Page last updated: 2024-08-23

4-boronophenylalanine and Brain Neoplasms

4-boronophenylalanine has been researched along with Brain Neoplasms in 50 studies

Research

Studies (50)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's22 (44.00)18.2507
2000's21 (42.00)29.6817
2010's6 (12.00)24.3611
2020's1 (2.00)2.80

Authors

AuthorsStudies
Adams, DM; Barth, RF; Cai, J; Hariharan, JR; Radcliffe, K; Soloway, AH; Wyzlic, IM1
Fukuda, H; Hiratsuka, J1
Hattori, Y; Hermawan, A; Ishimura, M; Kirihata, M; Meiyanto, E; Ohta, Y; Qodria, L; Ramadani, RD; Susidarti, RA; Utomo, RY1
Moss, RL; Sauerwein, WA; Wittig, A1
Barth, RF; Chandra, S; Haider, SA; Huo, T; Kabalka, GW; Shaikh, AL; Yang, W1
Chang, CW; Chang, WY; Chen, JC; Li, JJ; Wang, HE; Yang, FY1
Barth, RF2
Cruickshank, GS; Detta, A1
Bozzali, M; Cametti, C; Capuani, S; D'Amore, E; Gili, T; Lazzarino, G; Maraviglia, B; Muolo, M; Pastore, FS; Porcari, P; Russo, S1
Kumada, H; Matsuda, M; Matsumura, A; Nakai, K; Shirakawa, M; Tsurubuchi, T; Yamamoto, T1
Doi, A; Hiramatsu, R; Iida, K; Imahori, Y; Kawabata, S; Kirihata, M; Kumada, H; Kuroda, Y; Kuroiwa, T; Maruhashi, A; Masunaga, S; Michiue, H; Miyata, S; Miyatake, S; Nonoguchi, N; Ono, K; Sakurai, Y; Suzuki, M; Yokoyama, K1
Boddy, A; Braithwaite, R; Chester, M; Chopra, A; Croswell, G; Cruickshank, GS; Detta, A; Doran, J; Elliot, M; Ford, S; Ghani, Z; Graham, N; Green, S; Halbert, G; Hardie, J; James, ND; Lockyer, N; Ngoga, D; Sheehan, TM; Steinfeldt, H; Sugar, R; Vickerman, J; Wojnecki, C1
Barth, RF; Binns, P; Riley, K; Tjarks, W; Wu, G; Yang, W1
Cheng, X; Guo, G; Jiang, X; Mao, X; Wang, P; Zhang, W; Zhang, X; Zhen, H1
Chandra, S; Coderre, JA; Kabalka, GW; Lorey, DR; Smith, DR1
Coderre, JA; Micca, PL; Morris, GM; Nawrocky, MM; Weissfloch, LE1
Al-Madhoun, AS; Barth, RF; Byun, Y; Chandra, S; Eriksson, S; Johnsamuel, J; Smith, DR; Tjarks, W; Yang, W1
Bergenheim, AT; Capala, J; Henriksson, R; Roslin, M1
Brun, A; H-Stenstam, B; Pellettieri, L; Rezaei, A; Sköld, K1
Barth, RF; Chandra, S; Lorey, DR; Tjarks, W1
Flam, F1
Fukuda, H; Ichihashi, M; Mishima, Y1
Bailey, MQ; Barth, RF; Coderre, JA; Matalka, KZ; Moeschberger, ML; Rofstad, EK; Soloway, AH; Staubus, AE2
Allen, BJ; Jones, R; Mallesch, JL; McCarthy, WH; Moore, DE; Stening, WA1
Cai, J; Iwamoto, S; Kikuchi, H; Nemoto, H; Oda, Y; Ono, K; Takagaki, M; Yamamoto, Y1
Barth, RF; Carpenter, DE; Goodman, JH; Moeschberger, ML; Yang, W1
Barth, RF; Goodman, JH; Joel, DD; Moeschberger, ML; Nawrocky, MM; Rotaru, JH; Soloway, AH; Yang, W1
Barth, RF; Goodman, JH; Joel, DD; Moeschberger, ML; Nawrocky, MM; Rotaru, JH; Yang, W1
Bergland, R; Capala, J; Chadha, M; Chanana, AD; Coderre, JA; Elowitz, EH; Joel, DD; Liu, HB; Slatkin, DN1
Buonocore, E; Dyke, JP; Hübner, KF; Kabalka, GW; Longford, CP; Reddy, NK; Reid, WS; Roberts, TG; Smith, GT1
Fujii, R; Ido, T; Imahori, Y; Kusuki, T; Ohmori, Y; Ono, K; Ueda, S1
Bergland, RM; Chadha, M; Chanana, AD; Coderre, JA; Elowitz, EH; Joel, DD1
Capala, J; Chadha, M; Chanana, AD; Coderre, JA; Elowitz, EH; Iwai, J; Joel, DD; Liu, HB; Wielopolski, L1
Barth, RF; Bartus, RT; Goodman, JH; Moeschberger, ML; Yang, W1
Coderre, JA; Joel, DD; Micca, PL; Nawrocky, MM1
Ye, SJ1
Aziz, T; Capala, J; Chanana, A; Diaz, A; Peress, NS1
Barth, RF; Boesel, CP; Goodman, JH; Joel, DD; Moeschberger, ML; Nawrocky, MM; Ono, K; Rotaru, JH; Soloway, AH; Yang, W1
Barth, RF; Bartus, RT; Coderre, JA; Ferketich, AK; Goodman, JH; Moeschberger, ML; Nawrocky, MM; Rotaru, JH; Yang, W1
Barth, RF; Boesel, CP; Bresnahan, JC; Goettl, VM; Hadjiconstantinou, M; Joel, DD; Nawrocky, MM; Rotaru, JH; Wilkie, DA; Yang, W1
Busse, PM; Kiger, WS; Palmer, MR; Riley, KJ; Zamenhof, RG1
Barth, RF; Chandra, S; Coderre, JA; Joel, DD; Smith, DR; Yang, W1
Ehara, K; Hiratsuka, J; Iwakura, M; Kondoh, H; Mishima, Y; Tamaki, N1
Barth, RF; Bartus, RT; Coderre, JA; Ferketich, AK; Moeschberger, ML; Nawrocky, MM; Rofstad, EK; Rotaru, JH; Yang, W1
Adelman, LS; Cano, G; Harling, OK; Joyce, MA; Kerley, SE; Madoc-Jones, H; Saris, SC; Solares, GR; Wazer, DE; Zamenhof, RG1
Coderre, JA; Joel, DD; Micca, PL; Nawrocky, MM; Slatkin, DN1
Barth, RF; Fairchild, RG; Soloway, AH1
Coderre, JA; Fairchild, RG; Fand, I; Glass, JD; Joel, DD; Micca, PL1

Reviews

2 review(s) available for 4-boronophenylalanine and Brain Neoplasms

ArticleYear
Pharmacokinetics of
    Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine, 2020, Volume: 166

    Topics: Boron; Boron Compounds; Boron Neutron Capture Therapy; Brain Neoplasms; Glioblastoma; Humans; Isotopes; Melanoma; Neoplasms; Phenylalanine; Positron-Emission Tomography

2020
Boron neutron capture therapy at the crossroads: challenges and opportunities.
    Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine, 2009, Volume: 67, Issue:7-8 Suppl

    Topics: Animals; Borohydrides; Boron Compounds; Boron Neutron Capture Therapy; Brain Neoplasms; Fast Neutrons; Glioma; Humans; Nuclear Reactors; Phenylalanine; Radiation-Sensitizing Agents; Radiotherapy Planning, Computer-Assisted; Randomized Controlled Trials as Topic; Rats; Sulfhydryl Compounds

2009

Trials

5 trial(s) available for 4-boronophenylalanine and Brain Neoplasms

ArticleYear
A cancer research UK pharmacokinetic study of BPA-mannitol in patients with high grade glioma to optimise uptake parameters for clinical trials of BNCT.
    Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine, 2009, Volume: 67, Issue:7-8 Suppl

    Topics: Aged; Blood-Brain Barrier; Boron Compounds; Boron Neutron Capture Therapy; Brain Neoplasms; Glioma; Humans; Male; Mannitol; Phenylalanine; Radiation-Sensitizing Agents; United Kingdom

2009
Neuropathological postmortem evaluation of BNCT for GBM.
    Acta neurologica Scandinavica, 2007, Volume: 116, Issue:3

    Topics: Aged; Boron Compounds; Boron Neutron Capture Therapy; Brain; Brain Neoplasms; Follow-Up Studies; Glioblastoma; Humans; Middle Aged; Phenylalanine; Radiotherapy Dosage; Treatment Outcome

2007
Boron neutron capture therapy for glioblastoma multiforme using p-boronophenylalanine and epithermal neutrons: trial design and early clinical results.
    Journal of neuro-oncology, 1997, Volume: 33, Issue:1-2

    Topics: Adult; Boron Compounds; Boron Neutron Capture Therapy; Brain; Brain Neoplasms; Glioblastoma; Humans; Magnetic Resonance Imaging; Neutrons; Nuclear Reactors; Phenylalanine; Tissue Distribution

1997
Boron neutron-capture therapy (BNCT) for glioblastoma multiforme (GBM) using the epithermal neutron beam at the Brookhaven National Laboratory.
    International journal of radiation oncology, biology, physics, 1998, Mar-01, Volume: 40, Issue:4

    Topics: Aged; Boron; Boron Compounds; Boron Neutron Capture Therapy; Brain Neoplasms; Dose-Response Relationship, Radiation; Feasibility Studies; Glioblastoma; Humans; Middle Aged; Phenylalanine; Radiation-Sensitizing Agents; Radiotherapy Dosage; Treatment Outcome

1998
A pharmacokinetic model for the concentration of 10B in blood after boronophenylalanine-fructose administration in humans.
    Radiation research, 2001, Volume: 155, Issue:4

    Topics: Adult; Aged; Boron; Boron Compounds; Boron Neutron Capture Therapy; Brain Neoplasms; Female; Fructose; Glioblastoma; Humans; Infusions, Intravenous; Male; Melanoma; Middle Aged; Models, Biological; Phenylalanine; Skin Neoplasms

2001

Other Studies

43 other study(ies) available for 4-boronophenylalanine and Brain Neoplasms

ArticleYear
Boron-containing polyamines as DNA targeting agents for neutron capture therapy of brain tumors: synthesis and biological evaluation.
    Journal of medicinal chemistry, 1997, Nov-21, Volume: 40, Issue:24

    Topics: Animals; Antineoplastic Agents; Boron Compounds; Boron Neutron Capture Therapy; Brain Neoplasms; DNA; Female; Glioma; Pregnancy; Rats; Rats, Inbred F344; Spermidine; Spermine; Structure-Activity Relationship; Tumor Cells, Cultured

1997
Cellular uptake evaluation of pentagamaboronon-0 (PGB-0) for boron neutron capture therapy (BNCT) against breast cancer cells.
    Investigational new drugs, 2019, Volume: 37, Issue:6

    Topics: Biological Transport; Boron Compounds; Boron Neutron Capture Therapy; Brain Neoplasms; Cell Line, Tumor; Cell Survival; Curcumin; Female; Humans; Phenylalanine; Radiation-Sensitizing Agents

2019
Glioblastoma, brain metastases and soft tissue sarcoma of extremities: candidate tumors for BNCT.
    Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine, 2014, Volume: 88

    Topics: Animals; Borohydrides; Boron Compounds; Brain Neoplasms; Cell Line, Tumor; Extremities; Glioblastoma; Humans; Male; Mice; Mice, Nude; Phenylalanine; Radiotherapy Dosage; Sarcoma; Sulfhydryl Compounds; Tissue Distribution

2014
Effects of l-DOPA pre-loading on the uptake of boronophenylalanine using the F98 glioma and B16 melanoma models.
    Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine, 2014, Volume: 88

    Topics: Animals; Boron Compounds; Brain Neoplasms; Drug Synergism; Female; Glioma; Levodopa; Melanoma; Metabolic Clearance Rate; Mice; Mice, Inbred C57BL; Organ Specificity; Phenylalanine; Premedication; Tissue Distribution; Treatment Outcome

2014
Pharmacokinetic analysis and uptake of 18F-FBPA-Fr after ultrasound-induced blood-brain barrier disruption for potential enhancement of boron delivery for neutron capture therapy.
    Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2014, Volume: 55, Issue:4

    Topics: Animals; Apoptosis; Blood-Brain Barrier; Boron Compounds; Brain Neoplasms; Drug Delivery Systems; Glioma; Glycopeptides; In Situ Nick-End Labeling; Male; Neoplasm Transplantation; Neutron Capture Therapy; Phenylalanine; Positron-Emission Tomography; Radiopharmaceuticals; Rats; Rats, Inbred F344; Ultrasonics

2014
From the laboratory to the clinic: How translational studies in animals have lead to clinical advances in boron neutron capture therapy.
    Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine, 2015, Volume: 106

    Topics: Animals; Boron Compounds; Boron Neutron Capture Therapy; Brain Neoplasms; Melanoma; Phenylalanine; Translational Research, Biomedical

2015
L-amino acid transporter-1 and boronophenylalanine-based boron neutron capture therapy of human brain tumors.
    Cancer research, 2009, Mar-01, Volume: 69, Issue:5

    Topics: Boron Compounds; Boron Neutron Capture Therapy; Brain Neoplasms; Cell Proliferation; Humans; Immunohistochemistry; Large Neutral Amino Acid-Transporter 1; Phenylalanine; Proliferating Cell Nuclear Antigen

2009
Boronophenylalanine uptake in C6 glioma model is dramatically increased by L-DOPA preloading.
    Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine, 2009, Volume: 67, Issue:7-8 Suppl

    Topics: Animals; Boron Compounds; Boron Neutron Capture Therapy; Brain Neoplasms; Cell Line, Tumor; Glioma; In Vitro Techniques; Levodopa; Magnetic Resonance Imaging; Male; Phenylalanine; Radiation-Sensitizing Agents; Rats; Rats, Wistar

2009
Dose distribution and clinical response of glioblastoma treated with boron neutron capture therapy.
    Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine, 2009, Volume: 67, Issue:7-8 Suppl

    Topics: Adult; Aged; Borohydrides; Boron Compounds; Boron Neutron Capture Therapy; Brain Neoplasms; Disease-Free Survival; Female; Glioblastoma; Humans; Male; Middle Aged; Neoplasm Recurrence, Local; Phenylalanine; Photons; Radiotherapy Dosage; Retrospective Studies; Sulfhydryl Compounds; Survival Rate; Treatment Failure

2009
Survival benefit from boron neutron capture therapy for the newly diagnosed glioblastoma patients.
    Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine, 2009, Volume: 67, Issue:7-8 Suppl

    Topics: Borohydrides; Boron Compounds; Boron Neutron Capture Therapy; Brain Neoplasms; Clinical Protocols; Combined Modality Therapy; Glioblastoma; Humans; Japan; Phenylalanine; Prognosis; Radiation-Sensitizing Agents; Sulfhydryl Compounds; Survival Rate

2009
Boron neutron capture therapy of EGFR or EGFRvIII positive gliomas using either boronated monoclonal antibodies or epidermal growth factor as molecular targeting agents.
    Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine, 2009, Volume: 67, Issue:7-8 Suppl

    Topics: Animals; Antibodies, Monoclonal; Boron Compounds; Boron Neutron Capture Therapy; Brain Neoplasms; Cell Line, Tumor; ErbB Receptors; Glioma; Head and Neck Neoplasms; Humans; Phenylalanine; Radiation-Sensitizing Agents; Radiometry; Rats; Rats, Inbred F344

2009
Boron neutron capture therapy induces apoptosis of glioma cells through Bcl-2/Bax.
    BMC cancer, 2010, Dec-02, Volume: 10

    Topics: Apoptosis; bcl-2-Associated X Protein; Blotting, Western; Boron Compounds; Boron Neutron Capture Therapy; Brain Neoplasms; Cell Line, Tumor; Cell Proliferation; Cell Shape; Cell Survival; Cobalt Radioisotopes; Dose-Response Relationship, Radiation; Flow Cytometry; Gamma Rays; Glioblastoma; Humans; Microscopy, Electron, Transmission; Neutrons; Phenylalanine; Proto-Oncogene Proteins c-bcl-2; Radiation-Sensitizing Agents; Time Factors

2010
Imaging of fluorine and boron from fluorinated boronophenylalanine in the same cell at organelle resolution by correlative ion microscopy and confocal laser scanning microscopy.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2002, Volume: 8, Issue:8

    Topics: Boron; Boron Compounds; Brain Neoplasms; Fluorine; Glioblastoma; Humans; Image Processing, Computer-Assisted; Ions; Microscopy, Confocal; Mitochondria; Models, Chemical; Phenylalanine; Radiation-Sensitizing Agents; Time Factors; Tomography, Emission-Computed; Tumor Cells, Cultured

2002
Long-term infusions of p-boronophenylalanine for boron neutron capture therapy: evaluation using rat brain tumor and spinal cord models.
    Radiation research, 2002, Volume: 158, Issue:6

    Topics: Animals; Boron Compounds; Boron Neutron Capture Therapy; Brain; Brain Neoplasms; Dose-Response Relationship, Radiation; Male; Phenylalanine; Radiation-Sensitizing Agents; Radiometry; Rats; Rats, Inbred F344; Spinal Cord; Time Factors; X-Rays

2002
Boron-containing nucleosides as potential delivery agents for neutron capture therapy of brain tumors.
    Cancer research, 2004, Sep-01, Volume: 64, Issue:17

    Topics: Animals; Boron Compounds; Boron Neutron Capture Therapy; Brain Neoplasms; Cell Division; Glioma; Humans; Male; Mice; Mice, Inbred C3H; Mice, Nude; Middle Aged; Phenylalanine; Phosphorylation; Rats; Rats, Inbred F344; Spectrometry, Mass, Secondary Ion; Subcellular Fractions; Thymidine; Thymidine Kinase

2004
Distribution of BPA and metabolic assessment in glioblastoma patients during BNCT treatment: a microdialysis study.
    Journal of neuro-oncology, 2005, Volume: 71, Issue:3

    Topics: Blood Glucose; Boron Compounds; Boron Neutron Capture Therapy; Brain; Brain Neoplasms; Glioblastoma; Humans; Microdialysis; Phenylalanine; Radiation-Sensitizing Agents

2005
Quantitative subcellular imaging of boron compounds in individual mitotic and interphase human glioblastoma cells with imaging secondary ion mass spectrometry (SIMS).
    Journal of microscopy, 2008, Volume: 229, Issue:Pt 1

    Topics: Boron; Boron Compounds; Boron Neutron Capture Therapy; Brain Neoplasms; Cell Line; Glioblastoma; Humans; Interphase; Mitosis; Phenylalanine; Spectrometry, Mass, Secondary Ion

2008
Cancer treatment. Will history repeat for boron capture therapy?
    Science (New York, N.Y.), 1994, Jul-22, Volume: 265, Issue:5171

    Topics: Animals; Boron Compounds; Boron Neutron Capture Therapy; Brain Neoplasms; Clinical Trials as Topic; Glioblastoma; Humans; Japan; Phenylalanine; Radiation-Sensitizing Agents; United States

1994
[Neutron capture therapy for cancer].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1994, Volume: 21, Issue:3

    Topics: Boron Compounds; Boron Neutron Capture Therapy; Brain Neoplasms; Humans; Infusions, Intravenous; Melanoma; Phenylalanine; Skin Neoplasms

1994
A nude rat model for neutron capture therapy of human intracerebral melanoma.
    International journal of radiation oncology, biology, physics, 1994, Mar-30, Volume: 28, Issue:5

    Topics: Animals; Boron Compounds; Boron Neutron Capture Therapy; Brain; Brain Neoplasms; Female; Humans; Male; Melanoma; Mice; Middle Aged; Neoplasm Transplantation; Phenylalanine; Rats; Rats, Nude; Tumor Cells, Cultured

1994
The pharmacokinetics of p-Boronophenylalanine.fructose in human patients with glioma and metastatic melanoma.
    International journal of radiation oncology, biology, physics, 1994, Mar-30, Volume: 28, Issue:5

    Topics: Boron; Boron Compounds; Boron Neutron Capture Therapy; Brain Neoplasms; Glioma; Humans; Melanoma; Phenylalanine; Radiation-Sensitizing Agents

1994
Boron neutron capture therapy of intracerebral melanoma using boronophenylalanine as a capture agent.
    Cancer research, 1993, Jul-15, Volume: 53, Issue:14

    Topics: Animals; Boron; Boron Compounds; Boron Neutron Capture Therapy; Brain; Brain Neoplasms; Cell Survival; Humans; Male; Melanoma; Middle Aged; Phenylalanine; Radiation-Sensitizing Agents; Radiotherapy Dosage; Rats; Rats, Nude; Tissue Distribution

1993
Hydroxylforms of p-boronophenylalanine as potential boron carriers on boron neutron capture therapy for malignant brain tumors.
    Cancer research, 1996, May-01, Volume: 56, Issue:9

    Topics: Animals; Boron Compounds; Boron Neutron Capture Therapy; Brain Neoplasms; Cell Survival; Glioma; Humans; Hydroxylation; Male; Phenylalanine; Radiation-Sensitizing Agents; Rats; Rats, Inbred F344

1996
Enhanced delivery of boronophenylalanine for neutron capture therapy by means of intracarotid injection and blood-brain barrier disruption.
    Neurosurgery, 1996, Volume: 38, Issue:5

    Topics: Animals; Blood-Brain Barrier; Boron Compounds; Brain; Brain Neoplasms; Carotid Arteries; Dominance, Cerebral; Glioma; Injections, Intra-Arterial; Mannitol; Neoplasm Transplantation; Neutron Capture Therapy; Phenylalanine; Radiation-Sensitizing Agents; Rats; Rats, Inbred F344; Tissue Distribution; Tumor Cells, Cultured

1996
Boron neutron capture therapy of brain tumors: enhanced survival following intracarotid injection of either sodium borocaptate or boronophenylalanine with or without blood-brain barrier disruption.
    Cancer research, 1997, Mar-15, Volume: 57, Issue:6

    Topics: Alpha Particles; Animals; Blood-Brain Barrier; Borohydrides; Boron Compounds; Boron Neutron Capture Therapy; Brain; Brain Neoplasms; Carotid Arteries; Glioma; Injections, Intra-Arterial; Mannitol; Phenylalanine; Rats; Rats, Inbred F344; Sulfhydryl Compounds

1997
Enhanced survival of glioma bearing rats following boron neutron capture therapy with blood-brain barrier disruption and intracarotid injection of boronophenylalanine.
    Journal of neuro-oncology, 1997, Volume: 33, Issue:1-2

    Topics: Animals; Blood-Brain Barrier; Boron Compounds; Boron Neutron Capture Therapy; Brain Neoplasms; Carotid Arteries; Fructose; Glioma; Humans; Infusions, Intra-Arterial; Injections, Intra-Arterial; Male; Mannitol; Phenylalanine; Rats; Rats, Inbred F344; Survival Rate; Tissue Distribution

1997
Evaluation of fluorine-18-BPA-fructose for boron neutron capture treatment planning.
    Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 1997, Volume: 38, Issue:11

    Topics: Boron Compounds; Boron Neutron Capture Therapy; Brain Neoplasms; Female; Fluorine Radioisotopes; Fructose; Glioblastoma; Humans; Middle Aged; Phenylalanine; Radiation-Sensitizing Agents; Tomography, Emission-Computed

1997
Fluorine-18-labeled fluoroboronophenylalanine PET in patients with glioma.
    Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 1998, Volume: 39, Issue:2

    Topics: Astrocytoma; Boron Compounds; Brain Neoplasms; Cerebrovascular Circulation; Fluorine Radioisotopes; Glioblastoma; Glioma; Humans; Phenylalanine; Radiopharmaceuticals; Tomography, Emission-Computed

1998
Biodistribution of p-boronophenylalanine in patients with glioblastoma multiforme for use in boron neutron capture therapy.
    Neurosurgery, 1998, Volume: 42, Issue:3

    Topics: Boron Compounds; Brain; Brain Neoplasms; Craniotomy; Glioblastoma; Humans; Injections, Intravenous; Neutron Capture Therapy; Osmolar Concentration; Phenylalanine; Radiation-Sensitizing Agents; Scalp; Tissue Distribution

1998
Enhanced delivery of boronophenylalanine for neutron capture therapy of brain tumors using the bradykinin analog Cereport (Receptor-Mediated Permeabilizer-7).
    Neurosurgery, 1999, Volume: 44, Issue:2

    Topics: Animals; Boron Compounds; Boron Neutron Capture Therapy; Bradykinin; Brain Neoplasms; Carotid Arteries; Dose-Response Relationship, Drug; Glioma; Injections, Intra-Arterial; Injections, Intravenous; Phenylalanine; Radiation-Sensitizing Agents; Rats; Rats, Inbred F344; Tissue Distribution

1999
Effect of dose and infusion time on the delivery of p-boronophenylalanine for neutron capture therapy.
    Journal of neuro-oncology, 1999, Volume: 41, Issue:3

    Topics: Animals; Boron Compounds; Boron Neutron Capture Therapy; Brain Neoplasms; Glioblastoma; Gliosarcoma; Infusions, Intravenous; Metabolic Clearance Rate; Phenylalanine; Radiation-Sensitizing Agents; Rats; Tissue Distribution; Tumor Cells, Cultured

1999
Boron self-shielding effects on dose delivery of neutron capture therapy using epithermal beam and boronophenylalanine.
    Medical physics, 1999, Volume: 26, Issue:11

    Topics: Boron Compounds; Boron Neutron Capture Therapy; Brain Neoplasms; Humans; Models, Statistical; Monte Carlo Method; Phantoms, Imaging; Phenylalanine; Radiation Protection; Radiation-Sensitizing Agents; Radiotherapy Dosage

1999
Postmortem neuropathological features secondary to boron neutron capture therapy for glioblastoma multiforme.
    Journal of neuropathology and experimental neurology, 2000, Volume: 59, Issue:1

    Topics: Adult; Aged; Boron Compounds; Boron Neutron Capture Therapy; Brain; Brain Neoplasms; Dose-Response Relationship, Radiation; Female; Glioblastoma; Humans; Lewy Bodies; Male; Middle Aged; Nerve Degeneration; Neurofibrillary Tangles; Neurons; Phenylalanine; Radiation-Sensitizing Agents

2000
Boron neutron capture therapy of brain tumors: enhanced survival and cure following blood-brain barrier disruption and intracarotid injection of sodium borocaptate and boronophenylalanine.
    International journal of radiation oncology, biology, physics, 2000, Apr-01, Volume: 47, Issue:1

    Topics: Animals; Blood-Brain Barrier; Borohydrides; Boron Compounds; Boron Neutron Capture Therapy; Brain; Brain Neoplasms; Drug Screening Assays, Antitumor; Drug Therapy, Combination; Glioma; Injections, Intra-Arterial; Phenylalanine; Radiation-Sensitizing Agents; Radiobiology; Radiotherapy Dosage; Rats; Rats, Inbred F344; Sulfhydryl Compounds; Time Factors

2000
Improved survival after boron neutron capture therapy of brain tumors by Cereport-mediated blood-brain barrier modulation to enhance delivery of boronophenylalanine.
    Neurosurgery, 2000, Volume: 47, Issue:1

    Topics: Animals; Blood-Brain Barrier; Boron Compounds; Boron Neutron Capture Therapy; Bradykinin; Brain Neoplasms; Glioma; Phenylalanine; Radiation-Sensitizing Agents; Rats; Rats, Inbred F344; Survival Rate; Tissue Distribution

2000
Boron neutron capture therapy of brain tumors: functional and neuropathologic effects of blood-brain barrier disruption and intracarotid injection of sodium borocaptate and boronophenylalanine.
    Journal of neuro-oncology, 2000, Volume: 48, Issue:3

    Topics: Animals; Blood-Brain Barrier; Borohydrides; Boron Compounds; Boron Neutron Capture Therapy; Brain; Brain Neoplasms; Carotid Artery, Internal; Cerebral Hemorrhage; Cognition; Eye; Eye Diseases; Injections, Intra-Arterial; Male; Motor Activity; Neurotoxins; Neutrons; Phenylalanine; Radiation-Sensitizing Agents; Rats; Rats, Inbred F344; Sulfhydryl Compounds; Tissue Distribution

2000
Quantitative imaging and microlocalization of boron-10 in brain tumors and infiltrating tumor cells by SIMS ion microscopy: relevance to neutron capture therapy.
    Cancer research, 2001, Nov-15, Volume: 61, Issue:22

    Topics: Animals; Boron; Boron Compounds; Boron Neutron Capture Therapy; Brain Neoplasms; Drug Administration Schedule; Gliosarcoma; Infusions, Intravenous; Isotopes; Male; Phenylalanine; Rats; Rats, Inbred F344; Spectrometry, Mass, Secondary Ion

2001
Effect of boron neutron capture therapy for melanotic and amelanotic melanoma transplanted into mouse brain.
    Pigment cell research, 2002, Volume: 15, Issue:1

    Topics: Animals; Boron; Boron Compounds; Boron Neutron Capture Therapy; Brain; Brain Neoplasms; Isotopes; Melanins; Melanoma, Amelanotic; Melanoma, Experimental; Mice; Mice, Inbred C57BL; Neoplasm Transplantation; Phenylalanine; Radiation-Sensitizing Agents; Tumor Cells, Cultured

2002
Neutron capture therapy of intracerebral melanoma: enhanced survival and cure after blood-brain barrier opening to improve delivery of boronophenylalanine.
    International journal of radiation oncology, biology, physics, 2002, Mar-01, Volume: 52, Issue:3

    Topics: Animals; Blood-Brain Barrier; Boron Compounds; Boron Neutron Capture Therapy; Bradykinin; Brain Neoplasms; Humans; Mannitol; Melanoma; Osmosis; Phenylalanine; Radiation-Sensitizing Agents; Rats; Rats, Nude

2002
Boron neutron capture therapy for murine malignant gliomas.
    Cancer research, 1992, Sep-01, Volume: 52, Issue:17

    Topics: Animals; Boron Compounds; Brain; Brain Neoplasms; Glioma; Mice; Mice, Inbred C57BL; Neutrons; Phenylalanine; Radiation-Sensitizing Agents; Survival Analysis

1992
Control of intracerebral gliosarcomas in rats by boron neutron capture therapy with p-boronophenylalanine.
    Radiation research, 1992, Volume: 129, Issue:3

    Topics: Animals; Boron Compounds; Brain Neoplasms; Glioma; Male; Neoplasm Transplantation; Neutrons; Phenylalanine; Rats; Rats, Inbred F344

1992
Boron neutron capture therapy for cancer.
    Scientific American, 1990, Volume: 263, Issue:4

    Topics: Alpha Particles; Animals; Antibodies, Monoclonal; Boron; Boron Compounds; Brain Neoplasms; Glioblastoma; Humans; Immunotoxins; Isotopes; Melanoma; Mice; Neoplasms; Neutrons; Phenylalanine; Radiation Dosage

1990
Selective delivery of boron by the melanin precursor analogue p-boronophenylalanine to tumors other than melanoma.
    Cancer research, 1990, Jan-01, Volume: 50, Issue:1

    Topics: Animals; Boron Compounds; Brain Neoplasms; Cell Line; Drug Carriers; Glioma; Humans; Isotopes; Mammary Neoplasms, Experimental; Mice; Mice, Inbred BALB C; Mice, Nude; Neutrons; Phenylalanine; Rats; Tissue Distribution; Transplantation, Heterologous

1990