Page last updated: 2024-08-18

4-butyrolactone and Cystic Fibrosis

4-butyrolactone has been researched along with Cystic Fibrosis in 22 studies

Research

Studies (22)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	1 (4.55)	18.2507
2000's	15 (68.18)	29.6817
2010's	6 (27.27)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Coenye, T; Crabbé, A; Dandekar, AA; Lemarcq, A; Sass, A; Vandeplassche, E	1
Rousseau, S; Roussel, L	1
Grauer, DC; Janda, KD; Katz, AZ; Kaufmann, GF; Kravchenko, VV; Lehmann, M; Mathison, JC; Meijler, MM; Scott, DA; Ulevitch, RJ	1
Conibear, TCR; Givskov, M; Hume, EBH; Kjelleberg, S; Rice, SA; Willcox, MDP; Zhu, H	1
Barrett, DA; Cámara, M; Cifelli, PM; Erskine, P; Givskov, M; Holland, ED; Knox, A; Lewis, S; Ortori, CA; Righetti, K; Smyth, AR; Williams, P	1
Arant, RJ; Foskett, JK; Hofer, AM; Ianowski, JP; Illek, B; Isacoff, E; Machen, TE; Maiellaro, I; Matthes, E; Schwarzer, C; Shi, J; Vais, H; Wong, S	1
Blohmke, CJ; Hancock, RE; Mayer, ML; Sheridan, JA; Turvey, SE	1
Imperi, F; Leoni, L; Massai, F; Quattrucci, S; Visca, P; Zennaro, E	1
Conway, BA; Speert, DP; Venu, V	1
Eberl, L; Givskov, M; Huber, B; Köthe, M; Molin, S; Riedel, K	1
Altman, E; Bylund, J; Chu, KK; Conway, BA; Speert, DP	1
Eberl, L; Tümmler, B	1
Chole, RA; Jung, JY; Nason, R; Pashia, ME; Scholnick, S; Wang, EW	1
Eberl, L	1
Bjarnsholt, T; Givskov, M	1
Bazzo, R; Bottomley, MJ; Carfì, A; Muraglia, E	1
Brun, P; Figarella, C; Kammouni, W; Lazdunski, A; Marchand-Pinatel, S; Merten, MD; Saleh, A; Tubul, A	1
Eberl, L; Geisenberger, O; Givskov, M; Høiby, N; Riedel, K; Tümmler, B	1
Andersen, JB; Eberl, L; Givskov, M; Hentzer, M; Heydorn, A; Høiby, N; Mathee, K; Molin, S; Moser, C; Song, Z; Wu, H	1
Greenberg, EP; Moninger, TO; Parsek, MR; Schaefer, AL; Singh, PK; Welsh, MJ	1
Blanc, D; Favre-Bonté, S; Pache, JC; Pechère, JC; Robert, J; van Delden, C	1
Cámara, M; Hardman, A; Knox, AJ; Middleton, B; Rodgers, HC; Williams, P	1

Reviews

4 review(s) available for 4-butyrolactone and Cystic Fibrosis

Article	Year
Role of quorum sensing by Pseudomonas aeruginosa in microbial keratitis and cystic fibrosis. Microbiology (Reading, England), 2008, Volume: 154, Issue:Pt 8 Topics: 4-Butyrolactone; Cystic Fibrosis; Gene Expression Regulation, Bacterial; Humans; Keratitis; Pseudomonas aeruginosa; Pseudomonas Infections; Quorum Sensing; Virulence; Virulence Factors	2008
Pseudomonas aeruginosa and Burkholderia cepacia in cystic fibrosis: genome evolution, interactions and adaptation. International journal of medical microbiology : IJMM, 2004, Volume: 294, Issue:2-3 Topics: 4-Butyrolactone; Adaptation, Physiological; Biofilms; Burkholderia cepacia; Burkholderia Infections; Cystic Fibrosis; Evolution, Molecular; Gene Expression Regulation, Bacterial; Gene Transfer, Horizontal; Genome, Bacterial; Genomic Islands; Humans; Lung; Pseudomonas aeruginosa; Pseudomonas Infections; Recombination, Genetic; Signal Transduction; Virulence Factors	2004
Quorum sensing in the genus Burkholderia. International journal of medical microbiology : IJMM, 2006, Volume: 296, Issue:2-3 Topics: 4-Butyrolactone; Biofilms; Burkholderia; Burkholderia Infections; Cell Communication; Cystic Fibrosis; Humans; Pseudomonas aeruginosa; Signal Transduction; Virulence	2006
Quorum-sensing blockade as a strategy for enhancing host defences against bacterial pathogens. Philosophical transactions of the Royal Society of London. Series B, Biological sciences, 2007, Jul-29, Volume: 362, Issue:1483 Topics: 4-Butyrolactone; Anti-Bacterial Agents; Biofilms; Cystic Fibrosis; Humans; Pseudomonas aeruginosa; Pseudomonas Infections; Quorum Sensing; Virulence	2007

Trials

1 trial(s) available for 4-butyrolactone and Cystic Fibrosis

Article	Year
Garlic as an inhibitor of Pseudomonas aeruginosa quorum sensing in cystic fibrosis--a pilot randomized controlled trial. Pediatric pulmonology, 2010, Volume: 45, Issue:4 Topics: 4-Butyrolactone; Adolescent; Adult; Child; Cystic Fibrosis; Female; Garlic; Homoserine; Humans; Male; Middle Aged; Phytotherapy; Pilot Projects; Plant Oils; Plasma; Pseudomonas aeruginosa; Pseudomonas Infections; Quorum Sensing; Respiratory Function Tests; Sputum; Treatment Outcome; Young Adult	2010

Article

Year

Garlic as an inhibitor of Pseudomonas aeruginosa quorum sensing in cystic fibrosis--a pilot randomized controlled trial.

Pediatric pulmonology, 2010, Volume: 45, Issue:4

Topics: 4-Butyrolactone; Adolescent; Adult; Child; Cystic Fibrosis; Female; Garlic; Homoserine; Humans; Male; Middle Aged; Phytotherapy; Pilot Projects; Plant Oils; Plasma; Pseudomonas aeruginosa; Pseudomonas Infections; Quorum Sensing; Respiratory Function Tests; Sputum; Treatment Outcome; Young Adult

2010

Other Studies

17 other study(ies) available for 4-butyrolactone and Cystic Fibrosis

Article	Year
In vitro evolution of Pseudomonas aeruginosa AA2 biofilms in the presence of cystic fibrosis lung microbiome members. Scientific reports, 2019, 09-06, Volume: 9, Issue:1 Topics: 4-Butyrolactone; Adaptation, Physiological; Bacterial Proteins; Biofilms; Cystic Fibrosis; Drug Resistance, Bacterial; Humans; Lung; Microbiota; Mutation; Peptide Hydrolases; Phenotype; Pseudomonas aeruginosa; Pseudomonas Infections; Pyocyanine; Quorum Sensing; Virulence Factors	2019
Exposure of airway epithelial cells to Pseudomonas aeruginosa biofilm-derived quorum sensing molecules decrease the activity of the anti-oxidant response element bound by NRF2. Biochemical and biophysical research communications, 2017, 02-05, Volume: 483, Issue:2 Topics: 4-Butyrolactone; Antioxidant Response Elements; Biofilms; Cell Line; Cystic Fibrosis; Epithelial Cells; Gene Expression Regulation; Heme Oxygenase-1; Homoserine; Humans; Interleukin-8; Lung; NAD(P)H Dehydrogenase (Quinone); NF-E2-Related Factor 2; Pseudomonas aeruginosa; Pseudomonas Infections; Quorum Sensing	2017
Modulation of gene expression via disruption of NF-kappaB signaling by a bacterial small molecule. Science (New York, N.Y.), 2008, Jul-11, Volume: 321, Issue:5886 Topics: 4-Butyrolactone; Adult; Animals; Cyclic AMP Response Element-Binding Protein; Cystic Fibrosis; Female; Gene Expression Regulation; Homoserine; Humans; I-kappa B Kinase; I-kappa B Proteins; Immunity, Innate; Interferon-gamma; Lipopolysaccharides; Macrophage Activation; Macrophages; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Middle Aged; NF-kappa B; NF-KappaB Inhibitor alpha; Phosphorylation; Pseudomonas aeruginosa; Pseudomonas Infections; Signal Transduction; Toll-Like Receptors; Transcription Factor RelA	2008
Pseudomonas aeruginosa Homoserine lactone activates store-operated cAMP and cystic fibrosis transmembrane regulator-dependent Cl- secretion by human airway epithelia. The Journal of biological chemistry, 2010, Nov-05, Volume: 285, Issue:45 Topics: 4-Butyrolactone; Anions; Calcium; Calcium Signaling; Cell Line, Transformed; Chlorides; Cyclic AMP; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; Endoplasmic Reticulum; Enzyme Inhibitors; Gene Expression Regulation; Humans; Inositol 1,4,5-Trisphosphate Receptors; Membrane Proteins; Neoplasm Proteins; Pseudomonas aeruginosa; Pseudomonas Infections; Quorum Sensing; Respiratory Mucosa; Stromal Interaction Molecule 1	2010
The Pseudomonas aeruginosa autoinducer 3O-C12 homoserine lactone provokes hyperinflammatory responses from cystic fibrosis airway epithelial cells. PloS one, 2011, Jan-31, Volume: 6, Issue:1 Topics: 4-Butyrolactone; Calcium; Cystic Fibrosis; Cytokines; Epithelial Cells; Homoserine; Humans; Inflammation; Lactones; Pseudomonas aeruginosa; Respiratory System	2011
A multitask biosensor for micro-volumetric detection of N-3-oxo-dodecanoyl-homoserine lactone quorum sensing signal. Biosensors & bioelectronics, 2011, Apr-15, Volume: 26, Issue:8 Topics: 4-Butyrolactone; Biosensing Techniques; Cystic Fibrosis; High-Throughput Screening Assays; Homoserine; Humans; Pseudomonas aeruginosa; Quorum Sensing; Sputum	2011
Biofilm formation and acyl homoserine lactone production in the Burkholderia cepacia complex. Journal of bacteriology, 2002, Volume: 184, Issue:20 Topics: 4-Butyrolactone; Biofilms; Burkholderia cepacia; Burkholderia Infections; Culture Media; Cystic Fibrosis; Gene Expression Regulation, Bacterial; Humans; Polypropylenes; Signal Transduction	2002
Genetic analysis of functions involved in the late stages of biofilm development in Burkholderia cepacia H111. Molecular microbiology, 2002, Volume: 46, Issue:2 Topics: 4-Butyrolactone; Bacterial Proteins; Biofilms; Burkholderia cepacia; Burkholderia Infections; Cystic Fibrosis; DNA Transposable Elements; Gene Expression Regulation, Bacterial; Humans; Hydrophobic and Hydrophilic Interactions; Image Processing, Computer-Assisted; Microscopy, Confocal; Mutagenesis, Insertional; Polystyrenes; Signal Transduction; Surface Properties	2002
Production of exopolysaccharide by Burkholderia cenocepacia results in altered cell-surface interactions and altered bacterial clearance in mice. The Journal of infectious diseases, 2004, Sep-01, Volume: 190, Issue:5 Topics: 4-Butyrolactone; Animals; Bacterial Capsules; Biofilms; Burkholderia cepacia complex; Burkholderia Infections; Cystic Fibrosis; Disease Models, Animal; Electrophoresis, Gel, Pulsed-Field; Female; Humans; Mice; Mice, Inbred BALB C; Random Amplified Polymorphic DNA Technique	2004
Otopathogenic Pseudomonas aeruginosa strains as competent biofilm formers. Archives of otolaryngology--head & neck surgery, 2005, Volume: 131, Issue:11 Topics: 4-Butyrolactone; Bacterial Adhesion; Biofilms; Cell Adhesion; Cholesteatoma; Cystic Fibrosis; Gene Expression Regulation, Bacterial; Humans; Keratinocytes; Microbial Sensitivity Tests; Pneumonia; Pseudomonas aeruginosa; Pseudomonas Infections; Reverse Transcriptase Polymerase Chain Reaction	2005
Molecular insights into quorum sensing in the human pathogen Pseudomonas aeruginosa from the structure of the virulence regulator LasR bound to its autoinducer. The Journal of biological chemistry, 2007, May-04, Volume: 282, Issue:18 Topics: 4-Butyrolactone; Bacterial Proteins; Crystallography, X-Ray; Cystic Fibrosis; DNA-Binding Proteins; Escherichia coli Proteins; Humans; Lactones; Opportunistic Infections; Protein Structure, Tertiary; Pseudomonas aeruginosa; Pseudomonas Infections; Quorum Sensing; Structural Homology, Protein; Trans-Activators; Virulence Factors	2007
Pseudomonas aeruginosa quorum-sensing signal molecule N-(3-oxododecanoyl)-L-homoserine lactone inhibits expression of P2Y receptors in cystic fibrosis tracheal gland cells. Infection and immunity, 1999, Volume: 67, Issue:10 Topics: 4-Butyrolactone; Cell Line; Cystic Fibrosis; Homoserine; Humans; Ibuprofen; Pseudomonas aeruginosa; Purinergic P2 Receptor Antagonists; Receptors, Purinergic P2; Receptors, Purinergic P2Y2; RNA, Messenger; Trachea	1999
Production of N-acyl-L-homoserine lactones by P. aeruginosa isolates from chronic lung infections associated with cystic fibrosis. FEMS microbiology letters, 2000, Mar-15, Volume: 184, Issue:2 Topics: 4-Butyrolactone; Burkholderia cepacia; Burkholderia Infections; Chromatography, Thin Layer; Chronic Disease; Cystic Fibrosis; Gene Expression Regulation, Bacterial; Humans; Lung Diseases; Pseudomonas aeruginosa; Pseudomonas Infections; Signal Transduction	2000
Detection of N-acylhomoserine lactones in lung tissues of mice infected with Pseudomonas aeruginosa. Microbiology (Reading, England), 2000, Volume: 146 ( Pt 10) Topics: 4-Butyrolactone; Animals; Cystic Fibrosis; Disease Models, Animal; Gene Expression Regulation, Bacterial; Green Fluorescent Proteins; Humans; Luminescent Proteins; Lung; Mice; Mice, Inbred CBA; Pseudomonas aeruginosa; Pseudomonas Infections; Signal Transduction	2000
Quorum-sensing signals indicate that cystic fibrosis lungs are infected with bacterial biofilms. Nature, 2000, Oct-12, Volume: 407, Issue:6805 Topics: 4-Butyrolactone; Biofilms; Cystic Fibrosis; Gene Expression Regulation, Bacterial; Lung; Mucus; Pseudomonas aeruginosa; Pseudomonas Infections; Signal Transduction; Sputum	2000
Detection of Pseudomonas aeruginosa cell-to-cell signals in lung tissue of cystic fibrosis patients. Microbial pathogenesis, 2002, Volume: 32, Issue:3 Topics: 4-Butyrolactone; Adult; Bronchi; Cystic Fibrosis; Female; Homoserine; Humans; Lung; Male; Pseudomonas aeruginosa; Pseudomonas Infections; Signal Transduction	2002
Direct detection of N-acylhomoserine lactones in cystic fibrosis sputum. FEMS microbiology letters, 2002, Jan-22, Volume: 207, Issue:1 Topics: 4-Butyrolactone; Burkholderia cepacia; Burkholderia Infections; Cystic Fibrosis; Humans; Pseudomonas aeruginosa; Pseudomonas Infections; Signal Transduction; Sputum	2002