4-amylcinnamoylanthranilic-acid and Zika-Virus-Infection

Targeting a universal host protein exploited by most viruses would be a game-changing strategy that offers broad-spectrum solution and rapid pandemic control including the current COVID-19. Here, we found a common YxxØ-motif of multiple viruses that exploits host AP2M1 for intracellular trafficking. A library chemical,

Topics: A549 Cells; Adaptor Proteins, Vesicular Transport; Animals; Antiviral Agents; Betacoronavirus; Binding Sites; Cell Line, Tumor; Chlorocebus aethiops; Cinnamates; Coronavirus Infections; COVID-19; Dogs; HEK293 Cells; HIV Infections; HIV-1; Host-Pathogen Interactions; Humans; Influenza A virus; Influenza, Human; Madin Darby Canine Kidney Cells; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Knockout; Middle East Respiratory Syndrome Coronavirus; ortho-Aminobenzoates; Pandemics; Pneumonia, Viral; Protein Binding; Protein Transport; Receptor, Interferon alpha-beta; RNA, Viral; SARS-CoV-2; Transforming Growth Factor beta1; Vero Cells; Virus Replication; Zika Virus; Zika Virus Infection