4-butyrolactone has been researched along with Disease Models, Animal in 80 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (1.25) | 18.7374 |
| 1990's | 5 (6.25) | 18.2507 |
| 2000's | 22 (27.50) | 29.6817 |
| 2010's | 46 (57.50) | 24.3611 |
| 2020's | 6 (7.50) | 2.80 |
| Authors | Studies |
|---|---|
| Abdallah, HM; Abdel-Naim, AB; Alamoudi, AJ; Eid, BG; Ibrahim, SRM; Kammoun, AK; Mohamed, GA; Shaik, RA; Sirwi, A | 1 |
| Chen, G; Wu, L; Xie, CL; Yang, XW | 1 |
| Cai, YF; Guan, L; Luo, D; Peng, D; Qiao, HZ; Qiao, LJ; Tan, HY; Wang, Q; Wang, YX; Zhang, SJ | 1 |
| Tian-Qi, C; Yan-Fang, D; Yan-Yan, W; Yong-Hui, Z | 1 |
| Chen, H; Chen, S; Guo, M; Huang, Y; Jia, D; Lao, J; Li, Q; Liang, J; Tong, J | 1 |
| Breitinger, HG; Breitinger, U; Noureldin, N; Raafat, KM; Saleh, HA; Temraz, TA | 1 |
| Chari, A; Clayton, AL; Dale, C; Enomoto, S | 1 |
| Arcaro, JA; Leung, LS; Mirsattari, SM; Mousavi, SR; Tenney, JR | 1 |
| Biswas, R; Chatterjee, M; D'Morris, S; Mohan, CG; Nair, SS; Paul, V; Paul-Prasanth, B; Vanuopadath, M; Vasudevan, AK; Warrier, S | 1 |
| Azevedo, RB; de Lima, LI; de Souza de Almeida Leite, JR; Figueiró Longo, JP; Guimarães, MA; Jiang, CS; Mafud, AC; Mascarenhas, YP; Moraes, J; Muehlmann, LA; Py-Daniel, KR | 1 |
| Barbosa, ALDR; da Silva Martins, C; de Aguiar Magalhãres, D; de Brito, TV; de Sousa de Almeida Leite, JR; Fernando Pereira Vasconcelos, D; Guimarães Sousa, S; José Dias Júnior, G; Maria Costa Véras, L; Oliveira Silva, R; Rodolfo Pereira da Silva, F; Rodrigues de Carvalho, L; Santos Martins, D; Simião da C Júnior, J; Soares de Oliveira, J | 1 |
| Cao, MJ; Gao, YY; Lin, WX; Liu, B; Liu, GM; Liu, H; Liu, QM; Su, WJ; Xie, CL; Yang, XW | 1 |
| Ding, X; Feng, Z; Hu, Z; Li, X; Ni, W; Wu, A; Wu, D; Xuan, J; Zheng, G | 1 |
| Danko, G; Forcelli, PA; Hammack, R; Kobayashi, I; Santos, VR | 1 |
| Bowers, LW; Camp, KK; Fabian, CJ; Ford, NA; Hursting, SD; Kimler, BK; Lineberger, CG; Punjala, A; Rossi, EL | 1 |
| Chen, Q; Chen, Z; Deng, M; Li, Y; Liu, S; Ma, Y; Ming, J; Zhang, Y; Zhou, Y | 1 |
| Chen, J; Chen, T; Chen, Y; Lin, J; Shao, Z; Sheng, S; Wang, K; Wang, X; Xu, T; Ying, X; Zhang, Z | 1 |
| Chen, TT; Cui, J; Hua, YQ; Huang, TY; Li, MY; Lin, ZW; Yang, F | 1 |
| Gotoh, N; Hatanaka, A; Hayashi, D; Imai, Y; Ishii, K; Kanno, E; Kawakami, K; Maruyama, R; Miyairi, S; Otomaru, H; Sato, S; Shibuya, N; Tachi, M; Tanno, H | 1 |
| Filipek, B; Gawlik, K; Malawska, B; Pawlica-Gosiewska, D; Sałat, K; Solnica, B; Więckowski, K; Witalis, J | 1 |
| Chen, MM; Lu, YP; Peng, B; Sun, H; Wu, XM; Zhao, P; Zhu, L | 1 |
| Deng, M; Xie, X; Xin, J; Yang, Y; Zhang, J | 1 |
| Chen, C; Chen, YS; Du, JR; He, Q; Kuang, X; Li, LJ; Li, YJ; Liu, K; Wang, LF; Wang, Y; Zhang, MX | 1 |
| Boon, C; Chen, S; Deng, Y; Lim, A; Zhang, LH | 1 |
| Aziz, M; Kameoka, S; Matsuo, S; Wang, P; Yang, WL | 1 |
| Bisson, JF; Hidalgo, S; Simons, R; Verbruggen, M | 1 |
| Choi, SY; Eum, WS; Han, KH; Jeong, HJ; Jo, HS; Kim, DS; Kim, DW; Kim, HA; Kim, MJ; Park, EY; Park, J; Park, JH; Sohn, EJ; Son, O | 1 |
| Biasiotto, G; Cadei, M; Caimi, L; Di Lorenzo, D; Penza, M; Rossini, C; Smeds, AI; Zanella, I | 1 |
| Ham, YM; Han, HS; Jang, KH; Jang, SA; Jeong, YJ; Jung, YH; Kang, SC; Koo, HJ; Kwak, JH; Kwon, JE; Namkoong, S; Park, SY; Sohn, E; Sohn, EH; Yoon, WJ | 1 |
| Chen, CC; Cheong, E; Choi, EJ; Latchoumane, C; Lee, B; Lee, CJ; Lee, J; Lee, SE; Oh, SJ; Park, C; Saud, ZA; Shin, HS; Sun, N | 1 |
| Gao, YJ; Wang, XT; Zhang, ZJ; Zhao, LX; Zhu, MD | 1 |
| Huang, S; Meng, N; Miao, J; Peng, N; Su, L; Wang, SQ; Zhang, S; Zhang, Y; Zhao, B; Zhao, J | 1 |
| Golpasha, ID; Irani, S; Mousavi, SF; Owlia, P; Siadat, SD | 1 |
| Gotoh, N; Ishii, K; Kamimatsuno, R; Kanno, E; Kawakami, K; Maruyama, R; Miyairi, S; Miyasaka, T; Suzuki, A; Tachi, M; Takagi, N; Tanno, H | 1 |
| Forcelli, PA; Kulick, CV; N'Gouemo, P; Soper, C; Wicker, E | 1 |
| Liu, D; Shen, J; Xiao, W; Xu, Z; Yu, A | 1 |
| Arcaro, J; Chu, L; Kuo, M; Ma, J; Mirsattari, SM; Stan Leung, L | 1 |
| Chang, FK; Chen, SY; Chi, K; Fu, RH; Huang, PC; Huang, YC; Lin, PC; Lin, SZ; Liu, SP | 1 |
| Hsiao, HB; Hsieh, CC; Lin, H; Lin, WC; Wu, JB | 1 |
| Alimoradi, H; Baery, N; Barzegar-Fallah, A; Barzegar-Fallah, N; Malekmohammadi, N; Parsa, A; Soleymankhani, M | 1 |
| Bai, D; Chen, L; Duan, K; Guo, Q; Jin, S; Liu, Y; Wu, Q; Wu, Y | 1 |
| Cui, X; Ji, S; Li, M; Li, X; Liu, X | 1 |
| Lian, XY; Stringer, JL; Xu, K | 1 |
| Cheng, TY; Ke, CQ; Lin, G; Rudd, JA; Tang, CP; Yang, XZ; Ye, Y; Zhu, JY | 1 |
| Aleem, IS; Ashraf, A; Cortez, MA; Kanawaty, A; Liu, CC; Sadeghnia, HR; Shen, L; Snead, OC; Stewart, L; Trepanier, CH; Wu, Y | 1 |
| Chen, YS; Du, JR; Kuang, X; Wang, J; Wang, YN | 1 |
| Chen, YS; Du, JR; He, Y; Wang, CY; Wang, J; Yu, DK; Zhang, L | 1 |
| Koch, G; Nadal-Jimenez, P; Papaioannou, E; Quax, WJ; Setroikromo, R; Wahjudi, M | 1 |
| Bastos, JK; da Silva Ferreira, D; de Albuquerque, S; de Gaitani, CM; E Silva, ML; Esperandim, VR; Ferraudo, AS; Lira, AA; Marchetti, JM; Saraiva, J | 1 |
| Ahmed, M; Burnham, WM; Chan, KF; Chieverton, L; Liu, RR; Scott, BW; Wong, G; Wood, J | 1 |
| Kim, CJ; Kim, TD; Lee, JH; Lee, JY | 1 |
| Chen, D; Jiang, R; Khatibi, NH; Li, Y; Tang, J; Tu, L; Wang, C; Wang, S; Zhu, M | 1 |
| Akase, T; Asada, M; Huang, L; Ikeda, T; Minematsu, T; Morohoshi, T; Nagase, T; Nakagami, G; Ohta, Y; Sanada, H | 1 |
| Ding, ZB; Jiang, WG; Li, QQ; Lu, L; Shi, HS; Wang, SJ; Wang, X; Wu, P; Xu, CM; Zhu, WL | 1 |
| Gao, X; Jia, G; Ma, Z; Qin, X; Ren, Y; Zhang, L; Zhou, Y | 1 |
| Bi, J; Miao, J; Wang, P; Wei, L; Xie, Z; Xu, S; Yang, H; Yang, S; Zhao, B; Zhao, C | 1 |
| Librowski, T; Malawska, B; Moniczewski, A; Salat, K; Stanisz-Wallis, K; Wieckowski, K | 1 |
| Andrade E Silva, ML; Bastos, JK; Cunha, WR; da Silva Ferreira, D; de Albuquerque, S; Esperandim, VR; Saraiva, J; Sousa Rezende, KC | 1 |
| Chen, LM; Fu, LW; He, LR; Liang, YJ; Pan, QC; Xiong, HY; Yang, XP | 1 |
| Gauthier, YP; Palencia, M; Popoff, MY; Thibault, FM; Valade, E; Vidal, DR | 1 |
| Altman, E; Bylund, J; Chu, KK; Conway, BA; Speert, DP | 1 |
| Ferris, CF; King, JA; Marshall, PC; Tenney, JR | 1 |
| Landree, LE; Li, H; McCullough, LD; McFadden, J; Ronnett, GV; Zeng, Z | 1 |
| Eklund, PC; Mutanen, M; Oikarinen, SI; Pajari, AM; Sjöholm, RE; Smeds, AI | 1 |
| Kuhajda, FP; Landree, LE; Ronnett, GV | 1 |
| Brown, A; Bycroft, BW; Chhabra, SR; Pritchard, DI; Todd, I; Williams, P; Wood, P | 1 |
| Du, JR; Kuang, X; Liu, YX; Qian, ZM; Wang, CY; Yao, Y | 1 |
| Yamaguchi, K | 1 |
| Alvey, S; Gabrielson, E; Gabrielson, K; Hagemann, RL; Kuhajda, FP; Lee, JS; Orita, H; Pomper, MG | 1 |
| Dominguez, LG; Huo, JZ; Leshchenko, Y; Snead, OC; Velazquez, JL | 1 |
| Artru, AA; Michenfelder, JD; Steen, PA | 1 |
| Imai, H; Kurimoto, Y; Morita, S; Naiki, M; Suehiro, S; Taguchi, N; Takeoka, Y | 1 |
| Barie, PS; Cohen, SM; Darakchiev, B; Fantini, GA; Hariri, RJ; Siddiqi, FA | 1 |
| Fukuda, H; Ishige, K; Ito, Y | 1 |
| Ahotupa, M; Eckerman, C; Franke, AA; Kangas, L; Mäkelä, SI; Reunanen, M; Saarinen, NM; Salmi, SM; Santti, R; Wärri, A | 1 |
| Andersen, JB; Eberl, L; Givskov, M; Hentzer, M; Heydorn, A; Høiby, N; Mathee, K; Molin, S; Moser, C; Song, Z; Wu, H | 1 |
| Gabrielson, EW; Kuhajda, FP; Pinn, ML; Testa, JR | 1 |
| Senior, K | 1 |
| Bernasconi, R; Bittiger, H; Lauber, J; Leonhardt, T; Marescaux, C; Martin, P; Reymann, N; Rubio, V; Vergnes, M | 1 |
| Snead, OC | 1 |
1 review(s) available for 4-butyrolactone and Disease Models, Animal
| Article | Year |
|---|---|
[New developments in therapeutics for infectious diseases].
Topics: 4-Butyrolactone; Adjuvants, Immunologic; Animals; Anti-Bacterial Agents; Apoptosis; Cytokines; Disease Models, Animal; Galactosylceramides; Humans; Immunity, Cellular; Killer Cells, Natural; Legionnaires' Disease; Macrolides; Pneumonia, Pneumococcal; Pseudomonas aeruginosa; Pseudomonas Infections; Quorum Sensing; Th1 Cells; Vaccines | 2006 |
79 other study(ies) available for 4-butyrolactone and Disease Models, Animal
| Article | Year |
|---|---|
Mokko Lactone Attenuates Doxorubicin-Induced Hepatotoxicity in Rats: Emphasis on Sirt-1/FOXO1/NF-κB Axis.
Topics: 4-Butyrolactone; Alanine Transaminase; Alkaline Phosphatase; Animals; Antioxidants; Aspartate Aminotransferases; Catalase; Chemical and Drug Induced Liver Injury; Disease Models, Animal; Doxorubicin; Glutathione; Liver; Malondialdehyde; Nerve Tissue Proteins; NF-kappa B; Rats; Sesquiterpenes; Signal Transduction; Sirtuin 1; Superoxide Dismutase | 2021 |
Pharmacokinetics and Metabolism Study of Deep-Sea-Derived Butyrolactone I in Rats by UHPLC-MS/MS and UHPLC-Q-TOF-MS.
Topics: 4-Butyrolactone; Administration, Oral; Animals; Anti-Allergic Agents; Aspergillus; Biological Availability; Chromatography, High Pressure Liquid; Disease Models, Animal; Food Hypersensitivity; Infusions, Intravenous; Male; Rats; Rats, Sprague-Dawley; Tandem Mass Spectrometry | 2021 |
Ligustilide ameliorates cognitive impairment via AMPK/SIRT1 pathway in vascular dementia rat.
Topics: 4-Butyrolactone; AMP-Activated Protein Kinases; Animals; Cognitive Dysfunction; Dementia, Vascular; Disease Models, Animal; Maze Learning; Rats; Sirtuin 1 | 2022 |
Butyrolactone I attenuates inflammation in murine NASH by inhibiting the NF-κB signaling pathway.
Topics: 4-Butyrolactone; Animals; Disease Models, Animal; Inflammation; Lipopolysaccharides; Liver; Mice; Mice, Inbred C57BL; NF-kappa B; Non-alcoholic Fatty Liver Disease; Signal Transduction | 2022 |
3BDO Alleviates Seizures and Improves Cognitive Function by Regulating Autophagy in Pentylenetetrazol (PTZ)-Kindled Epileptic Mice Model.
Topics: 4-Butyrolactone; Animals; Autophagy; Cognition; Disease Models, Animal; Epilepsy; Hippocampus; Kindling, Neurologic; Mice; Pentylenetetrazole; Ribosomal Protein S6 Kinases, 70-kDa; Seizures; TOR Serine-Threonine Kinases | 2022 |
Sarcophine and (7S, 8R)-dihydroxydeepoxysarcophine from the Red Sea soft coral Sarcophyton glaucum as in vitro and in vivo modulators of glycine receptors.
Topics: 4-Butyrolactone; Animals; Anthozoa; Binding Sites; Binding, Competitive; Brain; Disease Models, Animal; Excitatory Amino Acid Antagonists; HEK293 Cells; Humans; Male; Mice; Protein Binding; Receptors, Glycine; Seizures; Strychnine | 2020 |
Quorum Sensing Attenuates Virulence in Sodalis praecaptivus.
Topics: 4-Butyrolactone; Animals; Bacterial Proteins; Bacterial Toxins; Chitinases; Disease Models, Animal; DNA, Bacterial; Enterobacteriaceae; Enterobacteriaceae Infections; Gene Deletion; Gene Expression Regulation, Bacterial; Genome, Bacterial; Insecticides; Phenotype; Quorum Sensing; Sequence Analysis, RNA; Survival; Symbiosis; Transcriptome; Virulence; Virulence Factors; Weevils | 2017 |
Functional connectivity of the hippocampus to the thalamocortical circuitry in an animal model of absence seizures.
Topics: 4-Butyrolactone; Animals; Cerebral Cortex; Cerebrovascular Circulation; Disease Models, Animal; Epilepsy, Absence; Functional Laterality; Hippocampus; Male; Neural Pathways; Oxygen; Rats, Sprague-Dawley; Rest; Thalamus; Time Factors | 2017 |
Mechanistic understanding of Phenyllactic acid mediated inhibition of quorum sensing and biofilm development in Pseudomonas aeruginosa.
Topics: 4-Butyrolactone; Animals; Anti-Bacterial Agents; Biofilms; Catheters; Computer Simulation; Disease Models, Animal; Gene Expression; Genetic Complementation Test; Lactates; Lactobacillus; Oryzias; Pseudomonas aeruginosa; Pseudomonas Infections; Pyocyanine; Quorum Sensing; Virulence Factors | 2017 |
Self-nanoemulsifying drug-delivery systems improve oral absorption and antischistosomal activity of epiisopiloturine.
Topics: 4-Butyrolactone; Administration, Oral; Animals; Biological Availability; Disease Models, Animal; Drug Delivery Systems; Emulsions; Humans; Imidazoles; Mice; Nanoparticles; Particle Size; Schistosoma mansoni; Schistosomiasis mansoni; Solubility | 2018 |
Epiisopiloturine, an imidazole alkaloid, reverses inflammation and lipid peroxidation parameters in the Crohn disease model induced by trinitrobenzenosulfonic acid in Wistar rats.
Topics: 4-Butyrolactone; Alkaloids; Animals; Anti-Inflammatory Agents; Crohn Disease; Disease Models, Animal; Female; Imidazoles; Inflammation; Intestinal Mucosa; Lipid Peroxidation; Rats, Wistar; Trinitrobenzenesulfonic Acid | 2018 |
Deep-Sea-Derived Butyrolactone I Suppresses Ovalbumin-Induced Anaphylaxis by Regulating Mast Cell Function in a Murine Model.
Topics: 4-Butyrolactone; Anaphylaxis; Animals; Aspergillus; Cells, Cultured; Disease Models, Animal; Female; Food Hypersensitivity; Histamine; Humans; Immunoglobulin E; Mast Cells; Mice; Mice, Inbred BALB C; Ovalbumin; Proto-Oncogene Proteins c-kit; Seawater | 2018 |
The Protective Effect of Ligustilide in Osteoarthritis: An in Vitro and in Vivo Study.
Topics: 4-Butyrolactone; ADAMTS5 Protein; Aged; Animals; Cell Survival; Cells, Cultured; Chondrocytes; Cyclooxygenase 2; Cytokines; Disease Models, Animal; Humans; Interleukin-1beta; Male; Matrix Metalloproteinase 3; Mice; Mice, Inbred C57BL; Middle Aged; NF-KappaB Inhibitor alpha; Nitric Oxide Synthase Type II; Osteoarthritis | 2018 |
Impact of strain, sex, and estrous cycle on gamma butyrolactone-evoked absence seizures in rats.
Topics: 4-Butyrolactone; Analysis of Variance; Animals; Convulsants; Disease Models, Animal; Dose-Response Relationship, Drug; Electrodes, Implanted; Electroencephalography; Estrous Cycle; Female; Immobility Response, Tonic; Male; Rats; Rats, Long-Evans; Rats, Sprague-Dawley; Rats, Wistar; Seizures; Sex Characteristics; Species Specificity | 2018 |
The flaxseed lignan secoisolariciresinol diglucoside decreases local inflammation, suppresses NFκB signaling, and inhibits mammary tumor growth.
Topics: 4-Butyrolactone; Animals; Anti-Inflammatory Agents; Biomarkers; Butylene Glycols; Cell Line, Tumor; Cell Survival; Cytokines; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Flax; Gene Expression Profiling; Glucosides; Immunohistochemistry; Lignans; Mammary Neoplasms, Animal; Mice; NF-kappa B; Signal Transduction | 2019 |
Ligustilide attenuates nitric oxide-induced apoptosis in rat chondrocytes and cartilage degradation via inhibiting JNK and p38 MAPK pathways.
Topics: 4-Butyrolactone; Animals; Apoptosis; Cartilage, Articular; Cell Nucleus Shape; Cell Survival; Chondrocytes; Disease Models, Animal; Enzyme Activation; Injections, Intra-Articular; JNK Mitogen-Activated Protein Kinases; Male; Membrane Potential, Mitochondrial; Nitric Oxide; Nitroprusside; Osteoarthritis; p38 Mitogen-Activated Protein Kinases; Rats, Sprague-Dawley | 2019 |
Ligustilide alleviated IL-1β induced apoptosis and extracellular matrix degradation of nucleus pulposus cells and attenuates intervertebral disc degeneration in vivo.
Topics: 4-Butyrolactone; Animals; Anti-Inflammatory Agents; Apoptosis; Cells, Cultured; Cyclooxygenase 2; Cytokines; Disease Models, Animal; Extracellular Matrix; Humans; Inflammation Mediators; Interleukin-1beta; Intervertebral Disc Degeneration; NF-kappa B; Nitric Oxide Synthase Type II; Nucleus Pulposus; Proteolysis; Rats; Rats, Sprague-Dawley; Signal Transduction | 2019 |
Ligustilide, a major bioactive component of Angelica sinensis, promotes bone formation via the GPR30/EGFR pathway.
Topics: 4-Butyrolactone; Angelica sinensis; Animals; Apoptosis; Bone Density Conservation Agents; Cell Line; Disease Models, Animal; Embryo, Nonmammalian; Gene Expression Regulation; Green Fluorescent Proteins; Larva; Mesenchymal Stem Cells; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Osteoblasts; Osteoporosis; Prednisolone; Primary Cell Culture; Proto-Oncogene Proteins c-bcl-2; Rats; Receptors, G-Protein-Coupled; Zebrafish; Zebrafish Proteins | 2019 |
Neutrophil-derived tumor necrosis factor-α contributes to acute wound healing promoted by N-(3-oxododecanoyl)-L-homoserine lactone from Pseudomonas aeruginosa.
Topics: 4-Butyrolactone; Animals; Antibodies, Anti-Idiotypic; Cell Proliferation; Disease Models, Animal; Epidermis; Homoserine; Male; Neovascularization, Physiologic; Neutrophils; Pseudomonas aeruginosa; Pseudomonas Infections; Rats; Rats, Sprague-Dawley; Tumor Necrosis Factor-alpha; Wound Healing | 2013 |
Evaluation of antinociceptive and antioxidant properties of 3-[4-(3-trifluoromethyl-phenyl)-piperazin-1-yl]-dihydrofuran-2-one in mice.
Topics: 4-Butyrolactone; Analgesics; Animals; Antioxidants; Brain; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Disease Models, Animal; Male; Mice; Pain; Pain Threshold; Piperazines; Streptozocin | 2013 |
Z-ligustilide activates the Nrf2/HO-1 pathway and protects against cerebral ischemia-reperfusion injury in vivo and in vitro.
Topics: 4-Butyrolactone; Animals; Blotting, Western; Brain Ischemia; Cell Line; Disease Models, Animal; Fluorescent Antibody Technique; Heme Oxygenase-1; Humans; Male; Neuroprotective Agents; NF-E2-Related Factor 2; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction | 2013 |
Radix Angelica Sinensis that contains the component Z-ligustilide promotes adult neurogenesis to mediate recovery from cognitive impairment.
Topics: 4-Butyrolactone; Adult Stem Cells; Angelica sinensis; Animals; Blotting, Western; Cell Differentiation; Cognition Disorders; Cranial Irradiation; Disease Models, Animal; Drugs, Chinese Herbal; Hippocampus; Immunohistochemistry; Male; Neural Stem Cells; Neurodegenerative Diseases; Neurogenesis; Rats; Rats, Wistar | 2013 |
Klotho upregulation contributes to the neuroprotection of ligustilide in an Alzheimer's disease mouse model.
Topics: 4-Butyrolactone; Aging; Alzheimer Disease; Amyloid beta-Peptides; Animals; Brain; Cells, Cultured; Disease Models, Animal; Forkhead Box Protein O1; Forkhead Transcription Factors; Gene Expression Regulation, Developmental; Glucuronidase; Insulin-Like Growth Factor I; Klotho Proteins; Male; Memory Disorders; Mice; Mice, Inbred Strains; Molecular Targeted Therapy; Neuroprotective Agents; Oxidative Stress; Peptide Fragments; Phosphorylation; Signal Transduction; tau Proteins; Up-Regulation | 2014 |
Cis-2-dodecenoic acid signal modulates virulence of Pseudomonas aeruginosa through interference with quorum sensing systems and T3SS.
Topics: 4-Butyrolactone; Animals; Antibiosis; Bacterial Secretion Systems; Biofilms; Burkholderia cenocepacia; Disease Models, Animal; Epithelial Cells; Fatty Acids, Monounsaturated; Gene Expression Profiling; HeLa Cells; Homoserine; Humans; Pseudomonas aeruginosa; Pseudomonas Infections; Quinolones; Quorum Sensing; Signal Transduction; Virulence; Virulence Factors; Zebrafish | 2013 |
Fatty acid synthase inhibitor C75 ameliorates experimental colitis.
Topics: 4-Butyrolactone; Animals; Chemokines; Colitis; Colon; Cyclooxygenase 2; Cytokines; Dextran Sulfate; Disease Models, Animal; Fatty Acid Synthases; Gene Expression Regulation; Humans; Male; Mice; Mice, Inbred C57BL; Nitric Oxide Synthase Type II | 2014 |
Preventive effects of lignan extract from flax hulls on experimentally induced benign prostate hyperplasia.
Topics: 4-Butyrolactone; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Drinking; Energy Intake; Flax; Hyperplasia; Lignans; Male; Phytotherapy; Plant Extracts; Prostate; Prostatic Hyperplasia; Rats, Wistar; Seeds; Testosterone Propionate; Weight Gain | 2014 |
PEP-1-PON1 protein regulates inflammatory response in raw 264.7 macrophages and ameliorates inflammation in a TPA-induced animal model.
Topics: 4-Butyrolactone; Animals; Anti-Inflammatory Agents; Cell Line; Cell Survival; Cyclooxygenase 2; Cytokines; Dermatitis, Contact; Disease Models, Animal; Lipopolysaccharides; Macrophages; Male; MAP Kinase Signaling System; Mice; Mice, Inbred ICR; NF-kappa B; Oxidative Stress; Reactive Oxygen Species; Tetradecanoylphorbol Acetate | 2014 |
Oilseeds ameliorate metabolic parameters in male mice, while contained lignans inhibit 3T3-L1 adipocyte differentiation in vitro.
Topics: 3T3-L1 Cells; 4-Butyrolactone; Adipocytes; Adipose Tissue; Adiposity; Animals; Cell Differentiation; Diet, High-Fat; Dietary Fats; Disease Models, Animal; Insulin Resistance; Lignans; Linseed Oil; Male; Metabolic Syndrome; Mice; Mice, Inbred C57BL; Sesame Oil | 2014 |
The analgesic and anti-inflammatory effects of Litsea japonica fruit are mediated via suppression of NF-κB and JNK/p38 MAPK activation.
Topics: 4-Butyrolactone; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cell Line; Cyclooxygenase 2; Cytokines; Disease Models, Animal; Fruit; Furans; Humans; Immunosuppression Therapy; Inflammation Mediators; Lipopolysaccharides; Litsea; Macrophages; Male; MAP Kinase Kinase 4; MAP Kinase Signaling System; Mice; Mice, Inbred ICR; NF-kappa B; Nitric Oxide; Nitric Oxide Synthase Type II; Pain; Phytotherapy; Plant Extracts | 2014 |
Rebound burst firing in the reticular thalamus is not essential for pharmacological absence seizures in mice.
Topics: 4-Butyrolactone; Action Potentials; Animals; Calcium Channels, T-Type; Disease Models, Animal; Electrophysiological Phenomena; Epilepsy, Absence; Mice; Mice, 129 Strain; Mice, Inbred C57BL; Mice, Knockout; Mice, Transgenic; Patch-Clamp Techniques; Thalamic Nuclei | 2014 |
Ligustilide inhibits microglia-mediated proinflammatory cytokines production and inflammatory pain.
Topics: 4-Butyrolactone; Animals; Anti-Inflammatory Agents; Calcium-Binding Proteins; Cell Line, Transformed; Cytokines; Disease Models, Animal; Dose-Response Relationship, Drug; Freund's Adjuvant; Inflammation; Lipopolysaccharides; Male; Mice; Microfilament Proteins; Microglia; Pain; Pain Measurement; Pain Threshold; RNA, Messenger; Spinal Cord; Time Factors | 2014 |
Heterogeneous nuclear ribonucleoprotein E1 regulates protein disulphide isomerase translation in oxidized low-density lipoprotein-activated endothelial cells.
Topics: 4-Butyrolactone; 5' Untranslated Regions; Animals; Apolipoproteins E; Atherosclerosis; Binding Sites; Cells, Cultured; Disease Models, Animal; DNA-Binding Proteins; Heterogeneous-Nuclear Ribonucleoproteins; Human Umbilical Vein Endothelial Cells; Humans; Lipoproteins, LDL; Mice, Inbred C57BL; Mice, Knockout; Mutation; Phosphorylation; Protein Disulfide-Isomerases; Proteomics; Proto-Oncogene Proteins c-akt; RNA-Binding Proteins; Transfection | 2015 |
Immunization with 3-oxododecanoyl-L-homoserine lactone-r-PcrV conjugate enhances survival of mice against lethal burn infections caused by Pseudomonas aeruginosa.
Topics: 4-Butyrolactone; Animals; Antibodies, Bacterial; Antigens, Bacterial; Bacterial Toxins; Burns; Disease Models, Animal; Female; Homoserine; Immunity, Humoral; Immunization; Liver; Mice; Mice, Inbred BALB C; Pore Forming Cytotoxic Proteins; Pseudomonas aeruginosa; Pseudomonas Infections; Skin; Spleen; Survival Rate; Vaccines, Conjugate | 2015 |
Promotion of acute-phase skin wound healing by Pseudomonas aeruginosa C
Topics: 4-Butyrolactone; Acute Disease; Analysis of Variance; Animals; Biopsy, Needle; Disease Models, Animal; Female; Homoserine; Immunohistochemistry; Neutrophils; Pseudomonas aeruginosa; Random Allocation; Rats; Rats, Sprague-Dawley; Statistics, Nonparametric; Tumor Necrosis Factor-alpha; Wound Healing; Wounds and Injuries | 2016 |
Optogenetic activation of superior colliculus neurons suppresses seizures originating in diverse brain networks.
Topics: 4-Butyrolactone; Acoustic Stimulation; Animals; Brain Stem; Disease Models, Animal; Electrocorticography; Epilepsy; Male; Neurons; Optogenetics; Pentylenetetrazole; Prosencephalon; Rats, Sprague-Dawley; Superior Colliculi; Thalamus | 2016 |
Ligustilide treatment promotes functional recovery in a rat model of spinal cord injury via preventing ROS production.
Topics: 4-Butyrolactone; Angelica sinensis; Animals; Disease Models, Animal; Drugs, Chinese Herbal; Male; Neuroprotective Agents; Phytotherapy; Polymerase Chain Reaction; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Recovery of Function; Spinal Cord Injuries | 2015 |
The hippocampus participates in a pharmacological rat model of absence seizures.
Topics: 4-Butyrolactone; Animals; Cerebral Cortex; Cortical Synchronization; Disease Models, Animal; Electrodes, Implanted; Epilepsy, Absence; GABA-A Receptor Agonists; Hippocampus; Male; Muscimol; Neural Pathways; Neurons; Rats, Long-Evans; Receptors, GABA-A; Seizures; Thalamus; Theta Rhythm | 2016 |
Therapeutic Effect of Ligustilide-Stimulated Adipose-Derived Stem Cells in a Mouse Thromboembolic Stroke Model.
Topics: 4-Butyrolactone; Adipose Tissue; Animals; Apoptosis; Cell- and Tissue-Based Therapy; Cells, Cultured; Chemokine CXCL12; Disease Models, Animal; Mice; Mice, Inbred BALB C; Receptors, CXCR4; Stem Cell Transplantation; Stem Cells; Stroke; Thromboembolism | 2016 |
Kinsenoside inhibits the inflammatory mediator release in a type-II collagen induced arthritis mouse model by regulating the T cells responses.
Topics: 4-Butyrolactone; Animals; Anti-Inflammatory Agents; Antirheumatic Agents; Arthritis, Experimental; Arthritis, Rheumatoid; Collagen Type II; Cytokines; Disease Models, Animal; Edema; Inflammation Mediators; Knee Joint; Male; Mice, Inbred DBA; Monosaccharides; Orchidaceae; Phytotherapy; Plant Extracts; T-Lymphocytes | 2016 |
Kelussia odoratissima Mozaff attenuates thromboembolic brain injury, possibly due to its Z-ligustilide content.
Topics: 4-Butyrolactone; Animals; Antioxidants; Apiaceae; Brain Edema; Catalase; Cerebral Cortex; Disease Models, Animal; Glutathione; Infarction, Middle Cerebral Artery; Male; Malondialdehyde; Oxidative Stress; Plant Extracts; Rats; Rats, Wistar; Stroke; Superoxide Dismutase; Tumor Necrosis Factor-alpha | 2016 |
Potential Use of Dimethyl Sulfoxide in Treatment of Infections Caused by Pseudomonas aeruginosa.
Topics: 4-Butyrolactone; Animals; Anti-Bacterial Agents; Biofilms; Dimethyl Sulfoxide; Disease Models, Animal; Female; Gene Expression Regulation, Bacterial; Glycolipids; Metalloproteases; Mice, Inbred C57BL; Pseudomonas aeruginosa; Pseudomonas Infections; Pyocyanine; Virulence Factors; Wound Infection | 2016 |
Screening of Bioactive Ingredients in Ligusticum Chuanxiong Hort for Protection against Myocardial Ischemia.
Topics: 4-Butyrolactone; Animals; Cardiotonic Agents; Chromatography, High Pressure Liquid; Coumaric Acids; Disease Models, Animal; Dogs; Ligusticum; Myocardial Infarction; Myocardial Ischemia; Plant Extracts; Reference Standards; Rhizome | 2016 |
Oral administration of fructose-1,6-diphosphate has anticonvulsant activity.
Topics: 4-Butyrolactone; Action Potentials; Administration, Oral; Animals; Anticonvulsants; Brain; Cerebral Cortex; Convulsants; Disease Models, Animal; Epilepsy; Fructosediphosphates; Male; Pilocarpine; Rats; Rats, Sprague-Dawley; Status Epilepticus; Treatment Outcome | 2008 |
Alkaloids from roots of Stemona sessilifolia and their antitussive activities.
Topics: 4-Butyrolactone; Alkaloids; Animals; Antitussive Agents; Azepines; Citric Acid; Cough; Disease Models, Animal; Guinea Pigs; Molecular Structure; Phytotherapy; Plant Extracts; Plant Roots; Stemonaceae | 2009 |
Infantile spasms and Down syndrome: a new animal model.
Topics: 4-Butyrolactone; Animals; Anticonvulsants; Baclofen; Brain; Disease Models, Animal; Down Syndrome; Electroencephalography; Ethosuximide; GABA Agonists; Genotype; Humans; Infant; Mice; Mice, Mutant Strains; Organophosphorus Compounds; Phenotype; Receptors, GABA-A; Receptors, GABA-B; Spasms, Infantile; Time Factors; Valproic Acid; Vigabatrin | 2009 |
Protective effect of Z-ligustilide against amyloid beta-induced neurotoxicity is associated with decreased pro-inflammatory markers in rat brains.
Topics: 4-Butyrolactone; Alzheimer Disease; Amyloid beta-Peptides; Animals; Brain; Disease Models, Animal; Humans; Inflammation Mediators; Injections, Intraventricular; Male; Maze Learning; Neuroprotective Agents; NF-kappa B; Rats; Rats, Wistar; Signal Transduction; Tumor Necrosis Factor-alpha | 2009 |
Z-ligustilide extracted from Radix Angelica Sinensis decreased platelet aggregation induced by ADP ex vivo and arterio-venous shunt thrombosis in vivo in rats.
Topics: 4-Butyrolactone; Adenosine Diphosphate; Angelica sinensis; Animals; Blood Coagulation; Depression, Chemical; Disease Models, Animal; Drugs, Chinese Herbal; Male; Platelet Aggregation; Rats; Rats, Sprague-Dawley; Thrombosis | 2009 |
Quorum-quenching acylase reduces the virulence of Pseudomonas aeruginosa in a Caenorhabditis elegans infection model.
Topics: 4-Butyrolactone; Acyl-Butyrolactones; Amidohydrolases; Animals; Caenorhabditis elegans; Disease Models, Animal; Homoserine; Hydrogen Cyanide; Pseudomonas aeruginosa; Quorum Sensing; Virulence | 2009 |
(-)-Hinokinin-loaded poly(D,-lactide-co-glycolide) microparticles for Chagas disease.
Topics: 4-Butyrolactone; Animals; Antiprotozoal Agents; Benzodioxoles; Chagas Disease; Delayed-Action Preparations; Dioxanes; Dioxoles; Disease Models, Animal; Humans; Lactic Acid; Lignans; Mice; Microspheres; Parasitemia; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Treatment Outcome; Trypanosoma cruzi | 2010 |
Cytogenesis in the adult rat dentate gyrus is increased following kindled seizures but is unaltered in pharmacological models of absence seizures.
Topics: 4-Butyrolactone; Animals; Animals, Newborn; Anticholesteremic Agents; Bromodeoxyuridine; Cell Count; Dentate Gyrus; Disease Models, Animal; Electroencephalography; Epilepsy, Absence; Gene Expression Regulation; Kindling, Neurologic; Male; Nerve Tissue Proteins; Neurogenesis; Rats; Rats, Long-Evans; trans-1,4-Bis(2-chlorobenzaminomethyl)cyclohexane Dihydrochloride | 2010 |
Antiasthmatic action of dibenzylbutyrolactone lignans from fruits of Forsythia viridissima on asthmatic responses to ovalbumin challenge in conscious guinea-pigs.
Topics: 4-Butyrolactone; Airway Resistance; Albuterol; Animals; Anti-Asthmatic Agents; Asthma; Bronchoalveolar Lavage Fluid; Cromolyn Sodium; Dexamethasone; Disease Models, Animal; Eosinophil Peroxidase; Forsythia; Fruit; Guinea Pigs; Lignans; Male; Molecular Structure; Ovalbumin; Phospholipases A2; Plant Extracts | 2011 |
Treatment with Z-ligustilide, a component of Angelica sinensis, reduces brain injury after a subarachnoid hemorrhage in rats.
Topics: 4-Butyrolactone; Angelica sinensis; Animals; Blood-Brain Barrier; Brain Edema; Disease Models, Animal; Dose-Response Relationship, Drug; In Situ Nick-End Labeling; Male; Neuroprotective Agents; Phytotherapy; Plant Oils; Random Allocation; Rats; Rats, Sprague-Dawley; Subarachnoid Hemorrhage; Vasospasm, Intracranial | 2011 |
The Pseudomonas aeruginosa quorum-sensing signal N-(3-oxododecanoyl) homoserine lactone can accelerate cutaneous wound healing through myofibroblast differentiation in rats.
Topics: 4-Butyrolactone; Animals; Cell Differentiation; Cells, Cultured; Cyclooxygenase 2; Disease Models, Animal; Gene Expression; Histocytochemistry; Homoserine; Inflammation; Male; Myofibroblasts; Neutrophils; Pseudomonas aeruginosa; Rats; Rats, Sprague-Dawley; Up-Regulation; Wound Healing; Wounds and Injuries | 2011 |
Increased Cdk5/p35 activity in the dentate gyrus mediates depressive-like behaviour in rats.
Topics: 4-Butyrolactone; Animals; Antidepressive Agents; Cold Temperature; Dentate Gyrus; Depression; Disease Models, Animal; Enzyme Activation; Exploratory Behavior; Food Preferences; Green Fluorescent Proteins; Injections, Intraventricular; Male; Phosphotransferases; Rats; Rats, Sprague-Dawley; Stress, Psychological; Sucrose; Time Factors; Transduction, Genetic | 2012 |
Identification and quantification of the major volatile constituents in antidepressant active fraction of xiaoyaosan by gas chromatography-mass spectrometry.
Topics: 4-Butyrolactone; Animals; Antidepressive Agents; Behavior, Animal; Depression; Disease Models, Animal; Drugs, Chinese Herbal; Gas Chromatography-Mass Spectrometry; Lactones; Male; Mice; Mice, Inbred ICR; Molecular Structure; Motor Activity; Palmitic Acid; Phytotherapy; Plants, Medicinal; Sesquiterpenes; Volatilization | 2012 |
A butyrolactone derivative 3BDO alleviates memory deficits and reduces amyloid-β deposition in an AβPP/PS1 transgenic mouse model.
Topics: 4-Butyrolactone; Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Autophagy; Brain; Disease Models, Animal; Insulysin; Maze Learning; Memory Disorders; Mice; Mice, Transgenic; Neprilysin; Presenilin-1; Signal Transduction | 2012 |
Analgesic, antioedematous and antioxidant activity of γ-butyrolactone derivatives in rodents.
Topics: 4-Butyrolactone; Administration, Oral; Analgesics; Animals; Antioxidants; Disease Models, Animal; Dose-Response Relationship, Drug; Edema; Free Radical Scavengers; Inflammation; Injections, Intraperitoneal; Male; Mice; Motor Activity; Pain; Rats; Rats, Wistar | 2012 |
In vivo infection by Trypanosoma cruzi: a morphometric study of tissue changes in mice.
Topics: 4-Butyrolactone; Animals; Antiprotozoal Agents; Benzodioxoles; Biometry; Cell Line; Chagas Disease; Dioxoles; Disease Models, Animal; Fibroblasts; Karyotyping; Lignans; Liver; Macaca mulatta; Male; Mice; Mice, Inbred BALB C; Spleen; Trypanosoma cruzi | 2013 |
Experimental chemotherapy against xenografts derived from multidrug resistant KBv200 cells and parental drug-sensitive KB cells in nude mice by annonaceous acetogenin 89-2.
Topics: 4-Butyrolactone; Animals; Annona; Antineoplastic Agents, Phytogenic; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cell Division; Disease Models, Animal; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Drugs, Chinese Herbal; Fatty Alcohols; Humans; KB Cells; Male; Mice; Mice, Nude; Neoplasm Transplantation; Neoplasms, Experimental; Plants, Medicinal; Xenograft Model Antitumor Assays | 2003 |
The PmlI-PmlR quorum-sensing system in Burkholderia pseudomallei plays a key role in virulence and modulates production of the MprA protease.
Topics: 4-Butyrolactone; Animals; Bacterial Proteins; Burkholderia pseudomallei; Disease Models, Animal; DNA Restriction Enzymes; Female; Melioidosis; Metalloendopeptidases; Mice; Virulence | 2004 |
Production of exopolysaccharide by Burkholderia cenocepacia results in altered cell-surface interactions and altered bacterial clearance in mice.
Topics: 4-Butyrolactone; Animals; Bacterial Capsules; Biofilms; Burkholderia cepacia complex; Burkholderia Infections; Cystic Fibrosis; Disease Models, Animal; Electrophoresis, Gel, Pulsed-Field; Female; Humans; Mice; Mice, Inbred BALB C; Random Amplified Polymorphic DNA Technique | 2004 |
fMRI of generalized absence status epilepticus in conscious marmoset monkeys reveals corticothalamic activation.
Topics: 4-Butyrolactone; Animals; Brain; Callithrix; Cerebral Cortex; Consciousness; Disease Models, Animal; Epilepsy, Absence; Magnetic Resonance Imaging; Male; Neural Pathways; Oxygen; Status Epilepticus; Thalamus | 2004 |
Pharmacological inhibition of AMP-activated protein kinase provides neuroprotection in stroke.
Topics: 4-Butyrolactone; Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Brain Ischemia; Cerebral Cortex; Constriction; Disease Models, Animal; Energy Metabolism; Enzyme Activation; Enzyme Inhibitors; Fatty Acid Synthases; Glucose; Hippocampus; Immunohistochemistry; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Middle Cerebral Artery; Multienzyme Complexes; Nerve Tissue Proteins; Neurons; Neuroprotective Agents; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Oxygen; Protein Serine-Threonine Kinases; Rats; Ribonucleotides; Stroke | 2005 |
The plant lignans matairesinol and secoisolariciresinol administered to Min mice do not protect against intestinal tumor formation.
Topics: 4-Butyrolactone; Adenomatous Polyposis Coli Protein; Animals; Butylene Glycols; Diet; Disease Models, Animal; Female; Furans; Intestinal Neoplasms; Lignans; Male; Mice; Mice, Inbred C57BL; Plants | 2006 |
The connections between C75 and obesity drug-target pathways.
Topics: 4-Butyrolactone; AMP-Activated Protein Kinases; Animals; Anorexia; Carnitine O-Palmitoyltransferase; Disease Models, Animal; Eating; Energy Metabolism; Enzyme Inhibitors; Fatty Acid Synthases; Fatty Acids; Feeding Behavior; Hypothalamus; Mice; Multienzyme Complexes; Obesity; Protein Serine-Threonine Kinases; Rats; Rhombencephalon | 2005 |
Alleviation of insulitis and moderation of diabetes in NOD mice following treatment with a synthetic Pseudomonas aeruginosa signal molecule, N-(3-oxododecanoyl)-L-homoserine lactone.
Topics: 4-Butyrolactone; Adjuvants, Immunologic; Animals; Diabetes Mellitus; Dimethyl Sulfoxide; Disease Models, Animal; Homoserine; Inflammation; Islets of Langerhans; Mice; Mice, Inbred NOD; Pancreatic Diseases; Pseudomonas aeruginosa | 2005 |
Neuroprotective role of Z-ligustilide against forebrain ischemic injury in ICR mice.
Topics: 4-Butyrolactone; Analysis of Variance; Animals; bcl-2-Associated X Protein; Brain Infarction; Caspase 3; Caspases; Disease Models, Animal; Dose-Response Relationship, Drug; Glutathione Peroxidase; Immunohistochemistry; Ischemic Attack, Transient; Malondialdehyde; Mice; Mice, Inbred ICR; Neuroprotective Agents; Prosencephalon; Proto-Oncogene Proteins c-bcl-2; Reperfusion; Superoxide Dismutase; Tetrazolium Salts | 2006 |
FDG-PET for pharmacodynamic assessment of the fatty acid synthase inhibitor C75 in an experimental model of lung cancer.
Topics: 4-Butyrolactone; Animals; Disease Models, Animal; Enzyme Inhibitors; Fatty Acid Synthases; Fluorodeoxyglucose F18; Lung Neoplasms; Positron-Emission Tomography; Rats | 2007 |
Typical versus atypical absence seizures: network mechanisms of the spread of paroxysms.
Topics: 4-Butyrolactone; Action Potentials; Animals; Cerebral Cortex; Cortical Spreading Depression; Cortical Synchronization; Disease Models, Animal; Electrodes, Implanted; Electroencephalography; Epilepsy, Absence; Hippocampus; Models, Neurological; Neural Inhibition; Neural Pathways; Rats; Rats, Long-Evans; Recruitment, Neurophysiological; Synaptic Transmission; Thalamus; trans-1,4-Bis(2-chlorobenzaminomethyl)cyclohexane Dihydrochloride | 2007 |
gamma-Hydroxybutyrate: cerebral metabolic, vascular, and protective effects.
Topics: 4-Butyrolactone; Animals; Brain; Cerebrovascular Circulation; Disease Models, Animal; Dogs; Furans; Hydroxybutyrates; Hypoxia; Male; Mice; Oxygen; Sodium Oxybate | 1980 |
2-Buten-4-olide (2-B4O) inhibits type II collagen-induced arthritis in Lewis rats.
Topics: 4-Butyrolactone; Animals; Antibody Formation; Arthritis, Rheumatoid; Arthrography; Collagen; Disease Models, Animal; Female; Furans; Hypersensitivity, Delayed; Rats; Rats, Inbred Lew | 1993 |
Attenuation of acute lung injury caused by hind-limb ischemia-reperfusion injury by butyrolactone anti-inflammatory agent FL1003.
Topics: 4-Butyrolactone; Acute Disease; Animals; Anti-Inflammatory Agents; Bronchoalveolar Lavage Fluid; Capillary Permeability; Disease Models, Animal; Drug Evaluation, Preclinical; Extravascular Lung Water; Hindlimb; Lipid Peroxidation; Lung; Lung Injury; Male; Organ Size; Rats; Rats, Sprague-Dawley; Reperfusion Injury | 1997 |
Pharmacological profiles of absence seizure-induced increases in CRE- and AP-1 DNA-binding activities in gamma-butyrolactone-treated mice.
Topics: 4-Butyrolactone; Activating Transcription Factor 2; Animals; Anticonvulsants; Brain; Brain Chemistry; Cerebral Cortex; Cyclic AMP Response Element-Binding Protein; Disease Models, Animal; DNA-Binding Proteins; Epilepsy, Absence; Ethosuximide; GABA Antagonists; Mice; Organophosphorus Compounds; Phosphinic Acids; Thalamus; Transcription Factor AP-1; Transcription Factors | 1998 |
Hydroxymatairesinol, a novel enterolactone precursor with antitumor properties from coniferous tree (Picea abies).
Topics: 4-Butyrolactone; Administration, Oral; Animals; Antineoplastic Agents, Phytogenic; Disease Models, Animal; Female; Furans; Genitalia, Male; Lignans; Male; Mammary Neoplasms, Experimental; Phytotherapy; Rats; Rats, Sprague-Dawley; Receptors, Estrogen; Trees; Uterus | 2000 |
Detection of N-acylhomoserine lactones in lung tissues of mice infected with Pseudomonas aeruginosa.
Topics: 4-Butyrolactone; Animals; Cystic Fibrosis; Disease Models, Animal; Gene Expression Regulation, Bacterial; Green Fluorescent Proteins; Humans; Luminescent Proteins; Lung; Mice; Mice, Inbred CBA; Pseudomonas aeruginosa; Pseudomonas Infections; Signal Transduction | 2000 |
Increased fatty acid synthase is a therapeutic target in mesothelioma.
Topics: 4-Butyrolactone; Animals; Antifungal Agents; Antineoplastic Agents; Cerulenin; Disease Models, Animal; Fatty Acid Synthases; Humans; Immunoenzyme Techniques; Mesothelioma; Mice; Mice, Nude; Neoplasm Transplantation; Neoplasms, Mesothelial; Paraffin Embedding; Prognosis; Tumor Cells, Cultured | 2001 |
Thin mice and fat mice respond differently to appetite suppressant.
Topics: 4-Butyrolactone; Animals; Disease Models, Animal; Fatty Acid Synthases; Mice; Obesity | 2002 |
Experimental absence seizures: potential role of gamma-hydroxybutyric acid and GABAB receptors.
Topics: 4-Butyrolactone; Animals; Baclofen; Brain; Cyclic GMP; Disease Models, Animal; Epilepsy, Absence; GABA-A Receptor Antagonists; Male; Organophosphorus Compounds; Rats; Rats, Inbred Strains; Receptors, GABA-A; Reference Values; Reproducibility of Results; Sodium Oxybate; Valproic Acid | 1992 |
Effect of gamma-crotonolactone in experimental models of generalized absence seizures.
Topics: 4-Butyrolactone; Animals; Anticonvulsants; Disease Models, Animal; Electroencephalography; Furans; Male; Pentylenetetrazole; Rats; Rats, Inbred Strains; Seizures; Sodium Oxybate; Time Factors | 1991 |