4-butyrolactone has been researched along with Brain Ischemia in 17 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (23.53) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (17.65) | 29.6817 |
| 2010's | 6 (35.29) | 24.3611 |
| 2020's | 4 (23.53) | 2.80 |
| Authors | Studies |
|---|---|
| Liu, J; Mao, Z; Seto, S; Tian, L; Wang, G; Wang, N; Wang, Y; Wu, Q | 2 |
| Ding, Y; Gao, C; Ji, X; Li, N; Li, S; Ren, C; Yang, Y; Zhang, W | 1 |
| Chen, C; Du, JR; Duan, W; Gan, YM; Liu, DL; Yang, YX | 1 |
| Du, JR; Liu, DL; Long, FY; Sang, N; Shi, MQ; Zhou, HJ | 1 |
| Chen, MM; Lu, YP; Peng, B; Sun, H; Wu, XM; Zhao, P; Zhu, L | 1 |
| Chen, C; Du, JR; He, Q; Kuang, X; Li, YJ; Wang, LF; Wang, YN; Yu, L | 1 |
| Guo, YZ; Jiang, LR; Ke, Y; Li, FM; Ma, J; Qian, ZM; Zhang, YT | 1 |
| Li, J; Li, L; Ma, H; Qi, HY; Wu, MX; Yang, N; Yu, J; Zhao, ZL; Zheng, DD | 1 |
| Feng, Z; Li, J; Lu, Y; Peng, B; Qian, Z; Wu, X; Zhao, P; Zhu, L | 1 |
| Landree, LE; Li, H; McCullough, LD; McFadden, J; Ronnett, GV; Zeng, Z | 1 |
| Du, JR; Kuang, X; Liu, YX; Peng, HY; Qian, ZM; Wang, CY; Zhang, GY | 1 |
| Du, JR; Kuang, X; Liu, YX; Peng, HY; Zhang, GY | 1 |
| Babiak, T; Hariri, RJ; Lavyne, MH; Tankosic, T | 1 |
| Beley, A; Beley, P; Bralet, AM; Bralet, J | 1 |
| Abe, K; Abe, T; Klatzo, I; Spatz, M | 1 |
| Strosznajder, J; Wikieł, H | 1 |
17 other study(ies) available for 4-butyrolactone and Brain Ischemia
| Article | Year |
|---|---|
Ligustilide attenuates ischemic stroke injury by promoting Drp1-mediated mitochondrial fission via activation of AMPK.
Topics: 4-Butyrolactone; AMP-Activated Protein Kinases; Animals; Apoptosis; Brain Ischemia; Dynamins; Ischemic Stroke; Mitochondrial Dynamics; Rats | 2022 |
Ligustilide ameliorates hippocampal neuronal injury after cerebral ischemia reperfusion through activating PINK1/Parkin-dependent mitophagy.
Topics: 4-Butyrolactone; Animals; Brain Ischemia; Hippocampus; Infarction, Middle Cerebral Artery; Ischemic Stroke; Mammals; Mitophagy; Protein Kinases; Rats; Reperfusion; Reperfusion Injury; Ubiquitin-Protein Ligases | 2022 |
Ligustilide provides neuroprotection by promoting angiogenesis after cerebral ischemia.
Topics: 4-Butyrolactone; Angiogenesis Inducing Agents; Animals; Behavior, Animal; Brain Ischemia; Cell Line; Male; Mice; Mice, Inbred C57BL; Neovascularization, Physiologic; Neuroprotective Agents | 2020 |
Phthalide derivative CD21 alleviates cerebral ischemia-induced neuroinflammation: Involvement of microglial M2 polarization via AMPK activation.
Topics: 4-Butyrolactone; AMP-Activated Protein Kinases; Animals; Behavior, Animal; Benzofurans; Brain Ischemia; Cell Line; Cell Polarity; Cytokines; Dose-Response Relationship, Drug; Encephalitis; Enzyme Activation; Infarction, Middle Cerebral Artery; Male; Mice; Mice, Inbred C57BL; Microglia; Neuroprotective Agents; Phenotype; Psychomotor Performance | 2020 |
Klotho upregulation contributes to the neuroprotection of ligustilide against cerebral ischemic injury in mice.
Topics: 4-Butyrolactone; Animals; Brain Ischemia; Glucuronidase; HEK293 Cells; Humans; Klotho Proteins; Male; Mice; Mice, Inbred C57BL; Neuroprotective Agents; Oxidative Stress; Signal Transduction; Up-Regulation | 2018 |
Z-ligustilide activates the Nrf2/HO-1 pathway and protects against cerebral ischemia-reperfusion injury in vivo and in vitro.
Topics: 4-Butyrolactone; Animals; Blotting, Western; Brain Ischemia; Cell Line; Disease Models, Animal; Fluorescent Antibody Technique; Heme Oxygenase-1; Humans; Male; Neuroprotective Agents; NF-E2-Related Factor 2; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction | 2013 |
Ligustilide ameliorates neuroinflammation and brain injury in focal cerebral ischemia/reperfusion rats: involvement of inhibition of TLR4/peroxiredoxin 6 signaling.
Topics: 4-Butyrolactone; Animals; Anti-Inflammatory Agents, Non-Steroidal; Astrocytes; Brain Ischemia; Cell Movement; Gene Expression Regulation; Inflammation; Injections, Intraperitoneal; Macrophage Activation; Male; Microglia; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Neurons; NF-kappa B; Oxidative Stress; Peroxiredoxin VI; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Signal Transduction; STAT3 Transcription Factor; T-Lymphocytes; Toll-Like Receptor 4 | 2014 |
(Z)-ligustilide increases ferroportin1 expression and ferritin content in ischemic SH-SY5Y cells.
Topics: 4-Butyrolactone; Antigens, CD; Apoferritins; Brain Ischemia; Cation Transport Proteins; Cell Line, Tumor; Cell Survival; Down-Regulation; Gene Expression Regulation; Glucose; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Neuroprotective Agents; Oxygen; Receptors, Transferrin | 2016 |
Intranasal Pretreatment with Z-Ligustilide, the Main Volatile Component of Rhizoma Chuanxiong, Confers Prophylaxis against Cerebral Ischemia via Nrf2 and HSP70 Signaling Pathways.
Topics: 4-Butyrolactone; Administration, Intranasal; Animals; Blood-Brain Barrier; Brain Ischemia; Drugs, Chinese Herbal; HSP70 Heat-Shock Proteins; Humans; Male; Neuroprotective Agents; NF-E2-Related Factor 2; Rats, Sprague-Dawley; Rhizome; Signal Transduction | 2017 |
Ligustilide alleviates brain damage and improves cognitive function in rats of chronic cerebral hypoperfusion.
Topics: 4-Butyrolactone; Animals; Brain Ischemia; Cognition; Hippocampus; Male; Maze Learning; Memory; Neuroprotective Agents; Parietal Lobe; Phytotherapy; Rats; Rats, Sprague-Dawley | 2012 |
Pharmacological inhibition of AMP-activated protein kinase provides neuroprotection in stroke.
Topics: 4-Butyrolactone; Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Brain Ischemia; Cerebral Cortex; Constriction; Disease Models, Animal; Energy Metabolism; Enzyme Activation; Enzyme Inhibitors; Fatty Acid Synthases; Glucose; Hippocampus; Immunohistochemistry; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Middle Cerebral Artery; Multienzyme Complexes; Nerve Tissue Proteins; Neurons; Neuroprotective Agents; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Oxygen; Protein Serine-Threonine Kinases; Rats; Ribonucleotides; Stroke | 2005 |
Neuroprotective effect of Z-ligustilide against permanent focal ischemic damage in rats.
Topics: 4-Butyrolactone; Animals; Body Temperature; Brain Edema; Brain Ischemia; Infarction, Middle Cerebral Artery; Male; Neurologic Examination; Neuroprotective Agents; Rats; Rats, Sprague-Dawley | 2007 |
Postischemic administration of Z-Ligustilide ameliorates cognitive dysfunction and brain damage induced by permanent forebrain ischemia in rats.
Topics: 4-Butyrolactone; Acetylcholinesterase; Angelica sinensis; Animals; Antioxidants; Brain Chemistry; Brain Ischemia; Cerebrovascular Circulation; Choline O-Acetyltransferase; Cognition Disorders; Male; Maze Learning; Parasympathetic Nervous System; Prosencephalon; Rats; Rats, Wistar; Reversal Learning | 2008 |
Effect of low dose gamma-butyrolactone therapy on forebrain neuronal ischemia in the unrestrained, awake rat.
Topics: 4-Butyrolactone; Animals; Brain Edema; Brain Ischemia; Caudate Nucleus; Cerebral Infarction; Cerebrovascular Circulation; Dose-Response Relationship, Drug; Female; Frontal Lobe; Furans; Male; Rats; Vertebrobasilar Insufficiency | 1983 |
[Cerebral protection by gamma-butyrolactone after induction of experimental ischemia in the rat].
Topics: 4-Butyrolactone; Animals; Brain Ischemia; Energy Metabolism; Furans; Male; Rats; Rats, Inbred Strains | 1982 |
Effect of endogenous central nervous system depressants in ischemic cerebral edema of gerbils.
Topics: 4-Butyrolactone; Animals; Blood-Brain Barrier; Brain Edema; Brain Ischemia; Furans; gamma-Aminobutyric Acid; Gerbillinae; Norepinephrine; Serotonin; Specific Gravity; Sucrose | 1980 |
Phosphatidylinositol degradation in ischemic brain specifically activated by synaptosomal enzymes.
Topics: 4-Butyrolactone; Animals; Atropine; Brain Ischemia; Cytosol; Gerbillinae; Phosphatidylinositols; Receptors, Cholinergic; Synaptosomes; Type C Phospholipases | 1987 |