    Topics: 4-Butyrolactone; Cell Line; Cyclooxygenase 1; Cyclooxygenase 2; Dinoprostone; Enzyme Induction; Fibroblasts; Homoserine; Humans; Inflammation; Isoenzymes; Lung; Membrane Proteins; NF-kappa B; Prostaglandin-Endoperoxide Synthases; Pseudomonas aeruginosa; RNA, Messenger; Up-Regulation; Virulence

2002
Alleviation of insulitis and moderation of diabetes in NOD mice following treatment with a synthetic Pseudomonas aeruginosa signal molecule, N-(3-oxododecanoyl)-L-homoserine lactone.
    Acta diabetologica, 2005, Volume: 42, Issue:3

    Topics: 4-Butyrolactone; Adjuvants, Immunologic; Animals; Diabetes Mellitus; Dimethyl Sulfoxide; Disease Models, Animal; Homoserine; Inflammation; Islets of Langerhans; Mice; Mice, Inbred NOD; Pancreatic Diseases; Pseudomonas aeruginosa

2005
Pseudomonas aeruginosa autoinducer modulates host cell responses through calcium signalling.
    Cellular microbiology, 2006, Volume: 8, Issue:10

    Topics: 4-Butyrolactone; Animals; Apoptosis; Calcium Signaling; Cytosol; Endoplasmic Reticulum; Endothelial Cells; Fibroblasts; Flow Cytometry; Homoserine; Humans; Inflammation; Inositol 1,4,5-Trisphosphate Receptors; Mice; NIH 3T3 Cells; Pseudomonas aeruginosa; Reverse Transcriptase Polymerase Chain Reaction; Virulence Factors

2006
Modulation of acute and chronic inflammatory processes by cacospongionolide B, a novel inhibitor of human synovial phospholipase A2.
    British journal of pharmacology, 1999, Volume: 126, Issue:1

    Topics: 4-Butyrolactone; Acute Disease; Animals; Anti-Infective Agents; Arthritis, Experimental; Chronic Disease; Dose-Response Relationship, Drug; Ear; Edema; Enzymes; Female; Humans; Inflammation; Leukocytes; Male; Mice; Phospholipases A; Phospholipases A2; Pyrans; Rats; Rats, Wistar; Synovial Fluid; U937 Cells

1999