Compounds > 4-aminoquinoline
Page last updated: 2024-08-24

4-aminoquinoline and Malaria, Falciparum

4-aminoquinoline has been researched along with Malaria, Falciparum in 19 studies

Research

Studies (19)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's2 (10.53)18.2507
2000's4 (21.05)29.6817
2010's12 (63.16)24.3611
2020's1 (5.26)2.80

Authors

AuthorsStudies
Chibale, K; Egan, TJ; Kuter, D; Nsumiwa, S; Wittlin, S1
Aderibigbe, BA; Nqoro, X1
Gut, J; Kumar, V; Rani, A; Rosenthal, PJ; Singh, A1
Agarwal, D; Awasthi, SK; Gupta, RD; Singh, S1
Chauhan, K; Chauhan, PM; Puri, SK; Saxena, JK; Sharma, M; Singh, SV; Srivastava, K; Srivastava, RK1
Castellà, S; Clos, MV; Fairlamb, AH; Galdeano, C; Gbedema, SY; Jones, DC; Kelly, JM; Muñoz-Torrero, D; Pérez, B; Sola, I; Taylor, MC; Viayna, E; Wright, CW1
Chibale, K; Egan, TJ; Jurva, U; Masimirembwa, CM; Njoroge, M; Ongarora, DS; Strydom, N; Wicht, K; Wiesner, L; Wittlin, S1
Callaghan, PS; Combrinck, JM; Dhingra, SK; Egan, TJ; Fidock, DA; Gabryszewski, SJ; Gnädig, NF; Hassett, MR; Henrich, PP; Lee, AH; Lewis, IA; Llinás, M; Musset, L; Roepe, PD; Siriwardana, A1
Katti, SB; Kondaparla, S; Manhas, A; Puri, SK; Soni, A; Srivastava, K1
Alumasa, J; de Dios, AC; Ekoue-Kovi, K; Iwaniuk, DP; Roepe, PD; Rosa, N; Whetmore, ED; Wolf, C1
Biot, C; Dal-Bianco, MP; Filali-Ansary, A; Issifou, S; Kremsner, PG; Lell, B; Mazuir, F; Mombo-Ngoma, G; Ospina Salazar, CL; Ramharter, M; Supan, C; Ter-Minassian, D1
Bjorkman, A; Cavaco, I; Gil, JP; Msellem, MI; Piedade, R1
Barho, M; Ortmann, R; Schlitzer, M; Schrader, FC; Steiner, I1
Khan, SI; Manohar, S; Rawat, DS1
Casey, GJ; Cowman, AF; Genton, B; Ginny, M; Mueller, I; Reeder, JC; Uranoli, M1
Björkman, A; Hwaihwanje, I; Kaneko, A; Kobayakawa, T; Mita, T; Osawa, H; Takahashi, N; Tanabe, K; Tsukahara, T1
Carme, B1
Adedeji, AA; Falade, AG; Falade, CO; Sowunmi, A1
Bauchet, J; Hatin, I; Le Bras, J; Legros, F; Trape, JF1

Reviews

1 review(s) available for 4-aminoquinoline and Malaria, Falciparum

ArticleYear
The antimalarial pipeline--an update.
    International journal of medical microbiology : IJMM, 2012, Volume: 302, Issue:4-5

    Topics: Aminoquinolines; Animals; Antimalarials; Clinical Trials as Topic; Drug Combinations; Drug Evaluation, Preclinical; Drug Resistance; Humans; Inhibitory Concentration 50; Malaria, Falciparum; Plasmodium falciparum

2012

Other Studies

18 other study(ies) available for 4-aminoquinoline and Malaria, Falciparum

ArticleYear
Structure-activity relationships for ferriprotoporphyrin IX association and β-hematin inhibition by 4-aminoquinolines using experimental and ab initio methods.
    Bioorganic & medicinal chemistry, 2013, Jul-01, Volume: 21, Issue:13

    Topics: Aminoquinolines; Antimalarials; Hemeproteins; Hemin; Humans; Malaria, Falciparum; Models, Molecular; Plasmodium falciparum; Structure-Activity Relationship

2013
4-Aminoquinoline-ferrocene Hybrids as Potential Antimalarials.
    Recent patents on anti-infective drug discovery, 2020, Volume: 15, Issue:2

    Topics: Aminoquinolines; Antimalarials; Drug Evaluation, Preclinical; Ferrous Compounds; Humans; Inhibitory Concentration 50; Malaria, Falciparum; Metallocenes; Parasitic Sensitivity Tests; Patents as Topic; Plasmodium falciparum

2020
Piperazine-linked 4-aminoquinoline-chalcone/ferrocenyl-chalcone conjugates: Synthesis and antiplasmodial evaluation.
    Chemical biology & drug design, 2017, Volume: 90, Issue:4

    Topics: Aminoquinolines; Antimalarials; Chalcone; Chloroquine; Drug Resistance; Ferrous Compounds; HeLa Cells; Humans; Malaria, Falciparum; Piperazines; Plasmodium falciparum

2017
In vitro synergistic interaction of potent 4-aminoquinolines in combination with dihydroartemisinin against chloroquine-resistant Plasmodium falciparum.
    Acta tropica, 2019, Volume: 199

    Topics: Aminoquinolines; Antimalarials; Artemisinins; Chloroquine; Drug Resistance; Drug Synergism; Drug Therapy, Combination; Humans; Malaria, Falciparum; Plasmodium falciparum

2019
Design and synthesis of a new class of 4-aminoquinolinyl- and 9-anilinoacridinyl Schiff base hydrazones as potent antimalarial agents.
    Chemical biology & drug design, 2014, Volume: 84, Issue:2

    Topics: Acridines; Aminoquinolines; Animals; Antimalarials; Chlorocebus aethiops; Hydrazones; Malaria, Falciparum; Male; Mice; Plasmodium falciparum; Schiff Bases; Vero Cells

2014
Synthesis, biological profiling and mechanistic studies of 4-aminoquinoline-based heterodimeric compounds with dual trypanocidal-antiplasmodial activity.
    Bioorganic & medicinal chemistry, 2015, Aug-15, Volume: 23, Issue:16

    Topics: Aminoquinolines; Animals; Antimalarials; Brain; Cell Line; Dimerization; Hemeproteins; Humans; Malaria, Falciparum; NADH, NADPH Oxidoreductases; Plasmodium falciparum; Rats; Trypanocidal Agents; Trypanosoma brucei brucei; Trypanosomiasis, African

2015
Antimalarial benzoheterocyclic 4-aminoquinolines: Structure-activity relationship, in vivo evaluation, mechanistic and bioactivation studies.
    Bioorganic & medicinal chemistry, 2015, Sep-01, Volume: 23, Issue:17

    Topics: Aminoquinolines; Animals; Antimalarials; Benzene Derivatives; Humans; Malaria; Malaria, Falciparum; Mice; Mice, Inbred C57BL; Plasmodium berghei; Plasmodium falciparum; Structure-Activity Relationship

2015
Evolution of Fitness Cost-Neutral Mutant PfCRT Conferring P. falciparum 4-Aminoquinoline Drug Resistance Is Accompanied by Altered Parasite Metabolism and Digestive Vacuole Physiology.
    PLoS pathogens, 2016, Volume: 12, Issue:11

    Topics: Aminoquinolines; Antimalarials; Drug Resistance; Genetic Fitness; Genotype; Humans; Malaria, Falciparum; Mass Spectrometry; Membrane Transport Proteins; Microbial Sensitivity Tests; Mutation; Plasmodium falciparum; Protozoan Proteins; Vacuoles

2016
Antimalarial activity of novel 4-aminoquinolines active against drug resistant strains.
    Bioorganic chemistry, 2017, Volume: 70

    Topics: Aminoquinolines; Animals; Antimalarials; Chlorocebus aethiops; Drug Discovery; Drug Resistance; Humans; Malaria; Malaria, Falciparum; Mice; Parasitic Sensitivity Tests; Plasmodium falciparum; Plasmodium yoelii; Vero Cells

2017
Synthesis and antimalarial activity of new chloroquine analogues carrying a multifunctional linear side chain.
    Bioorganic & medicinal chemistry, 2009, Sep-15, Volume: 17, Issue:18

    Topics: Aminoquinolines; Animals; Antimalarials; Chloroquine; Inhibitory Concentration 50; Malaria, Falciparum; Parasitic Sensitivity Tests; Plasmodium falciparum

2009
Pharmacokinetics of ferroquine, a novel 4-aminoquinoline, in asymptomatic carriers of Plasmodium falciparum infections.
    Antimicrobial agents and chemotherapy, 2012, Volume: 56, Issue:6

    Topics: Adolescent; Adult; Aminoquinolines; Antimalarials; Clinical Trials, Phase I as Topic; Ferrous Compounds; Humans; Malaria, Falciparum; Male; Metallocenes; Models, Statistical; Plasmodium falciparum; Young Adult

2012
Cytochrome 1A1 and 1B1 gene diversity in the Zanzibar islands.
    Tropical medicine & international health : TM & IH, 2012, Volume: 17, Issue:7

    Topics: Alleles; Aminoquinolines; Antimalarials; Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 CYP1A1; Cytochrome P-450 CYP1B1; Female; Genetic Variation; Genotype; Geography; Humans; Malaria, Falciparum; Male; Pharmacogenetics; Polymorphism, Genetic; Tanzania; Young Adult

2012
4-aminoquinoline-triazine-based hybrids with improved in vitro antimalarial activity against CQ-sensitive and CQ-resistant strains of Plasmodium falciparum.
    Chemical biology & drug design, 2013, Volume: 81, Issue:5

    Topics: Aminoquinolines; Animals; Antimalarials; Chlorocebus aethiops; Chloroquine; Drug Resistance; Hep G2 Cells; Humans; Malaria, Falciparum; Plasmodium falciparum; Triazines; Vero Cells

2013
Molecular analysis of Plasmodium falciparum from drug treatment failure patients in Papua New Guinea.
    The American journal of tropical medicine and hygiene, 2004, Volume: 70, Issue:3

    Topics: Aminoquinolines; Amodiaquine; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Chloroquine; Drug Resistance; Humans; Malaria, Falciparum; Membrane Proteins; Membrane Transport Proteins; Papua New Guinea; Plasmodium falciparum; Polymorphism, Genetic; Protozoan Proteins; Treatment Failure

2004
Rapid selection of dhfr mutant allele in Plasmodium falciparum isolates after the introduction of sulfadoxine/pyrimethamine in combination with 4-aminoquinolines in Papua New Guinea.
    Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases, 2006, Volume: 6, Issue:6

    Topics: Alleles; Aminoquinolines; Animals; Dihydropteroate Synthase; Drug Combinations; Drug Resistance, Multiple; Drug Therapy, Combination; Humans; Malaria, Falciparum; Mutation; Papua New Guinea; Plasmodium falciparum; Polymorphism, Genetic; Pyrimethamine; Selection, Genetic; Sulfadoxine; Tetrahydrofolate Dehydrogenase

2006
[Antimalarial measures in expatriates in the Congo. Trends 1989-1992].
    Annales de la Societe belge de medecine tropicale, 1993, Volume: 73, Issue:2

    Topics: Adult; Aminoquinolines; Antimalarials; Child; Child, Preschool; Congo; Ethnicity; Female; Health Knowledge, Attitudes, Practice; Humans; Malaria, Falciparum; Male; Patient Compliance; Phenanthrenes; Surveys and Questionnaires

1993
Comparative clinical characteristics and responses to oral 4-aminoquinoline therapy of malarious children who did and did not develop 4-aminoquinoline-induced pruritus.
    Annals of tropical medicine and parasitology, 2001, Volume: 95, Issue:7

    Topics: Acute Disease; Adolescent; Aminoquinolines; Animals; Antimalarials; Child; Child, Preschool; Drug Eruptions; Hepatomegaly; Humans; Infant; Malaria, Falciparum; Parasitemia; Plasmodium falciparum; Prospective Studies; Pruritus; Treatment Outcome

2001
Susceptibility of Plasmodium falciparum strains to mefloquine in an urban area in Senegal.
    Bulletin of the World Health Organization, 1992, Volume: 70, Issue:3

    Topics: Adolescent; Adult; Aminoquinolines; Animals; Antimalarials; Child; Child, Preschool; Chloroquine; Humans; In Vitro Techniques; Infant; Malaria, Falciparum; Mefloquine; Phenanthrenes; Plasmodium falciparum

1992