Compounds > 4-butyrolactone
Page last updated: 2024-08-18

4-butyrolactone and Ache

4-butyrolactone has been researched along with Ache in 18 studies

Research

Studies (18)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's5 (27.78)29.6817
2010's11 (61.11)24.3611
2020's2 (11.11)2.80

Authors

AuthorsStudies
Allen, PA; Kaut, KP; Tokar, DM1
Beale, B; Jarudecha, T; Kashemsant, N; Kwananocha, I; Lascelles, BDX; Lekcharoensuk, C; Peirone, B; Vijarnsorn, M1
Blé-González, EA; Córdova-de la Cruz, M; Gómez-Rivera, A; González-Cortázar, M; Lobato-García, CE; López-Rodríguez, R; Montiel-Ruiz, RM; Zamilpa, A1
Coetzee, JF; Cooper, VL; Jaberi-Douraki, M; Kleinhenz, K; Kleinhenz, MD; Lechtenberg, K; Mazloom, R; Schieber, T; Seagen, J; Sidhu, PK; Wulf, LW1
Filipek, B; Gawlik, K; Malawska, B; Pawlica-Gosiewska, D; Sałat, K; Solnica, B; Więckowski, K; Witalis, J1
Sałat, K; Sałat, R1
Barth, LA; Coetzee, JF; Gehring, R; Stock, ML; Wulf, LW1
Ham, YM; Han, HS; Jang, KH; Jang, SA; Jeong, YJ; Jung, YH; Kang, SC; Koo, HJ; Kwak, JH; Kwon, JE; Namkoong, S; Park, SY; Sohn, E; Sohn, EH; Yoon, WJ1
Gao, YJ; Wang, XT; Zhang, ZJ; Zhao, LX; Zhu, MD1
Dong, YL; Gao, YJ; Li, F; Qian, B; Zhang, ZJ; Zhao, LX1
Barth, LA; Coetzee, JF; Gehring, R; Hsu, WH; Millman, ST; Parsons, RL; Stock, ML; Van Engen, NK; Wang, C1
Joubert, KE1
Librowski, T; Malawska, B; Moniczewski, A; Salat, K; Stanisz-Wallis, K; Wieckowski, K1
Bajda, M; Bytnar, J; Filipek, B; Malawska, B; Sałat, K; Stables, JP; Więckowski, K1
Belpaire, FM; Buylaert, WA; De Paepe, P; Van Sassenbroeck, DK1
Clark, TP1
Aguilar-Guadarrama, AB; Gutiérrez, Mdel C; Rios, MY1
Du, J; Ke, Y; Qian, ZM; Wang, C; Yu, Y; Zhu, L1

Reviews

1 review(s) available for 4-butyrolactone and Ache

ArticleYear
The clinical pharmacology of cyclooxygenase-2-selective and dual inhibitors.
    The Veterinary clinics of North America. Small animal practice, 2006, Volume: 36, Issue:5

    Topics: 4-Butyrolactone; Animals; Anti-Inflammatory Agents, Non-Steroidal; Carbazoles; Cats; Cyclooxygenase 2 Inhibitors; Dogs; Etodolac; Meloxicam; Pain; Pain Measurement; Pyrazoles; Sulfones; Thiazines; Thiazoles

2006

Trials

4 trial(s) available for 4-butyrolactone and Ache

ArticleYear
The effectiveness of marine based fatty acid compound (PCSO-524) and firocoxib in the treatment of canine osteoarthritis.
    BMC veterinary research, 2019, Oct-17, Volume: 15, Issue:1

    Topics: 4-Butyrolactone; Animals; Anti-Inflammatory Agents, Non-Steroidal; Dinoprostone; Dog Diseases; Dogs; Double-Blind Method; Drug Therapy, Combination; Fatty Acids, Unsaturated; Female; Gait; Male; Osteoarthritis; Pain; Pain Measurement; Prospective Studies; Sulfones

2019
Transmammary delivery of firocoxib to piglets reduces stress and improves average daily gain after castration, tail docking, and teeth clipping1.
    Journal of animal science, 2019, Jul-02, Volume: 97, Issue:7

    Topics: 4-Butyrolactone; Animal Welfare; Animals; Anti-Inflammatory Agents, Non-Steroidal; Female; Hydrocortisone; Injections, Intramuscular; Lactation; Male; Orchiectomy; Pain; Pregnancy; Random Allocation; Sulfones; Swine; Tooth; Weaning

2019
The effects of firocoxib on cautery disbudding pain and stress responses in preweaned dairy calves.
    Journal of dairy science, 2015, Volume: 98, Issue:9

    Topics: 4-Butyrolactone; Animals; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Cattle; Cautery; Female; Horns; Hydrocortisone; Male; Neurotransmitter Agents; Pain; Substance P; Sulfones

2015
The effects of firocoxib (Previcox) in geriatric dogs over a period of 90 days.
    Journal of the South African Veterinary Association, 2009, Volume: 80, Issue:3

    Topics: 4-Butyrolactone; Aging; Animals; Anti-Inflammatory Agents, Non-Steroidal; Blood Chemical Analysis; Dog Diseases; Dogs; Female; Lameness, Animal; Male; Osteoarthritis; Pain; Severity of Illness Index; Sulfones; Treatment Outcome

2009

Other Studies

13 other study(ies) available for 4-butyrolactone and Ache

ArticleYear
Revisiting the factor structure of the Short-Form McGill Pain Questionnaire-2 (SF-MPQ-2): Evidence for a bifactor model in individuals with Chiari malformation.
    PloS one, 2023, Volume: 18, Issue:10

    Topics: 4-Butyrolactone; Adult; Data Accuracy; Humans; Pain; Pain Measurement; Reproducibility of Results; Surveys and Questionnaires

2023
Antinociceptive Effect of Hinokinin and Kaurenoic Acid Isolated from
    Molecules (Basel, Switzerland), 2020, Mar-24, Volume: 25, Issue:6

    Topics: 4-Butyrolactone; Analgesics; Animals; Aristolochia; Benzodioxoles; Chromatography, High Pressure Liquid; Diterpenes; Lignans; Magnetic Resonance Spectroscopy; Male; Mice; Pain; Pain Measurement; Plant Extracts

2020
Evaluation of antinociceptive and antioxidant properties of 3-[4-(3-trifluoromethyl-phenyl)-piperazin-1-yl]-dihydrofuran-2-one in mice.
    Naunyn-Schmiedeberg's archives of pharmacology, 2013, Volume: 386, Issue:6

    Topics: 4-Butyrolactone; Analgesics; Animals; Antioxidants; Brain; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Disease Models, Animal; Male; Mice; Pain; Pain Threshold; Piperazines; Streptozocin

2013
The application of support vector regression for prediction of the antiallodynic effect of drug combinations in the mouse model of streptozocin-induced diabetic neuropathy.
    Computer methods and programs in biomedicine, 2013, Volume: 111, Issue:2

    Topics: 4-Butyrolactone; Algorithms; Analgesics; Animals; Computer Simulation; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Drug Administration Schedule; Drug Combinations; Furans; gamma-Aminobutyric Acid; Hyperalgesia; Male; Mice; Pain; Pain Measurement; Pain Threshold; Piperazines; Pregabalin; Software; Streptozocin; Support Vector Machine; Time Factors

2013
Pharmacokinetics of firocoxib in preweaned calves after oral and intravenous administration.
    Journal of veterinary pharmacology and therapeutics, 2014, Volume: 37, Issue:5

    Topics: 4-Butyrolactone; Administration, Intravenous; Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Area Under Curve; Biological Availability; Cattle; Cattle Diseases; Female; Half-Life; Horns; Male; Pain; Sulfones; Weaning

2014
The analgesic and anti-inflammatory effects of Litsea japonica fruit are mediated via suppression of NF-κB and JNK/p38 MAPK activation.
    International immunopharmacology, 2014, Volume: 22, Issue:1

    Topics: 4-Butyrolactone; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cell Line; Cyclooxygenase 2; Cytokines; Disease Models, Animal; Fruit; Furans; Humans; Immunosuppression Therapy; Inflammation Mediators; Lipopolysaccharides; Litsea; Macrophages; Male; MAP Kinase Kinase 4; MAP Kinase Signaling System; Mice; Mice, Inbred ICR; NF-kappa B; Nitric Oxide; Nitric Oxide Synthase Type II; Pain; Phytotherapy; Plant Extracts

2014
Ligustilide inhibits microglia-mediated proinflammatory cytokines production and inflammatory pain.
    Brain research bulletin, 2014, Volume: 109

    Topics: 4-Butyrolactone; Animals; Anti-Inflammatory Agents; Calcium-Binding Proteins; Cell Line, Transformed; Cytokines; Disease Models, Animal; Dose-Response Relationship, Drug; Freund's Adjuvant; Inflammation; Lipopolysaccharides; Male; Mice; Microfilament Proteins; Microglia; Pain; Pain Measurement; Pain Threshold; RNA, Messenger; Spinal Cord; Time Factors

2014
Ligustilide Ameliorates Inflammatory Pain and Inhibits TLR4 Upregulation in Spinal Astrocytes Following Complete Freund's Adjuvant Peripheral Injection.
    Cellular and molecular neurobiology, 2016, Volume: 36, Issue:1

    Topics: 4-Butyrolactone; Animals; Astrocytes; Cells, Cultured; Freund's Adjuvant; Hot Temperature; Hyperalgesia; Inflammation; Male; Mice, Inbred ICR; Pain; RNA, Messenger; Spinal Cord; Toll-Like Receptor 4; Up-Regulation

2016
Analgesic, antioedematous and antioxidant activity of γ-butyrolactone derivatives in rodents.
    Behavioural pharmacology, 2012, Volume: 23, Issue:4

    Topics: 4-Butyrolactone; Administration, Oral; Analgesics; Animals; Antioxidants; Disease Models, Animal; Dose-Response Relationship, Drug; Edema; Free Radical Scavengers; Inflammation; Injections, Intraperitoneal; Male; Mice; Motor Activity; Pain; Rats; Rats, Wistar

2012
Search for anticonvulsant and analgesic active derivatives of dihydrofuran-2(3H)-one.
    Bioorganic & medicinal chemistry, 2012, Nov-01, Volume: 20, Issue:21

    Topics: 4-Butyrolactone; Analgesics; Anesthetics, Local; Animals; Anticonvulsants; Dose-Response Relationship, Drug; Electroshock; Male; Mice; Pain; Pain Measurement

2012
Characterization of the pharmacokinetic and pharmacodynamic interaction between gamma-hydroxybutyrate and ethanol in the rat.
    Toxicological sciences : an official journal of the Society of Toxicology, 2003, Volume: 73, Issue:2

    Topics: 4-Butyrolactone; Adjuvants, Anesthesia; Animals; Behavior, Animal; Central Nervous System Depressants; Dose-Response Relationship, Drug; Drug Synergism; Ethanol; Illicit Drugs; Injections, Intraperitoneal; Injections, Intravenous; Male; Pain; Postural Balance; Rats; Rats, Wistar; Reflex, Startle; Sleep; Sodium Oxybate

2003
Analgesic activity of affinin, an alkamide from Heliopsis longipes (Compositae).
    Journal of ethnopharmacology, 2007, Mar-21, Volume: 110, Issue:2

    Topics: 4-Butyrolactone; Alkenes; Amides; Analgesics; Animals; Asteraceae; Benzodioxoles; Brain; Dioxoles; Female; gamma-Aminobutyric Acid; In Vitro Techniques; Lignans; Medicine, Traditional; Methylene Chloride; Mexico; Mice; Pain; Plant Extracts; Plants, Medicinal; Polyunsaturated Alkamides

2007
Ligustilide attenuates pain behavior induced by acetic acid or formalin.
    Journal of ethnopharmacology, 2007, May-30, Volume: 112, Issue:1

    Topics: 4-Butyrolactone; Acetic Acid; Analgesics; Animals; Drugs, Chinese Herbal; Female; Formaldehyde; Medicine, Chinese Traditional; Mice; Mice, Inbred ICR; Pain; Pain Measurement

2007